The extended life span of Drosophila melanogaster eye-color (white and vermilion) mutants with impaired formation of kynurenine

Journal of Neural Transmission

Volumn 117, Issue 1, 2010, Pages 23-26

  Oxenkrug, Gregory F ^a  

^a TUFTS MEDICAL CENTER   (United States)

Author keywords

Aging; Drosophila; Kynurenines

Indexed keywords

DIOXYGENASE; KYNURENINE; TRYPTOPHAN;

AGING; ANIMAL EXPERIMENT; ARTICLE; DROSOPHILA MELANOGASTER; ENZYME ACTIVITY; EYE COLOR; FEMALE; FLY; LIFE EXTENSION; LIFESPAN; LIGHT ADAPTATION; MEMBRANE TRANSPORT; MUTANT; NONHUMAN; PIGMENTATION; PRIORITY JOURNAL; WILD TYPE;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BIOLOGICAL TRANSPORT, ACTIVE; DROSOPHILA MELANOGASTER; EYE; FEMALE; KYNURENINE; LONGEVITY; MUTATION; PIGMENTATION; SPECIES SPECIFICITY; TIME FACTORS; TRYPTOPHAN; TRYPTOPHAN OXYGENASE;

EID: 76949089290     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-009-0341-7     Document Type: Article

References (25)

