Favorable effects of flaxseed supplemented diet on liver and kidney functions in hypertensive Wistar rats

Journal of Oleo Science

Volumn 62, Issue 9, 2013, Pages 709-715

  Al Bishri, Widad M ^a  

^a KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

Author keywords

Flaxseed; Hypertension; Kidney; Liver

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BLOOD UREA NITROGENS; CARDIO-VASCULAR DISEASE; ESSENTIAL FATTY ACIDS; FLAXSEED; HYPERTENSION; KIDNEY;

AMINO ACIDS; BLOOD PRESSURE; INDUSTRIAL POISONS; LINOLEIC ACID; LIVER; NUTRITION; OILSEEDS; POLYUNSATURATED FATTY ACIDS; RATS; TISSUE;

FLAX;

LINOLEIC ACID; LINOLENIC ACID; LINSEED OIL;

ANIMAL; BLOOD PRESSURE; CHEMISTRY; COMPLICATION; DIET SUPPLEMENTATION; DRUG EFFECTS; HYPERTENSION; KIDNEY DISEASES; KIDNEY FUNCTION TEST; LIVER DISEASES; LIVER FUNCTION TEST; MALE; PATHOPHYSIOLOGY; RAT; WISTAR RAT; ARTICLE; DRUG EFFECT; KIDNEY DISEASE; LIVER DISEASE;

ALPHA-LINOLENIC ACID; ANIMALS; BLOOD PRESSURE; DIETARY SUPPLEMENTS; HYPERTENSION; KIDNEY DISEASES; KIDNEY FUNCTION TESTS; LINOLEIC ACID; LINSEED OIL; LIVER DISEASES; LIVER FUNCTION TESTS; MALE; RATS; RATS, WISTAR;

EID: 84883484250     PISSN: 13458957     EISSN: 13473352     Source Type: Journal    
DOI: 10.5650/jos.62.709     Document Type: Article

References (37)

