메뉴 건너뛰기




Volumn 19, Issue 33, 2013, Pages 5439-5445

Epigenetics of hepatocellular carcinoma: Role of microRNA

Author keywords

Biomarker; Cancer; Hepatocellular carcinoma; MicroRNA; Polymorphism

Indexed keywords

ANTAGOMIR; BIOLOGICAL MARKER; MICRORNA; MICRORNA 1; MICRORNA 101; MICRORNA 102; MICRORNA 10A; MICRORNA 125A; MICRORNA 125B; MICRORNA 139; MICRORNA 145; MICRORNA 199 3P; MICRORNA 199 5P; MICRORNA 21; MICRORNA 214; MICRORNA 221; MICRORNA 224; MICRORNA 7A; MICRORNA 7B; MICRORNA 7C; MICRORNA 7D; MICRORNA 7F 1; UNCLASSIFIED DRUG;

EID: 84883514750     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v19.i33.5439     Document Type: Review
Times cited : (68)

References (93)
  • 1
    • 79952303316 scopus 로고    scopus 로고
    • The etiology of hepatocellular carcinoma and consequences for treatment
    • [PMID: 21115577 DOI: 10.1634/theon cologist.2010-S4-14]
    • Sanyal AJ, Yoon SK, Lencioni R. The etiology of hepatocellular carcinoma and consequences for treatment. Oncologist 2010; 15 Suppl 4: 14-22 [PMID: 21115577 DOI: 10.1634/theon cologist.2010-S4-14]
    • (2010) Oncologist , vol.15 , Issue.SUPPL. 4 , pp. 14-22
    • Sanyal, A.J.1    Yoon, S.K.2    Lencioni, R.3
  • 3
    • 84861542135 scopus 로고    scopus 로고
    • MicroRNA-26a/b and their host genes cooperate to inhibit the G1/S transition by activating the pRb protein
    • [PMID: 22210897 DOI: 10.1093/nar/gkr1278]
    • Zhu Y, Lu Y, Zhang Q, Liu JJ, Li TJ, Yang JR, Zeng C, Zhuang SM. MicroRNA-26a/b and their host genes cooperate to inhibit the G1/S transition by activating the pRb protein. Nucleic Acids Res 2012; 40: 4615-4625 [PMID: 22210897 DOI: 10.1093/nar/gkr1278]
    • (2012) Nucleic Acids Res , vol.40 , pp. 4615-4625
    • Zhu, Y.1    Lu, Y.2    Zhang, Q.3    Liu, J.J.4    Li, T.J.5    Yang, J.R.6    Zeng, C.7    Zhuang, S.M.8
  • 5
    • 84873636632 scopus 로고    scopus 로고
    • miR-490-3p modulates cell growth and epithelial to mesenchymal transition of hepatocellular carcinoma cells by targeting endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3)
    • [PMID: 23212913 DOI: 10.1074/ jbc.M112.410506]
    • Zhang LY, Liu M, Li X, Tang H. miR-490-3p modulates cell growth and epithelial to mesenchymal transition of hepatocellular carcinoma cells by targeting endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3). J Biol Chem 2013; 288: 4035-4047 [PMID: 23212913 DOI: 10.1074/ jbc.M112.410506]
    • (2013) J Biol Chem , vol.288 , pp. 4035-4047
    • Zhang, L.Y.1    Liu, M.2    Li, X.3    Tang, H.4
  • 6
    • 82155182009 scopus 로고    scopus 로고
    • Epigenetic modulation of miR-122 facilitates human embryonic stem cell self-renewal and hepatocellular carcinoma proliferation
    • [PMID: 22140464 DOI: 10.1371/journal.pone.0027740]
    • Jung CJ, Iyengar S, Blahnik KR, Ajuha TP, Jiang JX, Farnham PJ, Zern M. Epigenetic modulation of miR-122 facilitates human embryonic stem cell self-renewal and hepatocellular carcinoma proliferation. PLoS One 2011; 6: e27740 [PMID: 22140464 DOI: 10.1371/journal.pone.0027740]
    • (2011) PLoS One , vol.6
    • Jung, C.J.1    Iyengar, S.2    Blahnik, K.R.3    Ajuha, T.P.4    Jiang, J.X.5    Farnham, P.J.6    Zern, M.7
  • 8
    • 84860350934 scopus 로고    scopus 로고
    • MicroRNA-520e suppresses growth of hepatoma cells by targeting the NF-κB-inducing kinase (NIK)
    • [PMID: 22105365 DOI: 10.1038/onc.2011.523]
    • Zhang S, Shan C, Kong G, Du Y, Ye L, Zhang X. MicroRNA-520e suppresses growth of hepatoma cells by targeting the NF-κB-inducing kinase (NIK). Oncogene 2012; 31: 3607-3620 [PMID: 22105365 DOI: 10.1038/onc.2011.523]
    • (2012) Oncogene , vol.31 , pp. 3607-3620
    • Zhang, S.1    Shan, C.2    Kong, G.3    Du, Y.4    Ye, L.5    Zhang, X.6
  • 10
    • 84863795851 scopus 로고    scopus 로고
    • Epigenetics of hepatocellular carcinoma: A new horizon
    • [PMID: 22882861]
    • Liu WR, Shi YH, Peng YF, Fan J. Epigenetics of hepatocellular carcinoma: a new horizon. Chin Med J (Engl) 2012; 125: 2349-2360 [PMID: 22882861]
    • (2012) Chin Med J (Engl) , vol.125 , pp. 2349-2360
    • Liu, W.R.1    Shi, Y.H.2    Peng, Y.F.3    Fan, J.4
  • 11
    • 84874541473 scopus 로고    scopus 로고
    • MicroRNAs in hepatocellular carcinoma: Regulation, function, and clinical implications
    • [PMID: 23431261 DOI: 10.1155/2013/924206]
    • Sun J, Lu H, Wang X, Jin H. MicroRNAs in hepatocellular carcinoma: regulation, function, and clinical implications. ScientificWorldJournal 2013; 2013: 924206 [PMID: 23431261 DOI: 10.1155/2013/924206]
    • (2013) ScientificWorldJournal , vol.2013 , pp. 924206
    • Sun, J.1    Lu, H.2    Wang, X.3    Jin, H.4
  • 12
    • 78649593548 scopus 로고    scopus 로고
    • A potentially functional polymorphism in the promoter region of miR-34b/c is associated with an increased risk for primary hepatocellular carcinoma
    • [PMID: 20309940 DOI: 10.1002/ ijc.25342]
    • Xu Y, Liu L, Liu J, Zhang Y, Zhu J, Chen J, Liu S, Liu Z, Shi H, Shen H, Hu Z. A potentially functional polymorphism in the promoter region of miR-34b/c is associated with an increased risk for primary hepatocellular carcinoma. Int J Cancer 2011; 128: 412-417 [PMID: 20309940 DOI: 10.1002/ ijc.25342]
    • (2011) Int J Cancer , vol.128 , pp. 412-417
    • Xu, Y.1    Liu, L.2    Liu, J.3    Zhang, Y.4    Zhu, J.5    Chen, J.6    Liu, S.7    Liu, Z.8    Shi, H.9    Shen, H.10    Hu, Z.11
  • 13
    • 84865778624 scopus 로고    scopus 로고
    • Association study of genetic variations in microRNAs with the risk of hepatitis B-related liver diseases
    • [PMID: 22658643 DOI: 10.1016/j.dld.2012.04.021]
    • Bae JS, Kim JH, Pasaje CF, Cheong HS, Lee TH, Koh IS, Lee HS, Kim YJ, Shin HD. Association study of genetic variations in microRNAs with the risk of hepatitis B-related liver diseases. Dig Liver Dis 2012; 44: 849-854 [PMID: 22658643 DOI: 10.1016/j.dld.2012.04.021]
