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Volumn 22, Issue 4, 2013, Pages 765-783

Cancer Immunotherapy. Current Status and Future Directions.

Author keywords

Adoptive cell therapy; Cancer immunotherapy; Cancer vaccine; Immune checkpoints; Immune modulating antibodies

Indexed keywords

ALPHA2B INTERFERON; ANTIMITOTIC AGENT; ANTINEOPLASTIC AGENT; BMS 936559; CANCER VACCINE; CD40 ANTIBODY; DACARBAZINE; DACTINOMYCIN; DOXORUBICIN; GEMCITABINE; GLYCOPROTEIN 100 PEPTIDE VACCINE; IMIQUIMOD; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 2; IPILIMUMAB; MITOMYCIN; NIVOLUMAB; ONCOLYTIC HERPES VIRUS; PEPTIDE VACCINE; PLACEBO; SIPULEUCEL T; UNCLASSIFIED DRUG; WART VIRUS VACCINE;

EID: 84883557586     PISSN: 10553207     EISSN: 15585042     Source Type: Journal    
DOI: 10.1016/j.soc.2013.06.005     Document Type: Review
Times cited : (23)

References (143)
  • 1
    • 0000937789 scopus 로고
    • II. Contribution to the knowledge of sarcoma
    • Coley W.B. II. Contribution to the knowledge of sarcoma. Ann Surg 1891, 14(3):199-220.
    • (1891) Ann Surg , vol.14 , Issue.3 , pp. 199-220
    • Coley, W.B.1
  • 2
    • 0003135066 scopus 로고
    • The treatment of inoperable sarcoma by bacterial toxins (the mixed toxins of the streptococcus erysipelas and the bacillus prodigiosus)
    • Surg Sect
    • Coley W.B. The treatment of inoperable sarcoma by bacterial toxins (the mixed toxins of the streptococcus erysipelas and the bacillus prodigiosus). Proc R Soc Med 1910, 3(Surg Sect):1-48.
    • (1910) Proc R Soc Med , vol.3 , pp. 1-48
    • Coley, W.B.1
  • 3
    • 41149158767 scopus 로고
    • End results in Hodgkin's disease and lymphosarcoma treated by the mixed toxins of erysipelas and bacillus prodigiosus, alone or combined with radiation
    • Coley W.B. End results in Hodgkin's disease and lymphosarcoma treated by the mixed toxins of erysipelas and bacillus prodigiosus, alone or combined with radiation. Ann Surg 1928, 88(4):641-667.
    • (1928) Ann Surg , vol.88 , Issue.4 , pp. 641-667
    • Coley, W.B.1
  • 4
    • 0028081705 scopus 로고
    • Coley's toxins, tumor necrosis factor and cancer research: a historical perspective
    • Wiemann B., Starnes C.O. Coley's toxins, tumor necrosis factor and cancer research: a historical perspective. Pharmacol Ther 1994, 64(3):529-564.
    • (1994) Pharmacol Ther , vol.64 , Issue.3 , pp. 529-564
    • Wiemann, B.1    Starnes, C.O.2
  • 5
  • 6
    • 20044369702 scopus 로고    scopus 로고
    • Antibody levels and protection after hepatitis B vaccination: results of a 15-year follow-up
    • McMahon B.J., Bruden D.L., Petersen K.M., et al. Antibody levels and protection after hepatitis B vaccination: results of a 15-year follow-up. Ann Intern Med 2005, 142(5):333-341.
    • (2005) Ann Intern Med , vol.142 , Issue.5 , pp. 333-341
    • McMahon, B.J.1    Bruden, D.L.2    Petersen, K.M.3
  • 7
    • 34248326338 scopus 로고    scopus 로고
    • Quadrivalent vaccine against human papillomavirus to prevent high-grade cervical lesions
    • FUTURE II Study Group
    • FUTURE II Study Group Quadrivalent vaccine against human papillomavirus to prevent high-grade cervical lesions. NEngl J Med 2007, 356(19):1915-1927.
    • (2007) NEngl J Med , vol.356 , Issue.19 , pp. 1915-1927
  • 8
    • 34248365967 scopus 로고    scopus 로고
    • Quadrivalent vaccine against human papillomavirus to prevent anogenital diseases
    • Garland S.M., Hernandez-Avila M., Wheeler C.M., et al. Quadrivalent vaccine against human papillomavirus to prevent anogenital diseases. NEngl J Med 2007, 356(19):1928-1943.
    • (2007) NEngl J Med , vol.356 , Issue.19 , pp. 1928-1943
    • Garland, S.M.1    Hernandez-Avila, M.2    Wheeler, C.M.3
  • 9
    • 34249047002 scopus 로고    scopus 로고
    • Efficacy of a quadrivalent prophylactic human papillomavirus (types 6, 11, 16, and 18) L1 virus-like-particle vaccine against high-grade vulval and vaginal lesions: a combined analysis of three randomised clinical trials
    • Joura E.A., Leodolter S., Hernandez-Avila M., et al. Efficacy of a quadrivalent prophylactic human papillomavirus (types 6, 11, 16, and 18) L1 virus-like-particle vaccine against high-grade vulval and vaginal lesions: a combined analysis of three randomised clinical trials. Lancet 2007, 369(9574):1693-1702.
    • (2007) Lancet , vol.369 , Issue.9574 , pp. 1693-1702
    • Joura, E.A.1    Leodolter, S.2    Hernandez-Avila, M.3
  • 10
    • 84855521575 scopus 로고    scopus 로고
    • HPV vaccine against anal HPV infection and anal intraepithelial neoplasia
    • Palefsky J.M., Giuliano A.R., Goldstone S., et al. HPV vaccine against anal HPV infection and anal intraepithelial neoplasia. NEngl J Med 2011, 365(17):1576-1585.
    • (2011) NEngl J Med , vol.365 , Issue.17 , pp. 1576-1585
    • Palefsky, J.M.1    Giuliano, A.R.2    Goldstone, S.3
  • 11
    • 4944267719 scopus 로고    scopus 로고
    • Dendritic cells: limited potential in immunotherapy
    • Soruri A., Zwirner J. Dendritic cells: limited potential in immunotherapy. Int J Biochem Cell Biol 2005, 37(2):241-245.
    • (2005) Int J Biochem Cell Biol , vol.37 , Issue.2 , pp. 241-245
    • Soruri, A.1    Zwirner, J.2
  • 12
    • 2442647551 scopus 로고    scopus 로고
    • Dendritic cell immunotherapy: mapping the way
    • Figdor C.G., de Vries I.J., Lesterhuis W.J., et al. Dendritic cell immunotherapy: mapping the way. Nat Med 2004, 10(5):475-480.
    • (2004) Nat Med , vol.10 , Issue.5 , pp. 475-480
    • Figdor, C.G.1    de Vries, I.J.2    Lesterhuis, W.J.3
  • 13
    • 33750040247 scopus 로고    scopus 로고
    • Sipuleucel-T (APC8015) for prostate cancer
    • So-Rosillo R., Small E.J. Sipuleucel-T (APC8015) for prostate cancer. Expert Rev Anticancer Ther 2006, 6(9):1163-1167.
    • (2006) Expert Rev Anticancer Ther , vol.6 , Issue.9 , pp. 1163-1167
    • So-Rosillo, R.1    Small, E.J.2
  • 14
    • 77955066199 scopus 로고    scopus 로고
    • Sipuleucel-T immunotherapy for castration resistant prostate cancer
    • Kantoff P.W., Higano C.S., Shore N.D., et al. Sipuleucel-T immunotherapy for castration resistant prostate cancer. NEngl J Med 2010, 363(5):411-422.
    • (2010) NEngl J Med , vol.363 , Issue.5 , pp. 411-422
    • Kantoff, P.W.1    Higano, C.S.2    Shore, N.D.3
  • 15
    • 0036668435 scopus 로고    scopus 로고
    • Use of bacille Calmette-Guerin in superficial bladder cancer
    • Meyer J.P., Persad R., Gillatt D.A. Use of bacille Calmette-Guerin in superficial bladder cancer. Postgrad Med J 2002, 78(922):449-454.
    • (2002) Postgrad Med J , vol.78 , Issue.922 , pp. 449-454
    • Meyer, J.P.1    Persad, R.2    Gillatt, D.A.3
  • 16
    • 0017130525 scopus 로고
    • Intracavitary bacillus Calmette-Guerin in the treatment of superficial bladder tumors
    • Morales A., Eidinger D., Bruce A.W. Intracavitary bacillus Calmette-Guerin in the treatment of superficial bladder tumors. JUrol 1976, 116(2):180-183.
