Targeting the Hsp90 molecular chaperone with novel macrolactams. Synthesis, structural, binding, and cellular studies.

ACS chemical biology

Volumn 6, Issue 12, 2011, Pages 1339-1347

  Day, James E H ^a   Sharp, Swee Y ^b   Rowlands, Martin G ^b   Aherne, Wynne ^b   Hayes, Angela ^b   Raynaud, Florence I ^b   Lewis, William ^b   Roe, S Mark ^b   Prodromou, Chrisostomos ^b   Pearl, Laurence H ^b   Workman, Paul ^b   Moody, Christopher J ^b  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

HEAT SHOCK PROTEIN 90; MACROCYCLIC LACTAM; MACROLIDE; RADICICOL;

ARTICLE; CELL PROLIFERATION; CELL STRAIN HCT116; CHEMICAL STRUCTURE; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; LIVER MICROSOME; METABOLISM; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; HCT116 CELLS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; LACTAMS, MACROCYCLIC; MACROLIDES; MICROSOMES, LIVER; MODELS, MOLECULAR;

EID: 84859716448     PISSN: None     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb200196e     Document Type: Article

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