Gender identity development in adolescence

Hormones and Behavior

Volumn 64, Issue 2, 2013, Pages 288-297

  Steensma, Thomas D ^a   Kreukels, Baudewijntje P C ^a   de Vries, Annelou L C ^a   Cohen Kettenis, Peggy T ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Adolescence; Disorders of sex development; Gender dysphoria; Gender identity; Gender non conformity; Gender variance; Identity development; Puberty

Indexed keywords

SEX HORMONE;

ADOLESCENT; ADOLESCENT DEVELOPMENT; BRAIN DEVELOPMENT; CHILD PARENT RELATION; GENDER DYSPHORIA; GENDER IDENTITY; GENETICS; HUMAN; NONHUMAN; PRENATAL EXPOSURE; PRIORITY JOURNAL; PUBERTY; REVIEW; SEXUAL DEVELOPMENT; SOCIAL ENVIRONMENT; SOCIAL PSYCHOLOGY;

ADOLESCENCE; DISORDERS OF SEX DEVELOPMENT; GENDER DYSPHORIA; GENDER IDENTITY; GENDER NON-CONFORMITY; GENDER VARIANCE; IDENTITY DEVELOPMENT; PUBERTY;

ADOLESCENT; ADOLESCENT DEVELOPMENT; ADOLESCENT PSYCHOLOGY; FEMALE; GENDER IDENTITY; GONADAL HORMONES; HUMANS; MALE; PSYCHOLOGY; SEX DIFFERENTIATION; SEXUAL MATURATION;

EID: 84883422124     PISSN: 0018506X     EISSN: 10956867     Source Type: Journal    
DOI: 10.1016/j.yhbeh.2013.02.020     Document Type: Review

References (109)

