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Volumn 22, Issue 4, 2013, Pages 823-840

Advances in Molecular and Clinical Subtyping of Breast Cancer and Their Implications for Therapy

Author keywords

Breast cancer; Endocrine therapy; HER2 positive; Intrinsic subtypes; Resistance; Triple negative

Indexed keywords

ANASTROZOLE; ANDROGEN RECEPTOR; AROMATASE INHIBITOR; BICALUTAMIDE; BUPARLISIB; CARBOPLATIN; CETUXIMAB; CISPLATIN; CLAUDIN; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; EVEROLIMUS; EXEMESTANE; FULVESTRANT; IRINOTECAN; LAPATINIB; LETROZOLE; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; PICTILISIB; PLATINUM COMPLEX; PROTEIN PIK3CA; RAPAMYCIN; TAMOXIFEN; TRASTUZUMAB; TRASTUZUMAB EMTANSINE; UNCLASSIFIED DRUG;

EID: 84883552212     PISSN: 10553207     EISSN: 15585042     Source Type: Journal    
DOI: 10.1016/j.soc.2013.06.006     Document Type: Review
Times cited : (33)

References (95)
  • 1
    • 0037478605 scopus 로고    scopus 로고
    • Repeated observation of breast tumor subtypes in independent gene expression data sets
    • Sorlie T., Tibshirani R., Parker J., et al. Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc Natl Acad Sci USA 2003, 100(14):8418-8423.
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.14 , pp. 8418-8423
    • Sorlie, T.1    Tibshirani, R.2    Parker, J.3
  • 2
    • 60849097255 scopus 로고    scopus 로고
    • Gene-expression signatures in breast cancer
    • Sotiriou C., Pusztai L. Gene-expression signatures in breast cancer. NEngl J Med 2009, 360(8):790-800.
    • (2009) NEngl J Med , vol.360 , Issue.8 , pp. 790-800
    • Sotiriou, C.1    Pusztai, L.2
  • 3
    • 34250887474 scopus 로고    scopus 로고
    • Taking gene-expression profiling to the clinic: when will molecular signatures become relevant to patient care?
    • Sotiriou C., Piccart M.J. Taking gene-expression profiling to the clinic: when will molecular signatures become relevant to patient care?. Nat Rev Cancer 2007, 7(7):545-553.
    • (2007) Nat Rev Cancer , vol.7 , Issue.7 , pp. 545-553
    • Sotiriou, C.1    Piccart, M.J.2
  • 4
    • 0034680102 scopus 로고    scopus 로고
    • Molecular portraits of human breast tumours
    • Perou C.M., Sorlie T., Eisen M.B., et al. Molecular portraits of human breast tumours. Nature 2000, 406(6797):747-752.
    • (2000) Nature , vol.406 , Issue.6797 , pp. 747-752
    • Perou, C.M.1    Sorlie, T.2    Eisen, M.B.3
  • 5
    • 0035845511 scopus 로고    scopus 로고
    • Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
    • Sorlie T., Perou C.M., Tibshirani R., et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA 2001, 98(19):10869-10874.
    • (2001) Proc Natl Acad Sci USA , vol.98 , Issue.19 , pp. 10869-10874
    • Sorlie, T.1    Perou, C.M.2    Tibshirani, R.3
  • 6
    • 34548863946 scopus 로고    scopus 로고
    • Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors
    • Herschkowitz J.I., Simin K., Weigman V.J., et al. Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors. Genome Biol 2007, 8(5):R76.
    • (2007) Genome Biol , vol.8 , Issue.5
    • Herschkowitz, J.I.1    Simin, K.2    Weigman, V.J.3
  • 7
    • 33646874546 scopus 로고    scopus 로고
    • The molecular portraits of breast tumors are conserved across microarray platforms
    • Hu Z., Fan C., Oh D.S., et al. The molecular portraits of breast tumors are conserved across microarray platforms. BMC Genomics 2006, 7:96.
    • (2006) BMC Genomics , vol.7 , pp. 96
    • Hu, Z.1    Fan, C.2    Oh, D.S.3
  • 8
    • 78650339362 scopus 로고    scopus 로고
    • Intrinsic breast tumor subtypes, race, and long-term survival in the Carolina Breast Cancer Study
    • O'Brien K.M., Cole S.R., Tse C.K., et al. Intrinsic breast tumor subtypes, race, and long-term survival in the Carolina Breast Cancer Study. Clin Cancer Res 2010, 16(24):6100-6110.
    • (2010) Clin Cancer Res , vol.16 , Issue.24 , pp. 6100-6110
    • O'Brien, K.M.1    Cole, S.R.2    Tse, C.K.3
  • 9
    • 78049308800 scopus 로고    scopus 로고
    • Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer
    • Prat A., Parker J.S., Karginova O., et al. Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer. Breast Cancer Res 2010, 12(5):R68.
    • (2010) Breast Cancer Res , vol.12 , Issue.5
    • Prat, A.1    Parker, J.S.2    Karginova, O.3
  • 10
    • 33847063053 scopus 로고    scopus 로고
    • The triple negative paradox: primary tumor chemosensitivity of breast cancer subtypes
    • Carey L.A., Dees E.C., Sawyer L., et al. The triple negative paradox: primary tumor chemosensitivity of breast cancer subtypes. Clin Cancer Res 2007, 13(8):2329-2334.
    • (2007) Clin Cancer Res , vol.13 , Issue.8 , pp. 2329-2334
    • Carey, L.A.1    Dees, E.C.2    Sawyer, L.3
  • 11
    • 23844549918 scopus 로고    scopus 로고
    • Breast cancer molecular subtypes respond differently to preoperative chemotherapy
    • Rouzier R., Perou C.M., Symmans W.F., et al. Breast cancer molecular subtypes respond differently to preoperative chemotherapy. Clin Cancer Res 2005, 11(16):5678-5685.
