New 2-piperazinylbenzimidazole derivatives as 5-HT3 antagonists. Synthesis and pharmacological evaluation

Journal of Medicinal Chemistry

Volumn 40, Issue 4, 1997, Pages 586-593

  Orjales, Aurelio ^a   Mosquera, Ramón ^a   Labeaga, Luis ^a   Rodes, Rosa ^a  

^a FAES   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

1 (PHENYLMETHYL) 2 (1 PIPERAZINYL) 1H BENZIMIDAZOLE; 1 METHYL 3 INDAZOLECARBOXYLIC ACID N TROPANYLAMIDE; 2 (1 PIPERAZINYL)BENZIMIDAZOLE DERIVATIVE; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 3 INDOLECARBOXYLIC ACID 2 (1 PIPERIDINYL)ETHYL ESTER; ANTIEMETIC AGENT; BENZIMIDAZOLE DERIVATIVE; CISPLATIN; GRANISETRON; HALOPERIDOL; RITANSERIN; SEROTONIN 3 ANTAGONIST; TRITIUM; TROPISETRON; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CANCER; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; DRUG STRUCTURE; DRUG SYNTHESIS; GUINEA PIG; LIGAND BINDING; MALE; NAUSEA; NONHUMAN; RAT; VOMITING;

ANIMALS; BENZIMIDAZOLES; GUINEA PIGS; INDAZOLES; MALE; MODELS, CHEMICAL; PIPERAZINES; PIPERIDINES; RATS; RATS, WISTAR; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; RECEPTORS, SEROTONIN, 5-HT3; RECEPTORS, SEROTONIN, 5-HT4; SEROTONIN ANTAGONISTS; TROPANES;

EID: 0031048479     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960442e     Document Type: Article

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