CCR7 Expression and Intratumoral FOXP3+ Regulatory T Cells are Correlated with Overall Survival and Lymph Node Metastasis in Gastric Cancer

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Zhou, Shuang ^a   Xu, Shuchang ^a   Tao, Huihong ^a   Zhen, Zhiwei ^a   Chen, Guolin ^a   Zhang, Zhiqiang ^a   Yang, Yaoqin ^a  

^a TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR7; TRANSCRIPTION FACTOR FOXP3;

ADULT; ANIMAL TISSUE; ARTICLE; CANCER CELL; CANCER PROGNOSIS; CONTROLLED STUDY; FEMALE; FOXP3+ T LYMPHOCYTE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; KAPLAN MEIER METHOD; LYMPH NODE METASTASIS; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; NONHUMAN; OVERALL SURVIVAL; PROPORTIONAL HAZARDS MODEL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; STOMACH CANCER; SURVIVAL TIME; TISSUE MICROARRAY; TUMOR ASSOCIATED LEUKOCYTE;

AGED; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; LYMPHATIC METASTASIS; LYMPHOCYTES, TUMOR-INFILTRATING; MALE; MIDDLE AGED; PROGNOSIS; RECEPTORS, CCR7; STOMACH NEOPLASMS; T-LYMPHOCYTES, REGULATORY; TISSUE ARRAY ANALYSIS;

EID: 84883533551     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0074430     Document Type: Article

References (40)