    • (2005) Clin Cancer Res , vol.11 , Issue.16 , pp. 5678-5685
    • Rouzier, R.1    Perou, C.M.2    Symmans, W.F.3
  • 12
    • 84861708138 scopus 로고    scopus 로고
    • Molecular biology in breast cancer: intrinsic subtypes and signaling pathways
    • Eroles P., Bosch A., Perez-Fidalgo J.A., et al. Molecular biology in breast cancer: intrinsic subtypes and signaling pathways. Cancer Treat Rev 2012, 38(6):698-707.
    • (2012) Cancer Treat Rev , vol.38 , Issue.6 , pp. 698-707
    • Eroles, P.1    Bosch, A.2    Perez-Fidalgo, J.A.3
  • 13
    • 77954740501 scopus 로고    scopus 로고
    • Metastatic behavior of breast cancer subtypes
    • Kennecke H., Yerushalmi R., Woods R., et al. Metastatic behavior of breast cancer subtypes. JClin Oncol 2010, 28(20):3271-3277.
    • (2010) JClin Oncol , vol.28 , Issue.20 , pp. 3271-3277
    • Kennecke, H.1    Yerushalmi, R.2    Woods, R.3
  • 14
    • 84877028141 scopus 로고    scopus 로고
    • Comprehensive molecular portraits of human breast tumours
    • Cancer Genome Atlas Network
    • Cancer Genome Atlas Network Comprehensive molecular portraits of human breast tumours. Nature 2012, 490(7418):61-70.
    • (2012) Nature , vol.490 , Issue.7418 , pp. 61-70
  • 15
    • 79957602579 scopus 로고    scopus 로고
    • St. Gallen 2011: Summary of the consensus discussion
    • Gnant M., Harbeck N., Thomssen C. St. Gallen 2011: Summary of the consensus discussion. Breast Care (Basel) 2011, 6(2):136-141.
    • (2011) Breast Care (Basel) , vol.6 , Issue.2 , pp. 136-141
    • Gnant, M.1    Harbeck, N.2    Thomssen, C.3
  • 16
    • 84866756366 scopus 로고    scopus 로고
    • The molecular profile of luminal B breast cancer
    • Creighton C.J. The molecular profile of luminal B breast cancer. Biologics 2012, 6:289-297.
    • (2012) Biologics , vol.6 , pp. 289-297
    • Creighton, C.J.1
  • 17
    • 32944481592 scopus 로고    scopus 로고
    • Breast cancer: achievements in adjuvant systemic therapies in the pre-genomic era
    • Colozza M., de Azambuja E., Cardoso F., et al. Breast cancer: achievements in adjuvant systemic therapies in the pre-genomic era. Oncologist 2006, 11(2):111-125.
    • (2006) Oncologist , vol.11 , Issue.2 , pp. 111-125
    • Colozza, M.1    de Azambuja, E.2    Cardoso, F.3
  • 18
    • 62449131093 scopus 로고    scopus 로고
    • Supervised risk predictor of breast cancer based on intrinsic subtypes
    • Parker J.S., Mullins M., Cheang M.C., et al. Supervised risk predictor of breast cancer based on intrinsic subtypes. JClin Oncol 2009, 27(8):1160-1167.
    • (2009) JClin Oncol , vol.27 , Issue.8 , pp. 1160-1167
    • Parker, J.S.1    Mullins, M.2    Cheang, M.C.3
  • 19
    • 79959520764 scopus 로고    scopus 로고
    • Molecular stratification of triple-negative breast cancers
    • Perou C.M. Molecular stratification of triple-negative breast cancers. Oncologist 2011, 16(Suppl 1):61-70.
    • (2011) Oncologist , vol.16 , Issue.SUPPL 1 , pp. 61-70
    • Perou, C.M.1
  • 20
    • 33744960226 scopus 로고    scopus 로고
    • Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study
    • Carey L.A., Perou C.M., Livasy C.A., et al. Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study. JAMA 2006, 295(21):2492-2502.
    • (2006) JAMA , vol.295 , Issue.21 , pp. 2492-2502
    • Carey, L.A.1    Perou, C.M.2    Livasy, C.A.3
  • 21
    • 45149094267 scopus 로고    scopus 로고
    • Basal-like breast cancer: a critical review
    • Rakha E.A., Reis-Filho J.S., Ellis I.O. Basal-like breast cancer: a critical review. JClin Oncol 2008, 26(15):2568-2581.
    • (2008) JClin Oncol , vol.26 , Issue.15 , pp. 2568-2581
    • Rakha, E.A.1    Reis-Filho, J.S.2    Ellis, I.O.3
  • 22
    • 33845215486 scopus 로고    scopus 로고
    • Basal phenotype identifies a poor prognostic subgroup of breast cancer of clinical importance
    • Rakha E.A., El-Rehim D.A., Paish C., et al. Basal phenotype identifies a poor prognostic subgroup of breast cancer of clinical importance. Eur J Cancer 2006, 42(18):3149-3156.
    • (2006) Eur J Cancer , vol.42 , Issue.18 , pp. 3149-3156
    • Rakha, E.A.1    El-Rehim, D.A.2    Paish, C.3
  • 23
    • 4143150688 scopus 로고    scopus 로고
    • Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma
    • Nielsen T.O., Hsu F.D., Jensen K., et al. Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma. Clin Cancer Res 2004, 10(16):5367-5374.
    • (2004) Clin Cancer Res , vol.10 , Issue.16 , pp. 5367-5374
    • Nielsen, T.O.1    Hsu, F.D.2    Jensen, K.3
  • 24
    • 78951482208 scopus 로고    scopus 로고
    • Deconstructing the molecular portraits of breast cancer
    • Prat A., Perou C.M. Deconstructing the molecular portraits of breast cancer. Mol Oncol 2011, 5(1):5-23.
    • (2011) Mol Oncol , vol.5 , Issue.1 , pp. 5-23
    • Prat, A.1    Perou, C.M.2
  • 25
    • 84860166698 scopus 로고    scopus 로고
    • Molecular profiling assays in breast cancer: are we ready for prime time?
    • 61
    • Gokmen-Polar Y., Badve S. Molecular profiling assays in breast cancer: are we ready for prime time?. Oncology (Williston Park) 2012, 26(4):350-357. 61.