    • (2012) Dig Liver Dis , vol.44 , pp. 849-854
    • Bae, J.S.1    Kim, J.H.2    Pasaje, C.F.3    Cheong, H.S.4    Lee, T.H.5    Koh, I.S.6    Lee, H.S.7    Kim, Y.J.8    Shin, H.D.9
  • 14
    • 84863245920 scopus 로고    scopus 로고
    • A genetic variant in the promoter region of miR-106b-25 cluster and risk of HBV infection and hepatocellular carcinoma
    • [PMID: 22393390 DOI: 10.1371/journal.pone.0032230]
    • Liu Y, Zhang Y, Wen J, Liu L, Zhai X, Liu J, Pan S, Chen J, Shen H, Hu Z. A genetic variant in the promoter region of miR-106b-25 cluster and risk of HBV infection and hepatocellular carcinoma. PLoS One 2012; 7: e32230 [PMID: 22393390 DOI: 10.1371/journal.pone.0032230]
    • (2012) PLoS One , vol.7
    • Liu, Y.1    Zhang, Y.2    Wen, J.3    Liu, L.4    Zhai, X.5    Liu, J.6    Pan, S.7    Chen, J.8    Shen, H.9    Hu, Z.10
  • 15
    • 84856138064 scopus 로고    scopus 로고
    • A genetic variant in miR 196a2 increased digestive system cancer risks: A meta-analysis of 15 case-control studies
    • [PMID: 22291993 DOI: 10.1371/journal.pone.0030585]
    • Guo J, Jin M, Zhang M, Chen K. A genetic variant in miR 196a2 increased digestive system cancer risks: a meta-analysis of 15 case-control studies. PLoS One 2012; 7: e30585 [PMID: 22291993 DOI: 10.1371/journal.pone.0030585]
    • (2012) PLoS One , vol.7
    • Guo, J.1    Jin, M.2    Zhang, M.3    Chen, K.4
  • 16
    • 84864397029 scopus 로고    scopus 로고
    • Association of polymorphism in pri-microRNAs-371-372-373 with the occurrence of hepatocellular carcinoma in hepatitis B virus infected patients
    • [PMID: 22848681 DOI: 10.1371/journal.pone.0041983]
    • Kwak MS, Lee DH, Cho Y, Cho EJ, Lee JH, Yu SJ, Yoon JH, Lee HS, Kim CY, Cheong JY, Cho SW, Shin HD, Kim YJ. Association of polymorphism in pri-microRNAs-371-372-373 with the occurrence of hepatocellular carcinoma in hepatitis B virus infected patients. PLoS One 2012; 7: e41983 [PMID: 22848681 DOI: 10.1371/journal.pone.0041983]
    • (2012) PLoS One , vol.7
    • Kwak, M.S.1    Lee, D.H.2    Cho, Y.3    Cho, E.J.4    Lee, J.H.5    Yu, S.J.6    Yoon, J.H.7    Lee, H.S.8    Kim, C.Y.9    Cheong, J.Y.10    Cho, S.W.11    Shin, H.D.12    Kim, Y.J.13
  • 17
    • 84862323436 scopus 로고    scopus 로고
    • Association study of microRNA polymorphisms with hepatocellular carcinoma in Korean population
    • [PMID: 22583825 DOI: 10.1016/j.gene.2012.05.014]
    • Kim WH, Min KT, Jeon YJ, Kwon CI, Ko KH, Park PW, Hong SP, Rim KS, Kwon SW, Hwang SG, Kim NK. Association study of microRNA polymorphisms with hepatocellular carcinoma in Korean population. Gene 2012; 504: 92-97 [PMID: 22583825 DOI: 10.1016/j.gene.2012.05.014]
    • (2012) Gene , vol.504 , pp. 92-97
    • Kim, W.H.1    Min, K.T.2    Jeon, Y.J.3    Kwon, C.I.4    Ko, K.H.5    Park, P.W.6    Hong, S.P.7    Rim, K.S.8    Kwon, S.W.9    Hwang, S.G.10    Kim, N.K.11
  • 18
    • 73949086088 scopus 로고    scopus 로고
    • An insertion/deletion polymorphism at miRNA-122-binding site in the interleukin-1alpha 3' untranslated region confers risk for hepatocellular carcinoma
    • [PMID: 19917630 DOI: 10.1093/carcin/bgp283]
    • Gao Y, He Y, Ding J, Wu K, Hu B, Liu Y, Wu Y, Guo B, Shen Y, Landi D, Landi S, Zhou Y, Liu H. An insertion/deletion polymorphism at miRNA-122-binding site in the interleukin-1alpha 3' untranslated region confers risk for hepatocellular carcinoma. Carcinogenesis 2009; 30: 2064-2069 [PMID: 19917630 DOI: 10.1093/carcin/bgp283]
    • (2009) Carcinogenesis , vol.30 , pp. 2064-2069
    • Gao, Y.1    He, Y.2    Ding, J.3    Wu, K.4    Hu, B.5    Liu, Y.6    Wu, Y.7    Guo, B.8    Shen, Y.9    Landi, D.10    Landi, S.11    Zhou, Y.12    Liu, H.13
  • 19
    • 72949115258 scopus 로고    scopus 로고
    • An insertion/deletion polymorphism in the 3' untranslated region of beta-transducin repeat-containing protein (betaTrCP) is associated with susceptibility for hepatocellular carcinoma in Chinese
    • [PMID: 19931512 DOI: 10.1016/ j.bbrc.2009.11.096]
    • Chen S, He Y, Ding J, Jiang Y, Jia S, Xia W, Zhao J, Lu M, Gu Z, Gao Y. An insertion/deletion polymorphism in the 3' untranslated region of beta-transducin repeat-containing protein (betaTrCP) is associated with susceptibility for hepatocellular carcinoma in Chinese. Biochem Biophys Res Commun 2010; 391: 552-556 [PMID: 19931512 DOI: 10.1016/ j.bbrc.2009.11.096]
    • (2010) Biochem Biophys Res Commun , vol.391 , pp. 552-556
    • Chen, S.1    He, Y.2    Ding, J.3    Jiang, Y.4    Jia, S.5    Xia, W.6    Zhao, J.7    Lu, M.8    Gu, Z.9    Gao, Y.10
  • 20
    • 84864974809 scopus 로고    scopus 로고
    • A miR-1231 binding site polymorphism in the 3'UTR of IFNAR1 is associated with hepatocellular carcinoma susceptibility
    • [PMID: 22824466 DOI: 10.1016/ j.gene.2012.06.073]
    • Zhou C, Yu Q, Chen L, Wang J, Zheng S, Zhang J. A miR-1231 binding site polymorphism in the 3'UTR of IFNAR1 is associated with hepatocellular carcinoma susceptibility. Gene 2012; 507: 95-98 [PMID: 22824466 DOI: 10.1016/ j.gene.2012.06.073]
    • (2012) Gene , vol.507 , pp. 95-98
    • Zhou, C.1    Yu, Q.2    Chen, L.3    Wang, J.4    Zheng, S.5    Zhang, J.6
  • 21
    • 84862920049 scopus 로고    scopus 로고
    • A polymorphism within ErbB4 is associated with risk for hepatocellular carcinoma in Chinese population
    • [PMID: 22294845 DOI: 10.3748/wjg. v18.i4.383]
    • Yu Q, Zhou CX, Chen NS, Zheng SD, Shen LM, Zhang JK. A polymorphism within ErbB4 is associated with risk for hepatocellular carcinoma in Chinese population. World J Gastroenterol 2012; 18: 383-387 [PMID: 22294845 DOI: 10.3748/wjg. v18.i4.383]
    • (2012) World J Gastroenterol , vol.18 , pp. 383-387
    • Yu, Q.1    Zhou, C.X.2    Chen, N.S.3    Zheng, S.D.4    Shen, L.M.5    Zhang, J.K.6
  • 22
    • 80051586183 scopus 로고    scopus 로고