    • (1976) JUrol , vol.116 , Issue.2 , pp. 180-183
    • Morales, A.1    Eidinger, D.2    Bruce, A.W.3
  • 17
    • 0029053868 scopus 로고
    • Intravesical bacillus Calmette-Guerin therapy prevents tumor progression and death from superficial bladder cancer: ten-year followup of a prospective randomized trial
    • Herr H.W., Schwalb D.M., Zhang Z.F., et al. Intravesical bacillus Calmette-Guerin therapy prevents tumor progression and death from superficial bladder cancer: ten-year followup of a prospective randomized trial. JClin Oncol 1995, 13(6):1404-1408.
    • (1995) JClin Oncol , vol.13 , Issue.6 , pp. 1404-1408
    • Herr, H.W.1    Schwalb, D.M.2    Zhang, Z.F.3
  • 18
    • 0041736386 scopus 로고    scopus 로고
    • Immune mechanisms in bacillus Calmette-Guerin immunotherapy for superficial bladder cancer
    • Bohle A., Brandau S. Immune mechanisms in bacillus Calmette-Guerin immunotherapy for superficial bladder cancer. JUrol 2003, 170(3):964-969.
    • (2003) JUrol , vol.170 , Issue.3 , pp. 964-969
    • Bohle, A.1    Brandau, S.2
  • 19
    • 0037066502 scopus 로고    scopus 로고
    • Decoding the patterns of self and nonself by the innate immune system
    • Medzhitov R., Janeway C.A. Decoding the patterns of self and nonself by the innate immune system. Science 2002, 296(5566):298-300.
    • (2002) Science , vol.296 , Issue.5566 , pp. 298-300
    • Medzhitov, R.1    Janeway, C.A.2
  • 20
    • 0037018097 scopus 로고    scopus 로고
    • Adjuvants of immunity: harnessing innate immunity to promote adaptive immunity
    • Bendelac A., Medzhitov R. Adjuvants of immunity: harnessing innate immunity to promote adaptive immunity. JExp Med 2002, 195(5):F19-F23.
    • (2002) JExp Med , vol.195 , Issue.5
    • Bendelac, A.1    Medzhitov, R.2
  • 21
    • 0036780681 scopus 로고    scopus 로고
    • Toll-like receptors as potential therapeutic targets for multiple diseases
    • Zuany-Amorim C., Hastewell J., Walker C. Toll-like receptors as potential therapeutic targets for multiple diseases. Nat Rev Drug Discov 2002, 1(10):797-807.
    • (2002) Nat Rev Drug Discov , vol.1 , Issue.10 , pp. 797-807
    • Zuany-Amorim, C.1    Hastewell, J.2    Walker, C.3
  • 22
    • 41649084839 scopus 로고    scopus 로고
    • Treatment of vulvar intraepithelial neoplasia with topical imiquimod
    • van Seters M., van Beurden M., ten Kate F.J., et al. Treatment of vulvar intraepithelial neoplasia with topical imiquimod. NEngl J Med 2008, 358(14):1465-1473.
    • (2008) NEngl J Med , vol.358 , Issue.14 , pp. 1465-1473
    • van Seters, M.1    van Beurden, M.2    ten Kate, F.J.3
  • 23
    • 2342473348 scopus 로고    scopus 로고
    • Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: results from two phase III, randomized, vehicle-controlled studies
    • Geisse J., Caro I., Lindholm J., et al. Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: results from two phase III, randomized, vehicle-controlled studies. JAm Acad Dermatol 2004, 50(5):722-733.
    • (2004) JAm Acad Dermatol , vol.50 , Issue.5 , pp. 722-733
    • Geisse, J.1    Caro, I.2    Lindholm, J.3
  • 24
    • 33745555459 scopus 로고    scopus 로고
    • Imiquimod for actinic keratosis: systematic review and meta-analysis
    • Hadley G., Derry S., Moore R.A. Imiquimod for actinic keratosis: systematic review and meta-analysis. JInvest Dermatol 2006, 126(6):1251-1255.
    • (2006) JInvest Dermatol , vol.126 , Issue.6 , pp. 1251-1255
    • Hadley, G.1    Derry, S.2    Moore, R.A.3
  • 25
    • 71049119365 scopus 로고    scopus 로고
    • Effectiveness of imiquimod limited to dermal melanoma metastases, with simultaneous resistance of subcutaneous metastasis
    • Turza K., Dengel L.T., Harris R.C., et al. Effectiveness of imiquimod limited to dermal melanoma metastases, with simultaneous resistance of subcutaneous metastasis. JCutan Pathol 2010, 37(1):94-98.
    • (2010) JCutan Pathol , vol.37 , Issue.1 , pp. 94-98
    • Turza, K.1    Dengel, L.T.2    Harris, R.C.3
  • 26
    • 77950370339 scopus 로고    scopus 로고
    • Phase II trial of imiquimod and HPV therapeutic vaccination in patients with vulval intraepithelial neoplasia
    • Daayana S., Elkord E., Winters U., et al. Phase II trial of imiquimod and HPV therapeutic vaccination in patients with vulval intraepithelial neoplasia. Br J Cancer 2010, 102(7):1129-1136.
    • (2010) Br J Cancer , vol.102 , Issue.7 , pp. 1129-1136
    • Daayana, S.1    Elkord, E.2    Winters, U.3
  • 27
    • 23944444807 scopus 로고    scopus 로고
    • The potential of oncolytic virus therapy for pancreatic cancer
    • Kasuya H., Takeda S., Nomoto S., et al. The potential of oncolytic virus therapy for pancreatic cancer. Cancer Gene Ther 2005, 12(9):725-736.
    • (2005) Cancer Gene Ther , vol.12 , Issue.9 , pp. 725-736
    • Kasuya, H.1    Takeda, S.2    Nomoto, S.3
  • 28
    • 73349133717 scopus 로고    scopus 로고
    • Phase II clinical trial of a granulocytemacrophage colony-stimulating factor-encoding, second-generation oncolytic herpesvirus in patients with unresectable metastatic melanoma
    • Senzer N.N., Kaufman H.L., Amatruda T., et al. Phase II clinical trial of a granulocytemacrophage colony-stimulating factor-encoding, second-generation oncolytic herpesvirus in patients with unresectable metastatic melanoma. JClin Oncol 2009, 27(34):5763-5771.
    • (2009) JClin Oncol , vol.27 , Issue.34 , pp. 5763-5771
    • Senzer, N.N.1    Kaufman, H.L.2    Amatruda, T.3
  • 29
    • 0017199306 scopus 로고
    • Selective invitro growth of T lymphocytes from normal human bone marrows
    • Morgan D.A., Ruscetti F.W., Gallo R. Selective invitro growth of T lymphocytes from normal human bone marrows. Science 1976, 193(4257):1007-1008.
    • (1976) Science , vol.193 , Issue.4257 , pp. 1007-1008
    • Morgan, D.A.1    Ruscetti, F.W.2    Gallo, R.3
  • 30
    • 0021837706 scopus 로고
    • Regression of established pulmonary metastases and subcutaneous tumor mediated by the systemic administration of highdose recombinant interleukin 2
    • Rosenberg S.A., Mule J.J., Spiess P.J., et al. Regression of established pulmonary metastases and subcutaneous tumor mediated by the systemic administration of highdose recombinant interleukin 2. JExp Med 1985, 161(5):1169-1188.
    • (1985) JExp Med , vol.161 , Issue.5 , pp. 1169-1188
    • Rosenberg, S.A.1    Mule, J.J.2    Spiess, P.J.3
  • 31
    • 0028266553 scopus 로고
    • Treatment of 283 consecutive patients with metastatic melanoma or renal cell cancer using high-dose bolus interleukin 2
    • Rosenberg S.A., Yang J.C., Topalian S.L., et al. Treatment of 283 consecutive patients with metastatic melanoma or renal cell cancer using high-dose bolus interleukin 2. JAMA 1994, 271(12):907-913.
    • (1994) JAMA , vol.271 , Issue.12 , pp. 907-913
    • Rosenberg, S.A.1    Yang, J.C.2    Topalian, S.L.3
  • 32
    • 0022349817 scopus 로고
    • Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer
    • Rosenberg S.A., Lotze M.T., Muul L.M., et al. Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer. NEngl J Med 1985, 313(23):1485-1492.
    • (1985) NEngl J Med , vol.313 , Issue.23 , pp. 1485-1492
    • Rosenberg, S.A.1    Lotze, M.T.2    Muul, L.M.3
  • 33
    • 0033848628 scopus 로고    scopus 로고
    • High-dose recombinant interleukin-2 therapy in patients with metastatic melanoma: long-term survival update
    • Atkins M.B., Kunkel L., Sznol M., et al. High-dose recombinant interleukin-2 therapy in patients with metastatic melanoma: long-term survival update. Cancer J Sci Am 2000, 6(Suppl 1):S11-S14.
