Non-celiac gluten sensitivity: Questions still to be answered despite increasing awareness

Cellular and Molecular Immunology

Volumn 10, Issue 5, 2013, Pages 383-392

  Volta, Umberto ^a   Caio, Giacomo ^a   Tovoli, Francesco ^a   De Giorgio, Roberto ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Celiac disease; Epithelial barrier function; Gut inflammation; Non celiac gluten sensitivity; Wheat allergy

Indexed keywords

GLIADIN ANTIBODY; IMMUNOGLOBULIN E ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; T LYMPHOCYTE RECEPTOR DELTA CHAIN; T LYMPHOCYTE RECEPTOR GAMMA CHAIN; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

ADAPTIVE IMMUNITY; CELIAC DISEASE; CLINICAL FEATURE; GLUTEN FREE DIET; HUMAN; ILEITIS; IMMUNOPATHOLOGY; INNATE IMMUNITY; INTESTINE LYMPHOMA; NON CELIAC GLUTEN SENSITIVITY; PATHOGENESIS; PATHOPHYSIOLOGY; PREVALENCE; REVIEW; ULCERATIVE JEJUNO ILEITIS; WHEAT ALLERGY;

CELIAC DISEASE; CYTOKINES; DIAGNOSIS, DIFFERENTIAL; EUROPE; FOOD HYPERSENSITIVITY; GLUTENS; HUMANS; IMMUNITY, INNATE; INFLAMMATION; INTESTINES; MICROBIOTA; PREVALENCE; UNITED STATES;

EID: 84883424555     PISSN: 16727681     EISSN: None     Source Type: Journal    
DOI: 10.1038/cmi.2013.28     Document Type: Review

References (55)

