Sedation of Critically III Patients during Mechanical Ventilation: A Comparison of Propofol and Midazolam

American Journal of Respiratory and Critical Care Medicine

Volumn 153, Issue 3, 1996, Pages 1012-1018

  Kress, John P ^a   O'Connor, Michael F ^a   Pohlman, Anne S ^a   Olson, David ^a   Lavoie, Annick ^a   Toledano, Alicia ^a   Hall, Jesse B ^a,b  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF CHICAGO MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MIDAZOLAM; MORPHINE; PROPOFOL;

ADULT; AGED; ARTICLE; ARTIFICIAL VENTILATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CRITICAL ILLNESS; DRUG EFFICACY; DRUG SCREENING; FEMALE; HUMAN; INTENSIVE CARE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY FAILURE; SEDATION;

APACHE; CONSCIOUS SEDATION; CRITICAL ILLNESS; FEMALE; HUMANS; HYPNOTICS AND SEDATIVES; INFUSIONS, INTRAVENOUS; MALE; MIDAZOLAM; MIDDLE AGED; OBSERVER VARIATION; OXYGEN CONSUMPTION; PATIENTS' ROOMS; PROPOFOL; PROSPECTIVE STUDIES; PSYCHOMOTOR PERFORMANCE; REPRODUCIBILITY OF RESULTS; RESPIRATION, ARTIFICIAL; SINGLE-BLIND METHOD; TIME FACTORS; WAKEFULNESS;

EID: 0030012049     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.153.3.8630539     Document Type: Article

References (25)

1. Bailie, G. R., I. D. Cockshott, E. J. Douglas, and B. J. M. Bowles. 1992. Pharmacokinetics of propofol during and after long term continuous infusion for maintenance of sedation in ICU patients. B. J. Anaesth. 68:486-491.
2. Albanese, J., C. Martin, B. Lacarelle, P. Saux, A. Durand, and F. Gouin. 1990. Pharmacokinetics of long-term propofol infusion used for sedation in ICU patients. Anesthesiology 73:214-217.
3. Snellen, F., P. Lauwers, R. Demeyere, G. Byttebier, and H. Van Aken. 1990. The use of midazolam versus propofol for short-term sedation following coronary artery bypass grafting. Intensive Care Med. 16: 312-316.
4. Carrasco, G., R. Molina, J. Costa, J. M. Soler, and L. Cabre. 1993. Propofol vs midazolam in short-, medium-, and long-term sedation of critically ill patients. Chest 103:557-564.
5. Aitkenhead, A. R., S. M. Willatts, G. R. Park, C. H. Collins, I. M. Ledingham, M. L. Pepperman, P. D. Coates, A. R. Bodenham, M. B. Smith, and P. G. M. Wallace. 1989. Comparison of propofol and midazolam for sedation in critically ill patients. Lancet 2:704-709.
6. Bennett, S. N., M. M. McNeil, L. A. Bland, M. J. Arduino, M. E. Villarino, D. M. Perrotta, D. A. Burwen, S. F. Wellbel, D. A. Pegues, P. S. Zeitz, and W. A. Jarvis. 1995. Postoperative infections traced to contamination of an intravenous anesthetic, propofol. N. Engl. J. Med. 333:147-154.
7. Pohlman, A. S., K. P. Simpson, and J. B. Hall. 1994. Continuous intravenous infusions of lorazepam versus midazolam for sedation during mechanical ventilatory support: a prospective, randomized study. Crit. Care Med. 22:1241-1247.
8. Higgins, T. L., J. P. Yared, F. G. Estafanous, J. P. Coyle, H. K. Ko, and D. B. Goodale. 1994. Propofol versus midazolam for intensive care unit sedation after coronary artery bypass grafting. Crit. Care Med. 22:1415-1423.
9. Beller, J. P., T. Pottecher, A. Lugnier, P. Mangin, and J. C. Otteni. 1988. Prolonged sedation with propofol in ICU patients: recovery and blood concentration changes during periodic interruptions in infusion. Br. J. Anaesth. 61:583-588.
10. Bion, J. F., B. K. Logan, P. M. Newman, M. J. Brodie, J. S. Oliver, T. C. Aitchison, and I. McA. Ledingham. 1986. Sedation in intensive care: morphine and renal function. Intensive Care Med. 12:359-365.
11. Moritz, F., J. Petit, N. Kaeffer, G. Oksenhendler, H. Papion, B. Hecketsweiler, N. Moore, and C. Winckler. 1993. Metabolic effects of propofol and flunitrazepam given for sedation after aortic surgery. Br. J. Anaesth. 70:451-453.
12. Harding, J., M. Kemper, and C. Weissman. 1994. Midazolam attenuates the metabolic and cardiopulmonary responses to an acute increase in oxygen demand. Chest 106:194-200.
13. Nimmo, G. R., S. J. Mackenzie, and I. S. Grant. 1994. Hemodynamic and oxygen transport effects of propofol infusion in critically ill adults. Anaesthesia 49:485-489.
14. Sivam, S. P., and I. K. Ho. 1985. GABA in morphine analgesia and tolerance. Life Sci. 37:199-208.
15. Newman, L. H., J. C. McDonald, P. G. M. Wallace, and I. M. Ledingham. 1987. Propofol infusion for sedation in intensive care. Anaesthesia 42:929-937.
16. Harris, C. E., R. M. Grounds, A. M. Murray, J. Lumley, D. Royston, and M. Morgan. 1990. Propofol for long-term sedation in the intensive care unit. Anaesthesia 45:366-372.
17. Shelly, M. P., L. Mendel, and G. R. Park. 1987. Failure of critically ill patients to metabolise midazolam. Anaesthesia 42:619-626.
18. Byatt, C. M., L. D. Lewis, S. Dawling, and G. M. Cochrane. 1984. Accumulation of midazolam after repeated dosage in patients receiving mechanical ventilation in an intensive care unit. B.M.J. 289: 799-800.
19. Rockaerts, P., F. Huygen, and S. de Lange. 1993. Infusion of propofol versus midazolam for sedation in the intensive care unit following coronary artery surgery. J. Cardiothorac. Vasc. Anesth. 7:142-147.
20. Ronan, K. P., T. J. Gallagher, B. George, and B. Hamby. 1995. Comparison of propofol and midazolam for sedation in intensive care unit patients. Crit. Care Med. 23:286-293.
21. Grounds, R. M., J. M. Lalor, J. Lumley, D. Royston, and M. Morgan. 1987. Propofol infusion for sedation in the intensive care unit: preliminary report. B.M.J. 294:397-400.
22. McMurray, T. J., P. S. Collier, I. W. Carson, S. M. Lyons, and P. Elliot. 1990. Propofol sedation after open heart surgery: a clinical and pharmacokinetic study. Anaesthesia 45:322-326.
23. Dundee, J. W., I. O. Samuel, W. Toner, and P. J. Howard. 1980. Midazolam: a water-soluble benzodiazepine. Studies in volunteers. Anesthesia 35:454-458.
24. Manthous, C. A., J. B. Hall, D. Olson, M. Singh, W. Chatila, A. Pohlman, R. Kushner, G. A. Schmidt, and L. D. H. Wood. 1995. Effect of cooling on oxygen consumption in febrile critically ill patients. Am. J. Respir. Crit. Care Med. 151:10-14.
25. Ramsey, M. A. E., T. M. Savege, B. R. J. Simpson, and R. Goodwin. 1974. Controlled sedation with alphalaxone-alphadolone. B.M.J. 2: 256-259.