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Volumn 73, Issue 12, 2014, Pages 2199-2207

TLR9 independent interferon α production by neutrophils on NETosis in response to circulating chromatin, a key lupus autoantigen

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; AUTOANTIGEN; CHROMATIN; TOLL LIKE RECEPTOR 9;

EID: 84883588616     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2012-203041     Document Type: Article
Times cited : (74)

References (45)
  • 1
    • 0027477318 scopus 로고
    • Nucleosome: A major immunogen for pathogenic autoantibody-inducing T cells of lupus
    • Mohan C, Adams S, Stanik V, et al. Nucleosome: a major immunogen for pathogenic autoantibody-inducing T cells of lupus. J Exp Med 1993;177:1367-81.
    • (1993) J Exp Med , vol.177 , pp. 1367-1381
    • Mohan, C.1    Adams, S.2    Stanik, V.3
  • 2
    • 0016687530 scopus 로고
    • Electron microscopic and biochemical evidence that chromatin structure is a repeating unit
    • Oudet P, Gross-Bellard M, Chambon P. Electron microscopic and biochemical evidence that chromatin structure is a repeating unit. Cell 1975;4:281-300.
    • (1975) Cell , vol.4 , pp. 281-300
    • Oudet, P.1    Gross-Bellard, M.2    Chambon, P.3
  • 3
    • 1842411320 scopus 로고    scopus 로고
    • Crystal structure of the nucleosome core particle at 2.8 A resolution
    • Luger K, Mader AW, Richmond RK, et al. Crystal structure of the nucleosome core particle at 2.8 A resolution. Nature 1997;389:251-60.
    • (1997) Nature , vol.389 , pp. 251-260
    • Luger, K.1    Mader, A.W.2    Richmond, R.K.3
  • 4
    • 70449094641 scopus 로고    scopus 로고
    • PPAR-delta senses and orchestrates clearance of apoptotic cells to promote tolerance
    • Mukundan L, Odegaard JI, Morel CR, et al. PPAR-delta senses and orchestrates clearance of apoptotic cells to promote tolerance. Nat Med 2009;15:1266-72.
    • (2009) Nat Med , vol.15 , pp. 1266-1272
    • Mukundan, L.1    Odegaard, J.I.2    Morel, C.R.3
  • 5
    • 34249780122 scopus 로고    scopus 로고
    • Circulating nucleosomes due to a defective clearance of dying cells: Consequences for systemic lupus erythematosus
    • Erbacher AI, Rönnefarth VM, Decker P. Circulating nucleosomes due to a defective clearance of dying cells: consequences for systemic lupus erythematosus. Autoimmunity 2007;40:311-4.
    • (2007) Autoimmunity , vol.40 , pp. 311-314
    • Erbacher, A.I.1    Rönnefarth, V.M.2    Decker, P.3
  • 6
    • 33748447541 scopus 로고    scopus 로고
    • Type I interferon in systemic lupus erythematosus and other autoimmune diseases
    • Banchereau J, Pascual V. Type I interferon in systemic lupus erythematosus and other autoimmune diseases. Immunity 2006;25:383-92.
    • (2006) Immunity , vol.25 , pp. 383-392
    • Banchereau, J.1    Pascual, V.2
  • 7
    • 0019972228 scopus 로고
    • Systemic lupus erythematosus: Presence in human serum of an unusual acid-labile leukocyte interferon
    • Preble OT, Black RJ, Friedman RM, et al . Systemic lupus erythematosus: presence in human serum of an unusual acid-labile leukocyte interferon. Science 1982;216:429-31.
    • (1982) Science , vol.216 , pp. 429-431
    • Preble, O.T.1    Black, R.J.2    Friedman, R.M.3
  • 8
    • 0035900481 scopus 로고    scopus 로고
    • Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus
    • Blanco P, Palucka AK, Gill M, et al. Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus. Science 2001;294:1540-3.