    • An insertion/deletion polymorphism in the 3' untranslated region of type I collagen a2 (COL1A2) is associated with susceptibility for hepatocellular carcinoma in a Chinese population
    • [PMID: 21665180 DOI: 10.1016/j.cancergen.2011.03.007]
    • Zhu Z, Jiang Y, Chen S, Jia S, Gao X, Dong D, Gao Y. An insertion/deletion polymorphism in the 3' untranslated region of type I collagen a2 (COL1A2) is associated with susceptibility for hepatocellular carcinoma in a Chinese population. Cancer Genet 2011; 204: 265-269 [PMID: 21665180 DOI: 10.1016/j.cancergen.2011.03.007]
    • (2011) Cancer Genet , vol.204 , pp. 265-269
    • Zhu, Z.1    Jiang, Y.2    Chen, S.3    Jia, S.4    Gao, X.5    Dong, D.6    Gao, Y.7
  • 23
    • 77951623294 scopus 로고    scopus 로고
    • Let-7g targets collagen type I alpha2 and inhibits cell migration in hepatocellular carcinoma
    • [PMID: 20338660 DOI: 10.1016/j.jhep.2009.12.025]
    • Ji J, Zhao L, Budhu A, Forgues M, Jia HL, Qin LX, Ye QH, Yu J, Shi X, Tang ZY, Wang XW. Let-7g targets collagen type I alpha2 and inhibits cell migration in hepatocellular carcinoma. J Hepatol 2010; 52: 690-697 [PMID: 20338660 DOI: 10.1016/j.jhep.2009.12.025]
    • (2010) J Hepatol , vol.52 , pp. 690-697
    • Ji, J.1    Zhao, L.2    Budhu, A.3    Forgues, M.4    Jia, H.L.5    Qin, L.X.6    Ye, Q.H.7    Yu, J.8    Shi, X.9    Tang, Z.Y.10    Wang, X.W.11
  • 24
    • 77957982588 scopus 로고    scopus 로고
    • microRNA-22, downregulated in hepatocellular carcinoma and correlated with prognosis, suppresses cell proliferation and tumourigenicity
    • [PMID: 20842113 DOI: 10.1038/sj.bjc.6605895]
    • Zhang J, Yang Y, Yang T, Liu Y, Li A, Fu S, Wu M, Pan Z, Zhou W. microRNA-22, downregulated in hepatocellular carcinoma and correlated with prognosis, suppresses cell proliferation and tumourigenicity. Br J Cancer 2010; 103: 1215-1220 [PMID: 20842113 DOI: 10.1038/sj.bjc.6605895]
    • (2010) Br J Cancer , vol.103 , pp. 1215-1220
    • Zhang, J.1    Yang, Y.2    Yang, T.3    Liu, Y.4    Li, A.5    Fu, S.6    Wu, M.7    Pan, Z.8    Zhou, W.9
  • 26
    • 77950602604 scopus 로고    scopus 로고
    • Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma
    • [PMID: 20041405 DOI: 10.1002/hep.23380]
    • Xiong Y, Fang JH, Yun JP, Yang J, Zhang Y, Jia WH, Zhuang SM. Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma. Hepatology 2010; 51: 836-845 [PMID: 20041405 DOI: 10.1002/hep.23380]
    • (2010) Hepatology , vol.51 , pp. 836-845
    • Xiong, Y.1    Fang, J.H.2    Yun, J.P.3    Yang, J.4    Zhang, Y.5    Jia, W.H.6    Zhuang, S.M.7
  • 27
    • 80054694898 scopus 로고    scopus 로고
    • MicroRNA-99a inhibits hepatocellular carcinoma growth and correlates with prognosis of patients with hepatocellular carcinoma
    • [PMID: 21878637 DOI: 10.1074/jbc.M111.270561]
    • Li D, Liu X, Lin L, Hou J, Li N, Wang C, Wang P, Zhang Q, Zhang P, Zhou W, Wang Z, Ding G, Zhuang SM, Zheng L, Tao W, Cao X. MicroRNA-99a inhibits hepatocellular carcinoma growth and correlates with prognosis of patients with hepatocellular carcinoma. J Biol Chem 2011; 286: 36677-36685 [PMID: 21878637 DOI: 10.1074/jbc.M111.270561]
    • (2011) J Biol Chem , vol.286 , pp. 36677-36685
    • Li, D.1    Liu, X.2    Lin, L.3    Hou, J.4    Li, N.5    Wang, C.6    Wang, P.7    Zhang, Q.8    Zhang, P.9    Zhou, W.10    Wang, Z.11    Ding, G.12    Zhuang, S.M.13    Zheng, L.14    Tao, W.15    Cao, X.16
  • 28
    • 70349976819 scopus 로고    scopus 로고
    • Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties
    • [PMID: 19617899 DOI: 10.1038/onc.2009.211]
    • Coulouarn C, Factor VM, Andersen JB, Durkin ME, Thor-geirsson SS. Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties. Oncogene 2009; 28: 3526-3536 [PMID: 19617899 DOI: 10.1038/onc.2009.211]
    • (2009) Oncogene , vol.28 , pp. 3526-3536
    • Coulouarn, C.1    Factor, V.M.2    Andersen, J.B.3    Durkin, M.E.4    Thor-geirsson, S.S.5
  • 29
    • 84855191863 scopus 로고    scopus 로고
    • The putative tumour suppressor microRNA-124 modulates hepatocellular carcinoma cell aggressiveness by repressing ROCK2 and EZH2
    • [PMID: 21672940 DOI: 10.1136/gut.2011.239145]
    • Zheng F, Liao YJ, Cai MY, Liu YH, Liu TH, Chen SP, Bian XW, Guan XY, Lin MC, Zeng YX, Kung HF, Xie D. The putative tumour suppressor microRNA-124 modulates hepatocellular carcinoma cell aggressiveness by repressing ROCK2 and EZH2. Gut 2012; 61: 278-289 [PMID: 21672940 DOI: 10.1136/gut.2011.239145]
    • (2012) Gut , vol.61 , pp. 278-289
    • Zheng, F.1    Liao, Y.J.2    Cai, M.Y.3    Liu, Y.H.4    Liu, T.H.5    Chen, S.P.6    Bian, X.W.7    Guan, X.Y.8    Lin, M.C.9    Zeng, Y.X.10    Kung, H.F.11    Xie, D.12
  • 30
    • 78650436438 scopus 로고    scopus 로고
    • The microRNA miR-139 suppresses metastasis and progression of hepatocellular carcinoma by downregulating Rho-kinase 2
    • [PMID: 20951699 DOI: 10.1053/j.gastro.2010.10.006]
    • Wong CC, Wong CM, Tung EK, Au SL, Lee JM, Poon RT, Man K, Ng IO. The microRNA miR-139 suppresses metastasis and progression of hepatocellular carcinoma by downregulating Rho-kinase 2. Gastroenterology 2011; 140: 322-331 [PMID: 20951699 DOI: 10.1053/j.gastro.2010.10.006]
    • (2011) Gastroenterology , vol.140 , pp. 322-331
    • Wong, C.C.1    Wong, C.M.2    Tung, E.K.3    Au, S.L.4    Lee, J.M.5    Poon, R.T.6    Man, K.7    Ng, I.O.8
  • 31
    • 84860752172 scopus 로고    scopus 로고
    • Tumorigenicity of cancer stem-like cells derived from hepatocarcinoma is regulated by microRNA-145
    • [PMID: 22378186 DOI: 10.3892/or.2012.1701]
    • Jia Y, Liu H, Zhuang Q, Xu S, Yang Z, Li J, Lou J, Zhang W. Tumorigenicity of cancer stem-like cells derived from hepatocarcinoma is regulated by microRNA-145. Oncol Rep 2012; 27: 1865-1872 [PMID: 22378186 DOI: 10.3892/or.2012.1701]
    • (2012) Oncol Rep , vol.27 , pp. 1865-1872
    • Jia, Y.1    Liu, H.2    Zhuang, Q.3    Xu, S.4    Yang, Z.5    Li, J.6    Lou, J.7    Zhang, W.8