1. Yanagihara S, Komura E, Nagafune J, Watarai H, Yamaguchi Y, (1998) EBI1/ CCR7 is a new member of dendritic cell chemokine receptor that is up-regulated upon maturation. J Immunol 161: 3096-3102.
2. Kakinuma T, Hwang ST, (2006) Chemokines, chemokine receptors, and cancer metastasis. J Leukoc Biol 79: 639-651.
3. Xu Y, Liu L, Qiu X, Liu Z, Li H, et al. (2012) CCL21/CCR7 prevents apoptosis via the ERK pathway in human non-small cell lung cancer cells. PLoS One 7: e33262.
4. Xu Y, Liu L, Qiu X, Jiang L, Huang B, et al. (2011) CCL21/CCR7 promotes G2/M phase progression via the ERK pathway in human non-small cell lung cancer cells. PLoS One 6: e21119.
5. Ding Y, Shimada Y, Maeda M, Kawabe A, Kaganoi J, et al. (2003) Association of CC chemokine receptor 7 with lymph node metastasis of esophageal squamous cell carcinoma. Clin Cancer Res 9: 3406-3412.
6. Cabioglu N, Yazici MS, Arun B, Broglio KR, Hortobagyi GN, et al. (2005) CCR7 and CXCR4 as novel biomarkers predicting axillary lymph node metastasis in T1 breast cancer. Clin Cancer Res 11: 5686-5693.
7. Schimanski CC, Bahre R, Gockel I, Junginger T, Simiantonaki N, et al. (2006) Chemokine receptor CCR7 enhances intrahepatic and lymphatic dissemination of human hepatocellular cancer. Oncol Rep 16: 109-113.
8. Wiley HE, Gonzalez EB, Maki W, Wu MT, Hwang ST, (2001) Expression of CC chemokine receptor-7 and regional lymph nodemetastasis of B16 murine melanoma. J Natl Cancer Inst 93: 1638-1643.
9. Byrne WL, Mills KH, Lederer JA, O'Sullivan GC, (2011) Targeting regulatory T cells in cancer. Cancer Res 71: 6915-6920.
10. Zou W, (2006) Regulatory T cells, tumor immunity and immunotherapy. Nat Rev Immunol 6: 295-307.
11. Hori S, Sakaguchi S, (2004) Foxp3: a critical regulator of the development and function of regulatory T cells. Microbes Infect 6: 745-751.
12. Coffer PJ, Burgering BM, (2004) Forkhead-box transcription factors and their role in the immune system. Nat Rev Immunol 4: 889-899.
13. Sakaguchi S, Yamaguchi T, Nomura T, Ono M, (2008) Regulatory T cells and immune tolerance. Cell 133: 775-787.
14. Gao Q, Qiu SJ, Fan J, Zhou J, Wang XY, et al. (2007) Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection. J Clin Oncol 25: 2586-2593.
15. Heimberger AB, Abou-Ghazal M, Reina-Ortiz C, Yang DS, Sun W, et al. (2008) Incidence and prognostic impact of Foxp3+ Regulatory T cells in human gliomas. Clin Cancer Res 14: 5166-5172.
16. Petersen RP, Campa MJ, Sperlazza J, Conlon D, Joshi MB, et al. (2006) Tumor infiltrating Foxp3+ regulatory T-cells are associated with recurrence in pathologic stage I NSCLC patients. Cancer 107: 2866-2872.
17. Curiel TJ, Coukos G, Zou L, Alvarez X, Cheng P, et al. (2004) Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med 10: 942-949.
18. Griffiths RW, Elkord E, Gilham DE, Ramani V, Clarke N, et al. (2007) Frequency of regulatory T cells in renal cell carcinoma patients and investigation of correlation with survival. Cancer Immunol Immunother 56: 1743-1753.
19. Bates GJ, Fox SB, Han C, Leek RD, Garcia JF, et al. (2006) Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse. J Clin Oncol 23: 5373-5380.
20. Fu J, Xu D, Liu Z, Shi M, Zhao P, et al. (2007) Increased regulatory T cells correlate with CD8 T-cell impairment and poor survival in hepatocellular carcinoma patients. Gastroenterology 132: 2328-2339.
21. Kamangar F, Dores GM, Anderson WF, (2006) Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol 24: 2137-2150.
22. Galon J, Costes A, Sanchez-Cabo F, Kirilovsky A, Mlecnik B, et al. (2006) Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 313: 1960-1964.
23. Lee AM, Clear AJ, Calaminici M, Davies AJ, Jordan S, et al. (2006) Number of CD4+ cells and location of forkhead box protein P3-positive cells in diagnostic follicular lymphoma tissue microarrays correlates with outcome. J Clin Oncol 24: 5052-5059.
24. Balkwill F, (2003) Chemokine biology in cancer. Semin Immunol 15: 49-55.
25. Mashino K, Sadanaga N, Yamaguchi H, Tanaka F, Ohta M, et al. (2002) Expression of chemokine receptor CCR7 is associated with lymph node metastasis of gastric carcinoma. Cancer Res 62: 2937-2941.
26. Takeuchi H, Fujimoto A, Tanaka M, Yamano T, Hsueh E, et al. (2004) CCL21 chemokine regulates chemokine receptor CCR7 bearing malignant melanoma cells. Clin Cancer Res 10: 2351-2358.
27. Takanami I, (2003) Overexpression of CCR7 mRNA in nonsmall cell lung cancer: correlation with lymph nodemetastasis. Int J Cancer 105: 186-189.
28. Oliveira-Neto HH, de Souza PP, da Silva MR, Mendonça EF, Silva TA, et al. (2013) The expression of chemokines CCL19, CCL21 and their receptor CCR7 in oral squamous cell carcinoma and its relevance to cervical lymph node metastasis. Tumour Biol 34: 65-70.
29. Gabriela C, Meytham M, Cinzia G, Piccio L, Kim JY, et al. (2000) Chemokines trigger immediate β2 integrin affinity and mobility changes: differential regulation and roles in lymphocytes arrest under flow. Immunity 13: 759-769.
30. Banham AH, Powrie FM, Suri-Payer E, (2006) FOXP3+ regulatory T cells: current controversies and future perspectives. Eur J Immunol 36: 2832-2836.
31. Liyanage UK, MooreTT, Joo HG, Tanaka Y, Herrmann V, et al. (2002) Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma. J Immunol 169: 2756-2761.
32. Näsman A, Romanitan M, Nordfors C, Grün N, Johansson H, et al. (2012) Tumor infiltrating CD8+ and Foxp3+ lymphocytes correlate to clinical outcome and human papillomavirus (HPV) status in tonsillar cancer. PLoS One 7: e38711.
33. Hiraoka N, Onozato K, KosugeT, Hirohashi S, (2006) Prevalence of FOXP3+ regulatory T cells increases during the progression of pancreatic ductal adenocarcinoma and its premalignant lesions. Clin Cancer Res 12: 5423-5434.
34. Yoon HH, Orrock JM, Foster NR, Sargent DJ, Smyrk TC, et al. (2012) Prognostic impact of FoxP3+ regulatory T cells in relation to CD8+ T lymphocyte density in human colon carcinomas. PLoS One 7: e42274.
35. Svensson H, Olofsson V, Lundin S, Yakkala C, Björck S, et al. (2012) Accumulation of CCR4+ CTLA-4hi FOXP3+ CD25hi regulatory T cells in colon adenocarcinomas correlate to reduced activation of conventional T cells. PLoS One 7: e30695.
36. Yang XH, Yamagiwa S, Ichida T, Matsuda Y, Sugahara S, et al. (2006) Increase of CD4+ CD25+ regulatory T-cells in the liver of patients with hepatocellular carcinoma. J Hepatol 45: 254-262.
37. Mizukami Y, Kono K, Kawaguchi Y, Akaike H, Kamimura K, et al. (2008) Localisation pattern of Foxp3+ regulatory T cell is associated with clinical behavior in gastric cancer. Brit J Cancer 98: 148-153.
38. Perrone G, Ruffini PA, Catalano V, Spino C, Santini D, et al. (2008) Intratumoural Foxp3+ Regulatory T cells are associated with adverse prognosis in radically resected gastric cancer. Eur J Can 44: 1875-1882.
39. deLeeuw RJ, Kost SE, Kakal JA, Nelson BH, (2012) The prognostic value of FoxP3+ tumor-infiltrating lymphocytes in cancer: a critical review of the literature. Clin Cancer Res 18: 3022-3029.
40. Kononen J, Bubendorf L, Kallioniemi A, Bärlund M, Schraml P, et al. (1998) Tissue microarrays for high throughout molecular profiling of tumor specimens. Nat Med 4: 844-847.