Flaxseed oil attenuates nonalcoholic fatty liver of hyperlipidemic hamsters

Journal of Agricultural and Food Chemistry

Volumn 57, Issue 11, 2009, Pages 5078-5083

  Yang, Shun Fa ^a,b   Tseng, Jung Kai ^a   Chang, Yuan Yen ^a   Chen, Yi Chen ^a  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Flaxseed oil; GSH; Hepatic cholesterol triacylglycerol contents; Matrix metallopro teinases; MDA; NAFL

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GELATINASE A; GELATINASE B; LINSEED OIL; MALONALDEHYDE;

ANIMAL; ARTICLE; DISEASE MODEL; DRUG EFFECT; ENZYMOLOGY; FATTY LIVER; GENE EXPRESSION; GENETICS; HAMSTER; HUMAN; HYPERLIPIDEMIA; LIVER; MALE; METABOLISM; SYRIAN HAMSTER;

ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; CRICETINAE; DISEASE MODELS, ANIMAL; FATTY LIVER; GENE EXPRESSION; HUMANS; HYPERLIPIDEMIAS; LINSEED OIL; LIVER; MALE; MALONDIALDEHYDE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MESOCRICETUS;

CRICETINAE;

EID: 67149123675     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf900499v     Document Type: Article

References (33)