1. Duncan, A. M.; Phipps, W. R.; Kurzer, M. S. Phytooestrogens. Best Pract. Res. Clin. Endocrinol. Metab. 17, 253-271(2003).
2. Peterson, J.; Dwyer, J.; Adlercreutz, H.; Scalbert, A.; Jacques, P.; McCullough, M. L. Dietary lignans: physiology and potential for cardiovascular disease risk reduction. Nutr. Rev. 68, 571-603 (2010).
3. Bhathena, S. J.; Velasquez, M. T. Beneficial role of dietary phytoestrogens in obesity and diabetes. Am. J. Clin Nutr. 76, 1191-1201(2002).
4. Makni, M.; Sefi, M.; Garouiel, M.; Fetoui, H.; Bou-dawara, T.; Zeghal, N. Dietary polyunsaturated fatty acid prevents hyperlipidemia and hepatic oxidant status in pregnant diabetic rats and their macrosomic offspring. J. Diabetes. Complications. 25, 267-274 (2011).
5. Lehraiki, A.; Attoumbré, J.; Bienaimé, C; Matifat, F; Bensaddek, L.; Nava-Saucedo, E.; Fliniaux, M.A.; Oua-did-Ahidouch, H.; Baltora-Rosset, S. Extraction of lignans from flaxseed and evaluation of their biological effects on breast cancer MCF-7 and MDA-MB-231 cell lines. J. Med. Food. 13, 834-841 (2010).
6. Bhatty, R. S. 1995. Nutrient composition of whole flaxseed and flaxseed meal. In Flaxseed in Human Nutrition (S. C. Cunnane and L. U. Thompson, eds.) pp. 22-42, AOCS Press, Champaign, IL.
7. Bassett, C. M.; Rodriguez-Leyva, D.; Pierce, G. N. Experimental and clinical research findings on the cardiovascular benefits of consuming flaxseed. Appl. Physiol. Nutr. Metab. 34, 965-974(2009).
8. Conner, W. E. Importance of n-3 fatty acids in health and disease. Am. J. Clin Nutr. 71, 171S-175S(2000).
9. Lackland, D. T.; Egan, B. M. The dominant role of systolic hypertension as a vascular risk factor: evidence from the southeastern United States. Am. J. Med. Sci 318, 365-368(1999).
10. Ogawa, A.; Suzuki, Y. Dietary alpha-linolenic acid inhibits angiotensin-converting enzyme activity and mRNA expression levels in the aorta of spontaneously hypertensive rats. J. Oleo Sci. 58, 355-360(2009).
11. Begg, D. P.; Sinclair, A. J.; Stahl, L. A.; Premaratna, S. D.; Hafandi, A.; Jois, M.; Weisinger, R. S. Hypertension induced by omega-3 polyunsaturated fatty acid deficiency is alleviated by alpha-linolenic acid regardless of dietary source. Hypertens. Res. 33, 808-813 (2010).
12. Singer, P. Alpha-linolenic acid vs. long-chain n-3 fatty acids in hypertension and hyperlipidemia. Nutrition 8, 133-135(1992).
13. Daun, J. K., Barthet, V. J., Chornick, T. L. and Duguid, S. 2003.Structure, composition, and variety development of flaxseed. In Flaxseedin Human Nutrition, 2nd Ed. (L. U. Thompson and S. C. Cunnane, eds.), pp. 1-40, AOCS Press, Champaign, IL.
14. Reis, F; Parada, B.; Teixeira de Lemos, E.; Garrido, P.; Dias, A.; Piloto, N.; Baptista, S.; Sereno, J.; Eufrásio, P.; Costa, E.; Rocha-Pereira, P.; Santos-Silva, A.; Figueire-do, A.; Mota, A.; Teixeira, F. Hypertension induced by immunosuppressive drugs: a comparative analysis between sirolimus and cyclosporine. Transplant. Proc. 41, 868-873(2009).
15. Louhelainen, M.; Merasto, S.; Finckenberg, P.; Lapatto, R.; Cheng, Z. J.; Mervaala, E. M. Lipoic acid supplementation prevents cyclosporine-induced hypertension and nephrotoxicity in spontaneously hypertensive rats. J. Hypertens. 24, 947-56(2006).
16. Lyson, T.; Ermel, L. D.; Belshaw, P. J.; Alberg, D. G.; Schreiber, S. L.; Victor, R. G. Cyclosporine- and FK506-induced sympathetic activation correlates with calcineurin-mediated inhibition of T-cell signaling. Circ. Res. 73, 596-602(1993).
17. Zhang, W.; Victor, R. G. Calcineurin inhibitors cause renal afferent activation in rats: a novel mechanism of cyclosporine-induced hypertension. Am. J. Hypertens. 13, 999-1004(2000).
18. Prasad, K. Hypocholesterolemic and antiatheroscle-rotic effect of flax lignan complex isolated from flaxseed. Atherosclerosis 179, 269-75 (2005).
19. Razi, S. S.; Latif, M. J.; Li, X.; Afthinos, J. N.; Ippagun-ta, N.; Schwartz, G.; Sagalovich, D.; Belsley, S. J.; Con-nery, C. P.; Jour, G.; Christofidou-Solomidou, M.; Bho-ra, F Y. Dietary flaxseed protects against lung ischemia reperfusion injury via inhibition of apoptosis and inflammation in a murine model. J. Surg. Res. 171, e113-e121(2011).