1. Adams G.R., Marshall S.K. A developmental social psychology of identity: understanding the person in context. J. Adolesc. 1996, 19:429-442.
2. American Psychiatric Association Diagnostic and statistical manual of mental disorders, fourth edition, text revision 2000, Author, Washington, DC. 4th edn.
3. Bartle-Haring S., Strimple R.E. Association of identity and intimacy: an exploration of gender and sex-role orientation. Psychol. Rep. 1996, 79:1255-1264.
4. Berenbaum S.A., Bailey J.M. Effects on gender identity of prenatal androgens and genital appearance: evidence from girls with congenital adrenal hyperplasia. J. Clin. Endocrinol. Metab. 2003, 88:1102-1106.
5. Berenbaum S.A., Beltz A.M. Sexual differentiation of human behavior: effects of prenatal and pubertal organizational hormones. Front. Neuroendocrinol. 2011, 32:183-200.
6. Berglund H., Lindstrom P., Dhejne-Helmy C., Savic I. Male-to-female transsexuals show sex-atypical hypothalamus activation when smelling odorous steroids. Cereb. Cortex 2008, 18:1900-1908.
7. Blanchard R. Typology of male-to-female transsexualism. Arch. Sex. Behav. 1985, 14:247-261.
8. Bockting W.O. Psychotherapy and the real-life experience: from gender dichtomy to gender identity. Sexologies 2008, 17:211-224.
9. Byne W., Bradley S.J., Coleman E., Eyler A.E., Green R., Menvielle E.J., Meyer-Bahlburg H.F.L., Pleak R.R., Tompkins D.A. Report of the American Psychiatric Association task force on treatment of gender dysphoria. Arch. Sex. Behav. 2012, 41:759-796.
10. Cadet P. Androgen insensitivity syndrome with a male sex-of living. Arch. Sex. Behav. 2011, 40:1101-1102.
11. Cantor J. New MRI studies support the Blanchard typology of male-to-female transsexualism. Arch. Sex. Behav. 2011, 40:863-864.
12. Chung W.C.J., de Vries G.J., Swaab D.F. Sexual differentiation of the bed nucleus of the stria terminalis in humans may extend into adulthood. J. Neurosci. 2002, 22:1027-1033.
13. Coates S. Ontogenesis of boyhood gender identity disorder. J. Am. Acad. Psychoanal. 1990, 18:414-438.
14. Cohen-Bendahan C.C., van de Beek C., Berenbaum S.A. Prenatal sex-hormone effect on child and adult sex-typed behavior: methods and findings. Neurosci. Biobehav. Rev. 2005, 29:353-384.
15. Cohen-Kettenis P.T. Gender identity disorders. A Clinician's Handbook of Child and Adolescent Psychiatry 2005, 695-725. Cambridge University Press, Cambridge. C. Gillberg (Ed.).
16. Cohen-Kettenis P.T. Gender change in 46, XY persons with 5alpha-reductase-2 deficiency and 17beta-hydroxysteroid dehydrogenase-3 deficiency. Arch. Sex. Behav. 2005, 34:399-410.
17. Cohen-Kettenis P.T., Pfäfflin F. The DSM diagnostic criteria for gender identity disorder in adolescents and adults. Arch. Sex. Behav. 2010, 39:499-513.
18. Cohen-Kettenis P.T., van Goozen S.H., Doorn C.D., Gooren L.J. Cognitive ability and cerebral lateralisation in transsexuals. Psychoneuroendocrinology 1998, 23:631-641.
19. Cohen-Kettenis P.T., Owen A., Kaijser V.G., Bradley S.J., Zucker K.J. Demographic characteristics, social competence, and problem behavior in children with gender identity disorder: a cross-national, cross-clinic comparative analysis. J. Abnorm. Child Psychol. 2003, 31:41-53.
20. Cohen-Kettenis P.T., Steensma T.D., de Vries A.L. Treatment of adolescents with gender dysphoria in the Netherlands. Child Adolesc. Psychiatr. Clin. N. Am. 2011, 20:689-700.
21. Coolidge F.L., Thede L.L., Young S.E. The heritability of gender identity disorder in a child and adolescent twin sample. Behav. Genet. 2002, 32:251-257.
22. De Vries A.L., Cohen-Kettenis P.T. Clinical management of gender dysphoria in children and adolescents: the Dutch approach. J. Homosex. 2012, 59:301-320.