    • (2000) Cancer J Sci Am , vol.6 , Issue.SUPPL 1
    • Atkins, M.B.1    Kunkel, L.2    Sznol, M.3
  • 34
    • 0033024863 scopus 로고    scopus 로고
    • High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993
    • Atkins M.B., Lotze M.T., Dutcher J.P., et al. High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993. JClin Oncol 1999, 17(7):2105-2116.
    • (1999) JClin Oncol , vol.17 , Issue.7 , pp. 2105-2116
    • Atkins, M.B.1    Lotze, M.T.2    Dutcher, J.P.3
  • 35
    • 48249117436 scopus 로고    scopus 로고
    • High-dose interleukin-2 for the treatment of metastatic renal cell carcinoma: a retrospective analysis of response and survival in patients treated in the surgery branch at the National Cancer Institute between 1986 and 2006
    • Klapper J.A., Downey S.G., Smith F.O., et al. High-dose interleukin-2 for the treatment of metastatic renal cell carcinoma: a retrospective analysis of response and survival in patients treated in the surgery branch at the National Cancer Institute between 1986 and 2006. Cancer 2008, 113(2):293-301.
    • (2008) Cancer , vol.113 , Issue.2 , pp. 293-301
    • Klapper, J.A.1    Downey, S.G.2    Smith, F.O.3
  • 36
    • 0000520727 scopus 로고
    • Virus interference. I. The interferon
    • Isaacs A., Lindenmann J. Virus interference. I. The interferon. Proc R Soc Lond B Biol Sci 1957, 147(927):258-267.
    • (1957) Proc R Soc Lond B Biol Sci , vol.147 , Issue.927 , pp. 258-267
    • Isaacs, A.1    Lindenmann, J.2
  • 37
    • 0034769960 scopus 로고    scopus 로고
    • Viruses and interferons
    • Sen G.C. Viruses and interferons. Annu Rev Microbiol 2001, 55:255-281.
    • (2001) Annu Rev Microbiol , vol.55 , pp. 255-281
    • Sen, G.C.1
  • 38
    • 0028234529 scopus 로고
    • Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
    • Darnell J.E., Kerr I.M., Stark G.R. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 1994, 264(5164):1415-1421.
    • (1994) Science , vol.264 , Issue.5164 , pp. 1415-1421
    • Darnell, J.E.1    Kerr, I.M.2    Stark, G.R.3
  • 39
    • 85047689957 scopus 로고    scopus 로고
    • The antitumor effects of IFN-alpha are abrogated in a STAT1-deficient mouse
    • Lesinski G.B., Anghelina M., Zimmerer J., et al. The antitumor effects of IFN-alpha are abrogated in a STAT1-deficient mouse. JClin Invest 2003, 112(2):170-180.
    • (2003) JClin Invest , vol.112 , Issue.2 , pp. 170-180
    • Lesinski, G.B.1    Anghelina, M.2    Zimmerer, J.3
  • 40
    • 33745989541 scopus 로고    scopus 로고
    • Neoadjuvant treatment of regional stage IIIB melanoma with high-dose interferon alfa-2b induces objective tumor regression in association with modulation of tumor infiltrating host cellular immune responses
    • Moschos S.J., Edington H.D., Land S.R., et al. Neoadjuvant treatment of regional stage IIIB melanoma with high-dose interferon alfa-2b induces objective tumor regression in association with modulation of tumor infiltrating host cellular immune responses. JClin Oncol 2006, 24(19):3164-3171.
    • (2006) JClin Oncol , vol.24 , Issue.19 , pp. 3164-3171
    • Moschos, S.J.1    Edington, H.D.2    Land, S.R.3
  • 41
    • 0030030347 scopus 로고    scopus 로고
    • Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial EST 1684
    • Kirkwood J.M., Strawderman M.H., Ernstoff M.S., et al. Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial EST 1684. JClin Oncol 1996, 14(1):7-17.
    • (1996) JClin Oncol , vol.14 , Issue.1 , pp. 7-17
    • Kirkwood, J.M.1    Strawderman, M.H.2    Ernstoff, M.S.3
  • 42
    • 0034088027 scopus 로고    scopus 로고
    • High- and low-dose interferon alfa-2b in high-risk melanoma: first analysis of intergroup trial E1690/S9111/C9190
    • Kirkwood J.M., Ibrahim J.G., Sondak V.K., et al. High- and low-dose interferon alfa-2b in high-risk melanoma: first analysis of intergroup trial E1690/S9111/C9190. JClin Oncol 2000, 18(12):2444-2458.
    • (2000) JClin Oncol , vol.18 , Issue.12 , pp. 2444-2458
    • Kirkwood, J.M.1    Ibrahim, J.G.2    Sondak, V.K.3
  • 43
    • 0035339880 scopus 로고    scopus 로고
    • High-dose interferon alfa-2b significantly prolongs relapse-free and overall survival compared with the GM2-KLH/QS-21 vaccine in patients with resected stage IIB-III melanoma: results of intergroup trial E1694/S9512/C509801
    • Kirkwood J.M., Ibrahim J.G., Sosman J.A., et al. High-dose interferon alfa-2b significantly prolongs relapse-free and overall survival compared with the GM2-KLH/QS-21 vaccine in patients with resected stage IIB-III melanoma: results of intergroup trial E1694/S9512/C509801. JClin Oncol 2001, 19(9):2370-2380.
    • (2001) JClin Oncol , vol.19 , Issue.9 , pp. 2370-2380
    • Kirkwood, J.M.1    Ibrahim, J.G.2    Sosman, J.A.3
  • 44
    • 7144264391 scopus 로고    scopus 로고
    • Adjuvant interferon alfa-2a treatment in resected primary stage II cutaneous melanoma. Austrian Malignant Melanoma Cooperative Group
    • Pehamberger H., Soyer H.P., Steiner A., et al. Adjuvant interferon alfa-2a treatment in resected primary stage II cutaneous melanoma. Austrian Malignant Melanoma Cooperative Group. JClin Oncol 1998, 16(4):1425-1429.
    • (1998) JClin Oncol , vol.16 , Issue.4 , pp. 1425-1429
    • Pehamberger, H.1    Soyer, H.P.2    Steiner, A.3
  • 45
    • 70350075563 scopus 로고    scopus 로고
    • Point: interferon-alpha for adjuvant therapy for melanoma patients
    • Sabel M.S., Sondak V.K. Point: interferon-alpha for adjuvant therapy for melanoma patients. JNatl Compr Canc Netw 2004, 2(1):61-68.
    • (2004) JNatl Compr Canc Netw , vol.2 , Issue.1 , pp. 61-68
    • Sabel, M.S.1    Sondak, V.K.2
  • 46
    • 84869212118 scopus 로고    scopus 로고
    • Long-term results of the randomized phase III trial EORTC 18991 of adjuvant therapy with pegylated interferon alfa-2b versus observation in resected stage III melanoma
    • Eggermont A.M., Suciu S., Testori A., et al. Long-term results of the randomized phase III trial EORTC 18991 of adjuvant therapy with pegylated interferon alfa-2b versus observation in resected stage III melanoma. JClin Oncol 2012, 30(31):3810-3818.
    • (2012) JClin Oncol , vol.30 , Issue.31 , pp. 3810-3818
    • Eggermont, A.M.1    Suciu, S.2    Testori, A.3
  • 47
    • 33749319703 scopus 로고    scopus 로고
    • Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
    • Galon J., Costes A., Sanchez-Cabo F., et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 2006, 313(5795):1960-1964.
    • (2006) Science , vol.313 , Issue.5795 , pp. 1960-1964
    • Galon, J.1    Costes, A.2    Sanchez-Cabo, F.3
  • 48
    • 0028867420 scopus 로고
    • Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
    • Tivol E.A., Borriello F., Schweitzer A.N., et al. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 1995, 3(5):541-547.
    • (1995) Immunity , vol.3 , Issue.5 , pp. 541-547
    • Tivol, E.A.1    Borriello, F.2    Schweitzer, A.N.3
  • 49
    • 0028791059 scopus 로고
    • Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4
    • Waterhouse P., Penninger J.M., Timms E., et al. Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4. Science 1995, 270(5238):985-988.
    • (1995) Science , vol.270 , Issue.5238 , pp. 985-988
    • Waterhouse, P.1    Penninger, J.M.2    Timms, E.3
  • 50
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi F.S., O'Day S.J., McDermott D.F., et al. Improved survival with ipilimumab in patients with metastatic melanoma. NEngl J Med 2010, 363(8):711-723.
