Bisdemethoxycurcumin inhibits PDGF-induced vascular smooth muscle cell motility and proliferation

Molecular Nutrition and Food Research

Volumn 57, Issue 9, 2013, Pages 1611-1618

  Hua, Yinan ^a   Dolence, Julia ^a   Ramanan, Shalini ^a   Ren, Jun ^a   Nair, Sreejayan ^a  

^a UNIVERSITY OF WYOMING COLLEGE OF HEALTH SCIENCES   (United States)

Author keywords

Curcumin; Migration; Platelet derived growth factor; Proliferation; Vascular smooth muscle cell

Indexed keywords

RATTUS;

4 HYDROXYBENZALDEHYDE; 4-HYDROXYBENZALDEHYDE; BENZALDEHYDE DERIVATIVE; BIS(4-HYDROXYCINNAMOYL)METHANE; CURCUMIN; DIDEMETHOXYCURCUMIN; DRUG DERIVATIVE; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; VANILLIN;

ANIMAL; ARTICLE; CELL MOTION; CELL PROLIFERATION; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; MALE; METABOLISM; MIGRATION; PHOSPHORYLATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROLIFERATION; RAT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; SPRAGUE DAWLEY RAT; VASCULAR SMOOTH MUSCLE; VASCULAR SMOOTH MUSCLE CELL;

CURCUMIN; MIGRATION; PLATELET-DERIVED GROWTH FACTOR; PROLIFERATION; VASCULAR SMOOTH MUSCLE CELL;

ANIMALS; BENZALDEHYDES; CELL MOVEMENT; CELL PROLIFERATION; CURCUMIN; ELECTROPHORESIS, POLYACRYLAMIDE GEL; MALE; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PHOSPHORYLATION; PLATELET-DERIVED GROWTH FACTOR; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; SIGNAL TRANSDUCTION;

EID: 84883464026     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201200852     Document Type: Article

References (34)