    • (2012) Oncology (Williston Park) , vol.26 , Issue.4 , pp. 350-357
    • Gokmen-Polar, Y.1    Badve, S.2
  • 26
    • 84869811250 scopus 로고    scopus 로고
    • Molecular subclasses of breast cancer: how do we define them? The IMPAKT 2012 Working Group Statement
    • Guiu S., Michiels S., Andre F., et al. Molecular subclasses of breast cancer: how do we define them? The IMPAKT 2012 Working Group Statement. Ann Oncol 2012, 23(12):2997-3006.
    • (2012) Ann Oncol , vol.23 , Issue.12 , pp. 2997-3006
    • Guiu, S.1    Michiels, S.2    Andre, F.3
  • 27
    • 81555199640 scopus 로고    scopus 로고
    • Microarrays in the 2010s: the contribution of microarray-based gene expression profiling to breast cancer classification, prognostication and prediction
    • Colombo P.E., Milanezi F., Weigelt B., et al. Microarrays in the 2010s: the contribution of microarray-based gene expression profiling to breast cancer classification, prognostication and prediction. Breast Cancer Res 2011, 13(3):212.
    • (2011) Breast Cancer Res , vol.13 , Issue.3 , pp. 212
    • Colombo, P.E.1    Milanezi, F.2    Weigelt, B.3
  • 28
    • 0037137519 scopus 로고    scopus 로고
    • Agene-expression signature as apredictor of survival in breast cancer
    • van de Vijver M.J., He Y.D., van't Veer L.J., et al. Agene-expression signature as apredictor of survival in breast cancer. NEngl J Med 2002, 347(25):1999-2009.
    • (2002) NEngl J Med , vol.347 , Issue.25 , pp. 1999-2009
    • van de Vijver, M.J.1    He, Y.D.2    van't Veer, L.J.3
  • 29
    • 33748693297 scopus 로고    scopus 로고
    • Validation and clinical utility of a 70-gene prognostic signature for women with node-negative breast cancer
    • Buyse M., Loi S., van't Veer L., et al. Validation and clinical utility of a 70-gene prognostic signature for women with node-negative breast cancer. JNatl Cancer Inst 2006, 98(17):1183-1192.
    • (2006) JNatl Cancer Inst , vol.98 , Issue.17 , pp. 1183-1192
    • Buyse, M.1    Loi, S.2    van't Veer, L.3
  • 30
    • 77950862535 scopus 로고    scopus 로고
    • The 70-gene prognosis signature predicts early metastasis in breast cancer patients between 55 and 70 years of age
    • Mook S., Schmidt M.K., Weigelt B., et al. The 70-gene prognosis signature predicts early metastasis in breast cancer patients between 55 and 70 years of age. Ann Oncol 2010, 21(4):717-722.
    • (2010) Ann Oncol , vol.21 , Issue.4 , pp. 717-722
    • Mook, S.1    Schmidt, M.K.2    Weigelt, B.3
  • 31
    • 33744814477 scopus 로고    scopus 로고
    • Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer
    • Paik S., Tang G., Shak S., et al. Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer. JClin Oncol 2006, 24(23):3726-3734.
    • (2006) JClin Oncol , vol.24 , Issue.23 , pp. 3726-3734
    • Paik, S.1    Tang, G.2    Shak, S.3
  • 32
    • 19944422061 scopus 로고    scopus 로고
    • Amultigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer
    • Paik S., Shak S., Tang G., et al. Amultigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. NEngl J Med 2004, 351(27):2817-2826.
    • (2004) NEngl J Med , vol.351 , Issue.27 , pp. 2817-2826
    • Paik, S.1    Shak, S.2    Tang, G.3
  • 33
    • 73249140371 scopus 로고    scopus 로고
    • Prognostic and predictive value of the 21-gene recurrence score assay in postmenopausal women with node-positive, oestrogen-receptor-positive breast cancer on chemotherapy: a retrospective analysis of a randomised trial
    • Albain K.S., Barlow W.E., Shak S., et al. Prognostic and predictive value of the 21-gene recurrence score assay in postmenopausal women with node-positive, oestrogen-receptor-positive breast cancer on chemotherapy: a retrospective analysis of a randomised trial. Lancet Oncol 2010, 11(1):55-65.
    • (2010) Lancet Oncol , vol.11 , Issue.1 , pp. 55-65
    • Albain, K.S.1    Barlow, W.E.2    Shak, S.3
  • 34
    • 50549123220 scopus 로고
    • On the treatment of inoperable cases of carcinoma of the mamma: suggestions for a new method of treatment with illustrative cases
    • Beatson G.T. On the treatment of inoperable cases of carcinoma of the mamma: suggestions for a new method of treatment with illustrative cases. Lancet 1896, 2:104-107.
    • (1896) Lancet , vol.2 , pp. 104-107
    • Beatson, G.T.1
  • 35
    • 84876968058 scopus 로고    scopus 로고
    • The development of endocrine therapy for women with breast cancer
    • Sainsbury R. The development of endocrine therapy for women with breast cancer. Cancer Treat Rev 2013, 39(5):507-517.
    • (2013) Cancer Treat Rev , vol.39 , Issue.5 , pp. 507-517
    • Sainsbury, R.1
  • 36
    • 84876720503 scopus 로고    scopus 로고
    • Endocrine therapy resistance: current status, possible mechanisms and overcoming strategies
    • Chang J., Fan W. Endocrine therapy resistance: current status, possible mechanisms and overcoming strategies. Anticancer Agents Med Chem 2013, 13(3):464-475.
    • (2013) Anticancer Agents Med Chem , vol.13 , Issue.3 , pp. 464-475
    • Chang, J.1    Fan, W.2
  • 37
    • 0034616656 scopus 로고    scopus 로고
    • Combined treatment with buserelin and tamoxifen in premenopausal metastatic breast cancer: a randomized study
    • Klijn J.G., Beex L.V., Mauriac L., et al. Combined treatment with buserelin and tamoxifen in premenopausal metastatic breast cancer: a randomized study. JNatl Cancer Inst 2000, 92(11):903-911.
