Are heat shock proteins therapeutic target for Parkinson's disease?

International Journal of Biological Sciences

Volumn 3, Issue 1, 2007, Pages 20-26

  Luo, Guang Rui ^a   Chen, Sheng ^b   Le, Wei Dong ^a  

^a Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Apoptosis; Heat shock proteins (HSPs); Parkinson's disease (PD); Ubiquitin proteasome system (UPS)

Indexed keywords

17 ALLYLAMINO 17 DEMETHOXYGELDAMYCIN; ALPHA SYNUCLEIN; BIMOCLOMOL; DJ 1 PROTEIN; GELDANAMYCIN; HEAT SHCOK PROTEIN 22; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 25; HEAT SHOCK PROTEIN 27; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; PAEONIFLORIN; PARKIN; PROSTAGLANDIN A1; PROTEASOME; RADICICOL; UBIQUITIN; UBIQUITIN THIOLESTERASE; UNCLASSIFIED DRUG; VALPROIC ACID;

DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOPAMINERGIC NERVE CELL; DRUG INHIBITION; GENE MUTATION; HOMEOSTASIS; HUMAN; MITOCHONDRIAL MEMBRANE; PARKINSON DISEASE; PATHOGENESIS; PROTEIN DEGRADATION; PROTEIN FOLDING; REVIEW;

EID: 33846483687     PISSN: 14492288     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijbs.3.20     Document Type: Review

References (68)