    • (2001) Science , vol.294 , pp. 1540-1543
    • Blanco, P.1    Palucka, A.K.2    Gill, M.3
  • 9
    • 82755187763 scopus 로고    scopus 로고
    • IFN-alpha and CD46 stimulation are associated with active lupus and skew natural T regulatory cell differentiation to type 1 regulatory T (Tr1) cells
    • Le Buanec H, Gougeon ML, Mathian A, et al. IFN-alpha and CD46 stimulation are associated with active lupus and skew natural T regulatory cell differentiation to type 1 regulatory T (Tr1) cells. Proc Natl Acad Sci USA 2011;108:18995-9000.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 18995-19000
    • Le Buanec, H.1    Gougeon, M.L.2    Mathian, A.3
  • 10
    • 0032728568 scopus 로고    scopus 로고
    • Major peptide autoepitopes for nucleosome-specific T cells of human lupus
    • Lu L, Kaliyaperumal A, Boumpas DT, et al. Major peptide autoepitopes for nucleosome-specific T cells of human lupus. J Clin Invest 1999;104:345-55.
    • (1999) J Clin Invest , vol.104 , pp. 345-355
    • Lu, L.1    Kaliyaperumal, A.2    Boumpas, D.T.3
  • 11
    • 0028803299 scopus 로고
    • Presence of nucleosome-restricted antibodies in patients with systemic lupus erythematosus
    • Chabre H, Amoura Z, Piette JC, et al. Presence of nucleosome-restricted antibodies in patients with systemic lupus erythematosus. Arthritis Rheum 1995;38:1485-91.
    • (1995) Arthritis Rheum , vol.38 , pp. 1485-1491
    • Chabre, H.1    Amoura, Z.2    Piette, J.C.3
  • 12
    • 0025284721 scopus 로고
    • Endogenous circulating DNA in systemic lupus erythematosus. Occurrence as multimeric complexes bound to histone
    • Rumore PM, Steinman CR. Endogenous circulating DNA in systemic lupus erythematosus. Occurrence as multimeric complexes bound to histone. J Clin Invest 1990;86:69-74.
    • (1990) J Clin Invest , vol.86 , pp. 69-74
    • Rumore, P.M.1    Steinman, C.R.2
  • 13
    • 0033546053 scopus 로고    scopus 로고
    • The nature of the principal type 1 interferon-producing cells in human blood
    • Siegal FP, Kadowaki N, Shodell M, et al. The nature of the principal type 1 interferon-producing cells in human blood. Science 1999;284:1835-7.
    • (1999) Science , vol.284 , pp. 1835-1837
    • Siegal, F.P.1    Kadowaki, N.2    Shodell, M.3
  • 14
    • 0034814052 scopus 로고    scopus 로고
    • Evidence for an interferon-inducible gene, Ifi202, in the susceptibility to systemic lupus
    • Rozzo SJ, Allard JD, Choubey D, et al. Evidence for an interferon-inducible gene, Ifi202, in the susceptibility to systemic lupus. Immunity 2001;15:435-43.
    • (2001) Immunity , vol.15 , pp. 435-443
    • Rozzo, S.J.1    Allard, J.D.2    Choubey, D.3
  • 15
    • 79955537167 scopus 로고    scopus 로고
    • IFN-alpha production by plasmacytoid dendritic cells stimulated with RNA-containing immune complexes is promoted by NK cells via MIP-1beta and LFA-1
    • Hagberg N, Berggren O, Leonard D, et al. IFN-alpha production by plasmacytoid dendritic cells stimulated with RNA-containing immune complexes is promoted by NK cells via MIP-1beta and LFA-1. J Immunol 2011;186:5085-94.
    • (2011) J Immunol , vol.186 , pp. 5085-5094
    • Hagberg, N.1    Berggren, O.2    Leonard, D.3
  • 16
    • 26844467349 scopus 로고    scopus 로고
    • Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus
    • Barrat FJ, Meeker T, Gregorio J, et al. Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus. J Exp Med 2005;202:1131-9.
    • (2005) J Exp Med , vol.202 , pp. 1131-1139
    • Barrat, F.J.1    Meeker, T.2    Gregorio, J.3
  • 17
    • 85047693371 scopus 로고    scopus 로고
    • Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9
    • Means TK, Latz E, Hayashi F, et al. Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9. J Clin Invest 2005;115:407-17.
    • (2005) J Clin Invest , vol.115 , pp. 407-417
    • Means, T.K.1    Latz, E.2    Hayashi, F.3
  • 18
    • 77953723966 scopus 로고    scopus 로고
    • TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus
    • Guiducci C, Gong M, Xu Z, et al. TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus. Nature 2010;465:937-41.