20. Velasquez, M. T.; Bhathena, S. J. Dietary phytoestrogens: a possible role in renal disease protection. Am. J. Kidney Dis. 37, 1056-1068(2001).
21. Udenigwe, C. C; Aluko, R. E. Multifunctional cationic peptide fractions from flaxseed protein hydrolysates. Plant Foods Hum. Nutr. 67, 1-9(2012).
22. Makni, M.; Sefi, M.; Fetoui, H.; Garouiel, M.; Gargouri, N. K.; Boudawara, T.; Zeghal, N. Flax and Pumpkin seeds mixture ameliorates diabetic nephropathy in rats. Food Chem. Toxicol. 48, 2407-2412 (2010).
23. Bhatia, A. L.; Sharma, A.; Patni, S.; Sharma, A. L. Prophylactic effect of flaxseed oil against radiation-induced hepatotoxicity in mice. Phytother Res. 21, 852-859(2007).
24. Makni, M.; Fetoui, H.; Gargouri, N. K.; Garouiel, M.; Zeghal, N. Antidiabetic effect of flax and pumpkin seed mixture powder: effect on hyperlipidemia and antioxidant status in alloxan diabetic rats. J. Diabetes Complications. 25, 339-345(2011).
25. Park, J. B.; Velasquez, M. T. Potential effects of lignan-enriched flaxseed powder on bodyweight, visceral fat, lipid profile, and blood pressure in rats. Fitoterapia 83, 941-946(2012).
26. Talom, R. T.; Judd, S. A.; McIntosh, D. D.; McNeill, J. R. High flaxseed (linseed) diet restores endothelial function in the mesenteric arterial bed of spontaneously hypertensive rats. Life Sci. 64, 1415-1425(1999).
27. Torgerson, J. S.; Lindroos, A. K.; Sjöström, C. D.; Ols-son, R.; Lissner, L.; Sjöström, L. Are elevated aminotransferases and decreased bilirubin additional characteristics of the metabolic syndrome? Obes. Res. 5, 105-114(1997).
28. Saruta, T. Effects of nicardipine on blood pressure and renal function in elderly hypertensive patients with renal dysfunction. Am. Heart J. 117, 243-249 (1989).
29. Yang, S. F; Tseng, J. K.; Chang, Y Y; Chen, Y C. Flaxseed oil attenuates nonalcoholic fatty liver of hyperlip-idemic hamsters. J. Agric. Food Chem. 57, 5078-5083 (2009).
30. Kaithwas, G.; Majumdar, D. K. Therapeutic effect of Linum usitatissimum (flaxseed/linseed) fixed oil on acute and chronic arthritic models in albino rats. In-flammopharmacology 18, 127-136(2010).
31. Khan, M.; Priyamvada, S.; Khan, S.; Khan, S.; Naqsh-bandi, A.; Yusufi, A. Protective effect of co-3 polyunsaturated fatty acids (PUFAs) on sodium nitroprusside-in-duced nephrotoxicity and oxidative damage in rat kidney. Hum Exp. Toxicol. 31, 1035-1049(2012).
32. Khan, M.; Priyamvada, S.; Khan, S.; Khan, S.; Naqsh-bandi, A.; Yusufi, A. Protective effect of co-3 polyunsaturated fatty acids (PUFAs) on L-arginine-induced nephrotoxicity and oxidative damage in rat kidney. Hum Exp. Toxicol. 31, 1035-1049(2012).
33. Tomaz Pacheco, J.; Beltrame Daleprame, J.; Teles Boaventura, G. Impact of dietary flaxseed (linum usitatissimum) supplementation on biochemical profile in healthy rats. Nutr. Hosp. 26, 798-802 (2011).
34. Abdel Moneim, A. E.; Dkhil, M. A.; Al-Quraishy, S. The protective effect of flaxseed oil on lead acetate-induced renal toxicity in rats. J. Hazard. Mater. 194, 250-255(2011).
35. Fernandes, M. B.; Caldas, H. C; Martins, L. R.; Fer-reira, C. C; Baptista, M. A.; Fernandes, I. M.; Abbud-Filho, M. Effects of polyunsaturated fatty acids (PUFAs) in the treatment of experimental chronic renal failure. Int. Urol. Nephrol. 44, 1571-1576(2012).
36. Ogborn, M. R.; Nitschmann, E.; Weiler, H.; Leswick, D.; Bankovic-Calic, N. Flaxseed ameliorates interstitial nephritis in rat polycystic kidney disease. Kidney Int. 55, 417-423(1999).
37. Miyazaki, M.; Takemura, N.; Watanabe, S.; Hata, N.; Misawa, Y; Okuyama, H. Dietary docosahexaenoic acid ameliorates, but rapeseed oil and safflower oil accelerate renal injury in stroke-prone spontaneously hypertensive rats as compared with soybean oil, which is associated with expression for renal transforming growth factor-beta, fibronectin and renin. Biochim. Biophys. Acta 1483, 101-110(2000).