    • (2000) JNatl Cancer Inst , vol.92 , Issue.11 , pp. 903-911
    • Klijn, J.G.1    Beex, L.V.2    Mauriac, L.3
  • 38
    • 84863078767 scopus 로고    scopus 로고
    • Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer
    • Baselga J., Campone M., Piccart M., et al. Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer. NEngl J Med 2012, 366(6):520-529.
    • (2012) NEngl J Med , vol.366 , Issue.6 , pp. 520-529
    • Baselga, J.1    Campone, M.2    Piccart, M.3
  • 39
    • 84871496915 scopus 로고    scopus 로고
    • Overcoming endocrine resistance in breast cancer: importance of mTOR inhibition
    • Gnant M. Overcoming endocrine resistance in breast cancer: importance of mTOR inhibition. Expert Rev Anticancer Ther 2012, 12(12):1579-1589.
    • (2012) Expert Rev Anticancer Ther , vol.12 , Issue.12 , pp. 1579-1589
    • Gnant, M.1
  • 40
    • 84858385940 scopus 로고    scopus 로고
    • Endocrine resistance in breast cancer: molecular pathways and rational development of targeted therapies
    • Roop R.P., Ma C.X. Endocrine resistance in breast cancer: molecular pathways and rational development of targeted therapies. Future Oncol 2012, 8(3):273-292.
    • (2012) Future Oncol , vol.8 , Issue.3 , pp. 273-292
    • Roop, R.P.1    Ma, C.X.2
  • 41
    • 0036633164 scopus 로고    scopus 로고
    • Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells
    • Clark A.S., West K., Streicher S., et al. Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells. Mol Cancer Ther 2002, 1(9):707-717.
    • (2002) Mol Cancer Ther , vol.1 , Issue.9 , pp. 707-717
    • Clark, A.S.1    West, K.2    Streicher, S.3
  • 42
    • 6944235337 scopus 로고    scopus 로고
    • Inhibition of mTOR activity restores tamoxifen response in breast cancer cells with aberrant Akt Activity
    • deGraffenried L.A., Friedrichs W.E., Russell D.H., et al. Inhibition of mTOR activity restores tamoxifen response in breast cancer cells with aberrant Akt Activity. Clin Cancer Res 2004, 10(23):8059-8067.
    • (2004) Clin Cancer Res , vol.10 , Issue.23 , pp. 8059-8067
    • deGraffenried, L.A.1    Friedrichs, W.E.2    Russell, D.H.3
  • 43
    • 54949142523 scopus 로고    scopus 로고
    • MTOR inhibition reverses acquired endocrine therapy resistance of breast cancer cells at the cell proliferation and gene-expression levels
    • Ghayad S.E., Bieche I., Vendrell J.A., et al. mTOR inhibition reverses acquired endocrine therapy resistance of breast cancer cells at the cell proliferation and gene-expression levels. Cancer Sci 2008, 99(10):1992-2003.
    • (2008) Cancer Sci , vol.99 , Issue.10 , pp. 1992-2003
    • Ghayad, S.E.1    Bieche, I.2    Vendrell, J.A.3
  • 44
    • 84864558874 scopus 로고    scopus 로고
    • Randomized phase II trial of everolimus in combination with tamoxifen in patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer with prior exposure to aromatase inhibitors: a GINECO study
    • Bachelot T., Bourgier C., Cropet C., et al. Randomized phase II trial of everolimus in combination with tamoxifen in patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer with prior exposure to aromatase inhibitors: a GINECO study. JClin Oncol 2012, 30(22):2718-2724.
    • (2012) JClin Oncol , vol.30 , Issue.22 , pp. 2718-2724
    • Bachelot, T.1    Bourgier, C.2    Cropet, C.3
  • 45
    • 84883554902 scopus 로고    scopus 로고
    • Reversal of tamoxifen resistance (hormone resistance) by addition of sirolimus (mTOR inhibitor) in metastatic breast cancer. European Multidisciplinary Cancer Conference, Stockholm. September 23-27. [abstract LBA16].
    • Bhattacharyya GS, Biswas J, Singh JK, etal. Reversal of tamoxifen resistance (hormone resistance) by addition of sirolimus (mTOR inhibitor) in metastatic breast cancer. European Multidisciplinary Cancer Conference, Stockholm. September 23-27, 2011. [abstract LBA16].
    • (2011)
    • Bhattacharyya, G.S.1    Biswas, J.2    Singh, J.K.3
  • 46
    • 84872518645 scopus 로고    scopus 로고
    • Randomized phase III placebo-controlled trial of letrozole plus oral temsirolimus as first-line endocrine therapy in postmenopausal women with locally advanced or metastatic breast cancer
    • Wolff A.C., Lazar A.A., Bondarenko I., et al. Randomized phase III placebo-controlled trial of letrozole plus oral temsirolimus as first-line endocrine therapy in postmenopausal women with locally advanced or metastatic breast cancer. JClin Oncol 2013, 31(2):195-202.
    • (2013) JClin Oncol , vol.31 , Issue.2 , pp. 195-202
    • Wolff, A.C.1    Lazar, A.A.2    Bondarenko, I.3
  • 47
    • 84872593587 scopus 로고    scopus 로고
    • Improving endocrine therapy for breast cancer: it's not that simple
    • Dees E.C., Carey L.A. Improving endocrine therapy for breast cancer: it's not that simple. JClin Oncol 2013, 31(2):171-173.
    • (2013) JClin Oncol , vol.31 , Issue.2 , pp. 171-173
    • Dees, E.C.1    Carey, L.A.2
  • 48
    • 84864549282 scopus 로고    scopus 로고
    • Reversing hormone resistance: have we found the golden key?
    • Rugo H.S., Keck S. Reversing hormone resistance: have we found the golden key?. JClin Oncol 2012, 30(22):2707-2709.
    • (2012) JClin Oncol , vol.30 , Issue.22 , pp. 2707-2709
    • Rugo, H.S.1    Keck, S.2
  • 49
    • 81755162797 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase and antiestrogen resistance in breast cancer
    • Miller T.W., Balko J.M., Arteaga C.L. Phosphatidylinositol 3-kinase and antiestrogen resistance in breast cancer. JClin Oncol 2011, 29(33):4452-4461.
