Downregulated adaptor protein p66Shc mitigates autophagy process by low nutrient and enhances apoptotic resistance in human lung adenocarcinoma A549 cells

FEBS Journal

Volumn 280, Issue 18, 2013, Pages 4522-4530

  Zheng, Zhichao ^a   Yang, Jie ^a   Zhao, Dan ^a   Gao, Dan ^a   Yan, Xiaojie ^a   Yao, Zhi ^a   Liu, Zhe ^a   Ma, Zhenyi ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

adaptor protein; apoptotic resistance; autophagy; nutrient deprivation; p66Shc

Indexed keywords

BECLIN 1; CASPASE 6; CASPASE 7; CASPASE 9; FOCAL ADHESION ASSOCIATED 66 ISOFORM OF THE SRC HOMOLOGY AND COLLAGEN; MICROTUBULE ASSOCIATED PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 1A LIGHT CHAIN PROTEIN 3B; MITOGEN ACTIVATED PROTEIN KINASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; SEQUESTOSOME 1 PROTEIN; SERINE; SHORT HAIRPIN RNA; THREONINE; TYROSINE; UNCLASSIFIED DRUG;

ANOIKIS; ARTICLE; AUTOPHAGY; CANCER CELL CULTURE; CANCER RESISTANCE; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME PHOSPHORYLATION; FOOD DEPRIVATION; HUMAN; HUMAN CELL; LUNG ADENOCARCINOMA; NUTRIENT CONTENT; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ADAPTOR PROTEIN; APOPTOTIC RESISTANCE; AUTOPHAGY; NUTRIENT DEPRIVATION; P66SHC;

ADENOCARCINOMA; AMINO ACIDS; APOPTOSIS; AUTOPHAGY; CASPASES; CELL LINE, TUMOR; CULTURE MEDIA; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; MICROTUBULE-ASSOCIATED PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEOPLASM PROTEINS; PHOSPHORYLATION; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-AKT; RNA, SMALL INTERFERING; RNA-BINDING PROTEINS; SHC SIGNALING ADAPTOR PROTEINS; SIGNAL TRANSDUCTION;

EID: 84883424865     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12416     Document Type: Article

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