    • (2010) NEngl J Med , vol.363 , Issue.8 , pp. 711-723
    • Hodi, F.S.1    O'Day, S.J.2    McDermott, D.F.3
  • 51
    • 79959772576 scopus 로고    scopus 로고
    • Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
    • Robert C., Thomas L., Bondarenko I., et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. NEngl J Med 2011, 364(26):2517-2526.
    • (2011) NEngl J Med , vol.364 , Issue.26 , pp. 2517-2526
    • Robert, C.1    Thomas, L.2    Bondarenko, I.3
  • 52
    • 0029947568 scopus 로고    scopus 로고
    • Enhancement of antitumor immunity by CTLA-4 blockade
    • Leach D.R., Krummel M.F., Allison J.P. Enhancement of antitumor immunity by CTLA-4 blockade. Science 1996, 271(5256):1734-1736.
    • (1996) Science , vol.271 , Issue.5256 , pp. 1734-1736
    • Leach, D.R.1    Krummel, M.F.2    Allison, J.P.3
  • 53
    • 0028675006 scopus 로고
    • Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors
    • Linsley P.S., Greene J.L., Brady W., et al. Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors. Immunity 1994, 1(9):793-801.
    • (1994) Immunity , vol.1 , Issue.9 , pp. 793-801
    • Linsley, P.S.1    Greene, J.L.2    Brady, W.3
  • 54
    • 0037015055 scopus 로고    scopus 로고
    • Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors
    • Riley J.L., Mao M., Kobayashi S., et al. Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors. Proc Natl Acad Sci USA 2002, 99(18):11790-11795.
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.18 , pp. 11790-11795
    • Riley, J.L.1    Mao, M.2    Kobayashi, S.3
  • 55
    • 33749038866 scopus 로고    scopus 로고
    • Reversal of the TCR stop signal by CTLA-4
    • Schneider H., Downey J., Smith A., et al. Reversal of the TCR stop signal by CTLA-4. Science 2006, 313(5795):1972-1975.
    • (2006) Science , vol.313 , Issue.5795 , pp. 1972-1975
    • Schneider, H.1    Downey, J.2    Smith, A.3
  • 56
    • 53749094183 scopus 로고    scopus 로고
    • CTLA-4 control over Foxp3+ regulatory Tcell function
    • Wing K., Onishi Y., Prieto-Martin P., et al. CTLA-4 control over Foxp3+ regulatory Tcell function. Science 2008, 322(5899):271-275.
    • (2008) Science , vol.322 , Issue.5899 , pp. 271-275
    • Wing, K.1    Onishi, Y.2    Prieto-Martin, P.3
  • 57
    • 0026700235 scopus 로고
    • Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death
    • Ishida Y., Agata Y., Shibahara K., et al. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J 1992, 11(11):3887-3895.
    • (1992) EMBO J , vol.11 , Issue.11 , pp. 3887-3895
    • Ishida, Y.1    Agata, Y.2    Shibahara, K.3
  • 58
    • 34547794178 scopus 로고    scopus 로고
    • PD-1 and PD-1 ligands: from discovery to clinical application
    • Okazaki T., Honjo T. PD-1 and PD-1 ligands: from discovery to clinical application. Int Immunol 2007, 19(7):813-824.
    • (2007) Int Immunol , vol.19 , Issue.7 , pp. 813-824
    • Okazaki, T.1    Honjo, T.2
  • 59
    • 84862882003 scopus 로고    scopus 로고
    • Tumor immunotherapy directed at PD-1
    • Ribas A. Tumor immunotherapy directed at PD-1. NEngl J Med 2012, 366(26):2517-2519.
    • (2012) NEngl J Med , vol.366 , Issue.26 , pp. 2517-2519
    • Ribas, A.1
  • 60
    • 78650265250 scopus 로고    scopus 로고
    • New monoclonal antibodies against B-cell antigens: possible new strategies for diagnosis of primary cutaneous B-cell lymphomas
    • Fanoni D., Tavecchio S., Recalcati S., et al. New monoclonal antibodies against B-cell antigens: possible new strategies for diagnosis of primary cutaneous B-cell lymphomas. Immunol Lett 2011, 134(2):157-160.
    • (2011) Immunol Lett , vol.134 , Issue.2 , pp. 157-160
    • Fanoni, D.1    Tavecchio, S.2    Recalcati, S.3
  • 61
    • 80051698136 scopus 로고    scopus 로고
    • IL-18 induces PD-1-dependent immunosuppression in cancer
    • Terme M., Ullrich E., Aymeric L., et al. IL-18 induces PD-1-dependent immunosuppression in cancer. Cancer Res 2011, 71(16):5393-5399.
    • (2011) Cancer Res , vol.71 , Issue.16 , pp. 5393-5399
    • Terme, M.1    Ullrich, E.2    Aymeric, L.3
  • 62
    • 0842325739 scopus 로고    scopus 로고
    • PD-L1/B7H-1 inhibits the effector phase of tumor rejection by T cell receptor (TCR) transgenic CD8+ T cells
    • Blank C., Brown I., Peterson A.C., et al. PD-L1/B7H-1 inhibits the effector phase of tumor rejection by T cell receptor (TCR) transgenic CD8+ T cells. Cancer Res 2004, 64(3):1140-1145.
    • (2004) Cancer Res , vol.64 , Issue.3 , pp. 1140-1145
    • Blank, C.1    Brown, I.2    Peterson, A.C.3
  • 63
    • 18544380239 scopus 로고    scopus 로고
    • Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion
    • Dong H., Strome S.E., Salomao D.R., et al. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med 2002, 8(8):793-800.
    • (2002) Nat Med , vol.8 , Issue.8 , pp. 793-800
    • Dong, H.1    Strome, S.E.2    Salomao, D.R.3
  • 64
    • 0037126021 scopus 로고    scopus 로고
    • Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
    • Iwai Y., Ishida M., Tanaka Y., et al. Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc Natl Acad Sci USA 2002, 99(19):12293-12297.
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.19 , pp. 12293-12297
    • Iwai, Y.1    Ishida, M.2    Tanaka, Y.3
  • 65
    • 0038273853 scopus 로고    scopus 로고
    • Blockade of B7-H1 improves myeloid dendritic cell mediated antitumor immunity
    • Curiel T.J., Wei S., Dong H., et al. Blockade of B7-H1 improves myeloid dendritic cell mediated antitumor immunity. Nat Med 2003, 9(5):562-567.
    • (2003) Nat Med , vol.9 , Issue.5 , pp. 562-567
    • Curiel, T.J.1    Wei, S.2    Dong, H.3
  • 66
    • 67449110979 scopus 로고    scopus 로고
    • Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PDL1
    • Kuang D.M., Zhao Q., Peng C., et al. Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PDL1. JExp Med 2009, 206(6):1327-1337.
    • (2009) JExp Med , vol.206 , Issue.6 , pp. 1327-1337
    • Kuang, D.M.1    Zhao, Q.2    Peng, C.3
  • 67
    • 55249113863 scopus 로고    scopus 로고
    • B7-H1 on myeloid-derived suppressor cells in immune suppression by a mouse model of ovarian cancer
    • Liu Y., Zeng B., Zhang Z., et al. B7-H1 on myeloid-derived suppressor cells in immune suppression by a mouse model of ovarian cancer. Clin Immunol 2008, 129(3):471-481.
    • (2008) Clin Immunol , vol.129 , Issue.3 , pp. 471-481
    • Liu, Y.1    Zeng, B.2    Zhang, Z.3
  • 68
    • 0141672946 scopus 로고    scopus 로고
    • Molecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large Bcell lymphoma related to Hodgkin lymphoma
    • Rosenwald A., Wright G., Leroy K., et al. Molecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large Bcell lymphoma related to Hodgkin lymphoma. JExp Med 2003, 198(6):851-862.
    • (2003) JExp Med , vol.198 , Issue.6 , pp. 851-862
    • Rosenwald, A.1    Wright, G.2    Leroy, K.3
  • 69
    • 10344220548 scopus 로고    scopus 로고
    • Costimulatory B7-H1 in renal cell carcinoma patients: indicator of tumor aggressiveness and potential therapeutic target
    • Thompson R.H., Gillett M.D., Cheville J.C., et al. Costimulatory B7-H1 in renal cell carcinoma patients: indicator of tumor aggressiveness and potential therapeutic target. Proc Natl Acad Sci USA 2004, 101(49):17174-17179.