1. Hartl F. Molecular chaperones in cellular protein folding. Nature. 1996; 381(6583): 571-9.
2. Hightower LE. Heat shock, stress proteins, chaperones, and proteotoxicity. Cell.1991; 66(2): 191-7.
3. Benn SC, Woolf CJ. Adult neuron survival strategies-slamming on the brakes. Nat Rev Neurosci. 2004; 5(9): 686-700.
4. Meriin AB, Sherman MY. Role of molecular chaperones in neurodegenerative disorders. Int J Hyperthermia. 2005; 21(5): 403-19
5. Berke SJ, Paulson HL. Protein aggregation and the ubiquitin proteasome pathway: gaining the upper hand on neurodegeneration. Curr Opin Genet Dev. 2003; 13(3): 253-61.
6. Grunblatt E, Mandel S, Jacob-Hirsch J, et al. Gene expression profiling of parkinsonian substantia nigra pars compacta; alterations in ubiquitin-proteasome, heat shock protein, iron and oxidative stress regulated proteins, cell adhesion/cellular matrix and vesicle trafficking genes. J Neural Transm. 2004;111(12):1543-73.
7. Zhang Y, James M, Middleton FA, Davis RL. Transcriptional analysis of multiple brain regions in Parkinson's disease supports the involvement of specific protein processing, energy metabolism, and signaling pathways, and suggests novel disease mechanisms. Am J Med Genet B Neuropsychiatr Genet. 2005; 137(1): 5-16.
8. McLean PJ, Kawamata H, Shariff S, et al. TorsinA and heat shock proteins act as molecular chapersones: suppression of alpha-synuclein aggregation. J Neurochem. 2002; 83(4): 846-54.
9. Dedmon MM, Christodoulou J, Wilson MR, Dobson CM. Heat shock protein 70 inhibits alpha-synuclein fibril formation via preferential binding to prefibrillar species. J Biol Chem. 2005; 280(15): 14733-40.
10. Le W, Appel SH. Mutant genes responsible for Parkinson's disease. Curr Opin Pharmacol. 2004; 4:79-84.
11. Moore, DJ, West AB, Dawson VL, Dawson TM. Molecular pathophysiology of Parkinson's disease. Annu. Rev. Neurosci. 2005. 28:57-87.
12. McNaught KS, Perl DP, Brownell AL, Olanow CW. Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease. Ann Neurol. 2004; 56(1): 149-62.
13. Wu YR, Wang CK, Chen CM, et al. Analysis of heat-shock protein 70 gene polymorphisms and the risk of Parkinson's disease. Hum Genet 2004; 114(3): 236-41
14. Macario AJ, Conway de Macario E. Sick chaperones, cell stress, and disease. N Engl J Med. 2005; 353(14): 1489-501.
15. Chen Q, Thorpe J, Keller JN. Alpha-synuclein alters proteasome function, protein synthesis, and stationary phase viability. J Biol Chem. 2005; 280(34): 30009-17.
16. Tanaka Y, Engelender S, Igarashi S, et al. Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis. Hum Mol Genet. 2001; 10(9): 919-26.
17. Kluchen J, Shin Y, Masliah E, Hyman BT, McLean PJ. Hsp70 reduces alpha-synuclein aggregation and toxicity. J Biol Chem. 2004; 279(24): 25497-502.
18. Cuervo AM, Stefanis L, Fredenburg R, Lansbury PT, Sulzer D. Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science. 2004; 305(5688): 1292-5.
19. Shimura H, Hattori N, Kubo S, et al. Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nat Genet. 2000; 25(3): 302-5.
20. Kim SJ, Sung JY, Um JW, et al. Parkin cleaves intracellular alpha-synuclein inclusions via the activation of calpain. J Biol Chem. 2003; 278(43): 41890-9.
21. Kalia SK, Lee S, Smith PD, Liu L, Crocker SJ, Thorarinsdottir TE, Glover JR, Fon EA, Parkin DS, Lozano AM. BAG5 inhibits parkin and enhances dopaminergic neuron degeneration. Neuron. 2004; 44:931-45
22. Liu Y, Fallon L, Lashuel HA, Liu Z, Lansbury PT Jr. The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility. Cell. 2002; 111(2): 209-18.
23. Osaka H, Wang YL, Takada K, et al. Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron. Hum. Mol. Genet. 2003; 12(16): 1945-58
24. Ardley HC, Scott GB, Rose SA, Tan NG, Robinson PA. UCH-L1 aggresome formation in response to proteasome impairment indicates a role in inclusion formation in Parkinson's disease. J Neurochem. 2004; 90(2): 379-91