23. De Vries A.L., Doreleijers T.A., Cohen-Kettenis P.T. Disorders of sex development and gender identity outcome in adolescence and adulthood: understanding gender identity development and its clinical implications. Pediatr. Endocrinol. Rev. 2007, 4:343-351.
24. Dessens A.B., Slijper F.M., Drop S.L. Gender dysphoria and gender change in chromosomal females with congenital adrenal hyperplasia. Arch. Sex. Behav. 2005, 34:389-397.
25. Diamond L.M., Butterworth M. Questioning gender and sexual identity: dynamic links over time. Sex Roles 2008, 59:365-376.
26. Egan S.K., Perry D.G. Gender identity: a multidimensional analysis with implications for psychosocial adjustment. Dev. Psychol. 2001, 37:451-463.
27. Ellis A. The sexual psychology of human hermaphrodites. Psychosom. Med. 1945, 7:108-125.
28. Emory L.E., Williams D.H., Cole C.M., Amparo E.G., Meyer W.J. Anatomic variation of the corpus callosum in persons with gender dysphoria. Arch. Sex. Behav. 1991, 20:409-417.
29. Erikson E.H. Identity, Youth and Crisis 1968, W.W. Norton, Inc., New York.
30. Fagot B.I., Leinbach M.D. Gender identity: some thoughts on an old concept. J. Am. Acad. Child Psychiatry 1985, 24:684-688.
31. Fausto-Sterling A. Sexing the Body: Gender Politics and the Construction of Sexuality 2000, Basic Books, New York.
32. Flor-Henry P. EEG analysis of male to female transsexuals: discriminant function and source analysis. Clin. EEG Neurosci. 2010, 41:219-222.
33. Galambos N., Almeida D., Petersen A. Masculinity, femininity and sex role attitudes in early adolescence: exploring gender intensification. Child Dev. 1990, 61:1905-1914.
34. Garcia-Falgueras A., Ligtenberg L., Kruijver F.P., Swaab D.F. Galanin neurons in the intermediate nucleus (InM) of the human hypothalamus in relation to sex, age, and gender identity. J. Comp. Neurol. 2011, 519:3061-3084.
35. Giedd J.N., Raznahan A., Mills K., Lenroot R.K. Review: magnetic resonance imaging of male/female differences in human adolescent brain anatomy. Biol. Sex Differ. 2012, 3:19.
36. Gizewski E.R., Krause E., Schlamann M., Happich F., Ladd M.E., Forsting M., Senf W. Specific cerebral activation due to visual erotic stimuli in male-to-female transsexuals compared with male and female controls: an fMRI study. J. Sex. Med. 2009, 6:440-448.
37. Green R. Sexual Identity Conflict in Children and Adults 1974, Basic Books, New York.
38. Haraldsen I.R., Opjordsmoen S., Egeland T., Finset A. Sex-sensitive cognitive performance in untreated patients with early onset gender identity disorder. Psychoneuroendocrinology 2003, 28:906-915.
39. Heylens G., De Cuypere G., Zucker K.J., Schelfaut C., Elaut E., Vanden Bossche H., De Baere E., T'Sjoen G. Gender identity disorder in twins: a review of the case report literature. J. Sex. Med. 2012, 9:751-757.
40. Hill J.P., Lynch M.E. The intensification of gender-related role expectations during early adolescence. Girls at Puberty: Biological and Psychosocial Perspectives 1983, 201-228. Plenum, New York. J. Brooks-Gunn, A. Petersen (Eds.).
41. Hines M. Gonadal hormones and sexual differentiation of human brain and behavior. Hormones, Brain and Behavior 2009, Academic Press, San Diego. 2nd ed. D.W. Pfaff, A.P. Arnold, A.M. Etgen, S.E. Fahrbach, R.T. Rubin (Eds.).
42. Hughes I.A., Houk C., Ahmed S.F., Lee P.A. Consensus statement on management of intersex disorders. Arch. Dis. Child. 2006, 91:554-563.
43. Hunter R.G. Epigenetic effects of stress and corticosteroids in the brain. Front. Cell. Neurosci. 2012, 6:1-18.
44. Johnson T.W., Wassersug R.J. Gender identity disorder outside the binary: when gender identity disorder-not otherwise specified is not good enough. Arch. Sex. Behav. 2010, 39:597-598.
45. Jordan-Young R. Hormones, context, and "Brain Gender": a review of evidence from congenital adrenal hyperplasia. Soc. Sci. Med. 2012, 74:1738-1744.