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.49 , pp. 17174-17179
    • Thompson, R.H.1    Gillett, M.D.2    Cheville, J.C.3
  • 70
    • 33847611968 scopus 로고    scopus 로고
    • Programmed cell death 1 ligand 1 and tumorinfiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer
    • Hamanishi J., Mandai M., Iwasaki M., et al. Programmed cell death 1 ligand 1 and tumorinfiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer. Proc Natl Acad Sci USA 2007, 104(9):3360-3365.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.9 , pp. 3360-3365
    • Hamanishi, J.1    Mandai, M.2    Iwasaki, M.3
  • 71
    • 4243096258 scopus 로고    scopus 로고
    • B7-H1 expression on non-small cell lung cancer cells and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression
    • Konishi J., Yamazaki K., Azuma M., et al. B7-H1 expression on non-small cell lung cancer cells and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression. Clin Cancer Res 2004, 10(15):5094-5100.
    • (2004) Clin Cancer Res , vol.10 , Issue.15 , pp. 5094-5100
    • Konishi, J.1    Yamazaki, K.2    Azuma, M.3
  • 72
    • 34247532726 scopus 로고    scopus 로고
    • Clinical significance and therapeutic potential of the programmed death-1 ligand/programmed death-1 pathway in human pancreatic cancer
    • Nomi T., Sho M., Akahori T., et al. Clinical significance and therapeutic potential of the programmed death-1 ligand/programmed death-1 pathway in human pancreatic cancer. Clin Cancer Res 2007, 13(7):2151-2157.
    • (2007) Clin Cancer Res , vol.13 , Issue.7 , pp. 2151-2157
    • Nomi, T.1    Sho, M.2    Akahori, T.3
  • 73
    • 70349485580 scopus 로고    scopus 로고
    • Human prostate-infiltrating CD8+ T lymphocytes are oligoclonal and PD-1+
    • Sfanos K.S., Bruno T.C., Meeker A.K., et al. Human prostate-infiltrating CD8+ T lymphocytes are oligoclonal and PD-1+. Prostate 2009, 69(15):1694-1703.
    • (2009) Prostate , vol.69 , Issue.15 , pp. 1694-1703
    • Sfanos, K.S.1    Bruno, T.C.2    Meeker, A.K.3
  • 74
    • 70349569569 scopus 로고    scopus 로고
    • Tumor antigen-specific CD8 Tcells infiltrating the tumor express high levels of PD-1 and are functionally impaired
    • Ahmadzadeh M., Johnson L.A., Heemskerk B., et al. Tumor antigen-specific CD8 Tcells infiltrating the tumor express high levels of PD-1 and are functionally impaired. Blood 2009, 114(8):1537-1544.
    • (2009) Blood , vol.114 , Issue.8 , pp. 1537-1544
    • Ahmadzadeh, M.1    Johnson, L.A.2    Heemskerk, B.3
  • 75
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian S.L., Hodi F.S., Brahmer J.R., et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. NEngl J Med 2012, 366(26):2443-2454.
    • (2012) NEngl J Med , vol.366 , Issue.26 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 76
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • Brahmer J.R., Tykodi S.S., Chow L.Q., et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. NEngl J Med 2012, 366(26):2455-2465.
    • (2012) NEngl J Med , vol.366 , Issue.26 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.3
  • 77
    • 42649125225 scopus 로고    scopus 로고
    • PD-1 and its ligands in tolerance and immunity
    • Keir M.E., Butte M.J., Freeman G.J., et al. PD-1 and its ligands in tolerance and immunity. Annu Rev Immunol 2008, 26:677-704.
    • (2008) Annu Rev Immunol , vol.26 , pp. 677-704
    • Keir, M.E.1    Butte, M.J.2    Freeman, G.J.3
  • 78
    • 0033180181 scopus 로고    scopus 로고
    • Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
    • Nishimura H., Nose M., Hiai H., et al. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 1999, 11(2):141-151.
    • (1999) Immunity , vol.11 , Issue.2 , pp. 141-151
    • Nishimura, H.1    Nose, M.2    Hiai, H.3
  • 79
    • 17644389199 scopus 로고    scopus 로고
    • TNF/TNFR family members in costimulation of T cell responses
    • Watts T.H. TNF/TNFR family members in costimulation of T cell responses. Annu Rev Immunol 2005, 23:23-68.
    • (2005) Annu Rev Immunol , vol.23 , pp. 23-68
    • Watts, T.H.1
  • 80
    • 33646419260 scopus 로고    scopus 로고
    • Agonist anti-GITR antibody enhances vaccine induced CD8(+) T-cell responses and tumor immunity
    • Cohen A.D., Diab A., Perales M.A., et al. Agonist anti-GITR antibody enhances vaccine induced CD8(+) T-cell responses and tumor immunity. Cancer Res 2006, 66(9):4904-4912.
    • (2006) Cancer Res , vol.66 , Issue.9 , pp. 4904-4912
    • Cohen, A.D.1    Diab, A.2    Perales, M.A.3
  • 81
    • 41149173311 scopus 로고    scopus 로고
    • The promise of 4-1BB (CD137)-mediated immunomodulation and the immunotherapy of cancer
    • Lynch D.H. The promise of 4-1BB (CD137)-mediated immunomodulation and the immunotherapy of cancer. Immunol Rev 2008, 222:277-286.
    • (2008) Immunol Rev , vol.222 , pp. 277-286
    • Lynch, D.H.1
  • 82
    • 42249097689 scopus 로고    scopus 로고
    • OX40 triggering blocks suppression byregulatory T cells and facilitates tumor rejection
    • Piconese S., Valzasina B., Colombo M.P. OX40 triggering blocks suppression byregulatory T cells and facilitates tumor rejection. JExp Med 2008, 205(4):825-839.
    • (2008) JExp Med , vol.205 , Issue.4 , pp. 825-839
    • Piconese, S.1    Valzasina, B.2    Colombo, M.P.3
  • 83
    • 33646876477 scopus 로고    scopus 로고
    • Glucocorticoid-induced TNF receptor family related gene activation overcomes tolerance/ignorance to melanoma differentiation antigens and enhances antitumor immunity
    • Ramirez-Montagut T., Chow A., Hirschhorn-Cymerman D., et al. Glucocorticoid-induced TNF receptor family related gene activation overcomes tolerance/ignorance to melanoma differentiation antigens and enhances antitumor immunity. JImmunol 2006, 176(11):6434-6442.
    • (2006) JImmunol , vol.176 , Issue.11 , pp. 6434-6442
    • Ramirez-Montagut, T.1    Chow, A.2    Hirschhorn-Cymerman, D.3
  • 84
    • 2942592429 scopus 로고    scopus 로고
    • Therapeutic targeting of the effector T-cell costimulatory molecule OX40
    • Sugamura K., Ishii N., Weinberg A.D. Therapeutic targeting of the effector T-cell costimulatory molecule OX40. Nat Rev Immunol 2004, 4(6):420-431.
    • (2004) Nat Rev Immunol , vol.4 , Issue.6 , pp. 420-431
    • Sugamura, K.1    Ishii, N.2    Weinberg, A.D.3
  • 85
    • 0032984496 scopus 로고    scopus 로고
    • CD40 activation invivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy
    • Diehl L., den Boer A.T., Schoenberger S.P., et al. CD40 activation invivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy. Nat Med 1999, 5(7):774-779.
    • (1999) Nat Med , vol.5 , Issue.7 , pp. 774-779
    • Diehl, L.1    den Boer, A.T.2    Schoenberger, S.P.3
  • 86
    • 75149179545 scopus 로고    scopus 로고
    • Immune stimulatory receptor CD40 is required for T-cell suppression and T regulatory cell activation mediated by myeloid-derived suppressor cells in cancer
    • Pan P.Y., Ma G., Weber K.J., et al. Immune stimulatory receptor CD40 is required for T-cell suppression and T regulatory cell activation mediated by myeloid-derived suppressor cells in cancer. Cancer Res 2010, 70(1):99-108.
    • (2010) Cancer Res , vol.70 , Issue.1 , pp. 99-108
    • Pan, P.Y.1    Ma, G.2    Weber, K.J.3
  • 87
    • 0032984347 scopus 로고    scopus 로고
    • Conversion of tumor-specific CD4+ T-cell tolerance to T-cell priming through invivo ligation of CD40
    • Sotomayor E.M., Borrello I., Tubb E., et al. Conversion of tumor-specific CD4+ T-cell tolerance to T-cell priming through invivo ligation of CD40. Nat Med 1999, 5(7):780-787.
    • (1999) Nat Med , vol.5 , Issue.7 , pp. 780-787
    • Sotomayor, E.M.1    Borrello, I.2    Tubb, E.3
  • 88
    • 9144261696 scopus 로고    scopus 로고
    • Activation of dendritic cells that crosspresent tumor-derived antigen licenses CD8+ CTL to cause tumor eradication
    • van Mierlo G.J., Boonman Z.F., Dumortier H.M., et al. Activation of dendritic cells that crosspresent tumor-derived antigen licenses CD8+ CTL to cause tumor eradication. JImmunol 2004, 173(11):6753-6759.
