The mysterious case of the c. elegans gut granule: Death anthranilic acid and the kynurenine pathway

Frontiers in Genetics

Volumn 4, Issue AUG, 2013, Pages

  Coburn, Cassandra ^a   Gems, David ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Aging; C. elegans; Death fluorescence; Gut granule; Kynurenine; Lipofuscin; Organismal death; Tryptophan

Indexed keywords

EID: 84883526767     PISSN: None     EISSN: 16648021     Source Type: Journal    
DOI: 10.3389/fgene.2013.00151     Document Type: Article

References (46)

1. Altschul, S. F., Gish, W., Miller, W., Myers, E. W., and Lipman, D. J. (1990). Basic local alignment search tool. J. Mol. Biol. (05)80360-2
2. Babu, P. (1974). Biochemical genetics of Caenorhabditis elegans. Mol. Gen. Genet. 135, 39-44. doi: 10.1007/BF00433899
3. Bernabucci, M., Notartomaso, S., Zappulla, C., Fazio, F., Cannella, M., Motolese, M., et al. (2012). N-acetyl-cysteine causes analgesia activation of type-2 metabotropic glutamate receptors. Mol. Pain 8, 77. doi: 10.1186/1744-8069-8-77
4. Bhat, S. G., and Babu, P. (1980). Mutagen sensitivity of kynureninase mutants of the nematode Caenorhabditis elegans 10.1007/BF00268072
5. Chitwood, B. G., and Chitwood, M. B. (1950). An Introduction to Nematology. Baltimore: University Park Press.
6. Clokey, G. V., and Jacobson, L. A. (1986). The autofluorescent "lipofuscin granules" in the intestinal cells of Caenorhabditis elegans Ageing Dev. 35, 79-94. doi: 10.1016/0047-6374(86)90068-0
7. Coburn, C., Allman, E., Mahanti, P., Benedetto, A., Cabreiro, F., Pincus, Z., et al. (2013). Anthranilate fluorescence marks a calcium promotes organismal death in C. elegans. PLoS Biol. 11:e1001613. doi: 10.1371/journal.pbio.1001613
8. Davis, B. O. Jr., Anderson, G. L., and Dusenbery, D. B. (1982). Total luminescence spectroscopy of fluorescence changes during aging Biochemistry 21, 4089-4095. doi: 10.1021/bi00260a027
9. Fallarino, F., Grohmann, U., Vacca, C., Bianchi, R., Orabona, C., Spreca, A., et al. (2002). T cell apoptosis by tryptophan catabolism. doi: 10.1038/sj.cdd.4401073
10. Felix, M. A., and Braendle, C. (2010). The natural history of Caenorhabditis elegans. Curr. Biol. 20, R965-R969. doi: 10.1016/j.cub.
11. Fletcher, B. L., Dillard, C. J., and Tappel, A. L. (1973). Measurement of fluorescent lipid peroxidation products in biological systems -9. doi: 10.1016/0003-2697(73)90327-8
12. Fujii, M., Adachi, N., Shikatani, K., and Ayusawa, D. (2009). [FeFe]-hydrogenase-like gene is involved in the regulation of sensitivity nematode. Genes Cells 14, 457-468. doi: 10.1111/j.1365-2443.2009.01282.x
13. Gems, D., and de la Guardia, Y. (2012). Alternative perspectives on aging in C. elegans: reactive oxygen species or hyperfunction? 329. doi: 10.1089/ars.2012.4840
14. Gerstbrein, B., Stamatas, G., Kollias, N., and Driscoll, M. (2005). In vivo spectrofluorimetry reveals endogenous biomarkers that report restriction in Caenorhabditis elegans. Aging Cell 4, 127-137. doi: 10.1111/j.1474-9726.2005.00153.x
15. Gill, M. S. (2006). Endocrine targets for pharmacological intervention in aging in Caenorhabditis elegans. Aging Cell 9726.2006.00186.x
16. Hermann, G. J., Schroeder, L. K., Hieb, C. A., Kershner, A. M., Rabbitts, B. M., Fonarev, P., et al. (2005). Genetic analysis of lysosomal elegans. Mol. Biol. Cell 16, 3273-3288. doi: 10.1091/mbc.E05-01-0060
17. Hilmas, C., Pereira, E., Alkondon, M., Rassoulpour, A., Schwarcz, R., and Albuquerque, E. (2001). The brain metabolite kynurenic receptor activity and increases non-alpha7 nicotinic receptor expression: physiopathological implications. J. Neurosci.
18. Hodgkin, J., and Partridge, F. A. (2008). Caenorhabditis elegans meets microsporidia: the nematode killers from Paris. 10.1371/journal.pbio.1000005
19. Jain, C., Yun, M., Politz, S. M., and Rao, R. P. (2009). A pathogenesis assay using Saccharomyces cerevisiae and Caenorhabditis elegans AP-1, Yap1, and host dual oxidase BLI-3 in fungal pathogenesis. Eukaryot. Cell 8, 1218-1227. doi: 10.1128/EC.00367-
20. Jung, T., Bader, N., and Grune, T. (2007). Lipofuscin: formation, distribution, and metabolic consequences. Ann. N. Y. Acad. Sci. 10.1196/annals.1404.008
21. Kanehisa, L. (2012). Kyoto Encyclopedia of Genes and Genomes, C. elegans, Tryptophan [Online]. Available at: http://www.kegg.cel00380 [accessed December 27, 2012].
22. Klass, M. R. (1977). Aging in the nematode Caenorhabditis elegans: major biological and environmental factors influencing life span. doi: 10.1016/0047-6374(77)90043-4