    • (2010) Nature , vol.465 , pp. 937-941
    • Guiducci, C.1    Gong, M.2    Xu, Z.3
  • 19
    • 79953677484 scopus 로고    scopus 로고
    • Network analysis of associations between serum interferon-alpha activity, autoantibodies, and clinical features in systemic lupus erythematosus
    • Weckerle CE, Franek BS, Kelly JA, et al. Network analysis of associations between serum interferon-alpha activity, autoantibodies, and clinical features in systemic lupus erythematosus. Arthritis Rheum 2011;63:1044-53.
    • (2011) Arthritis Rheum , vol.63 , pp. 1044-1053
    • Weckerle, C.E.1    Franek, B.S.2    Kelly, J.A.3
  • 20
    • 59649107055 scopus 로고    scopus 로고
    • TLR7-dependent and FcgammaR-independent production of type I interferon in experimental mouse lupus
    • Lee PY, Kumagai Y, Li Y, et al. TLR7-dependent and FcgammaR-independent production of type I interferon in experimental mouse lupus. J Exp Med 2008;205:2995-3006.
    • (2008) J Exp Med , vol.205 , pp. 2995-3006
    • Lee, P.Y.1    Kumagai, Y.2    Li, Y.3
  • 21
    • 77951935256 scopus 로고    scopus 로고
    • A distinct subset of proinflammatory neutrophils isolated from patients with systemic lupus erythematosus induces vascular damage and synthesizes type I IFNs
    • Denny MF, Yalavarthi S, Zhao W, et al. A distinct subset of proinflammatory neutrophils isolated from patients with systemic lupus erythematosus induces vascular damage and synthesizes type I IFNs. J Immunol 2010;184:3284-97.
    • (2010) J Immunol , vol.184 , pp. 3284-3297
    • Denny, M.F.1    Yalavarthi, S.2    Zhao, W.3
  • 22
    • 0037451167 scopus 로고    scopus 로고
    • Interferon and granulopoiesis signatures in systemic lupus erythematosus blood
    • Bennett L, Palucka AK, Arce E, et al. Interferon and granulopoiesis signatures in systemic lupus erythematosus blood. J Exp Med 2003;197:711-23.
    • (2003) J Exp Med , vol.197 , pp. 711-723
    • Bennett, L.1    Palucka, A.K.2    Arce, E.3
  • 23
    • 79952476762 scopus 로고    scopus 로고
    • Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus
    • Garcia-Romo GS, Caielli S, Vega B, et al. Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus. Sci Transl Med 2011;3:73ra20.
    • (2011) Sci Transl Med , vol.3 , pp. 73ra20
    • Garcia-Romo, G.S.1    Caielli, S.2    Vega, B.3
  • 24
    • 79952468782 scopus 로고    scopus 로고
    • Neutrophils activate plasmacytoid dendritic cells by releasing self-DNA-peptide complexes in systemic lupus erythematosus
    • Lande R, Ganguly D, Facchinetti V, et al. Neutrophils activate plasmacytoid dendritic cells by releasing self-DNA-peptide complexes in systemic lupus erythematosus. Sci Transl Med 2011;3:73 ra19.
    • (2011) Sci Transl Med , vol.3 , pp. 73ra19
    • Lande, R.1    Ganguly, D.2    Facchinetti, V.3
  • 25
    • 1542287347 scopus 로고    scopus 로고
    • Neutrophil extracellular traps kill bacteria
    • Brinkmann V, Reichard U, Goosmann C, et al. Neutrophil extracellular traps kill bacteria. Science 2004;303:1532-5.
    • (2004) Science , vol.303 , pp. 1532-1535
    • Brinkmann, V.1    Reichard, U.2    Goosmann, C.3
  • 26
    • 33751564664 scopus 로고    scopus 로고
    • TLR2/TLR4-independent neutrophil activation and recruitment upon endocytosis of nucleosomes reveals a new pathway of innate immunity in systemic lupus erythematosus
    • Rönnefarth VM, Erbacher AIM, Lamkemeyer T, et al. TLR2/TLR4-independent neutrophil activation and recruitment upon endocytosis of nucleosomes reveals a new pathway of innate immunity in systemic lupus erythematosus. J Immunol 2006;177:7740-9.