    • (2004) JImmunol , vol.173 , Issue.11 , pp. 6753-6759
    • van Mierlo, G.J.1    Boonman, Z.F.2    Dumortier, H.M.3
  • 89
    • 33947506186 scopus 로고    scopus 로고
    • Clinical activity and immune modulation in cancer patients treated with CP-870,893, a novel CD40 agonist monoclonal antibody
    • Vonderheide R.H., Flaherty K.T., Khalil M., et al. Clinical activity and immune modulation in cancer patients treated with CP-870,893, a novel CD40 agonist monoclonal antibody. JClin Oncol 2007, 25(7):876-883.
    • (2007) JClin Oncol , vol.25 , Issue.7 , pp. 876-883
    • Vonderheide, R.H.1    Flaherty, K.T.2    Khalil, M.3
  • 90
    • 33748416499 scopus 로고    scopus 로고
    • Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412
    • Suntharalingam G., Perry M.R., Ward S., et al. Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412. NEngl J Med 2006, 355(10):1018-1028.
    • (2006) NEngl J Med , vol.355 , Issue.10 , pp. 1018-1028
    • Suntharalingam, G.1    Perry, M.R.2    Ward, S.3
  • 91
    • 84873411673 scopus 로고    scopus 로고
    • Clinical targeting of the TNF and TNFR superfamilies
    • Croft M., Benedict C.A., Ware C.F. Clinical targeting of the TNF and TNFR superfamilies. Nat Rev Drug Discov 2013, 12(2):147-168.
    • (2013) Nat Rev Drug Discov , vol.12 , Issue.2 , pp. 147-168
    • Croft, M.1    Benedict, C.A.2    Ware, C.F.3
  • 92
    • 84858758766 scopus 로고    scopus 로고
    • Adoptive immunotherapy for cancer: harnessing the T cell response
    • Restifo N.P., Dudley M.E., Rosenberg S.A. Adoptive immunotherapy for cancer: harnessing the T cell response. Nat Rev Immunol 2012, 12(4):269-281.
    • (2012) Nat Rev Immunol , vol.12 , Issue.4 , pp. 269-281
    • Restifo, N.P.1    Dudley, M.E.2    Rosenberg, S.A.3
  • 93
    • 84859153479 scopus 로고    scopus 로고
    • Raising the bar: the curative potential of human cancer immunotherapy
    • Rosenberg S.A. Raising the bar: the curative potential of human cancer immunotherapy. Sci Transl Med 2012, 4(127):127ps8.
    • (2012) Sci Transl Med , vol.4 , Issue.127
    • Rosenberg, S.A.1
  • 94
    • 0024166189 scopus 로고
    • Use of tumor-infiltrating lymphocytes and interleukin-2 in the immunotherapy of patients with metastatic melanoma. A preliminary report
    • Rosenberg S.A., Packard B.S., Aebersold P.M., et al. Use of tumor-infiltrating lymphocytes and interleukin-2 in the immunotherapy of patients with metastatic melanoma. A preliminary report. NEngl J Med 1988, 319(25):1676-1680.
    • (1988) NEngl J Med , vol.319 , Issue.25 , pp. 1676-1680
    • Rosenberg, S.A.1    Packard, B.S.2    Aebersold, P.M.3
  • 95
    • 20244366111 scopus 로고    scopus 로고
    • Adoptive cell transfer therapy following nonmyeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma
    • Dudley M.E., Wunderlich J.R., Yang J.C., et al. Adoptive cell transfer therapy following nonmyeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma. JClin Oncol 2005, 23(10):2346-2357.
    • (2005) JClin Oncol , vol.23 , Issue.10 , pp. 2346-2357
    • Dudley, M.E.1    Wunderlich, J.R.2    Yang, J.C.3
  • 96
    • 20044363610 scopus 로고    scopus 로고
    • CD8+ T cell immunity against a tumor/selfantigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells
    • Antony P.A., Piccirillo C.A., Akpinarli A., et al. CD8+ T cell immunity against a tumor/selfantigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells. JImmunol 2005, 174(5):2591-2601.
    • (2005) JImmunol , vol.174 , Issue.5 , pp. 2591-2601
    • Antony, P.A.1    Piccirillo, C.A.2    Akpinarli, A.3
  • 97
    • 0041975925 scopus 로고    scopus 로고
    • Anti-tumor T cell response and protective immunity in mice that received sublethal irradiation and immune reconstitution
    • Ma J., Urba W.J., Si L., et al. Anti-tumor T cell response and protective immunity in mice that received sublethal irradiation and immune reconstitution. Eur J Immunol 2003, 33(8):2123-2132.
    • (2003) Eur J Immunol , vol.33 , Issue.8 , pp. 2123-2132
    • Ma, J.1    Urba, W.J.2    Si, L.3
  • 98
    • 10744226452 scopus 로고    scopus 로고
    • IL-15 enhances the invivo antitumor activity of tumor-reactive CD8+ T cells
    • Klebanoff C.A., Finkelstein S.E., Surman D.R., et al. IL-15 enhances the invivo antitumor activity of tumor-reactive CD8+ T cells. Proc Natl Acad Sci USA 2004, 101(7):1969-1974.
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.7 , pp. 1969-1974
    • Klebanoff, C.A.1    Finkelstein, S.E.2    Surman, D.R.3
  • 99
    • 25844484607 scopus 로고    scopus 로고
    • Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells
    • Gattinoni L., Finkelstein S.E., Klebanoff C.A., et al. Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells. JExp Med 2005, 202(7):907-912.
    • (2005) JExp Med , vol.202 , Issue.7 , pp. 907-912
    • Gattinoni, L.1    Finkelstein, S.E.2    Klebanoff, C.A.3
  • 100
    • 79960299888 scopus 로고    scopus 로고
    • Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy
    • Rosenberg S.A., Yang J.C., Sherry R.M., et al. Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy. Clin Cancer Res 2011, 17(13):4550-4557.
    • (2011) Clin Cancer Res , vol.17 , Issue.13 , pp. 4550-4557
    • Rosenberg, S.A.1    Yang, J.C.2    Sherry, R.M.3
  • 101
    • 0037829421 scopus 로고    scopus 로고
    • Generation of tumor-infiltrating lymphocyte cultures for use in adoptive transfer therapy for melanoma patients
    • Dudley M.E., Wunderlich J.R., Shelton T.E., et al. Generation of tumor-infiltrating lymphocyte cultures for use in adoptive transfer therapy for melanoma patients. JImmunother 2003, 26(4):332-342.
    • (2003) JImmunother , vol.26 , Issue.4 , pp. 332-342
    • Dudley, M.E.1    Wunderlich, J.R.2    Shelton, T.E.3
  • 102
    • 70149114880 scopus 로고    scopus 로고
    • Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen
    • Johnson L.A., Morgan R.A., Dudley M.E., et al. Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen. Blood 2009, 114(3):535-546.
    • (2009) Blood , vol.114 , Issue.3 , pp. 535-546
    • Johnson, L.A.1    Morgan, R.A.2    Dudley, M.E.3
  • 103
    • 20544457460 scopus 로고    scopus 로고
    • Adoptive T cell therapy: addressing challenges in cancer immunotherapy
    • Yee C. Adoptive T cell therapy: addressing challenges in cancer immunotherapy. JTransl Med 2005, 3(1):17.
    • (2005) JTransl Med , vol.3 , Issue.1 , pp. 17
    • Yee, C.1
  • 104
    • 79953310550 scopus 로고    scopus 로고
    • White paper on adoptive cell therapy for cancer with tumor-infiltrating lymphocytes: a report of the CTEP subcommittee on adoptive cell therapy
    • Weber J., Atkins M., Hwu P., et al. White paper on adoptive cell therapy for cancer with tumor-infiltrating lymphocytes: a report of the CTEP subcommittee on adoptive cell therapy. Clin Cancer Res 2011, 17(7):1664-1673.
    • (2011) Clin Cancer Res , vol.17 , Issue.7 , pp. 1664-1673
    • Weber, J.1    Atkins, M.2    Hwu, P.3
  • 105
    • 33749624177 scopus 로고    scopus 로고
    • Cancer regression in patients after transfer of genetically engineered lymphocytes
    • Morgan R.A., Dudley M.E., Wunderlich J.R., et al. Cancer regression in patients after transfer of genetically engineered lymphocytes. Science 2006, 314(5796):126-129.