    • (2011) JClin Oncol , vol.29 , Issue.33 , pp. 4452-4461
    • Miller, T.W.1    Balko, J.M.2    Arteaga, C.L.3
  • 50
    • 84883553973 scopus 로고    scopus 로고
    • Phase III randomized study of the oral pan-PI3K inhibitor BKM120 with fulvestrant in postmenopausal women with HR+/HER2- locally advanced or metastatic breast cancer resistant to aromatase inhibitor - BELLE-2
    • [abstract OT2-3-09]
    • Baselga J., Campone M., Cortes J., et al. Phase III randomized study of the oral pan-PI3K inhibitor BKM120 with fulvestrant in postmenopausal women with HR+/HER2- locally advanced or metastatic breast cancer resistant to aromatase inhibitor - BELLE-2. Cancer Res 2012, 72(Suppl 24). [abstract OT2-3-09].
    • (2012) Cancer Res , vol.72 , Issue.SUPPL 24
    • Baselga, J.1    Campone, M.2    Cortes, J.3
  • 51
    • 84876864740 scopus 로고    scopus 로고
    • Abrogating endocrine resistance by targeting ERalpha and PI3K in breast cancer
    • Fox E.M., Arteaga C.L., Miller T.W. Abrogating endocrine resistance by targeting ERalpha and PI3K in breast cancer. Front Oncol 2012, 2:145.
    • (2012) Front Oncol , vol.2 , pp. 145
    • Fox, E.M.1    Arteaga, C.L.2    Miller, T.W.3
  • 52
    • 73949139238 scopus 로고    scopus 로고
    • How to treat hormone receptor-positive, human epidermal growth factor receptor 2-amplified breast cancer
    • Cortes J., Baselga J. How to treat hormone receptor-positive, human epidermal growth factor receptor 2-amplified breast cancer. JClin Oncol 2009, 27(33):5492-5494.
    • (2009) JClin Oncol , vol.27 , Issue.33 , pp. 5492-5494
    • Cortes, J.1    Baselga, J.2
  • 53
    • 77649173208 scopus 로고    scopus 로고
    • Lapatinib restores hormone sensitivity with differential effects on estrogen receptor signaling in cell models of human epidermal growth factor receptor 2-negative breast cancer with acquired endocrine resistance
    • Leary A.F., Drury S., Detre S., et al. Lapatinib restores hormone sensitivity with differential effects on estrogen receptor signaling in cell models of human epidermal growth factor receptor 2-negative breast cancer with acquired endocrine resistance. Clin Cancer Res 2010, 16(5):1486-1497.
    • (2010) Clin Cancer Res , vol.16 , Issue.5 , pp. 1486-1497
    • Leary, A.F.1    Drury, S.2    Detre, S.3
  • 54
    • 73949105921 scopus 로고    scopus 로고
    • Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: results from the randomized phase III TAnDEM study
    • Kaufman B., Mackey J.R., Clemens M.R., et al. Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: results from the randomized phase III TAnDEM study. JClin Oncol 2009, 27(33):5529-5537.
    • (2009) JClin Oncol , vol.27 , Issue.33 , pp. 5529-5537
    • Kaufman, B.1    Mackey, J.R.2    Clemens, M.R.3
  • 55
    • 73149115341 scopus 로고    scopus 로고
    • Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer
    • Johnston S., Pippen J., Pivot X., et al. Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer. JClin Oncol 2009, 27(33):5538-5546.
    • (2009) JClin Oncol , vol.27 , Issue.33 , pp. 5538-5546
    • Johnston, S.1    Pippen, J.2    Pivot, X.3
  • 56
    • 77949754385 scopus 로고    scopus 로고
    • Phase II, randomized trial to compare anastrozole combined with gefitinib or placebo in postmenopausal women with hormone receptor-positive metastatic breast cancer
    • Cristofanilli M., Valero V., Mangalik A., et al. Phase II, randomized trial to compare anastrozole combined with gefitinib or placebo in postmenopausal women with hormone receptor-positive metastatic breast cancer. Clin Cancer Res 2010, 16(6):1904-1914.
    • (2010) Clin Cancer Res , vol.16 , Issue.6 , pp. 1904-1914
    • Cristofanilli, M.1    Valero, V.2    Mangalik, A.3
  • 57
    • 77949882440 scopus 로고    scopus 로고
    • The effects of gefitinib in tamoxifen-resistant and hormone-insensitive breast cancer: a phase II study
    • Gutteridge E., Agrawal A., Nicholson R., et al. The effects of gefitinib in tamoxifen-resistant and hormone-insensitive breast cancer: a phase II study. Int J Cancer 2010, 126(8):1806-1816.
    • (2010) Int J Cancer , vol.126 , Issue.8 , pp. 1806-1816
    • Gutteridge, E.1    Agrawal, A.2    Nicholson, R.3
  • 58
    • 79952259688 scopus 로고    scopus 로고
    • Gefitinib or placebo in combination with tamoxifen in patients with hormone receptor-positive metastatic breast cancer: a randomized phase II study
    • Osborne C.K., Neven P., Dirix L.Y., et al. Gefitinib or placebo in combination with tamoxifen in patients with hormone receptor-positive metastatic breast cancer: a randomized phase II study. Clin Cancer Res 2011, 17(5):1147-1159.
    • (2011) Clin Cancer Res , vol.17 , Issue.5 , pp. 1147-1159
    • Osborne, C.K.1    Neven, P.2    Dirix, L.Y.3
  • 59
    • 84883561171 scopus 로고    scopus 로고
    • Study of Anastrozole+/- AZD8931 in Postmenopausal Women With Endocrine Therapy Naive Breast Cancer (MINT). ClinicalTrials.gov Identifier: NCT01151215. Available at: Accessed March 10.
    • Study of Anastrozole+/- AZD8931 in Postmenopausal Women With Endocrine Therapy Naive Breast Cancer (MINT). ClinicalTrials.gov Identifier: NCT01151215. Available at: Accessed March 10, 2013. http://clinicaltrials.gov/ct2/show/NCT01151215.