1. World Health Organization. Obesity and overweight, 2006; http://www.who.int/mediacentre/factsheets/fs311/en/.
2. Vuppalanchi, R.; Chalasani, N. Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: selected practical issues in their evaluation and management. Hepatology 2009, 49, 306-317.
3. Adams, L. A.; Lindor, K. D. Nonalcoholic fatty liver disease. Ann. Epidemiol. 2007, 17, 863-869.
4. Shahidi, F.; Miraliakbari, H. Omega-3 (n-3) fatty acids in health and disease: Part 1. Cardiovascular disease and cancer. J. Med. Food 2004, 7, 387-401.
5. Sinclair, A. J.; Attar-Bashi, N. M.; Li, D. What is the role of α-linolenic acid for mammals? Lipids 2002, 37, 1113-1123.
6. Emken, E. A.; Adlof, R. O.; Duval, A. M.; Nelson, G. J. Effect of dietary docosahexaenoicacid on desaturation and uptake in vivo of isotope-labeled oleic, linoleic, and linolenic acids by male subjects. Lipids 1999, 34, 785-791.
7. Zhao, G.; Etherton, T. D.; Martin, K. R.; West, S. G.; Gillies, P. J.; Kris-Etherton, P. M. Dietary α-linolenic acid reduces inflammatory and lipid cardiovascular risk factors in hypercholesterolemic men and women. J. Nutr. 2004, 134, 2991-2997.
8. Svegliati-Baroni, G.; Candelaresi, C.; Saccomanno, S.; Ferretti, G.; Bachetti, T.; Marzioni, M.; De Minicis, S.; Nobili, L.; Salzano, R.; Omenetti, A.; Pacetti, D.; Sigmund, S.; Benedetti, A.; Casini, A. A model of insulin resistance and nonalcoholic steatohepatitis in rats: role of peroxisome proliferator-activated receptor-α and n-3 poly-unsaturated fatty acid treatment on liver injury. Am. J. Pathol. 2006, 169, 846-860.
9. Huber, J.; Löffler, M.; Bilban, M.; Reimers, M.; Kadl, A.; Todoric, J.; Zeyda, M.; Geyeregger, R.; Schreiner, M.; Weichhart, T.; Leitinger, N.; Waldhäusl, W.; Stulnig, T. M. Prevention of high-fat diet-induced adipose tissue remodeling in obese diabetic mice by n-3 polyunsaturated fatty acids. Int. J. Obes. 2007, 31, 1004-1013.
10. Bloedon, L. T.; Szapary, P. O. Flaxseed and cardiovascular risk. Nutr. Rev. 2004, 62, 18-27.
11. National Research Council. Composition of Feed Ingredients; National Academy Press: Washington, DC, 1993; pp 64-71.
12. Tzang, B. S.; Yang, S. F.; Fu, S. G.; Yang, H. C.; Sun, H. L.; Chen, Y. C. Effects of dietary flaxseed oil on cholesterol metabolism of hamsters. Food Chem. 2009, 114, 1450-1455.
13. Chen, Y.; Hozawa, S.; Sawamura, S.; Sato, S.; Fukuyama, N.; Tsuji, C.; Mine, T.; Okada, Y.; Tanino, R.; Ogushi, Y.; Nakazawa, H. Deficiency of inducible nitric oxide synthase exacerbates hepatic fibrosis in mice fed high-fat diet. Biochem. Biophys. Res. Commun. 2005, 326, 45-51.
14. Benyon, R. C.; Arthur, M. J. Extracellular matrix degradation and the role of hepatic stellate cells. Semin. Liver Dis. 2001, 21, 373-384.
15. Shyu, M. H.; Kao, T. C.; Yen, G. C. Hsian-tsao (Mesona procumbens Heml.) prevents against rat liver fibrosis induced by CC14 via inhibition of hepatic stellate cells activation. Food Chem. Toxicoi. 2008, 46, 3707-3713.
16. Dhar, P.; Chattopadhya, K.; Bhattacharyya, D.; Biswas, A.; Roy, B.; Ghosh, S. Ameliorative influence of sesame lignans on lipid profile and lipid peroxidation in induced diabetic rats. J. Agric. Food Chem. 2007, 55, 5875-5880.
17. Hung, M. Y.; Fu, T. Y.; Shih, P. H.; Lee, C. P.; Yen, G. C. Du-Zhong (Eucommia ulmoides Oliv.) leaves inhibit CCU-induced hepatic damage in rats. Food Chem. Toxicol. 2006, 44, 1424-1431.
18. Masutomo, K.; Makino, N.; Fushiki, M. S. Effects of losartan on the collagen degradative enzymes in hypertrophic and congestive types of cardiomyopathic hamsters. Mol. Cell. Biochem. 2001, 224, 19-27.
19. Yang, S. F.; Chu, S. C.; Liu, S. I.; Chen, Y. C.; Chang, Y. Z.; Hsieh, Y. S. Antimetastatic activities of Selaginella tamariscina (Beauv.) on lung cancer cells in vitro and in vivo. J. Ethnopharmacol. 2007, 110, 483-489.
20. Yang, L.; Leung, K. Y.; Cao, Y.; Huang, Y.; Ratnayake, W. M. N.; Chen, Z. Y. Alpha-linolenic acid but not conjugated linolenic acid is hypocholesterolaemic in hamsters. Br. J. Nutr. 2005, 93, 433-438.
21. Kim, H. K.; Choi, S.; Choi, H. Suppression of hepatic fatty acid synthase by feeding α-linolenic acid rich perilla oil lowers plasma triacylglycerol level in rats. J. Nutr, Biochem. 2004, 15, 485-492.
22. Prasad, K. Flaxseed: a source of hypocholesterolemic and anti-atherogenic agents. Drug News Per spect. 2000, 13, 99-104.
23. Pellizzon, M. A.; Billheimer, J. T.; Bloedon, L.; Szapary, P. O.; Rader, D. J. Flaxseed reduces plasma cholesterol levels in hyperch-olesterolemic mouse models. J. Am. Coll. Nutr. 2007, 26, 66-75.
24. Lieber, C.; Leo, M.; Mak, K.; Xu, Y.; Cao, Q.; Ren, C.; Ponomar-enko, A.; DeCarli, L. Model of nonalcoholic steatohepatitis. Am. J. Clin. Nutr. 2004, 79, 502-509.
25. Gonzalez, M. J.; Gray, J. I.; Schemmel, R. A.; Dugan, L. Jr.; Welsch, C. W. Lipid peroxidation products are elevated in fish oil diets even in the presence of added antioxidants. J. Nutr. 1992, 122, 2190-2195.
26. Schuman, B. E.; Squires, E. J.; Leeson, S. Effect of dietary flaxseed, flax oil and n-3 fatty acid supplement on hepatic and plasma characteristics relevant to fatty liver haemorrhagic syndrome in laying hens. Br. Poult. Sci. 2000, 41, 465-472.
27. Yuan, Y. V.; Kitts, D. D. Dietary (n-3) fat and cholesterol alter tissue antioxidant enzymes and susceptibility to oxidation in SHR and WKY rats. J. Nutr. 2002, 133, 679-688.
28. Nagase, H.; Woessner, J. F. Jr. Matrix metalloproteinases. J. Biol. Chem. 1999, 274, 21491-21494.
29. Watanabe, Y.; Haruyama, T.; Akaike, T. Liver-derived matrix metalloproteinase-9 (gelatinase B) recruits progenitor cells from bone marrow into the blood circulation. Biol. Pharm. Bull. 2003, 26, 564-568.
30. Ito, Y.; Abril, E. R.; Bethea, N. W.; McCuskey, R. S. Inhibition of matrix metalloproteinases minimizes hepatic microvascular injury in response to acetaminophen in mice. Toxicol. Sci. 2005, 83, 190-196.
31. Alwayn, I. P. J.; Andersson, C.; Lee, S.; Arsenault, D. A.; Bistrian, B. R.; Gura, K. M.; Nose, V.; Zauscher, B.; Moses, M.; Puder, M. Inhibition of matrix metalloproteinase increases PPAR-α and IL-6 and prevents dietary-induced hepatic steatosis and injury in a murine model. Am. J. Physiol. Gastrointest. Liver Physiol. 2006, 291, G1011-G1019.
32. Calder, P. C. Polyunsaturated fatty acids, inflammatory processes and inflammatory bowel diseases. Mol. Nutr. Food Res. 2008, 52, 885-897.
33. Fernandes, J. C.; Martel-Pelletier, J.; Pelletier, J. P. The role of cytokines in osteoarthritis oathophysiology. Biorheology 2002, 39, 237-246.