    • (2006) Science , vol.314 , Issue.5796 , pp. 126-129
    • Morgan, R.A.1    Dudley, M.E.2    Wunderlich, J.R.3
  • 106
    • 79952187823 scopus 로고    scopus 로고
    • Tcells targeting carcinoembryonic antigen can mediate regression of metastatic colorectal cancer but induce severe transient colitis
    • Parkhurst M.R., Yang J.C., Langan R.C., et al. Tcells targeting carcinoembryonic antigen can mediate regression of metastatic colorectal cancer but induce severe transient colitis. Mol Ther 2011, 19(3):620-626.
    • (2011) Mol Ther , vol.19 , Issue.3 , pp. 620-626
    • Parkhurst, M.R.1    Yang, J.C.2    Langan, R.C.3
  • 107
    • 79952304769 scopus 로고    scopus 로고
    • Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1
    • Robbins P.F., Morgan R.A., Feldman S.A., et al. Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1. JClin Oncol 2011, 29(7):917-924.
    • (2011) JClin Oncol , vol.29 , Issue.7 , pp. 917-924
    • Robbins, P.F.1    Morgan, R.A.2    Feldman, S.A.3
  • 108
    • 79955969751 scopus 로고    scopus 로고
    • Molecular identification of an MHC-independent ligand recognized by a human {alpha}/{beta} T-cell receptor
    • Hanada K., Wang Q.J., Inozume T., et al. Molecular identification of an MHC-independent ligand recognized by a human {alpha}/{beta} T-cell receptor. Blood 2011, 117(18):4816-4825.
    • (2011) Blood , vol.117 , Issue.18 , pp. 4816-4825
    • Hanada, K.1    Wang, Q.J.2    Inozume, T.3
  • 109
    • 0031080901 scopus 로고    scopus 로고
    • Implications for immunosurveillance of altered HLA class I phenotypes in human tumours
    • Garrido F., Ruiz-Cabello F., Cabrera T., et al. Implications for immunosurveillance of altered HLA class I phenotypes in human tumours. Immunol Today 1997, 18(2):89-95.
    • (1997) Immunol Today , vol.18 , Issue.2 , pp. 89-95
    • Garrido, F.1    Ruiz-Cabello, F.2    Cabrera, T.3
  • 110
    • 78549278144 scopus 로고    scopus 로고
    • Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19
    • Kochenderfer J.N., Wilson W.H., Janik J.E., et al. Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19. Blood 2010, 116(20):4099-4102.
    • (2010) Blood , vol.116 , Issue.20 , pp. 4099-4102
    • Kochenderfer, J.N.1    Wilson, W.H.2    Janik, J.E.3
  • 111
    • 84863337890 scopus 로고    scopus 로고
    • B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells
    • Kochenderfer J.N., Dudley M.E., Feldman S.A., et al. B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells. Blood 2012, 119(12):2709-2720.
    • (2012) Blood , vol.119 , Issue.12 , pp. 2709-2720
    • Kochenderfer, J.N.1    Dudley, M.E.2    Feldman, S.A.3
  • 112
    • 80051720194 scopus 로고    scopus 로고
    • Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia
    • Porter D.L., Levine B.L., Kalos M., et al. Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. NEngl J Med 2011, 365(8):725-733.
    • (2011) NEngl J Med , vol.365 , Issue.8 , pp. 725-733
    • Porter, D.L.1    Levine, B.L.2    Kalos, M.3
  • 113
    • 80051775476 scopus 로고    scopus 로고
    • Tcells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia
    • Kalos M., Levine B.L., Porter D.L., et al. Tcells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia. Sci Transl Med 2011, 3(95):95ra73.
    • (2011) Sci Transl Med , vol.3 , Issue.95
    • Kalos, M.1    Levine, B.L.2    Porter, D.L.3
  • 114
    • 33646440024 scopus 로고    scopus 로고
    • Treatment of metastatic renal cell carcinoma with autologous T-lymphocytes genetically retargeted against carbonic anhydrase IX: first clinical experience
    • Lamers C.H., Sleijfer S., Vulto A.G., et al. Treatment of metastatic renal cell carcinoma with autologous T-lymphocytes genetically retargeted against carbonic anhydrase IX: first clinical experience. JClin Oncol 2006, 24(13):e20-e22.
    • (2006) JClin Oncol , vol.24 , Issue.13
    • Lamers, C.H.1    Sleijfer, S.2    Vulto, A.G.3
  • 115
    • 33947265424 scopus 로고    scopus 로고
    • Adoptive transfer of chimeric antigen receptor redirected cytolytic T lymphocyte clones in patients with neuroblastoma
    • Park J.R., Digiusto D.L., Slovak M., et al. Adoptive transfer of chimeric antigen receptor redirected cytolytic T lymphocyte clones in patients with neuroblastoma. Mol Ther 2007, 15(4):825-833.
    • (2007) Mol Ther , vol.15 , Issue.4 , pp. 825-833
    • Park, J.R.1    Digiusto, D.L.2    Slovak, M.3
  • 116
    • 33750699642 scopus 로고    scopus 로고
    • Aphase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer
    • Kershaw M.H., Westwood J.A., Parker L.L., et al. Aphase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer. Clin Cancer Res 2006, 12(20 Pt 1):6106-6115.
    • (2006) Clin Cancer Res , vol.12 , Issue.20 PART 1 , pp. 6106-6115
    • Kershaw, M.H.1    Westwood, J.A.2    Parker, L.L.3
  • 117
    • 77950475517 scopus 로고    scopus 로고
    • Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2
    • Morgan R.A., Yang J.C., Kitano M., et al. Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2. Mol Ther 2010, 18(4):843-851.
    • (2010) Mol Ther , vol.18 , Issue.4 , pp. 843-851
    • Morgan, R.A.1    Yang, J.C.2    Kitano, M.3
  • 118
    • 0017079968 scopus 로고
    • Regression of established tumors and induction of tumor immunity by intratumor chemotherapy
    • Bast R.C., Segerling M., Ohanian S.H., et al. Regression of established tumors and induction of tumor immunity by intratumor chemotherapy. JNatl Cancer Inst 1976, 56(4):829-832.
    • (1976) JNatl Cancer Inst , vol.56 , Issue.4 , pp. 829-832
    • Bast, R.C.1    Segerling, M.2    Ohanian, S.H.3
  • 119
    • 75749147533 scopus 로고    scopus 로고
    • Immunogenic death of colon cancer cells treated with oxaliplatin
    • Tesniere A., Schlemmer F., Boige V., et al. Immunogenic death of colon cancer cells treated with oxaliplatin. Oncogene 2010, 29(4):482-491.
    • (2010) Oncogene , vol.29 , Issue.4 , pp. 482-491
    • Tesniere, A.1    Schlemmer, F.2    Boige, V.3
  • 120
    • 33846057130 scopus 로고    scopus 로고
    • Calreticulin exposure dictates the immunogenicity of cancer cell death
    • Obeid M., Tesniere A., Ghiringhelli F., et al. Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat Med 2007, 13(1):54-61.
    • (2007) Nat Med , vol.13 , Issue.1 , pp. 54-61
    • Obeid, M.1    Tesniere, A.2    Ghiringhelli, F.3
  • 121
    • 50349091770 scopus 로고    scopus 로고
    • Combination of docetaxel and recombinant vaccine enhances T-cell responses and antitumor activity: effects of docetaxel on immune enhancement
    • Garnett C.T., Schlom J., Hodge J.W. Combination of docetaxel and recombinant vaccine enhances T-cell responses and antitumor activity: effects of docetaxel on immune enhancement. Clin Cancer Res 2008, 14(11):3536-3544.
    • (2008) Clin Cancer Res , vol.14 , Issue.11 , pp. 3536-3544
    • Garnett, C.T.1    Schlom, J.2    Hodge, J.W.3
  • 122
    • 77956680680 scopus 로고    scopus 로고
    • Anovel chemoimmunomodulating property of docetaxel: suppression of myeloid-derived suppressor cells in tumor bearers
    • Kodumudi K.N., Woan K., Gilvary D.L., et al. Anovel chemoimmunomodulating property of docetaxel: suppression of myeloid-derived suppressor cells in tumor bearers. Clin Cancer Res 2010, 16(18):4583-4594.
    • (2010) Clin Cancer Res , vol.16 , Issue.18 , pp. 4583-4594
    • Kodumudi, K.N.1    Woan, K.2    Gilvary, D.L.3
  • 123
    • 15944410592 scopus 로고    scopus 로고
    • Inhibition of CD4(+)25+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide
    • Lutsiak M.E., Semnani R.T., De Pascalis R., et al. Inhibition of CD4(+)25+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide. Blood 2005, 105(7):2862-2868.
    • (2005) Blood , vol.105 , Issue.7 , pp. 2862-2868
    • Lutsiak, M.E.1    Semnani, R.T.2    De Pascalis, R.3
  • 124
    • 33847368549 scopus 로고    scopus 로고
    • Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients
    • Ghiringhelli F., Menard C., Puig P.E., et al. Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients. Cancer Immunol Immunother 2007, 56(5):641-648.