    • (2013)
  • 60
    • 34347395733 scopus 로고    scopus 로고
    • Trastuzumab-mechanism of action and use in clinical practice
    • Hudis C.A. Trastuzumab-mechanism of action and use in clinical practice. NEngl J Med 2007, 357(1):39-51.
    • (2007) NEngl J Med , vol.357 , Issue.1 , pp. 39-51
    • Hudis, C.A.1
  • 61
    • 37049183697 scopus 로고
    • Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon D.J., Clark G.M., Wong S.G., et al. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987, 235(4785):177-182.
    • (1987) Science , vol.235 , Issue.4785 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3
  • 62
    • 0024337144 scopus 로고
    • Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer
    • Slamon D.J., Godolphin W., Jones L.A., et al. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 1989, 244(4905):707-712.
    • (1989) Science , vol.244 , Issue.4905 , pp. 707-712
    • Slamon, D.J.1    Godolphin, W.2    Jones, L.A.3
  • 63
    • 65349101151 scopus 로고    scopus 로고
    • Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941
    • Junttila T.T., Akita R.W., Parsons K., et al. Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941. Cancer Cell 2009, 15(5):429-440.
    • (2009) Cancer Cell , vol.15 , Issue.5 , pp. 429-440
    • Junttila, T.T.1    Akita, R.W.2    Parsons, K.3
  • 64
    • 0035874898 scopus 로고    scopus 로고
    • Down-regulation of the erbB-2 receptor by trastuzumab (herceptin) enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast and ovarian cancer cell lines that overexpress erbB-2
    • Cuello M., Ettenberg S.A., Clark A.S., et al. Down-regulation of the erbB-2 receptor by trastuzumab (herceptin) enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast and ovarian cancer cell lines that overexpress erbB-2. Cancer Res 2001, 61(12):4892-4900.
    • (2001) Cancer Res , vol.61 , Issue.12 , pp. 4892-4900
    • Cuello, M.1    Ettenberg, S.A.2    Clark, A.S.3
  • 65
    • 0037099532 scopus 로고    scopus 로고
    • Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt Is required for antibody-mediated effects on p27, cyclin D1, and antitumor action
    • Yakes F.M., Chinratanalab W., Ritter C.A., et al. Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt Is required for antibody-mediated effects on p27, cyclin D1, and antitumor action. Cancer Res 2002, 62(14):4132-4141.
    • (2002) Cancer Res , vol.62 , Issue.14 , pp. 4132-4141
    • Yakes, F.M.1    Chinratanalab, W.2    Ritter, C.A.3
  • 66
    • 0035869407 scopus 로고    scopus 로고
    • Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    • Slamon D.J., Leyland-Jones B., Shak S., et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. NEngl J Med 2001, 344(11):783-792.
    • (2001) NEngl J Med , vol.344 , Issue.11 , pp. 783-792
    • Slamon, D.J.1    Leyland-Jones, B.2    Shak, S.3
  • 67
    • 26844503270 scopus 로고    scopus 로고
    • Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer
    • Piccart-Gebhart M.J., Procter M., Leyland-Jones B., et al. Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. NEngl J Med 2005, 353(16):1659-1672.
    • (2005) NEngl J Med , vol.353 , Issue.16 , pp. 1659-1672
    • Piccart-Gebhart, M.J.1    Procter, M.2    Leyland-Jones, B.3
  • 68
    • 26844536978 scopus 로고    scopus 로고
    • Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
    • Romond E.H., Perez E.A., Bryant J., et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. NEngl J Med 2005, 353(16):1673-1684.
    • (2005) NEngl J Med , vol.353 , Issue.16 , pp. 1673-1684
    • Romond, E.H.1    Perez, E.A.2    Bryant, J.3
  • 69
    • 75149145066 scopus 로고    scopus 로고
    • Neoadjuvant chemotherapy with trastuzumab followed by adjuvant trastuzumab versus neoadjuvant chemotherapy alone, in patients with HER2-positive locally advanced breast cancer (the NOAH trial): a randomised controlled superiority trial with a parallel HER2-negative cohort
    • Gianni L., Eiermann W., Semiglazov V., et al. Neoadjuvant chemotherapy with trastuzumab followed by adjuvant trastuzumab versus neoadjuvant chemotherapy alone, in patients with HER2-positive locally advanced breast cancer (the NOAH trial): a randomised controlled superiority trial with a parallel HER2-negative cohort. Lancet 2010, 375(9712):377-384.
    • (2010) Lancet , vol.375 , Issue.9712 , pp. 377-384
    • Gianni, L.1    Eiermann, W.2    Semiglazov, V.3
  • 70
    • 77951624086 scopus 로고    scopus 로고
    • Neoadjuvant treatment with trastuzumab in HER2-positive breast cancer: results from the GeparQuattro study
    • Untch M., Rezai M., Loibl S., et al. Neoadjuvant treatment with trastuzumab in HER2-positive breast cancer: results from the GeparQuattro study. JClin Oncol 2010, 28(12):2024-2031.
    • (2010) JClin Oncol , vol.28 , Issue.12 , pp. 2024-2031
    • Untch, M.1    Rezai, M.2    Loibl, S.3
  • 71
    • 77957352037 scopus 로고    scopus 로고
    • PTEN, PIK3CA, p-AKT, and p-p70S6K status: association with trastuzumab response and survival in patients with HER2-positive metastatic breast cancer
    • Esteva F.J., Guo H., Zhang S., et al. PTEN, PIK3CA, p-AKT, and p-p70S6K status: association with trastuzumab response and survival in patients with HER2-positive metastatic breast cancer. Am J Pathol 2010, 177(4):1647-1656.
    • (2010) Am J Pathol , vol.177 , Issue.4 , pp. 1647-1656
    • Esteva, F.J.1    Guo, H.2    Zhang, S.3
  • 72
    • 35148885729 scopus 로고    scopus 로고
    • Afunctional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer
    • Berns K., Horlings H.M., Hennessy B.T., et al. Afunctional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer. Cancer Cell 2007, 12(4):395-402.
    • (2007) Cancer Cell , vol.12 , Issue.4 , pp. 395-402
    • Berns, K.1    Horlings, H.M.2    Hennessy, B.T.3
  • 73
    • 5144226211 scopus 로고    scopus 로고
    • PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients
    • Nagata Y., Lan K.H., Zhou X., et al. PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients. Cancer Cell 2004, 6(2):117-127.