1. Volta U, de Giorgio R. New understanding of gluten sensitivity. Nat Rev Gastroenterol Hepatol 2012; 9: 295-299.
2. Sapone A, Bai JC, Ciacci C, Dolinsek J, Green PH, Hadijvassiliou M et al. Spectrum of gluten-related disorders: consensus on new nomenclature and classification. BMC Med 2012; 10: 13.
3. Gibert A, Espadaler M, Angel Canela M, Sánchez A, Vaqué C, Rafecas M. Consumption of gluten-free products: should be the threshold value for traces amounts of gluten be at 20, 100 or 200 p.p.m.? Eur J Gastroenterol Hepatol 2006; 18: 1187-1195.
4. Belderok B. Developments in bread-making processes. Plant Food Hum Nutr 2000; 55: 1-86.
5. Gobbetti M, Rizzello CG, Di Cagno R, de Angelis M. Sordough lactobacilli and coeliac disease. Food Microbiol 2007; 24: 187-196.
6. Volta U, Villanacci V. Celiac disease: diagnostic criteria in progress. Cell Mol Immunol 2011; 8: 96-102.
7. Inonata N. Wheat allergy. Cur Opin Aller Clin Immunol 2009; 9: 238-243.
8. Blomfeldt TO, Kuktaite R, Johansson E, Hedenqvist MS. Mechanical properties and network structure of wheat gluten forms. Biomacromolecules 2011; 12: 1707-1715.
9. Fraser JS, Engel W, Ellis HJ, Moodie SJ, Pollock EL, Wieser H et al. Coeliac disease: in vivo toxicity of the putative immunodominant epitope. Gut 2003; 52: 1698-1702.
10. Drago S, El Asmar R, Di Pierro M, Clemente MG, Tripathi A, Sapone A et al. Gliadin, zonulin, and gut permeability: effects on celiac and nonceliac mucosa and intestinal cell lines. Scand J Gastroenterol 2006; 41: 408-419.
11. Dolfini E, Roncoroni L, Elli L, Fumagalli C, Colombo R, Ramponi S et al. Cytoskeleton reorganization and ultrastructural damage induced by gliadin in a three-dimensional in vitro model. World J Gastroenterol 2005; 11: 7597-7601.
12. Cooper BT, Holmes GK, Ferguson R, Thompson RA, Allan RN, Cooke WT. Gluten-sensitive diarrhea without evidence of celiac disease. Gastroenterology 1980; 79: 801-806.
13. Kaukinen K, Turjanmaa K, Mäki M, Partanen J, Venäläinen R, Reunala T et al. Intolerance to cerealsis not specific for celiac disease. Scand J Gastroenterol 2000; 35: 942-946.
14. Verdu EF, Armstrong D, Murray JA. Between celiac disease and irritable bowel syndrome: the 'no man's land' of gluten sensitivity. Am J Gastroenterol 2009; 104: 1587-1594.
15. Troncone R, Jabri B. Coeliac disease and gluten sensitivity. J Intern Med 2011; 269: 582-590.
16. Di Sabatino A, Corazza GR. Non-celiac gluten sensitivity: sense or sensibility? Ann Intern Med 2012; 156: 309-311.
17. Lundin KEA, Alaedini A. Non-celiac gluten sensitivity. Gastrointest Endoscopy Clin N Am 2012; 22: 723-734.
18. Brown AC. Gluten sensitivity: problems of an emerging condition separate from celiac disease. Expert Rev Gastroenterol Hepatol 2012; 6: 41-53.
19. Godlee F. Gluten sensitivity: real or not? BMJ 2012; 345: e8450.
20. Anonymus patient, Rostami K, Hogg-Kollars S. Non-coeliac gluten sensitivity: a patient's journey. BMJ 2012; 345: e7982.
21. Sollid LM, Jabri B. Triggers and drivers of autoimmunity: lessons from celiac disease. Nat Rev Immunol 2013; 13: 294-302.
22. Marietta EV, Murray JA. Animal models in gluten sensitivity. Semin Immunopathol 2012; 34: 497-511.
23. Turvet SE, Broide DH. Innate immunity. J Allergy Clin Immunol 2010; 125(Suppl 2): S24-S32.
24. Bendelac A, Savage PB, Teyton L. The biology of NKT cells. Annu Rev Immunol 2007; 25: 297-336.
25. Bonilla FA, Oettgen HC. Adaptive immunity. J Allergy Clin Immunol 2010; 125(Suppl 2): S33-S40.
26. Zhu J, Yamane H, Paul WE. Differentiation of effector CD4T cell populations. Annu Rev Immunol 2010; 28: 445-489.
27. Crotty S. Follicular helper CD4 T cells (TFH). Annu Rev Immunol 2011; 29: 621-623.
28. Crome SQ, Wang AY, Levings MK. Translational mini-review series on Th17 cells: function and regulation of human T helper 17 cells in health and disease. Clin Exp Immunol 2010; 159: 109-119.
29. Bilate AM, Lafaille JJ. Induced CD41 FoxP31 regulatory T cells in immune tolerance. Annu Rev Immunol 2012: 30: 733-758.
30. Castellanos-Rubio A, Santin I, Irastorza I, Castaño L, Carlos Vitoria J, Ramon Bilbao J. TH17 (and TH1) signatures of intestinal biopsies of CD patients in response to gliadin. Autoimmunity 2009; 42: 69-73.
31. Harris KM, Fasano A, Mann DL. Cutting edge: IL-1 controls the IL-23 response induced by gliadin, the etiologic agent in celiac disease. J Immunol 2008; 181: 4457-4460.
32. Monteleone I, Pallone F, Monteleone G. Interleukin-23 and Th17 cells in the control of gut inflammation. Mediators Inflamm 2009; 2009: 297645.