25. Li HM, Niki T, Taira T, Iguchi-Ariga SM, Ariga H. Association of DJ-1 with chaperones and enhanced association and colocalization with mitochondrial Hsp70 by oxidative stree. Free Radic Res. 2005; 39(10): 1091-9
26. Zhou Y, Gu G, Goodlett DR, et al. Analysis of alpha-synuclein-associated proteins by quantitative proteomics. J Biol Chem. 2004; 279(37): 39155-64.
27. Uryu K, Richter-Landsberg C, Welch W, et al. Convergence of heat shock protein 90 with ubiquitin in filamentous alpha-synuclein inclusions of alpha-synucleinopathies. Am J Pathol. 2006; 168(3): 947-61.
28. Waza M, Adachi H, Katsuno M, et al. Modulation of Hsp90 function in neurodegenerative disorders: a molecular-targeted therapy against disease-causing protein. J Mol Med. 2006; 84(8): 635-46.
29. Bharadwaj S, Ali A, Ovsenek N. Multiple components of the HSP90 chaperone complex function in regulation of heat shock factor 1 in vivo. Mol Cell Biol. 1999; 19(12): 8033-41.
30. Sabbah M, Radanyi C, Redeuilh G, Balieu E. The 90 kDA heat-shock protein (hsp90) modulates the binding of the estrogen receptor to its cognate DNA. Biochem J. 1996; 314(pt 1): 205-213.
31. Zhang X, Clark AF, Yorio T. Heat shock protein 90 is an essential molecular chaperone for nuclear transport of glucocorticoid receptor beta. Invest Ophthalmol Vis Sci. 2006; 47(2): 700-8.
32. Crookes WJ, Olsen LJ. The effects of chaperones and the influence of protein assembly on peroxisomal protein import. J Biol Chem 1998; 273(27): 17236-42.
33. Mor G, Nilsen J, Horvath T, et al. Estrogen and microglia: A regulatory system that affects the brain. J Neurobiol. 1999; 40(4): 484-96.
34. Jeon GS, Park SW, Kim DW, et al. Glial expression of the 90-kDa heat shock protein (HSP90) and the 94-kDa glucose-regulated protein (GRP94) following an excitotoxic lesion in the mouse hippocampus. Glia. 2004; 48(3): 250-8.
35. Li R, Huang YG, Fang D, Le WD. (-)-Epigallocatechin gallate inhibits lipopolysaccharide-induced microglial activation and protects against inflammation-mediated dopaminergic neuronal injury. J Neurosci Res. 2004; 78(5): 723-31.
36. Palermo CM, Westlake CA, Gasiewicz TA. Epigallocatechin gallate inhibits aryl hydrocarbon receptor gene transcription through an indirect mechanism involving binding to a 90 kDa heat shock protein. Biochemistry. 2005; 44(13): 5041-52.
37. Auluck PK, Chan HY, Trojanowski JQ, Lee VM, Bonini NM. Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease. Science. 2002; 295(5556): 865-8.
38. Tsai YC, Fishman PS, Thakor NV, Oyler GA. Parkin facilitates the elimination of expanded polyglutamine proteins and leads to preservation of proteasome function. J Biol Chem. 2003; 278(24): 22044-55.
39. Pan TH, Li XQ, Xie WJ, Jankovic J, Le WD. Valproic acid-mediated Hsp70 induction and anti-apoptotic neuroprotection in SH-SY5Y cells. FEBS Lett. 2005; 579(30): 6716-20.
40. Shen HY, He JC, Wang Y, Huang QY, Chen JF. Geldanamycin induces heat shock protein 70 and protects against MPTP-induced dopaminergic neurotoxicity in mice. J Biol Chem. 2005; 280(48): 39962-9
41. Miron T, Vancompernolle K, Vandekerckhove J, Wilchek M, Geiger B. A 25-kD inhibitor of actin polymerization is a low molecular mass heat shock protein. J Cell Biol. 1991; 114(2): 255-61.
42. Huot J, Houle F, Marceau F, Landry J. Oxidative stress-induced actin reorganization mediated by the p38 mitogen-activated protein kinase/heat shock protein 27 pathway in vascular endothelial cells. Circ Res. 1997; 80(3): 383-392.
43. Shimura H, Miura-Shimura Y, Kosik KS. Binding of tau to heat shock protein 27 leads to decreased concentration of hyperphosphorylated tau and enhanced cell survival. J Biol Chem. 2004; 279(17): 17957-62.
44. Concannon CG, Gorman AM, Samali A. On the role of Hsp27 in regulating apoptosis. Apoptosis. 2003; 8(1): 61-70.
45. Yun SJ, Hahm DH, Lee EH. Immobilization stress induces the expression of alphaB-crystallin in rat hippocampus: implications of glial activation in stress-mediated hippocampal degeneration. Neurosci Lett. 2002; 324(1): 45-8.