  • 32
    • 80054959463 scopus 로고    scopus 로고
    • Underexpressed microRNA-199b-5p targets hypoxia-inducible factor-1α in hepatocellular carcinoma and predicts prognosis of hepatocellular carcinoma patients
    • [PMID: 21557766 DOI: 10.1111/j.1440-1746.2011.06758.x]
    • Wang C, Song B, Song W, Liu J, Sun A, Wu D, Yu H, Lian J, Chen L, Han J. Underexpressed microRNA-199b-5p targets hypoxia-inducible factor-1α in hepatocellular carcinoma and predicts prognosis of hepatocellular carcinoma patients. J Gastroenterol Hepatol 2011; 26: 1630-1637 [PMID: 21557766 DOI: 10.1111/j.1440-1746.2011.06758.x]
    • (2011) J Gastroenterol Hepatol , vol.26 , pp. 1630-1637
    • Wang, C.1    Song, B.2    Song, W.3    Liu, J.4    Sun, A.5    Wu, D.6    Yu, H.7    Lian, J.8    Chen, L.9    Han, J.10
  • 33
    • 84868134355 scopus 로고    scopus 로고
    • MicroRNA-10b promotes migration and invasion through CADM1 in human hepatocellular carcinoma cells
    • [PMID: 22528944 DOI: 10.1007/s13277-012-0396-1]
    • Li QJ, Zhou L, Yang F, Wang GX, Zheng H, Wang DS, He Y, Dou KF. MicroRNA-10b promotes migration and invasion through CADM1 in human hepatocellular carcinoma cells. Tumour Biol 2012; 33: 1455-1465 [PMID: 22528944 DOI: 10.1007/s13277-012-0396-1]
    • (2012) Tumour Biol , vol.33 , pp. 1455-1465
    • Li, Q.J.1    Zhou, L.2    Yang, F.3    Wang, G.X.4    Zheng, H.5    Wang, D.S.6    He, Y.7    Dou, K.F.8
  • 34
    • 84861037699 scopus 로고    scopus 로고
    • miR-17-5p as a novel prognostic marker for hepatocellular carcinoma
    • [PMID: 22583011 DOI: 10.3109/08941939.20 11.618523]
    • Chen L, Jiang M, Yuan W, Tang H. miR-17-5p as a novel prognostic marker for hepatocellular carcinoma. J Invest Surg 2012; 25: 156-161 [PMID: 22583011 DOI: 10.3109/08941939.20 11.618523]
    • (2012) J Invest Surg , vol.25 , pp. 156-161
    • Chen, L.1    Jiang, M.2    Yuan, W.3    Tang, H.4
  • 35
    • 84877263372 scopus 로고    scopus 로고
    • Expression of microRNAs, miR-21, miR-31, miR-122, miR-145, miR-146a, miR-200c, miR-221, miR-222, and miR-223 in patients with hepatocellular carcinoma or intrahepatic cholangiocarcinoma and its prognostic significance
    • [PMID: 22213236 DOI: 10.1002/mc.21864]
    • Karakatsanis A, Papaconstantinou I, Gazouli M, Lyberopoulou A, Polymeneas G, Voros D. Expression of microRNAs, miR-21, miR-31, miR-122, miR-145, miR-146a, miR-200c, miR-221, miR-222, and miR-223 in patients with hepatocellular carcinoma or intrahepatic cholangiocarcinoma and its prognostic significance. Mol Carcinog 2013; 52: 297-303 [PMID: 22213236 DOI: 10.1002/mc.21864]
    • (2013) Mol Carcinog , vol.52 , pp. 297-303
    • Karakatsanis, A.1    Papaconstantinou, I.2    Gazouli, M.3    Lyberopoulou, A.4    Polymeneas, G.5    Voros, D.6
  • 36
    • 84855955131 scopus 로고    scopus 로고
    • MicroRNA-135a contributes to the development of portal vein tumor thrombus by promoting metastasis in hepatocellular carcinoma
    • [PMID: 21888875 DOI: 10.1016/ j.jhep.2011.08.008]
    • Liu S, Guo W, Shi J, Li N, Yu X, Xue J, Fu X, Chu K, Lu C, Zhao J, Xie D, Wu M, Cheng S, Liu S. MicroRNA-135a contributes to the development of portal vein tumor thrombus by promoting metastasis in hepatocellular carcinoma. J Hepatol 2012; 56: 389-396 [PMID: 21888875 DOI: 10.1016/ j.jhep.2011.08.008]
    • (2012) J Hepatol , vol.56 , pp. 389-396
    • Liu, S.1    Guo, W.2    Shi, J.3    Li, N.4    Yu, X.5    Xue, J.6    Fu, X.7    Chu, K.8    Lu, C.9    Zhao, J.10    Xie, D.11    Wu, M.12    Cheng, S.13    Liu, S.14
  • 37
    • 84857052156 scopus 로고    scopus 로고
    • Upregulation of microRNA-155 promotes cancer cell invasion and predicts poor survival of hepatocellular carcinoma following liver transplantation
    • [PMID: 22071603 DOI: 10.1007/s00432-011-1076-z]
    • Han ZB, Chen HY, Fan JW, Wu JY, Tang HM, Peng ZH. Upregulation of microRNA-155 promotes cancer cell invasion and predicts poor survival of hepatocellular carcinoma following liver transplantation. J Cancer Res Clin Oncol 2012; 138: 153-161 [PMID: 22071603 DOI: 10.1007/s00432-011-1076-z]
    • (2012) J Cancer Res Clin Oncol , vol.138 , pp. 153-161
    • Han, Z.B.1    Chen, H.Y.2    Fan, J.W.3    Wu, J.Y.4    Tang, H.M.5    Peng, Z.H.6
  • 38
    • 84861935924 scopus 로고    scopus 로고
    • MicroRNA-182 downregulates metastasis suppressor 1 and contributes to metastasis of hepatocellular carcinoma
    • [PMID: 22681717 DOI: 10.1186/1471-2407-12-227]
    • Wang J, Li J, Shen J, Wang C, Yang L, Zhang X. MicroRNA-182 downregulates metastasis suppressor 1 and contributes to metastasis of hepatocellular carcinoma. BMC Cancer 2012; 12: 227 [PMID: 22681717 DOI: 10.1186/1471-2407-12-227]
    • (2012) BMC Cancer , vol.12 , pp. 227
    • Wang, J.1    Li, J.2    Shen, J.3    Wang, C.4    Yang, L.5    Zhang, X.6
  • 39
    • 76049108572 scopus 로고    scopus 로고
    • MiR-222 overexpression confers cell migratory advantages in hepatocellular carcinoma through enhancing AKT signaling
    • [PMID: 20103675 DOI: 10.1158/1078-0432.CCR-09-1840]
    • Wong QW, Ching AK, Chan AW, Choy KW, To KF, Lai PB, Wong N. MiR-222 overexpression confers cell migratory advantages in hepatocellular carcinoma through enhancing AKT signaling. Clin Cancer Res 2010; 16: 867-875 [PMID: 20103675 DOI: 10.1158/1078-0432.CCR-09-1840]
    • (2010) Clin Cancer Res , vol.16 , pp. 867-875
    • Wong, Q.W.1    Ching, A.K.2    Chan, A.W.3    Choy, K.W.4    To, K.F.5    Lai, P.B.6    Wong, N.7
  • 43
    • 78649972032 scopus 로고    scopus 로고
    • Serum microRNA profiles serve as novel biomarkers for HBV infection and diagnosis of HBVpositive hepatocarcinoma
    • [PMID: 21098710 DOI: 10.1158/0008-5472.CAN-10-1001]