23. Masse, I., Molin, L., Mouchiroud, L., Vanhems, P., Palladino, F., Billaud, M., et al. (2008). A novel role for the SMG-1 kinase in lifespan resistance in Caenorhabditis elegans. PLoS ONE 3:e3354. doi: 10.1371/journal.pone.0003354
24. Minniti, A. N., Cataldo, R., Trigo, C., Vasquez, L., Mujica, P., Leighton, F., et al. (2009). Methionine sulfoxide reductase A expression 16/FOXO pathway in Caenorhabditis elegans. Aging Cell 8, 690-705. doi: 10.1111/j.1474-9726.2009.00521.x
25. Munn, D. H., Zhou, M., Attwood, J. T., Bondarev, I., Conway, S. J., Marshall, B., et al. (1998). Prevention of allogeneic fetal rejection Science 281, 1191-1193. doi: 10.1126/science.281.5380.1191
26. O'Rourke, E. J., Soukas, A. A., Carr, C. E., and Ruvkun, G. (2009). C. elegans major fats are stored in vesicles distinct from lysosome 10, 430-435. doi: 10.1016/j.cmet.2009.10.002
27. Oxenkrug, G. F. (2010). The extended life span of Drosophilamelanogaster eye-color (white and vermilion) mutants with impaired Neural Transm. 117, 23-26. doi: 10.1007/s00702-009-0341-7
28. Oxenkrug, G. F., Navrotskaya, V., Voroboyva, L., and Summergrad, P. (2011). Extension of life span of Drosophila melanogaster kynurenine metabolism. Fly 5, 307-309. doi: 10.4161/fly.5.4.18414
29. Perkins, M. N., and Stone, T. W. (1982). An iontophoretic investigation of the actions of convulsant kynurenines and their interaction quinolinic acid. Brain Res. 247, 184-187. doi: 10.1016/0006-8993(82)91048-4
30. Piscianz, E., Cuzzoni, E., De Iudicibus, S., Valencic, E., Decorti, G., and Tommasini, A. (2011). Differential action of 3- activation of stimulated lymphocytes. Int. Immunopharmacol. 11, 2242-2245. doi: 10.1016/j.intimp.2011.09.009
31. Quiel, J. A., and Bender, J. (2003). Glucose conjugation of anthranilate by the Arabidopsis UGT74F2 glucosyltransferase is required fluorescence. J. Biol. Chem. 278, 6275-6281. doi: 10.1074/jbc.M211822200
32. Raposo, G., and Marks, M. S. (2007). Melanosomes - dark organelles enlighten endosomal membrane transport. Nat. Rev. Mol. Cell 10.1038/nrm2258
33. Roh, H. C., Collier, S., Guthrie, J., Robertson, J. D., and Kornfeld, K. (2012). Lysosome-related organelles in intestinal cells are a zinc Metab.15, 88-99. doi: 10.1016/j.cmet.2011.12.003
34. Rothman, S., and Olney, J. (1987). Excitotoxicity and the NMDA receptor. Trends Neurosci. 10, 299-302. doi: 10.1016/0166
35. Rothman, S., and Olney, J. (1995). Excitotoxicity and the NMDA receptor - still lethal after eight years. Trends Neurosci. 93869-Y
36. Saito, K., Nowak, T. S. Jr., Markey, S. P., and Heyes, M. P. (1993). Mechanism of delayed increases in kynurenine pathway metabolism following transient cerebral ischemia. J. Neurochem. 60, 180-192. doi: 10.1111/j.1471-4159.1993.tb05836.x
37. Sasaki, T., Mizuguchi, S., and Honda, K. (2012). Growth inhibitory effects of anthranilic acid and its derivatives against 113, 726-729. doi: 10.1016/j.jbiosc.2012.01.012
38. Schwarcz, R., Bruno, J. P., Muchowski, P. J., and Wu, H. Q. (2012). Kynurenines in the mammalian brain: when physiology meets 465-477. doi: 10.1038/nrn3257
39. Siddiqui, S. S., and Babu, P. (1980). Kynurenine hydroxylase mutants of the nematode Caenorhabditis elegans. Mol. Gen. Genet. 10.1007/BF00268441
40. Stone, T. W., Forrest, C. M., Stoy, N., and Darlington, L. G. (2012). Involvement of kynurenines in Huntington's disease and stroke Trans. 119, 261-274. doi: 10.1007/s00702-011-0676-8
41. Stone, T. W., and Perkins, M. N. (1981). Quinolinic acid: a potent endogenous excitant at amino acid receptors in CNS. 10.1016/0014-2999(81)90587-2
42. van der Goot, A., and Nollen, E. (2013). Tryptophan metabolism: entering the field of aging and age-related pathologies. 10.1016/j.molmed.2013.02.007
43. van der Goot, A., Zhu, W., Vàzquez-Manrique, R., Seinstra, R., Dettmer, K., Michels, H., et al. (2012). Delaying aging and the aging homeostasis by inhibition of tryptophan degradation. Proc. Natl. Acad. Sci. U.S.A. 109, 14912-14917. doi: 10.1073/pnas.1203083109
44. Vecsei, L., Szalardy, L., Fulop, F., and Toldi, J. (2013). Kynurenines in the CNS: recent advances and new questions. Nat. Rev. Drug 10.1038/nrd3793
45. Yamashima, T., and Oikawa, S. (2009). The role of lysosomal rupture in neuronal death. Prog. Neurobiol. 89, 343-358. doi: 10.1016/
46. Yamashima, T., Saido, T. C., Takita, M., Miyazawa, A., Yamano, J., Miyakawa, A., et al. (1996). Transient brain ischaemia provokes responses prior to delayed neuronal death in monkeys. Eur. J. Neurosci. 8, 1932-1944. doi: 10.1111/j.1460-9568.1996.tb01337.x