46. Rekas A, Adda CG, Andrew Aquilina J, et al. Interaction of the molecular chaperone alphaB-crystallin with alpha-synuclein: effects on amyloid fibril formation and chaperone activity. J Mol Biol. 2004; 340(5): 1167-83.
47. Goldbaum O, Richter-Landsberg C. Proteolytic stress causes heat shock protein induction, tau ubiquitination, and the recruitment of ubiquitin to tau-positive aggregates in oligodendrocytes in culture. J Neurosci. 2004; 24(25): 5748-57.
48. Dong Z, Wolfer DP, Lipp HP, Bueler H. Hsp70 gene transfer by adeno-associated virus inhibits MPTP-induced nigrostriatal degeneration in the mouse model of Parkinson's disease. Mol Ther. 2005; 11(1): 80-8.
49. Jenner P. Oxidative stress in Parkinson's disease. Ann Neurol 2003; 53 (Suppl 3):S26-36.
50. Beere HM, Green DR. Stress management - heat shock protein-70 and the regulation of apoptosis. Trends Cell Biol. 2001; 11(1): 6-10.
51. Kamradt MC, Lu M, Werner ME, et al. The small heat shock protein alpha B-crystallin is a novel inhibitor of TRAIL-induced apoptosis that suppresses the activation of caspase-3. J Biol Chem. 2005; 280(12): 11059-66.
52. Smith WW, Pei Z, Jiang H, et al. Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration. Proc Natl Acad Sci U S A. 2005; 102(51): 18676-81.
53. West AB, Moore DJ, Biskup S, et al. Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity. Proc Natl Acad Sci U S A. 2005 Nov 15; 102(46): 16842-7.
54. Palacino JJ, Sagi D, Goldberg MS, et al. Mitochondrial dysfunction and oxidative damage in parkin-deficient mice. J. Biol. Chem. 2004. 279(18): 18614-22.
55. Winklhofer KF, Henn IH, Kay-Jackson PC, Heller U, Tatzelt J. Inactivation of parkin by oxidative stress and C-terminal truncations: a protective role of molecular chaperones. J Biol Chem. 2003; 278(47): 47199-208.
56. Schwartz AL. The Ubiquitin-proteasome pathway and pathogenesis of human disease. Annu Rev Med. 1999;50:57-74.
57. Hernandez F, Diaz-Hernandez M, Avila J, Lucas JJ. Testing the ubiquitin-proteasome hypothesis of neurodegeneration in vivo. Trends Neurosci. 2004; 27(2): 66-9.
58. Mytilineou C, McNaught KS, Shashidharan P, et al. Inhibition of proteasome activity sensitizes dopamine neurons to protein alterations and oxidative stress. J Neural Transm. 2004; 111(10-11): 1237-51.
59. Minami Y, Kawasaki H, Minami M, et al. A critical role for the proteasome activator PA28 in the Hsp90-dependent protein refolding. J Biol Chem. 2000; 275(12): 9055-61.
60. Whittier JE, Xiong Y, Rechsteiner MC, Squier TC. Hsp90 enhances degradation of oxidized calmodulin by the 20 S proteasome. J Biol Chem. 2004; 279(44): 46135-42.
61. Kim D, Kim SH, Li GC. Proteasome inhibitors MG132 and lactacystin hyperphosphorylate HSF1 and induce hsp70 and hsp27 expression. Biochem Biophys Res Commun. 1999; 254(1): 264-8
62. Robertson JD, Datta K, Biswal SS, Kehrer JP. Heat-shock protein 70 antisense oligomers enhance proteasome inhibitor-induced apoptosis. Biochem J. 1999; 344(2): 477-85.
63. Wang X, Qin ZH, Leng Y, et al. Prostaglandin A1 inhibits rotenone-induced apoptosis in SH-SY5Y cells. J Neurochem. 2002; 83(5): 1094-102.
64. Zou J, Guo Y, Guettouche T, Smith DF, Voellmy R. Repression of heat shock transcription factor HSF1activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1. Cell. 1998; 94(4): 471-80.
65. Auluck PK, Chan HY, Trojanowski JQ, Lee VM, Bonini NM. Mechanisms of Suppression of {alpha}-Synuclein Neurotoxicity by Geldanamycin in Drosophila. J Biol Chem. 2005; 280(4): 2873-8.
66. Yan D, Saito K, Ohmi Y, et al. A novel heat shock protein-inducing compound. Cell Stress Chaperones. 2004; 9(4): 378-89.
67. Nanasi PP, Jednakovits A. Multilateral in vivo and in vitro protective effects of the novel heat shock protein coinducer, bimoclomol: results of preclinical studies. Cardiovasc Drug Rev. 2001; 19(2): 133-51.
68. Hargitai J, Lewis H, Boros I, et al. A heat shock protein co-inducer, acts by the prolonged activation of heat shock factor-1. Biochem Biophys Res Commun. 2003; 307(3): 689-95.