    • Li LM, Hu ZB, Zhou ZX, Chen X, Liu FY, Zhang JF, Shen HB, Zhang CY, Zen K. Serum microRNA profiles serve as novel biomarkers for HBV infection and diagnosis of HBVpositive hepatocarcinoma. Cancer Res 2010; 70: 9798-9807 [PMID: 21098710 DOI: 10.1158/0008-5472.CAN-10-1001]
    • (2010) Cancer Res , vol.70 , pp. 9798-9807
    • Li, L.M.1    Hu, Z.B.2    Zhou, Z.X.3    Chen, X.4    Liu, F.Y.5    Zhang, J.F.6    Shen, H.B.7    Zhang, C.Y.8    Zen, K.9
  • 46
    • 84866393036 scopus 로고    scopus 로고
    • MiR-124 suppresses cell proliferation in hepatocellular carcinoma by targeting PIK3CA
    • [PMID: 22940133 DOI: 10.1016/j.bbrc.2012.08.075]
    • Lang Q, Ling C. MiR-124 suppresses cell proliferation in hepatocellular carcinoma by targeting PIK3CA. Biochem Biophys Res Commun 2012; 426: 247-252 [PMID: 22940133 DOI: 10.1016/j.bbrc.2012.08.075]
    • (2012) Biochem Biophys Res Commun , vol.426 , pp. 247-252
    • Lang, Q.1    Ling, C.2
  • 50
    • 77950095763 scopus 로고    scopus 로고
    • TGFbeta-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3
    • [PMID: 20023698 DOI: 10.1038/onc.2009.468]
    • Wang B, Hsu SH, Majumder S, Kutay H, Huang W, Jacob ST, Ghoshal K. TGFbeta-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3. Oncogene 2010; 29: 1787-1797 [PMID: 20023698 DOI: 10.1038/onc.2009.468]
    • (2010) Oncogene , vol.29 , pp. 1787-1797
    • Wang, B.1    Hsu, S.H.2    Majumder, S.3    Kutay, H.4    Huang, W.5    Jacob, S.T.6    Ghoshal, K.7
  • 51
    • 70450285075 scopus 로고    scopus 로고
    • MicroRNA-122 inhibits tumorigenic properties of hepatocellular carcinoma cells and sensitizes these cells to sorafenib
    • [PMID: 19726678 DOI: 10.1074/jbc. M109.016774]
    • Bai S, Nasser MW, Wang B, Hsu SH, Datta J, Kutay H, Yadav A, Nuovo G, Kumar P, Ghoshal K. MicroRNA-122 inhibits tumorigenic properties of hepatocellular carcinoma cells and sensitizes these cells to sorafenib. J Biol Chem 2009; 284: 32015-32027 [PMID: 19726678 DOI: 10.1074/jbc. M109.016774]
    • (2009) J Biol Chem , vol.284 , pp. 32015-32027
    • Bai, S.1    Nasser, M.W.2    Wang, B.3    Hsu, S.H.4    Datta, J.5    Kutay, H.6    Yadav, A.7    Nuovo, G.8    Kumar, P.9    Ghoshal, K.10
  • 53
    • 51749088101 scopus 로고    scopus 로고
    • Let-7a microRNA suppresses therapeutics-induced cancer cell death by targeting caspase-3
    • [PMID: 18758960 DOI: 10.1007/ s10495-008-0256-z]
    • Tsang WP, Kwok TT. Let-7a microRNA suppresses therapeutics-induced cancer cell death by targeting caspase-3. Apoptosis 2008; 13: 1215-1222 [PMID: 18758960 DOI: 10.1007/ s10495-008-0256-z]
    • (2008) Apoptosis , vol.13 , pp. 1215-1222
    • Tsang, W.P.1    Kwok, T.T.2
  • 54
    • 84863781353 scopus 로고    scopus 로고
    • Downregulation of HMGA2 by the pan-deacetylase inhibitor panobinostat is dependent on hsa-let-7b expression in liver cancer cell lines
    • [PMID: 22683924 DOI: 10.1016/j.yexcr.2012.04.018]
    • Di Fazio P, Montalbano R, Neureiter D, Alinger B, Schmidt A, Merkel AL, Quint K, Ocker M. Downregulation of HMGA2 by the pan-deacetylase inhibitor panobinostat is dependent on hsa-let-7b expression in liver cancer cell lines. Exp Cell Res 2012; 318: 1832-1843 [PMID: 22683924 DOI: 10.1016/j.yexcr.2012.04.018]
    • (2012) Exp Cell Res , vol.318 , pp. 1832-1843
    • Di Fazio, P.1    Montalbano, R.2    Neureiter, D.3    Alinger, B.4    Schmidt, A.5    Merkel, A.L.6    Quint, K.7    Ocker, M.8
  • 55
    • 84555170184 scopus 로고    scopus 로고
    • Let-7c microRNA expression and clinical significance in hepatocellular carcinoma
    • [PMID: 22289550]
    • Zhu XM, Wu LJ, Xu J, Yang R, Wu FS. Let-7c microRNA expression and clinical significance in hepatocellular carcinoma. J Int Med Res 2011; 39: 2323-2329 [PMID: 22289550]
    • (2011) J Int Med Res , vol.39 , pp. 2323-2329
    • Zhu, X.M.1    Wu, L.J.2    Xu, J.3    Yang, R.4    Wu, F.S.5
  • 56
    • 34250163202 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha regulates a microRNA-mediated signaling cascade responsible for hepatocellular proliferation
    • [PMID: 17438130 DOI: 10.1128/MCB.00317-07]
    • Shah YM, Morimura K, Yang Q, Tanabe T, Takagi M, Gonzalez FJ. Peroxisome proliferator-activated receptor alpha regulates a microRNA-mediated signaling cascade responsible for hepatocellular proliferation. Mol Cell Biol 2007; 27: 4238-4247 [PMID: 17438130 DOI: 10.1128/MCB.00317-07]
    • (2007) Mol Cell Biol , vol.27 , pp. 4238-4247
    • Shah, Y.M.1    Morimura, K.2    Yang, Q.3    Tanabe, T.4    Takagi, M.5    Gonzalez, F.J.6
  • 57
    • 78649561463 scopus 로고    scopus 로고
    • Hsa-let-7g inhibits proliferation of hepatocellular carcinoma cells by downregulation of c-Myc and upregulation of p16(INK4A)
    • [PMID: 20309945 DOI: 10.1002/ijc.25336]
    • Lan FF, Wang H, Chen YC, Chan CY, Ng SS, Li K, Xie D, He ML, Lin MC, Kung HF. Hsa-let-7g inhibits proliferation of hepatocellular carcinoma cells by downregulation of c-Myc and upregulation of p16(INK4A). Int J Cancer 2011; 128: 319-331 [PMID: 20309945 DOI: 10.1002/ijc.25336]
    • (2011) Int J Cancer , vol.128 , pp. 319-331
    • Lan, F.F.1    Wang, H.2    Chen, Y.C.3    Chan, C.Y.4    Ng, S.S.5    Li, K.6    Xie, D.7    He, M.L.8    Lin, M.C.9    Kung, H.F.10
  • 58
    • 77951620660 scopus 로고    scopus 로고
    • The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma
    • [PMID: 20347499 DOI: 10.1016/j.jhep.2009.12.024]
    • Shimizu S, Takehara T, Hikita H, Kodama T, Miyagi T, Hosui A, Tatsumi T, Ishida H, Noda T, Nagano H, Doki Y, Mori M, Hayashi N. The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma. J Hepatol 2010; 52: 698-704 [PMID: 20347499 DOI: 10.1016/j.jhep.2009.12.024]
    • (2010) J Hepatol , vol.52 , pp. 698-704
    • Shimizu, S.1    Takehara, T.2    Hikita, H.3    Kodama, T.4    Miyagi, T.5    Hosui, A.6    Tatsumi, T.7    Ishida, H.8    Noda, T.9    Nagano, H.10    Doki, Y.11    Mori, M.12    Hayashi, N.13
  • 59
    • 59149098054 scopus 로고    scopus 로고