    • (2007) Cancer Immunol Immunother , vol.56 , Issue.5 , pp. 641-648
    • Ghiringhelli, F.1    Menard, C.2    Puig, P.E.3
  • 125
    • 0042591416 scopus 로고    scopus 로고
    • Synergy between chemotherapy and immunotherapy in the treatment of established murine solid tumors
    • Nowak A.K., Robinson B.W., Lake R.A. Synergy between chemotherapy and immunotherapy in the treatment of established murine solid tumors. Cancer Res 2003, 63(15):4490-4496.
    • (2003) Cancer Res , vol.63 , Issue.15 , pp. 4490-4496
    • Nowak, A.K.1    Robinson, B.W.2    Lake, R.A.3
  • 126
    • 32944468708 scopus 로고    scopus 로고
    • Combination of p53 cancer vaccine with chemotherapy in patients with extensive stage small cell lung cancer
    • Antonia S.J., Mirza N., Fricke I., et al. Combination of p53 cancer vaccine with chemotherapy in patients with extensive stage small cell lung cancer. Clin Cancer Res 2006, 12(3 Pt 1):878-887.
    • (2006) Clin Cancer Res , vol.12 , Issue.3 PART 1 , pp. 878-887
    • Antonia, S.J.1    Mirza, N.2    Fricke, I.3
  • 127
    • 33644760431 scopus 로고    scopus 로고
    • Arandomized phase II study of concurrent docetaxel plus vaccine versus vaccine alone in metastatic androgen-independent prostate cancer
    • Arlen P.M., Gulley J.L., Parker C., et al. Arandomized phase II study of concurrent docetaxel plus vaccine versus vaccine alone in metastatic androgen-independent prostate cancer. Clin Cancer Res 2006, 12(4):1260-1269.
    • (2006) Clin Cancer Res , vol.12 , Issue.4 , pp. 1260-1269
    • Arlen, P.M.1    Gulley, J.L.2    Parker, C.3
  • 128
    • 4143103624 scopus 로고    scopus 로고
    • Clinical responsiveness of glioblastoma multiforme to chemotherapy after vaccination
    • Wheeler C.J., Das A., Liu G., et al. Clinical responsiveness of glioblastoma multiforme to chemotherapy after vaccination. Clin Cancer Res 2004, 10(16):5316-5326.
    • (2004) Clin Cancer Res , vol.10 , Issue.16 , pp. 5316-5326
    • Wheeler, C.J.1    Das, A.2    Liu, G.3
  • 129
    • 84857815877 scopus 로고    scopus 로고
    • Immunologic correlates of the abscopal effect in a patient with melanoma
    • Postow M.A., Callahan M.K., Barker C.A., et al. Immunologic correlates of the abscopal effect in a patient with melanoma. NEngl J Med 2012, 366(10):925-931.
    • (2012) NEngl J Med , vol.366 , Issue.10 , pp. 925-931
    • Postow, M.A.1    Callahan, M.K.2    Barker, C.A.3
  • 130
    • 84863115998 scopus 로고    scopus 로고
    • Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape
    • Woo S.R., Turnis M.E., Goldberg M.V., et al. Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape. Cancer Res 2012, 72(4):917-927.
    • (2012) Cancer Res , vol.72 , Issue.4 , pp. 917-927
    • Woo, S.R.1    Turnis, M.E.2    Goldberg, M.V.3
  • 131
    • 77957744369 scopus 로고    scopus 로고
    • Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity
    • Sakuishi K., Apetoh L., Sullivan J.M., et al. Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity. JExp Med 2010, 207(10):2187-2194.
    • (2010) JExp Med , vol.207 , Issue.10 , pp. 2187-2194
    • Sakuishi, K.1    Apetoh, L.2    Sullivan, J.M.3
  • 132
    • 77749279776 scopus 로고    scopus 로고
    • PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
    • Curran M.A., Montalvo W., Yagita H., et al. PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors. Proc Natl Acad Sci USA 2010, 107(9):4275-4280.
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.9 , pp. 4275-4280
    • Curran, M.A.1    Montalvo, W.2    Yagita, H.3
  • 133
    • 38649087921 scopus 로고    scopus 로고
    • Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis
    • Swann J.B., Vesely M.D., Silva A., et al. Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis. Proc Natl Acad Sci USA 2008, 105(2):652-656.
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.2 , pp. 652-656
    • Swann, J.B.1    Vesely, M.D.2    Silva, A.3
  • 134
    • 54849440346 scopus 로고    scopus 로고
    • Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin-cyclophosphamide chemotherapy
    • Diaz-Montero C.M., Salem M.L., Nishimura M.I., et al. Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin-cyclophosphamide chemotherapy. Cancer Immunol Immunother 2009, 58(1):49-59.
    • (2009) Cancer Immunol Immunother , vol.58 , Issue.1 , pp. 49-59
    • Diaz-Montero, C.M.1    Salem, M.L.2    Nishimura, M.I.3
  • 135
    • 48549085973 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells promote cross-tolerance in B-cell lymphoma by expanding regulatory T cells
    • Serafini P., Mgebroff S., Noonan K., et al. Myeloid-derived suppressor cells promote cross-tolerance in B-cell lymphoma by expanding regulatory T cells. Cancer Res 2008, 68(13):5439-5449.
    • (2008) Cancer Res , vol.68 , Issue.13 , pp. 5439-5449
    • Serafini, P.1    Mgebroff, S.2    Noonan, K.3
  • 136
    • 34248172324 scopus 로고    scopus 로고
    • Altered macrophage differentiation and immune dysfunction in tumor development
    • Sica A., Bronte V. Altered macrophage differentiation and immune dysfunction in tumor development. JClin Invest 2007, 117(5):1155-1166.
    • (2007) JClin Invest , vol.117 , Issue.5 , pp. 1155-1166
    • Sica, A.1    Bronte, V.2
  • 137
    • 70350728931 scopus 로고    scopus 로고
    • Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation
    • Solinas G., Germano G., Mantovani A., et al. Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation. JLeukoc Biol 2009, 86(5):1065-1073.
    • (2009) JLeukoc Biol , vol.86 , Issue.5 , pp. 1065-1073
    • Solinas, G.1    Germano, G.2    Mantovani, A.3
  • 138
    • 77950950894 scopus 로고    scopus 로고
    • Macrophage diversity enhances tumor progression and metastasis
    • Qian B.Z., Pollard J.W. Macrophage diversity enhances tumor progression and metastasis. Cell 2010, 141(1):39-51.
    • (2010) Cell , vol.141 , Issue.1 , pp. 39-51
    • Qian, B.Z.1    Pollard, J.W.2
  • 139
    • 48349102876 scopus 로고    scopus 로고
    • Macrophage polarization in tumour progression
    • Sica A., Larghi P., Mancino A., et al. Macrophage polarization in tumour progression. Semin Cancer Biol 2008, 18(5):349-355.
    • (2008) Semin Cancer Biol , vol.18 , Issue.5 , pp. 349-355
    • Sica, A.1    Larghi, P.2    Mancino, A.3
  • 140
    • 0041386189 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells in patients with gastrointestinal malignancies: possible involvement of regulatory T cells in disease progression
    • Sasada T., Kimura M., Yoshida Y., et al. CD4+CD25+ regulatory T cells in patients with gastrointestinal malignancies: possible involvement of regulatory T cells in disease progression. Cancer 2003, 98(5):1089-1099.
    • (2003) Cancer , vol.98 , Issue.5 , pp. 1089-1099
    • Sasada, T.1    Kimura, M.2    Yoshida, Y.3
  • 141
    • 4644237613 scopus 로고    scopus 로고
    • Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    • Curiel T.J., Coukos G., Zou L., et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med 2004, 10(9):942-949.
    • (2004) Nat Med , vol.10 , Issue.9 , pp. 942-949
    • Curiel, T.J.1    Coukos, G.2    Zou, L.3
  • 142
    • 34247261531 scopus 로고    scopus 로고
    • Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse
    • Bates G.J., Fox S.B., Han C., et al. Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse. JClin Oncol 2006, 24(34):5373-5380.
    • (2006) JClin Oncol , vol.24 , Issue.34 , pp. 5373-5380
    • Bates, G.J.1    Fox, S.B.2    Han, C.3
  • 143
    • 79952193038 scopus 로고    scopus 로고
    • Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling
    • Tan W., Zhang W., Strasner A., et al. Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling. Nature 2011, 470(7335):548-553.
    • (2011) Nature , vol.470 , Issue.7335 , pp. 548-553
    • Tan, W.1    Zhang, W.2    Strasner, A.3


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