46. Kohlberg L.A. A cognitive-developmental analysis of children's sex role concepts and attitudes. The Development of Sex Differences 1966, 82-173. Stanford Univ. Press, Stanford, CA. E.E. Maccoby (Ed.).
47. Kreukels B.P.C. Beeldvormend onderzoek naar de effecten van geslachtshormonen op de hersenen - onderzoek bij transseksuelen [Imaging studies into the effects of sex hormones in the brain - studies on transsexuals]. Neuropraxis 2011, 15:151-158.
48. Kroger J. Gender and identity: the intersection of structure, content, and context. Sex Roles 1997, 36:747-770.
49. Kroger J. Why is identity achievement so exclusive?. Identity Int. J. Theory Res. 2007, 7:331-348.
50. Kroger J. Identity development during adolescence. Blackwell Handbook of Adolescene 2008, 205-226. Blackwell Publishing Ltd., Oxford, UK. G.R. Adams, M.D. Berzonsky (Eds.).
51. Lawrence A.A. Sexual orientation versus age of onset as bases for typologies (subtypes) for gender identity disorder in adolescents and adults. Arch. Sex. Behav. 2010, 39:514-545.
52. Lee T. Trans(re)lations: lesbian and female to male transsexual accounts of identity. Women's Stud. Int. Forum 2001, 24:347-357.
53. Lenroot R.K., Giedd J.N. Sex differences in the adolescent brain. Brain Cogn. 2010, 72:46-55.
54. Lobel T.E., Bar-David E., Gruber R., Lau S., Bar-Tal Y. Gender scheme and social judgments: a developmental study of children from Hong Kong. Sex Roles 2000, 43:19-42.
55. Luders E., Sanchez F.J., Gaser C., Toga A.W., Narr K.L., Hamilton L.S., Vilain E. Regional gray matter variation in male-to-female transsexualism. NeuroImage 2009, 46:904-907.
56. Marantz S., Coates S. Mothers of boys with gender identity disorder: a comparison of matched controls. J. Am. Acad. Child Adolesc. Psychiatry 1991, 30:310-315.
57. Marcia J.E. Development and validation of ego identity status. J. Pers. Soc. Psychol. 1966, 3:551-558.
58. Ego identity: A handbook for psychosocial research 1993, Springer Verlag, New York. J.E. Marcia, A.S. Waterman, D.R. Matteson, S.L. Archer, J.L. Orlofsky (Eds.).
59. Mazur T. Gender dysphoria and gender change in androgen insensitivity or micropenis. Arch. Sex. Behav. 2005, 34:411-421.
60. McCarthy M.M., Arnold A.P., Ball G.F., Blaustein J.D., De Vries G.J. Sex differences in the brain: the not so inconvenient truth. J. Neurosci. 2012, 32:2241-2247.
61. McHale S.M., Kim J.Y., Dotterer A.M., Crouter A.C., Booth A. The development of gendered interests and personality qualities from middle childhood through adolescence: a biosocial analysis. Child Dev. 2009, 80:482-495.
62. Merke D.P., Bornstein S.R. Congenital adrenal hyperplasia. Lancet 2005, 365:2125-2136.
63. Meyer-Bahlburg H.F. Gender identity outcome in female-raised 46, XY persons with penile agenesis, cloacal exstrophy of the bladder, or penile ablation. Arch. Sex. Behav. 2005, 34:423-438.
64. Meyer-Bahlburg H.F. Transsexualism ("gender identity disorder") - a CNS-limited form of intersexuality. Hormonal and Genetic Basis of Sexual Differentiation Disorders and Hot Topics in Endocrinology 2011, 75-79. Springer Science+Business Media, New York. M.I. New, J.L. Simpson (Eds.).
65. Money J. The concept of gender identity disorder in childhood and adolescence after 39 years. J. Sex Marital Ther. 1994, 20:163-177.
66. Nawata H., Ogomori K., Tanaka M., Nishimura R., Urashima H., Yano R., Takano K., Kuwabara Y. Regional cerebral blood flow changes in female to male gender identity disorder. Psychiatry Clin. Neurosci. 2010, 64:157-161.
67. Ngun T.C., Gharamani N., Sanchez F.J., Bocklandt S., Vilain E. The genetics of sex differences in brain and behavior. Front. Neuroendocrinol. 2011, 32:227-246.
68. Nguyen T.V., McCracken J., Ducharme S., Botteron K.N., Mahabir M., Johnson W., Israel M., Evans A.C., Karama S. Testosterone-related cortical maturation across childhood and adolescence. Cereb. Cortex 2012, 10.1093/cercor/bhs125.