    • MicroRNA-101, down-regulated in hepatocellular carcinoma, promotes apoptosis and suppresses tumorigenicity
    • [PMID: 19155302 DOI: 10.1158/0008-5472.CAN-08-2886]
    • Su H, Yang JR, Xu T, Huang J, Xu L, Yuan Y, Zhuang SM. MicroRNA-101, down-regulated in hepatocellular carcinoma, promotes apoptosis and suppresses tumorigenicity. Cancer Res 2009; 69: 1135-1142 [PMID: 19155302 DOI: 10.1158/0008-5472.CAN-08-2886]
    • (2009) Cancer Res , vol.69 , pp. 1135-1142
    • Su, H.1    Yang, J.R.2    Xu, T.3    Huang, J.4    Xu, L.5    Yuan, Y.6    Zhuang, S.M.7
  • 60
    • 84870307887 scopus 로고    scopus 로고
    • miR-101 is down-regulated by the hepatitis B virus x protein and induces aberrant DNA methylation by targeting DNA methyltransferase 3A
    • [PMID: 23124077 DOI: 10.1016/j.cellsig.2012.10.013]
    • Wei X, Xiang T, Ren G, Tan C, Liu R, Xu X, Wu Z. miR-101 is down-regulated by the hepatitis B virus x protein and induces aberrant DNA methylation by targeting DNA methyltransferase 3A. Cell Signal 2013; 25: 439-446 [PMID: 23124077 DOI: 10.1016/j.cellsig.2012.10.013]
    • (2013) Cell Signal , vol.25 , pp. 439-446
    • Wei, X.1    Xiang, T.2    Ren, G.3    Tan, C.4    Liu, R.5    Xu, X.6    Wu, Z.7
  • 61
    • 84870518867 scopus 로고    scopus 로고
    • MicroRNA-101 suppresses SOX9-dependent tumorigenicity and promotes favorable prognosis of human hepatocellular carcinoma
    • [PMID: 23178713 DOI: 10.1016/j.febslet.2012.10.053]
    • Zhang Y, Guo X, Xiong L, Kong X, Xu Y, Liu C, Zou L, Li Z, Zhao J, Lin N. MicroRNA-101 suppresses SOX9-dependent tumorigenicity and promotes favorable prognosis of human hepatocellular carcinoma. FEBS Lett 2012; 586: 4362-4370 [PMID: 23178713 DOI: 10.1016/j.febslet.2012.10.053]
    • (2012) FEBS Lett , vol.586 , pp. 4362-4370
    • Zhang, Y.1    Guo, X.2    Xiong, L.3    Kong, X.4    Xu, Y.5    Liu, C.6    Zou, L.7    Li, Z.8    Zhao, J.9    Lin, N.10
  • 62
    • 50849115468 scopus 로고    scopus 로고
    • miR-122 targets an anti-apoptotic gene, Bcl-w, in human hepatocellular carcinoma cell lines
    • [PMID: 18692484 DOI: 10.1016/j.bbrc.2008.07.154]
    • Lin CJ, Gong HY, Tseng HC, Wang WL, Wu JL. miR-122 targets an anti-apoptotic gene, Bcl-w, in human hepatocellular carcinoma cell lines. Biochem Biophys Res Commun 2008; 375: 315-320 [PMID: 18692484 DOI: 10.1016/j.bbrc.2008.07.154]
    • (2008) Biochem Biophys Res Commun , vol.375 , pp. 315-320
    • Lin, C.J.1    Gong, H.Y.2    Tseng, H.C.3    Wang, W.L.4    Wu, J.L.5
  • 63
    • 79960043127 scopus 로고    scopus 로고
    • The Putative PAX8/PPARγ Fusion Oncoprotein Exhibits Partial Tumor Suppressor Activity through Up-Regulation of Micro-RNA-122 and Dominant-Negative PPARγ Activity
    • [PMID: 21779480 DOI: 10.1177/1947601 911405045]
    • Reddi HV, Madde P, Milosevic D, Hackbarth JS, Algeciras-Schimnich A, McIver B, Grebe SK, Eberhardt NL. The Putative PAX8/PPARγ Fusion Oncoprotein Exhibits Partial Tumor Suppressor Activity through Up-Regulation of Micro-RNA-122 and Dominant-Negative PPARγ Activity. Genes Cancer 2011; 2: 46-55 [PMID: 21779480 DOI: 10.1177/1947601 911405045]
    • (2011) Genes Cancer , vol.2 , pp. 46-55
    • Reddi, H.V.1    Madde, P.2    Milosevic, D.3    Hackbarth, J.S.4    Algeciras-Schimnich, A.5    McIver, B.6    Grebe, S.K.7    Eberhardt, N.L.8
  • 64
    • 84862777271 scopus 로고    scopus 로고
    • MicroRNA-122 suppresses cell proliferation and induces cell apoptosis in hepatocellular carcinoma by directly targeting Wnt/β-catenin pathway
    • [PMID: 22276989 DOI: 10.1111/j.1478-3231.2011.02750.x]
    • Xu J, Zhu X, Wu L, Yang R, Yang Z, Wang Q, Wu F. MicroRNA-122 suppresses cell proliferation and induces cell apoptosis in hepatocellular carcinoma by directly targeting Wnt/β-catenin pathway. Liver Int 2012; 32: 752-760 [PMID: 22276989 DOI: 10.1111/j.1478-3231.2011.02750.x]
    • (2012) Liver Int , vol.32 , pp. 752-760
    • Xu, J.1    Zhu, X.2    Wu, L.3    Yang, R.4    Yang, Z.5    Wang, Q.6    Wu, F.7
  • 65
    • 84862805764 scopus 로고    scopus 로고
    • MicroRNA-125b induces cancer cell apoptosis through suppression of Bcl-2 expression
    • [PMID: 22293115 DOI: 10.1016/j.jgg.2011.12.003]
    • Zhao A, Zeng Q, Xie X, Zhou J, Yue W, Li Y, Pei X. MicroRNA-125b induces cancer cell apoptosis through suppression of Bcl-2 expression. J Genet Genomics 2012; 39: 29-35 [PMID: 22293115 DOI: 10.1016/j.jgg.2011.12.003]
    • (2012) J Genet Genomics , vol.39 , pp. 29-35
    • Zhao, A.1    Zeng, Q.2    Xie, X.3    Zhou, J.4    Yue, W.5    Li, Y.6    Pei, X.7
  • 67
    • 84874487252 scopus 로고    scopus 로고
    • Sirtuin7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors MiR-125a-5p and MiR-125b
    • [PMID: 23079745 DOI: 10.1002/hep.26101]
    • Kim JK, Noh JH, Jung KH, Eun JW, Bae HJ, Kim MG, Chang YG, Shen Q, Park WS, Lee JY, Borlak J, Nam SW. Sirtuin7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors MiR-125a-5p and MiR-125b. Hepatology 2013; 57: 1055-1067 [PMID: 23079745 DOI: 10.1002/hep.26101]
    • (2013) Hepatology , vol.57 , pp. 1055-1067
    • Kim, J.K.1    Noh, J.H.2    Jung, K.H.3    Eun, J.W.4    Bae, H.J.5    Kim, M.G.6    Chang, Y.G.7    Shen, Q.8    Park, W.S.9    Lee, J.Y.10    Borlak, J.11    Nam, S.W.12
  • 68
    • 78049521995 scopus 로고    scopus 로고
    • MicroRNA-125b suppressesed human liver cancer cell proliferation and metastasis by directly targeting oncogene LIN28B2
    • [PMID: 20827722 DOI: 10.1002/hep.23904]
    • Liang L, Wong CM, Ying Q, Fan DN, Huang S, Ding J, Yao J, Yan M, Li J, Yao M, Ng IO, He X. MicroRNA-125b suppressesed human liver cancer cell proliferation and metastasis by directly targeting oncogene LIN28B2. Hepatology 2010; 52: 1731-1740 [PMID: 20827722 DOI: 10.1002/hep.23904]
    • (2010) Hepatology , vol.52 , pp. 1731-1740
    • Liang, L.1    Wong, C.M.2    Ying, Q.3    Fan, D.N.4    Huang, S.5    Ding, J.6    Yao, J.7    Yan, M.8    Li, J.9    Yao, M.10    Ng, I.O.11    He, X.12