33. Monteleone I, Sarra M, del Vecchio BG, Paoluzi OA, Franze E, Fina D et al. Characterization of IL-17A-producing cells in celiac disease mucosa. J Immunol 2010; 184: 2211-2218.
34. Sapone A, Lammers K, Casolaro V, Cammarota M, Giuliano MT, de Rosa M et al. Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity. BMC Med 2011; 9: 23.
35. Sapone A, Lammers KM, Mazzarella G, Mikhailenko I, Carteni M, Casolaro V et al. Differential mucosal IL-17 expression in two gliadin-induced disorders: gluten sensitivity and the autoimmune enteropathy celiac disease. Int Arch AllergyImmunol 2010; 152: 75-80.
36. Vorobjova T, Uibo O, Heilman K, Rägo T, Honkanen J, Vaarala O et al. Increased FOXP3 expression in small-bowel mucosa of children with coeliac disease and type I diabetes mellitus.Scand J Gastroenterol 2009; 44: 422-430.
37. Hansson T, Ulfgren AK, Lindroos E, DannAEus A, Dahlbom I, Klareskog L. Transforming growth factor-beta (TGF-beta) and tissue transglutaminase expression in the small intestine in children with coeliac disease. Scand J Immunol 2002; 56: 530-537.
38. Schuppan D. Current concepts of celiac disease pathogenesis. Gastroenterology 2000; 119: 234-242.
39. Biesiekierski JR, Newnham ED, Irving PM, Barrett JS, Haines M, Doecke JD et al. Gluten causes gastrointestinal symptoms in subjects without celiac disease: a double-blind randomized placebo-controlled trial. Am J Gastroenterol 2011; 106: 508-514.
40. Vaquez-Roque MI, Camilleri M, Smyrk T, Murray JA, Marietta E, O'Neill J et al. A controlled trial of gluten-free diet in patients with irritable bowel syndrome-diarrhea: effects on bowel frequency and intestinal function. Gastroenterology 2013; 144: 903-911.
41. Verdu EF, Huang X, Natividad J, Lu J, Blennerhassett PA, David CS et al. Gliadin-dependent neuromuscular and epithelial secretory responses in gluten-sensitive HLA-DQ8 transgenic mice. Am J Physiol Gastrointest Liver Physiol 2008; 294: G217-G225.
42. Natividad JM, Huang X, Slack E, Jury J, Sanz Y, David C et al. Host responses to intestinal microbial antigensin gluten sensitive mice. PLos ONE 2009; 4: e6472.
43. Junker Y, Zeissig S, Kim SJ, Barisani D, Wieser H, Leffler DA et al. Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4. J Exp Med 2012; 209: 2395-2408.
44. Gibson PR, Sheperd SJ. Food choice as a key management strategy for functional gastrointestinal symptoms. Am J Gastroenterol 2012; 107: 657-666.
45. Corazza GR, Frazzoni M, Strocchi A, Prati C, Sarchielli P, Capelli M et al. Alimentary exorphin actions on motility and hormonal secretion of gastrointestinal tract. InFraioli F, Isidori A, MazzettiM(ed.). Opioid Peptides in the Periphery. Amsterdam: Elsevier Sciences Publisher, 1984: 243-247.
46. Suarez FL, Savaiano DA, Levitt MD. A comparison of symptoms after the consumption of milk or lactose-hydrolyzed milk by people with selfreported severe lactose intolerance. N Engl J Med 1995; 333: 1-4.
47. Carroccio A, Mansueto P, Iacono G, Soresi M, D'Alcamo A, Cavataio F et al. Non-celiac wheat sensitivity diagnosed by double-blind placebo-controlled challenge: exploring a new clinical entity. Am J Gastroenterol 2012; 107: 1898-1906.
48. Volta U, Tovoli F, Cicola R, Parisi C, Fabbri A, Piscaglia M et al. Serological tests in gluten sensitività (nonceliac gluten intolerance). J Clin Gastroenterol 2012; 46: 680-685.
49. Volta U. Indagine su sensibilità al glutine non celiaca: risultati preliminari. Celiachia Notizie 2013, 1: 58-60.
50. Dezi R, Niveloni S, Sugai E, Pedreira S, Smecuol E, Vazquez H et al. Gluten sensitivity in the rectal mucosa of first-degree relatives of celiac disease patients. Am J Gastroenterol 1997; 92: 1326-1330.
51. Bizzaro N, Tozzoli R, Villalta D, Fabris M, Tonutti E. Cutting-edge issues in celiac disease and in gluten intolerance. Clin Rev Allerg Immunol 2012; 42: 279-287.
52. Volta U, Granito A, Parisi C, Fabbri A, Fiorini E, Piscaglia M et al. Deamidated gliadin peptide antibodies as a routine test for celiac disease: a prospective analysis. J Clin Gastroenterol 2010; 44: 186-190.
53. Volta U, Corazza GR, Frisoni M, Valentini RA, Molinaro N, Bianchi FB et al. IgA antigliadin antibodies and persistence of jejunal lesions in adult celiac disease. Digestion 1990; 47: 111-114.
54. Oberhuber G, Granditsch G, Vogelsang H. The histopathology of coeliac disease: time for a stndardized report scheme for pathologists. Eur J Gastroenterol Hepatol 1999; 11: 1185-1194.
55. Not T, Ziberna F, Vatta S, Quaglia S, Martelossi S, Villanacci V et al. Cryptic genetic gluten intolerance revealed by intestinal antitransglutaminase antibodies and response to gluten-free diet. Gut 2011; 60: 1487-1493.