    • (2004) Cancer Cell , vol.6 , Issue.2 , pp. 117-127
    • Nagata, Y.1    Lan, K.H.2    Zhou, X.3
  • 74
    • 73149122573 scopus 로고    scopus 로고
    • Loss of HER2 amplification following trastuzumab-based neoadjuvant systemic therapy and survival outcomes
    • Mittendorf E.A., Wu Y., Scaltriti M., et al. Loss of HER2 amplification following trastuzumab-based neoadjuvant systemic therapy and survival outcomes. Clin Cancer Res 2009, 15(23):7381-7388.
    • (2009) Clin Cancer Res , vol.15 , Issue.23 , pp. 7381-7388
    • Mittendorf, E.A.1    Wu, Y.2    Scaltriti, M.3
  • 75
    • 34247588567 scopus 로고    scopus 로고
    • Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer
    • Scaltriti M., Rojo F., Ocana A., et al. Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer. JNatl Cancer Inst 2007, 99(8):628-638.
    • (2007) JNatl Cancer Inst , vol.99 , Issue.8 , pp. 628-638
    • Scaltriti, M.1    Rojo, F.2    Ocana, A.3
  • 76
    • 84871238855 scopus 로고    scopus 로고
    • Frequent mutational activation of the PI3K-AKT pathway in trastuzumab-resistant breast cancer
    • Chandarlapaty S., Sakr R.A., Giri D., et al. Frequent mutational activation of the PI3K-AKT pathway in trastuzumab-resistant breast cancer. Clin Cancer Res 2012, 18(24):6784-6791.
    • (2012) Clin Cancer Res , vol.18 , Issue.24 , pp. 6784-6791
    • Chandarlapaty, S.1    Sakr, R.A.2    Giri, D.3
  • 77
    • 77949884661 scopus 로고    scopus 로고
    • Randomized study of lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer
    • Blackwell K.L., Burstein H.J., Storniolo A.M., et al. Randomized study of lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer. JClin Oncol 2010, 28(7):1124-1130.
    • (2010) JClin Oncol , vol.28 , Issue.7 , pp. 1124-1130
    • Blackwell, K.L.1    Burstein, H.J.2    Storniolo, A.M.3
  • 78
    • 84857236823 scopus 로고    scopus 로고
    • Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): a randomised, open-label, multicentre, phase 3 trial
    • Baselga J., Bradbury I., Eidtmann H., et al. Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): a randomised, open-label, multicentre, phase 3 trial. Lancet 2012, 379(9816):633-640.
    • (2012) Lancet , vol.379 , Issue.9816 , pp. 633-640
    • Baselga, J.1    Bradbury, I.2    Eidtmann, H.3
  • 79
    • 84883553842 scopus 로고    scopus 로고
    • ALTTO (Adjuvant Lapatinib And/Or Trastuzumab Treatment Optimisation) Study; BIG 2-06/N063D. ClinicalTrials.gov Identifier: NCT00490139. Available at: Accessed March 27.
    • ALTTO (Adjuvant Lapatinib And/Or Trastuzumab Treatment Optimisation) Study; BIG 2-06/N063D. ClinicalTrials.gov Identifier: NCT00490139. Available at: Accessed March 27, 2013. http://clinicaltrials.gov/ct2/show/NCT00490139.
    • (2013)
  • 80
    • 77949903478 scopus 로고    scopus 로고
    • Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy
    • Baselga J., Gelmon K.A., Verma S., et al. Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy. JClin Oncol 2010, 28(7):1138-1144.
    • (2010) JClin Oncol , vol.28 , Issue.7 , pp. 1138-1144
    • Baselga, J.1    Gelmon, K.A.2    Verma, S.3
  • 81
    • 84862914692 scopus 로고    scopus 로고
    • Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer
    • Baselga J., Cortes J., Kim S.B., et al. Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer. NEngl J Med 2012, 366(2):109-119.
    • (2012) NEngl J Med , vol.366 , Issue.2 , pp. 109-119
    • Baselga, J.1    Cortes, J.2    Kim, S.B.3
  • 82
    • 84855297353 scopus 로고    scopus 로고
    • Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): a randomised multicentre, open-label, phase 2 trial
    • Gianni L., Pienkowski T., Im Y.H., et al. Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): a randomised multicentre, open-label, phase 2 trial. Lancet Oncol 2012, 13(1):25-32.
    • (2012) Lancet Oncol , vol.13 , Issue.1 , pp. 25-32
    • Gianni, L.1    Pienkowski, T.2    Im, Y.H.3
  • 83
    • 84883553839 scopus 로고    scopus 로고
    • CMS tackles patients' use of home medications at hospitals, MTM program fulfillment
    • Thompson C.A. CMS tackles patients' use of home medications at hospitals, MTM program fulfillment. Am J Health Syst Pharm 2013, 70(7):562-565.
    • (2013) Am J Health Syst Pharm , vol.70 , Issue.7 , pp. 562-565
    • Thompson, C.A.1
  • 84
    • 34547661993 scopus 로고    scopus 로고
    • Triple-negative breast cancer: Clinical features and patterns of recurrence
    • Dent R., Trudeau M., Pritchard K.I., et al. Triple-negative breast cancer: Clinical features and patterns of recurrence. Clin Cancer Res 2007, 13(15):4429-4434.
    • (2007) Clin Cancer Res , vol.13 , Issue.15 , pp. 4429-4434
    • Dent, R.1    Trudeau, M.2    Pritchard, K.I.3
  • 85
    • 79960015997 scopus 로고    scopus 로고
    • Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies
    • Lehmann B.D., Bauer J.A., Chen X., et al. Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. JClin Invest 2011, 121(7):2750-2767.
    • (2011) JClin Invest , vol.121 , Issue.7 , pp. 2750-2767
    • Lehmann, B.D.1    Bauer, J.A.2    Chen, X.3
  • 86
    • 75749143502 scopus 로고    scopus 로고
    • Pathologic complete response rates in young women with BRCA1-positive breast cancers after neoadjuvant chemotherapy
    • Byrski T., Gronwald J., Huzarski T., et al. Pathologic complete response rates in young women with BRCA1-positive breast cancers after neoadjuvant chemotherapy. JClin Oncol 2010, 28(3):375-379.