    • (2006) J Immunol , vol.177 , pp. 7740-7749
    • Rönnefarth, V.M.1    Erbacher, A.I.M.2    Lamkemeyer, T.3
  • 27
    • 0029811831 scopus 로고    scopus 로고
    • Dual reactivity of several monoclonal anti-nucleosome autoantibodies for double-stranded DNA and a short segment of histone H3
    • Stemmer C, Richalet-Secordel P, van Bruggen M, et al. Dual reactivity of several monoclonal anti-nucleosome autoantibodies for double-stranded DNA and a short segment of histone H3. J Biol Chem 1996;271:21257-61.
    • (1996) J Biol Chem , vol.271 , pp. 21257-21261
    • Stemmer, C.1    Richalet-Secordel, P.2    Van Bruggen, M.3
  • 28
    • 14844351293 scopus 로고    scopus 로고
    • Nucleosome, the main autoantigen in systemic lupus erythematosus, induces direct dendritic cell activation via a MyD88-independent pathway: Consequences on inflammation
    • Decker P, Singh-Jasuja H, Haager S, et al. Nucleosome, the main autoantigen in systemic lupus erythematosus, induces direct dendritic cell activation via a MyD88-independent pathway: consequences on inflammation. J Immunol 2005;174:3326-34.
    • (2005) J Immunol , vol.174 , pp. 3326-3334
    • Decker, P.1    Singh-Jasuja, H.2    Haager, S.3
  • 29
    • 0034619794 scopus 로고    scopus 로고
    • A Toll-like receptor recognizes bacterial DNA
    • Hemmi H, Takeuchi O, Kawai T, et al. A Toll-like receptor recognizes bacterial DNA. Nature 2000;408:740-5.
    • (2000) Nature , vol.408 , pp. 740-745
    • Hemmi, H.1    Takeuchi, O.2    Kawai, T.3
  • 30
    • 0032484987 scopus 로고    scopus 로고
    • CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells
    • Henn V, Slupsky JR, Grafe M, et al. CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature 1998;391:591-4.
    • (1998) Nature , vol.391 , pp. 591-594
    • Henn, V.1    Slupsky, J.R.2    Grafe, M.3
  • 31
    • 0038445960 scopus 로고    scopus 로고
    • Platelet-mediated modulation of adaptive immunity. A communication link between innate and adaptive immune compartments
    • Elzey BD, Tian J, Jensen RJ, et al. Platelet-mediated modulation of adaptive immunity. A communication link between innate and adaptive immune compartments. Immunity 2003;19:9-19.
    • (2003) Immunity , vol.19 , pp. 9-19
    • Elzey, B.D.1    Tian, J.2    Jensen, R.J.3
  • 32
    • 77956454663 scopus 로고    scopus 로고
    • Platelet CD154 potentiates interferon-alpha secretion by plasmacytoid dendritic cells in systemic lupus erythematosus
    • Duffau P, Seneschal J, Nicco C, et al. Platelet CD154 potentiates interferon-alpha secretion by plasmacytoid dendritic cells in systemic lupus erythematosus. Sci Transl Med 2010;2:47ra63.
    • (2010) Sci Transl Med , vol.2 , pp. 47ra63
    • Duffau, P.1    Seneschal, J.2    Nicco, C.3
  • 33
    • 29244450802 scopus 로고    scopus 로고
    • Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA
    • Barton GM, Kagan JC, Medzhitov R. Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. Nat Immunol 2006;7:49-56.
    • (2006) Nat Immunol , vol.7 , pp. 49-56
    • Barton, G.M.1    Kagan, J.C.2    Medzhitov, R.3
  • 34
    • 29244471275 scopus 로고    scopus 로고
    • A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA
    • Ishii KJ, Coban C, Kato H, et al. A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. Nat Immunol 2006;7:40-8.
    • (2006) Nat Immunol , vol.7 , pp. 40-48
    • Ishii, K.J.1    Coban, C.2    Kato, H.3
  • 35
    • 84879205728 scopus 로고    scopus 로고
    • AIM2 facilitates the apoptotic DNA-induced systemic lupus erythematosus via arbitrating macrophage functional maturation
    • Zhang W, Cai Y, Xu W, et al. AIM2 facilitates the apoptotic DNA-induced systemic lupus erythematosus via arbitrating macrophage functional maturation. J Clin Immunol 2013;33:925-37.