1. Newby, A. C., Zaltsman, A. B., Molecular mechanisms in intimal hyperplasia. J. Pathol. 2000, 190, 300-309.
2. Willis, A. I., Pierre-Paul, D., Sumpio, B. E., Gahtan, V., Vascular smooth muscle cell migration: current research and clinical implications. Vasc. Endovascular. Surg. 2004, 38, 11-23.
3. Aggarwal, B. B., Sung, B., Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. Trends Pharmacol. Sci. 2009, 30, 85-94.
4. Epstein, J., Sanderson, I. R., Macdonald, T. T., Curcumin as a therapeutic agent: the evidence from in vitro, animal and human studies. Br. J. Nutr. 2010, 103, 1545-1557.
5. Lin, J. K., Molecular targets of curcumin. Adv. Exp. Med. Biol. 2007, 595, 227-243.
6. Yang, X., Thomas, D. P., Zhang, X., Culver, B. W. et al., Curcumin inhibits platelet-derived growth factor-stimulated vascular smooth muscle cell function and injury-induced neointima formation. Arterioscler. Thromb. Vasc. Biol. 2006, 26, 85-90.
7. Basnet, P., Skalko-Basnet, N., Curcumin: an anti-inflammatory molecule from a curry spice on the path to cancer treatment. Molecules 2011, 16, 4567-4598.
8. Kurien, B. T., Scofield, R. H., (2009) Increasing aqueous solubility of curcumin for improving bioavailability. Trends Pharmacol. Sci. 2011, 30, 334-335; author reply 335.
9. Liu, Y. L., Yang, H. P., Gong, L., Tang, C. L. et al., Hypomethylation effects of curcumin, demethoxycurcumin and bisdemethoxycurcumin on WIF-1 promoter in non-small cell lung cancer cell lines. Mol. Med. Rep. 2011, 4, 675-679.
10. Ahmed, T., Enam, S. A., Gilani, A. H., Curcuminoids enhance memory in an amyloid-infused rat model of Alzheimer's disease. Neuroscience 2011, 169, 1296-1306.
11. Yodkeeree, S., Chaiwangyen, W., Garbisa, S., Limtrakul, P., Curcumin, demethoxycurcumin and bisdemethoxycurcumin differentially inhibit cancer cell invasion through the down-regulation of MMPs and uPA. J. Nutr. Biochem. 2009, 20, 87-95.
12. Pugazhenthi, S., Akhov, L., Selvaraj, G., Wang, M., Alam, J., Regulation of heme oxygenase-1 expression by demethoxy curcuminoids through Nrf2 by a PI3-kinase/Akt-mediated pathway in mouse beta-cells. Am. J. Physiol. Endocrinol. Metab. 2007, 293, E645-655.
13. Sreejayan Rao, M. N., Curcuminoids as potent inhibitors of lipid peroxidation. J. Pharm. Pharmacol. 1994, 46, 1013-1016.
14. Sreejayan, N., Lin, Y., Hassid, A., NO attenuates insulin signaling and motility in aortic smooth muscle cells via protein tyrosine phosphatase 1B-mediated mechanism. Arterioscler. Thromb. Vasc. Biol. 2002, 22, 1086-1092.
15. Sarkar, R., Meinberg, E. G., Stanley, J. C., Gordon, D. et al., Nitric oxide reversibly inhibits the migration of cultured vascular smooth muscle cells. Circ. Res. 1996, 78, 225-230.
16. Dong, F., Yang, X., Sreejayan, N., Ren, J., Chromium (D-phenylalanine)3 improves obesity-induced cardiac contractile defect in ob/ob mice. Obesity (Silver Spring) 2007, 15, 2699-2711.
17. Stratton, M. S., Yang, X., Sreejayan, N., Ren, J., Impact of insulin-like growth factor-I on migration, proliferation and Akt-ERK signaling in early and late-passages of vascular smooth muscle cells. Cardiovasc. Toxicol. 2007, 7, 273-281.
18. Heldin, C. H., Westermark, B., Mechanism of action and in vivo role of platelet-derived growth factor. Physiol. Rev. 1999, 79, 1283-1316.
19. Sundaresan, M., Yu, Z. X., Ferrans, V. J., Irani, K. et al., Requirement for generation of H2O2 for platelet-derived growth factor signal transduction. Science 1995, 270, 296-299.
20. Rhee, S. G., Kang, S. W., Jeong, W., Chang, T. S. et al., Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxins. Curr. Opin. Cell Biol. 2005, 17, 183-189.
21. Kappert, K., Sparwel, J., Sandin, A., Seiler, A. et al., Antioxidants relieve phosphatase inhibition and reduce PDGF signaling in cultured VSMCs and in restenosis. Arterioscler Thromb. Vasc. Biol. 2006, 26, 2644-2651.
22. Sreejayan, N., Rao, M. N., Free radical scavenging activity of curcuminoids. Arzneimittelforschung 1996, 46, 169-171.
23. Matsunaga, T., Endo, S., Soda, M., Zhao, H. T. et al., Potent and selective inhibition of the tumor marker AKR1B10 by bisdemethoxycurcumin: probing the active site of the enzyme with molecular modeling and site-directed mutagenesis. Biochem. Biophys. Res. Commun. 2009, 389, 128-132.
24. Fiala, M., Liu, P. T., Espinosa-Jeffrey, A., Rosenthal, M. J. et al., Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin. Proc. Natl. Acad. Sci. USA 2007, 104, 12849-12854.
25. Sandur, S. K., Pandey, M. K., Sung, B., Ahn, K. S. et al., Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. Carcinogenesis 2007, 28, 1765-1773.
26. Zhongfa, L., Chiu, M., Wang, J., Chen, W. et al., Enhancement of curcumin oral absorption and pharmacokinetics of curcuminoids and curcumin metabolites in mice. Cancer Chemother. Pharmacol. 2012, 69, 679-689.
27. Ross, R., The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 1993, 362, 801-809.
28. Raines, E. W., PDGF and cardiovascular disease. Cytokine Growth Factor Rev. 2004, 15, 237-254.
29. Majesky, M. W., Reidy, M. A., Bowen-Pope, D. F., Hart, C. E. et al., PDGF ligand and receptor gene expression during repair of arterial injury. J. Cell. Biol. 1990, 111, 2149-2158.
30. Ferns, G. A., Raines, E. W., Sprugel, K. H., Motani, A. S. et al. Inhibition of neointimal smooth muscle accumulation after angioplasty by an antibody to PDGF. Science 1991, 253, 1129-1132.
31. Sirois, M. G., Simons, M., Edelman, E. R., Antisense oligonucleotide inhibition of PDGFR-beta receptor subunit expression directs suppression of intimal thickening. Circulation 1997, 95, 669-676.
32. Andrae, J., Gallini, R., Betsholtz, C., Role of platelet-derived growth factors in physiology and medicine. Genes. Dev. 2008, 22, 1276-1312.
33. Buchdunger, E., O'Reilly, T., Wood, J., Pharmacology of imatinib (STI571). Eur. J. Cancer 2002, 38(Suppl 5), S28-36.
34. Yardley, D. A., Burris, H. A., 3rd, Markus, T., Spigel, D. R. et al., Phase II trial of docetaxal plus imatinib mesylate in the treatment of patients with metastatic breast cancer. Clin. Breast. Cancer 2009, 9, 237-242.