  • 69
    • 84863111015 scopus 로고    scopus 로고
    • Ectopic expression of MiR-125a inhibits the proliferation and metastasis of hepatocellular carcinoma by targeting MMP11 and VEGF
    • [PMID: 22768249 DOI: 10.1371/journal.pone.0040169]
    • Bi Q, Tang S, Xia L, Du R, Fan R, Gao L, Jin J, Liang S, Chen Z, Xu G, Nie Y, Wu K, Liu J, Shi Y, Ding J, Fan D. Ectopic expression of MiR-125a inhibits the proliferation and metastasis of hepatocellular carcinoma by targeting MMP11 and VEGF. PLoS One 2012; 7: e40169 [PMID: 22768249 DOI: 10.1371/journal.pone.0040169]
    • (2012) PLoS One , vol.7
    • Bi, Q.1    Tang, S.2    Xia, L.3    Du, R.4    Fan, R.5    Gao, L.6    Jin, J.7    Liang, S.8    Chen, Z.9    Xu, G.10    Nie, Y.11    Wu, K.12    Liu, J.13    Shi, Y.14    Ding, J.15    Fan, D.16
  • 70
    • 84873323368 scopus 로고    scopus 로고
    • Histone lysine methyltransferase, suppressor of variegation 3-9 homolog 1, promotes hepatocellular carcinoma progression and is negatively regulated by microRNA-125b
    • [PMID: 22991213 DOI: 10.1002/hep.26083]
    • Fan DN, Tsang FH, Tam AH, Au SL, Wong CC, Wei L, Lee JM, He X, Ng IO, Wong CM. Histone lysine methyltransferase, suppressor of variegation 3-9 homolog 1, promotes hepatocellular carcinoma progression and is negatively regulated by microRNA-125b. Hepatology 2013; 57: 637-647 [PMID: 22991213 DOI: 10.1002/hep.26083]
    • (2013) Hepatology , vol.57 , pp. 637-647
    • Fan, D.N.1    Tsang, F.H.2    Tam, A.H.3    Au, S.L.4    Wong, C.C.5    Wei, L.6    Lee, J.M.7    He, X.8    Ng, I.O.9    Wong, C.M.10
  • 71
    • 84878728402 scopus 로고    scopus 로고
    • Derepression of c-Fos caused by microRNA-139 down-regulation contributes to the metastasis of human hepatocellular carcinoma
    • [PMID: 23001723 DOI: 10.1002/cbf.2902]
    • Fan Q, He M, Deng X, Wu WK, Zhao L, Tang J, Wen G, Sun X, Liu Y. Derepression of c-Fos caused by microRNA-139 down-regulation contributes to the metastasis of human hepatocellular carcinoma. Cell Biochem Funct 2013; 31: 319-324 [PMID: 23001723 DOI: 10.1002/cbf.2902]
    • (2013) Cell Biochem Funct , vol.31 , pp. 319-324
    • Fan, Q.1    He, M.2    Deng, X.3    Wu, W.K.4    Zhao, L.5    Tang, J.6    Wen, G.7    Sun, X.8    Liu, Y.9
  • 72
    • 84864183740 scopus 로고    scopus 로고
    • MiR-145 modulates multiple components of the insulin-like growth factor pathway in hepatocellular carcinoma
    • [PMID: 22431718 DOI: 10.1093/carcin/bgs130]
    • Law PT, Ching AK, Chan AW, Wong QW, Wong CK, To KF, Wong N. MiR-145 modulates multiple components of the insulin-like growth factor pathway in hepatocellular carcinoma. Carcinogenesis 2012; 33: 1134-1141 [PMID: 22431718 DOI: 10.1093/carcin/bgs130]
    • (2012) Carcinogenesis , vol.33 , pp. 1134-1141
    • Law, P.T.1    Ching, A.K.2    Chan, A.W.3    Wong, Q.W.4    Wong, C.K.5    To, K.F.6    Wong, N.7
  • 73
    • 67651154718 scopus 로고    scopus 로고
    • MicroRNA-195 suppresses tumorigenicity and regulates G1/S transition of human hepatocellular carcinoma cells
    • [PMID: 19441017 DOI: 10.1002/hep.22919]
    • Xu T, Zhu Y, Xiong Y, Ge YY, Yun JP, Zhuang SM. MicroRNA-195 suppresses tumorigenicity and regulates G1/S transition of human hepatocellular carcinoma cells. Hepatology 2009; 50: 113-121 [PMID: 19441017 DOI: 10.1002/hep.22919]
    • (2009) Hepatology , vol.50 , pp. 113-121
    • Xu, T.1    Zhu, Y.2    Xiong, Y.3    Ge, Y.Y.4    Yun, J.P.5    Zhuang, S.M.6
  • 74
    • 84865627754 scopus 로고    scopus 로고
    • MiR-195 regulates cell apoptosis of human hepatocellular carcinoma cells by targeting LATS2
    • [PMID: 22888524]
    • Yang X, Yu J, Yin J, Xiang Q, Tang H, Lei X. MiR-195 regulates cell apoptosis of human hepatocellular carcinoma cells by targeting LATS2. Pharmazie 2012; 67: 645-651 [PMID: 22888524]
    • (2012) Pharmazie , vol.67 , pp. 645-651
    • Yang, X.1    Yu, J.2    Yin, J.3    Xiang, Q.4    Tang, H.5    Lei, X.6
  • 75
    • 77953773201 scopus 로고    scopus 로고
    • MiR-199a-3p regulates mTOR and c-Met to influence the doxorubicin sensitivity of human hepatocarcinoma cells
    • [PMID: 20501828 DOI: 10.1158/0008-5472.CAN-10-0145]
    • Fornari F, Milazzo M, Chieco P, Negrini M, Calin GA, Grazi GL, Pollutri D, Croce CM, Bolondi L, Gramantieri L. MiR-199a-3p regulates mTOR and c-Met to influence the doxorubicin sensitivity of human hepatocarcinoma cells. Cancer Res 2010; 70: 5184-5193 [PMID: 20501828 DOI: 10.1158/0008-5472.CAN-10-0145]
    • (2010) Cancer Res , vol.70 , pp. 5184-5193
    • Fornari, F.1    Milazzo, M.2    Chieco, P.3    Negrini, M.4    Calin, G.A.5    Grazi, G.L.6    Pollutri, D.7    Croce, C.M.8    Bolondi, L.9    Gramantieri, L.10
  • 76
    • 79961140116 scopus 로고    scopus 로고
    • MicroRNA miR-199a-3p regulates cell proliferation and survival by targeting caveolin-2
    • [PMID: 21807947 DOI: 10.1242/jcs.077529]
    • Shatseva T, Lee DY, Deng Z, Yang BB. MicroRNA miR-199a-3p regulates cell proliferation and survival by targeting caveolin-2. J Cell Sci 2011; 124: 2826-2836 [PMID: 21807947 DOI: 10.1242/jcs.077529]
    • (2011) J Cell Sci , vol.124 , pp. 2826-2836
    • Shatseva, T.1    Lee, D.Y.2    Deng, Z.3    Yang, B.B.4
  • 78
    • 84863834241 scopus 로고    scopus 로고
    • Cisplatininduced downregulation of miR-199a-5p increases drug resistance by activating autophagy in HCC cell
    • [PMID: 22713463 DOI: 10.1016/j.bbrc.2012.06.048]
    • Xu N, Zhang J, Shen C, Luo Y, Xia L, Xue F, Xia Q. Cisplatininduced downregulation of miR-199a-5p increases drug resistance by activating autophagy in HCC cell. Biochem Biophys Res Commun 2012; 423: 826-831 [PMID: 22713463 DOI: 10.1016/j.bbrc.2012.06.048]
    • (2012) Biochem Biophys Res Commun , vol.423 , pp. 826-831
    • Xu, N.1    Zhang, J.2    Shen, C.3    Luo, Y.4    Xia, L.5    Xue, F.6    Xia, Q.7