    • (2013) J Clin Immunol , vol.33 , pp. 925-937
    • Zhang, W.1    Cai, Y.2    Xu, W.3
  • 36
    • 84877702832 scopus 로고    scopus 로고
    • DNA-dependent activator of IFN-regulatory factors (DAI) promotes lupus nephritis by activating the calcium pathway
    • Zhang W, Zhou Q, Xu W, et al. DNA-dependent activator of IFN-regulatory factors (DAI) promotes lupus nephritis by activating the calcium pathway. J Biol Chem 2013;288:13534-50.
    • (2013) J Biol Chem , vol.288 , pp. 13534-13550
    • Zhang, W.1    Zhou, Q.2    Xu, W.3
  • 37
    • 84869794842 scopus 로고    scopus 로고
    • STING manifests self DNA-dependent inflammatory disease
    • Ahn J, Gutman D, Saijo S, et al. STING manifests self DNA-dependent inflammatory disease. Proc Natl Acad Sci USA 2012;109:19386-91.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 19386-19391
    • Ahn, J.1    Gutman, D.2    Saijo, S.3
  • 38
    • 79951777504 scopus 로고    scopus 로고
    • Nucleosome-induced neutrophil activation occurs independently of TLR9 and endosomal acidification: Implications for systemic lupus erythematosus
    • Lindau D, Rönnefarth V, Erbacher A, et al. Nucleosome-induced neutrophil activation occurs independently of TLR9 and endosomal acidification: implications for systemic lupus erythematosus. Eur J Immunol 2011;41:669-81.
    • (2011) Eur J Immunol , vol.41 , pp. 669-681
    • Lindau, D.1    Rönnefarth, V.2    Erbacher, A.3
  • 39
    • 0344492212 scopus 로고    scopus 로고
    • Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus
    • Baechler EC, Batliwalla FM, Karypis G, et al. Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus. Proc Natl Acad Sci USA 2003;100:2610-5.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 2610-2615
    • Baechler, E.C.1    Batliwalla, F.M.2    Karypis, G.3
  • 40
    • 59649126956 scopus 로고    scopus 로고
    • Induction of inflammatory and immune responses by HMGB1-nucleosome complexes: Implications for the pathogenesis of SLE
    • Urbonaviciute V, Furnrohr BG, Meister S, et al. Induction of inflammatory and immune responses by HMGB1-nucleosome complexes: implications for the pathogenesis of SLE. J Exp Med 2008;205:3007-18.
    • (2008) J Exp Med , vol.205 , pp. 3007-3018
    • Urbonaviciute, V.1    Furnrohr, B.G.2    Meister, S.3
  • 41
    • 77953088427 scopus 로고    scopus 로고
    • Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis
    • Hakkim A, Furnrohr BG, Amann K, et al. Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis. Proc Natl Acad Sci USA 2010;107:9813-8.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 9813-9818
    • Hakkim, A.1    Furnrohr, B.G.2    Amann, K.3
  • 42
    • 60749104535 scopus 로고    scopus 로고
    • HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA
    • Roberts TL, Idris A, Dunn JA, et al. HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science 2009;323:1057-60.
    • (2009) Science , vol.323 , pp. 1057-1060
    • Roberts, T.L.1    Idris, A.2    Dunn, J.A.3
  • 43
    • 78650674088 scopus 로고    scopus 로고
    • Aim2 deficiency stimulates the expression of IFN-inducible Ifi202, a lupus susceptibility murine gene within the Nba2 autoimmune susceptibility locus
    • Panchanathan R, Duan X, Shen H, et al. Aim2 deficiency stimulates the expression of IFN-inducible Ifi202, a lupus susceptibility murine gene within the Nba2 autoimmune susceptibility locus. J Immunol 2010;185:7385-93.
    • (2010) J Immunol , vol.185 , pp. 7385-7393
    • Panchanathan, R.1    Duan, X.2    Shen, H.3
  • 44
    • 70349943834 scopus 로고    scopus 로고
    • STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
    • Ishikawa H, Ma Z, Barber GN. STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature 2009;461:788-92.
    • (2009) Nature , vol.461 , pp. 788-792
    • Ishikawa, H.1    Ma, Z.2    Barber, G.N.3
  • 45
    • 84857799686 scopus 로고    scopus 로고
    • Interferon-alpha as a treatment target in systemic lupus erythematosus
    • Meyer O. Interferon-alpha as a treatment target in systemic lupus erythematosus. Joint Bone Spine 2012;79:113-16.
    • (2012) Joint Bone Spine , vol.79 , pp. 113-116
    • Meyer, O.1


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