    • (2010) JClin Oncol , vol.28 , Issue.3 , pp. 375-379
    • Byrski, T.1    Gronwald, J.2    Huzarski, T.3
  • 87
    • 77949908546 scopus 로고    scopus 로고
    • Efficacy of neoadjuvant cisplatin in triple-negative breast cancer
    • Silver D.P., Richardson A.L., Eklund A.C., et al. Efficacy of neoadjuvant cisplatin in triple-negative breast cancer. JClin Oncol 2010, 28(7):1145-1153.
    • (2010) JClin Oncol , vol.28 , Issue.7 , pp. 1145-1153
    • Silver, D.P.1    Richardson, A.L.2    Eklund, A.C.3
  • 88
    • 80054117561 scopus 로고    scopus 로고
    • TBCRC009: A multicenter phase II study ofcisplatin or carboplatin for metastatic triple-negative breast cancer and evaluation of p63/p73 as a biomarker of response
    • [abstract 1025]
    • Isakoff S.J., Goss P.E., Mayer E.L., et al. TBCRC009: A multicenter phase II study ofcisplatin or carboplatin for metastatic triple-negative breast cancer and evaluation of p63/p73 as a biomarker of response. JClin Oncol 2011, 29(15, Suppl). [abstract 1025].
    • (2011) JClin Oncol , vol.29 , Issue.15 SUPPL
    • Isakoff, S.J.1    Goss, P.E.2    Mayer, E.L.3
  • 89
    • 84864101306 scopus 로고    scopus 로고
    • TBCRC 001: randomized phase II study of cetuximab in combination with carboplatin in stage IV triple-negative breast cancer
    • Carey L.A., Rugo H.S., Marcom P.K., et al. TBCRC 001: randomized phase II study of cetuximab in combination with carboplatin in stage IV triple-negative breast cancer. JClin Oncol 2012, 30(21):2615-2623.
    • (2012) JClin Oncol , vol.30 , Issue.21 , pp. 2615-2623
    • Carey, L.A.1    Rugo, H.S.2    Marcom, P.K.3
  • 90
    • 43549106185 scopus 로고    scopus 로고
    • Preliminary results of a randomized phase II study of weekly irinotecan/carboplatin with or without cetuximab in patients with metastatic breast cancer
    • [abstract 308, presented data at SABCS 2007]
    • O'Shaughnessy J., Weckstein D., Vukelja S. Preliminary results of a randomized phase II study of weekly irinotecan/carboplatin with or without cetuximab in patients with metastatic breast cancer. Breast Cancer Res Treat 2007, 106:S32. [abstract 308, presented data at SABCS 2007].
    • (2007) Breast Cancer Res Treat , vol.106
    • O'Shaughnessy, J.1    Weckstein, D.2    Vukelja, S.3
  • 91
    • 84860697370 scopus 로고    scopus 로고
    • Cetuximab+ cisplatin in estrogen receptor-negative, progesterone receptor-negative, HER2-negative (triple-negative) metastatic breast cancer: results of the randomized phase II BALI-1 trial
    • PD01-01. Presented data at SABCS 2010
    • Baselga J., Stemmer S., Pego A. Cetuximab+ cisplatin in estrogen receptor-negative, progesterone receptor-negative, HER2-negative (triple-negative) metastatic breast cancer: results of the randomized phase II BALI-1 trial. Cancer Res 2010, 70(24, Suppl 2). PD01-01. Presented data at SABCS 2010.
    • (2010) Cancer Res , vol.70 , Issue.24 SUPPL 2
    • Baselga, J.1    Stemmer, S.2    Pego, A.3
  • 92
    • 33745603978 scopus 로고    scopus 로고
    • An estrogen receptor-negative breast cancer subset characterized by a hormonally regulated transcriptional program and response to androgen
    • Doane A.S., Danso M., Lal P., et al. An estrogen receptor-negative breast cancer subset characterized by a hormonally regulated transcriptional program and response to androgen. Oncogene 2006, 25(28):3994-4008.
    • (2006) Oncogene , vol.25 , Issue.28 , pp. 3994-4008
    • Doane, A.S.1    Danso, M.2    Lal, P.3
  • 93
    • 22744448864 scopus 로고    scopus 로고
    • Identification of molecular apocrine breast tumours by microarray analysis
    • Farmer P., Bonnefoi H., Becette V., et al. Identification of molecular apocrine breast tumours by microarray analysis. Oncogene 2005, 24(29):4660-4671.
    • (2005) Oncogene , vol.24 , Issue.29 , pp. 4660-4671
    • Farmer, P.1    Bonnefoi, H.2    Becette, V.3
  • 94
    • 84873092076 scopus 로고    scopus 로고
    • Targeting the androgen receptor (AR) in women with AR+ ER-/PR- metastatic breast cancer (MBC)
    • [abstract 1006]
    • Gucalp A., Tolaney S., Isakoff S. Targeting the androgen receptor (AR) in women with AR+ ER-/PR- metastatic breast cancer (MBC). JClin Oncol 2012, 30(Suppl). [abstract 1006].
    • (2012) JClin Oncol , vol.30 , Issue.SUPPL
    • Gucalp, A.1    Tolaney, S.2    Isakoff, S.3
  • 95
    • 84883554322 scopus 로고    scopus 로고
    • Phase I/II trial of abiraterone acetate (AA) in estrogen receptor (ERα) or androgen receptor (AR) positive metastatic breast cancer (MBC). Presented at the ESMO 2012 Conference, Vienna, September 28-October 2.
    • Ng CH, Macpherson I, Rea D, etal. Phase I/II trial of abiraterone acetate (AA) in estrogen receptor (ERα) or androgen receptor (AR) positive metastatic breast cancer (MBC). Presented at the ESMO 2012 Conference, Vienna, September 28-October 2, 2012.
    • (2012)
    • Ng, C.H.1    Macpherson, I.2    Rea, D.3


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