  • 79
    • 84865107292 scopus 로고    scopus 로고
    • MicroRNA-214 downregulation contributes to tumor angiogenesis by inducing secretion of the hepatoma-derived growth factor in human hepatoma
    • [PMID: 22613005 DOI: 10.1016/ j.jhep.2012.04.031]
    • Shih TC, Tien YJ, Wen CJ, Yeh TS, Yu MC, Huang CH, Lee YS, Yen TC, Hsieh SY. MicroRNA-214 downregulation contributes to tumor angiogenesis by inducing secretion of the hepatoma-derived growth factor in human hepatoma. J Hepatol 2012; 57: 584-591 [PMID: 22613005 DOI: 10.1016/ j.jhep.2012.04.031]
    • (2012) J Hepatol , vol.57 , pp. 584-591
    • Shih, T.C.1    Tien, Y.J.2    Wen, C.J.3    Yeh, T.S.4    Yu, M.C.5    Huang, C.H.6    Lee, Y.S.7    Yen, T.C.8    Hsieh, S.Y.9
  • 80
    • 84870380377 scopus 로고    scopus 로고
    • MiR-214 inhibits cell growth in hepatocellular carcinoma through suppression of β-catenin
    • [PMID: 23068095 DOI: 10.1016/j.bbrc.2012.10.039]
    • Wang X, Chen J, Li F, Lin Y, Zhang X, Lv Z, Jiang J. MiR-214 inhibits cell growth in hepatocellular carcinoma through suppression of β-catenin. Biochem Biophys Res Commun 2012; 428: 525-531 [PMID: 23068095 DOI: 10.1016/j.bbrc.2012.10.039]
    • (2012) Biochem Biophys Res Commun , vol.428 , pp. 525-531
    • Wang, X.1    Chen, J.2    Li, F.3    Lin, Y.4    Zhang, X.5    Lv, Z.6    Jiang, J.7
  • 81
    • 84866040307 scopus 로고    scopus 로고
    • MiR-214 targets β-catenin pathway to suppress invasion, stem-like traits and recurrence of human hepatocellular carcinoma
    • [PMID: 22962603 DOI: 10.1371/journal.pone.0044206]
    • Xia H, Ooi LL, Hui KM. MiR-214 targets β-catenin pathway to suppress invasion, stem-like traits and recurrence of human hepatocellular carcinoma. PLoS One 2012; 7: e44206 [PMID: 22962603 DOI: 10.1371/journal.pone.0044206]
    • (2012) PLoS One , vol.7
    • Xia, H.1    Ooi, L.L.2    Hui, K.M.3
  • 82
    • 84873294160 scopus 로고    scopus 로고
    • MicroRNA-10a is involved in the metastatic process by regulating Eph tyrosine kinase receptor A4-mediated epithelial-mesenchymal transition and adhesion in hepatoma cells
    • [PMID: 22996586 DOI: 10.1002/hep.26071]
    • Yan Y, Luo YC, Wan HY, Wang J, Zhang PP, Liu M, Li X, Li S, Tang H. MicroRNA-10a is involved in the metastatic process by regulating Eph tyrosine kinase receptor A4-mediated epithelial-mesenchymal transition and adhesion in hepatoma cells. Hepatology 2013; 57: 667-677 [PMID: 22996586 DOI: 10.1002/hep.26071]
    • (2013) Hepatology , vol.57 , pp. 667-677
    • Yan, Y.1    Luo, Y.C.2    Wan, H.Y.3    Wang, J.4    Zhang, P.P.5    Liu, M.6    Li, X.7    Li, S.8    Tang, H.9
  • 83
    • 34547524771 scopus 로고    scopus 로고
    • MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer
    • [PMID: 17681183 DOI: 10.1053/j.gastro.2007.05.022]
    • Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST, Patel T. MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 2007; 133: 647-658 [PMID: 17681183 DOI: 10.1053/j.gastro.2007.05.022]
    • (2007) Gastroenterology , vol.133 , pp. 647-658
    • Meng, F.1    Henson, R.2    Wehbe-Janek, H.3    Ghoshal, K.4    Jacob, S.T.5    Patel, T.6
  • 84
    • 77952948062 scopus 로고    scopus 로고
    • Overexpression of miR-21 promotes an in vitro metastatic phenotype by targeting the tumor suppressor RHOB
    • [PMID: 20460403 DOI: 10.1158/1541-7786.MCR-09-0465]
    • Connolly EC, Van Doorslaer K, Rogler LE, Rogler CE. Overexpression of miR-21 promotes an in vitro metastatic phenotype by targeting the tumor suppressor RHOB. Mol Cancer Res 2010; 8: 691-700 [PMID: 20460403 DOI: 10.1158/1541-7786.MCR-09-0465]
    • (2010) Mol Cancer Res , vol.8 , pp. 691-700
    • Connolly, E.C.1    van Doorslaer, K.2    Rogler, L.E.3    Rogler, C.E.4
  • 85
    • 84863236989 scopus 로고    scopus 로고
    • miR-21 promotes migration and invasion by the miR-21-PDCD4-AP-1 feedback loop in human hepatocellular carcinoma
    • [PMID: 22322403 DOI: 10.3892/ or.2012.1682]
    • Zhu Q, Wang Z, Hu Y, Li J, Li X, Zhou L, Huang Y. miR-21 promotes migration and invasion by the miR-21-PDCD4-AP-1 feedback loop in human hepatocellular carcinoma. Oncol Rep 2012; 27: 1660-1668 [PMID: 22322403 DOI: 10.3892/ or.2012.1682]
    • (2012) Oncol Rep , vol.27 , pp. 1660-1668
    • Zhu, Q.1    Wang, Z.2    Hu, Y.3    Li, J.4    Li, X.5    Zhou, L.6    Huang, Y.7
  • 90
    • 84874363544 scopus 로고    scopus 로고
    • Involvement of microRNA-224 in cell proliferation, migration, invasion, and anti-apoptosis in hepatocellular carcinoma
    • [PMID: 22989374 DOI: 10.1111/j.1440-1746.2012.07271.x]
    • Zhang Y, Takahashi S, Tasaka A, Yoshima T, Ochi H, Chayama K. Involvement of microRNA-224 in cell proliferation, migration, invasion, and anti-apoptosis in hepatocellular carcinoma. J Gastroenterol Hepatol 2013; 28: 565-575 [PMID: 22989374 DOI: 10.1111/j.1440-1746.2012.07271.x]
    • (2013) J Gastroenterol Hepatol , vol.28 , pp. 565-575
    • Zhang, Y.1    Takahashi, S.2    Tasaka, A.3    Yoshima, T.4    Ochi, H.5    Chayama, K.6
  • 93
    • 45149128115 scopus 로고    scopus 로고
    • Profiling microRNA expression in hepatocellular carcinoma reveals microRNA-224 up-regulation and apoptosis inhibitor-5 as a microRNA-224-specific target
    • [PMID: 18319255 DOI: 10.1074/jbc.M707629200]
    • Wang Y, Lee AT, Ma JZ, Wang J, Ren J, Yang Y, Tantoso E, Li KB, Ooi LL, Tan P, Lee CG. Profiling microRNA expression in hepatocellular carcinoma reveals microRNA-224 up-regulation and apoptosis inhibitor-5 as a microRNA-224-specific target. J Biol Chem 2008; 283: 13205-13215 [PMID: 18319255 DOI: 10.1074/jbc.M707629200]
    • (2008) J Biol Chem , vol.283 , pp. 13205-13215
    • Wang, Y.1    Lee, A.T.2    Ma, J.Z.3    Wang, J.4    Ren, J.5    Yang, Y.6    Tantoso, E.7    Li, K.B.8    Ooi, L.L.9    Tan, P.10    Lee, C.G.11


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.