1. VN Anisimov SV Mylnikov TI Oparina VK Khavinson 1997 Effect of melatonin and pineal peptide preparation epithalamin on life span and free radical oxidation in Drosophila melanogaster Mech Ageing Dev 97 81 91 10.1016/S0047-6374(97)01897-6 1:CAS:528:DyaK2sXksVWjtrY%3D 9226628 (Pubitemid 27283171)
2. GW Beadle B Ephrussi 1936 Development of eye colors in Drosophila: transplantation experiments with suppressor of vermilion Proc Natl Acad Sci USA 22 536 540 10.1073/pnas.22.9.536 1:STN:280:DC%2BD28zhvVKjuw%3D%3D 16588105
3. E Bonilla S Medina-Leendertz S Díaz 2002 Extensión of life span and stress resistance of Drosophila melanogaster by long-term supplementation with melatonin Exp Gerontol 37 629 638 10.1016/S0531-5565(01) 00229-7 1:CAS:528:DC%2BD38XitFWlsL8%3D 11909680 (Pubitemid 34224108)
4. J Borycz JA Borycz A Kubów V Lloyd IA Meinertzhagen 2008 Drosophila ABC transporter mutants white, brown and scarlet have altered contents and distribution of biogenic amines in the brain J Exp Biol 211 Pt 21 3454 3466 10.1242/jeb.021162 1:CAS:528:DC%2BD1MXlvValtQ%3D%3D 18931318
5. B Frick K Schroecksnadel G Neurauter 2004 Increasing production of homocysteine and neopterin and degradation of tryptophan with older age Clin Biochem 37 684 687 10.1016/j.clinbiochem.2004.02.007 1:CAS:528: DC%2BD2cXmsVGgs70%3D 15302611 (Pubitemid 39078460)
6. JB Gramsbergen W Schmidt WA Turski R Schwarcz 1992 Age-related changes in kynurenic acid production in rat brain Brain Res 588 1 5 10.1016/0006-8993(92) 91337-E 1:CAS:528:DyaK38Xls1Clsro%3D 1393560
7. L Guarente 2007 Sirtuin genes function as anti-aging genes in yeast, Caenorhabditis elegans, and Drosophila Cold Spring Harb Symp Quant Biol 72 483 488 10.1101/sqb.2007.72.024 1:CAS:528:DC%2BD1cXnvVWltrg%3D 18419308
8. AJ Howells KM Summers RL Ryall 1977 Developmental patterns of 3-hydroxykynurenine accumulation in white and various other eye color mutants of Drosophila melanogaster Biochem Genet 15 1049 1059 10.1007/BF00484496 1:CAS:528:DyaE1cXmtVehuw%3D%3D 414739
9. MG Kamyshev 1980 Longevity and its relation to the locomotor activity in tryptophan-xanthommatin metabolic pathway mutant of Drosophila Dokl Acad Nauk USSR 253 1476 1480 1:CAS:528:DyaL3MXhtlSkuw%3D%3D
10. M Karasek 2004 Melatonin, human aging, and age-related diseases Exp Gerontol 39 1723 1729 10.1016/j.exger.2004.04.012 1:CAS:528:DC%2BD2cXhtVCltLfP 15582288 (Pubitemid 39576142)
11. Y Kudo CA Boyd IL Sargent CW Redman 2001 Tryptophan degradation by human placental indoleamine 2, 3-dioxygenase regulates lymphocyte proliferation J Physiol 535 Pt 1 207 215 10.1111/j.1469-7793.2001.00207.x 1:CAS:528: DC%2BD3MXms12ltbc%3D 11507170 (Pubitemid 32782737)
12. SM Mackenzie MR Brooker TR Gill GB Cox AJ Howells GD Ewart 1999 Mutations in the white gene of Drosophila melanogaster affecting ABC transporters that determine eye colouration Biochim Biophys Acta 1419 173 185 10.1016/S0005- 2736(99)00064-4 1:CAS:528:DyaK1MXltV2mtbY%3D 10407069 (Pubitemid 29322708)
13. F Moroni P Russi V Carlá G Lombardi 1988 Kynurenic acid is present in the rat brain and its content increases during development and aging processes Neurosci Lett 94 145 150 10.1016/0304-3940(88)90285-6 1:CAS:528:DyaL1MXhvVyjtA%3D%3D 2468114 (Pubitemid 18259184)
14. GF Oxenkrug 2007 Genetic and hormonal regulation of the kynurenine pathway of tryptophan metabolism: new target for clinical intervention in vascular dementia, depression and aging Ann N Y Acad Sci 1122 35 49 10.1196/annals.1403.003 1:CAS:528:DC%2BD1cXhtVOks7c%3D (Pubitemid 350249540)
15. Oxenkrug GF (2009) Metabolic syndrome, age-associated neuroendocrine disorders and dysregulation of tryptophan-kynurenine pathway metabolism. Ann N Y Acad Sci (in press)
16. M Pertovaara A Raitala T Lehtimäki 2006 Indoleamine 2,3-dioxygenase activity in nonagenarians is markedly increased and predicts mortality Mech Ageing Dev 127 497 499 1:CAS:528:DC%2BD28XjvVWmsLw%3D 16513157
17. A Petrosyan I-H Hsich K Saberi 2007 Age-dependent stability of sensimotor functions in the late life-extended Drosophila mutant Methuselah Behav Genet 37 585 594 10.1007/s10519-007-9159-y 17534708 (Pubitemid 46956693)
18. EV Savvateeva-Popova AV Popov T Heinemann P Riederer 2003 Drosophila mutants of the kynurenine pathway as a model for ageing studies Adv Exp Med Biol 527 713 722 1:CAS:528:DC%2BD2cXktlOju7s%3D 15206794
19. LL Searles RS Ruth AM Pret RA Fridell AJ Ali 1990 Structure and transcription of the Drosophila melanogaster vermilion gene and several mutant alleles Mol Cell Biol 10 1423 1431 1:CAS:528:DyaK3cXksFensbg%3D 2108317
20. L Seroude 2002 Differential gene expression and aging Sci World J 2 618 631 1:CAS:528:DC%2BD38XjsVynsr8%3D
21. DT Sullivan MC Sullivan 1975 Transport defects as the physiological basis for eye color mutants of Drosophila melanogaster Biochem Genet 13 603 613 10.1007/BF00484918 1:CAS:528:DyaE28XhsV2gtQ%3D%3D 812484
22. DT Sullivan LA Bell DR Paton MC Sullivan 1980 Genetic and functional analysis of tryptophan transport in malpighian tubules of Drosophila Biochem Genet 18 1109 1130 10.1007/BF00484342 1:CAS:528:DyaL3MXhtFyhsrw%3D 6788034 (Pubitemid 11156738)
23. R Tearle 1991 Tissue specific effects of ommochrome pathway mutations in Drosophila melanogaster Genet Res 57 257 266 10.1017/S0016672300029402 1:CAS:528:DyaK3MXlslKnsr0%3D 1909678
24. EM Urbańska P Luchowski E Luchowska J Pniewski R Woźniak M Chodakowska-Zebrowska J Lazarewicz 2006 Serum kynurenic acid positively correlates with cardiovascular disease risk factor, homocysteine: a study in stroke patients Pharmacol Rep 58 507 511 16963796
25. HA Walsh S Daya 1997 Inhibition of hepatic tryptophan-2,3-dioxygenase: superior potency of melatonin over serotonin J Pineal Res 23 20 23 10.1111/j.1600-079X.1997.tb00330.x 1:CAS:528:DyaK2sXmt1Oqu70%3D 9379342