69. Nieder T.O., Herff M., Cerwanka S., Preuss W.F., Cohen-Kettenis P.T., De Cuypere G., Herbold Haraldsen I.R., Richter-Appelt H. Age of onset and sexual orientation in transsexual males and females. J. Sex. Med. 2011, 8:783-791.
70. Nuttbrock L., Bockting W., Mason M., Hwanhng S., Rosenblum A., Marci M., Becker J. A further assessment of Blanchard's typology of homosexual versus non-homosexual or autogynephylic gender dysphoria. Arch. Sex. Behav. 2011, 40:247-257.
71. Olson J., Forbes C., Belzer M. Management of the transgender adolescent. Arch. Pediatr. Adolesc. Med. 2011, 165:171-176.
72. Paus T., Nawaz-Khan I., Leonard G., Perron M., Pike G.B., Pitiot A., Richer L., Susman E., Veillette S., Pausova Z. Sexual dimorphism in the adolescent brain: role of testosterone and androgen receptor in global and local volumes of grey and white matter. Horm. Behav. 2010, 57:63-75.
73. Peper J.S., Brouwer R.M., Schnack H.G., van Baal G.C., van Leeuwen M., van den Berg S.M., Delemarre-Van de Waal H.A., Boomsma D.I., Kahn R.S., Hulshoff Pol H.E. Sex steroids and brain structure in pubertal boys and girls. Psychoneuroendocrinology 2009, 34:332-342.
74. Priess H.A., Lindberg S.M., Hyde J.S. Adolescent gender-role identity and mental health: gender intensification revisited. Child Dev. 2009, 80:1531-1544.
75. Rametti G., Carrillo B., Gomez-Gil E., Junque C., Segovia S., Gomez A., Guillamon A. White matter microstructure in female to male transsexuals before cross-sex hormonal treatment. A diffusion tensor imaging study. J. Psychiatr. Res. 2011, 45:199-204.
76. Rametti G., Carrillo B., Gómez-Gil E., Junque C., Zubiarre-Elorza L., Segovia S., Gomez A., Guillamon A. The microstructure of white matter in male to female transsexuals before cross-sex hormonal treatment. A DTI study. J. Psychiatr. Res. 2011, 45:949-954.
77. Richter-Appelt H., Discher C., Gedrose B. Gender identity and recalled gender related childhood play-behaviour in adult individuals with different forms of intersexuality. Anthropol. Anz. 2005, 63:241-256.
78. Ruble D.N., Martin C.L. Gender development. Handbook of Child Psychology: Vol. 3. Personality and Social Development 1998, 933-1016. Wiley, New York. 5th ed. N. Eisenberg (Ed.).
79. Ruble D.N., Martin C.L., Berenbaum S.A. Gender development. Handbook of Child Psychology: Vol. 3, Social, Emotional, and Personality Development 2006, 858-932. Jogn Wiley & Sons Inc., Hoboken, NJ. 6th ed. E. Eisenberg, W. Damon, R.M. Lerner (Eds.).
80. Savic I., Arver S. Sex dimorphism of the brain in male-to-female transsexuals. Cereb. Cortex 2011, 21:2525-2533.
81. Schöning S., Engelien A., Bauer C., Kugel H., Kersting A., Roestel C., Zwitserlood P., Pyka M., Dannlowski U., Lehmann W., Heindel W., Arolt V., Konrad C. Neuroimaging differences in spatial cognition between men and male-to-female transsexuals before and during hormone therapy. J. Sex. Med. 2010, 7:1858-1867.
82. Schulz K.M., Molenda-Figueira H.A., Sisk C.L. Back to the future: the organizational-activational hypothesis adapted to puberty and adolescence. Horm. Behav. 2009, 55:597-604.
83. Serbin L.A., Poulin-Dubois D., Colburne K.A., Sen M.G., Eichstedt J.A. Gender stereotyping in infancy: visual preferences for and knowledge of gender-stereotyped toys in the second year. Int. J. Behav. Dev. 2001, 25:7-15.
84. Sisk C.L., Zehr J.L. Pubertal hormones organize the adolescent brain and behavior. Front. Neuroendocrinol. 2005, 26:163-174.
85. Sochting I., Skoe E.E., Marcia J.E. Care-oriented moral reasoning and prosocial behavior: a question of gender or sex role orientation?. Sex Roles 1994, 31:131-147.
86. Steensma T.D., Biemond R., de Boer F., Cohen-Kettenis P.T. Desisting and persisting gender dysphoria after childhood: a qualitative follow-up study. Clin. Child Psychol. Psychiatry 2011, 16:499-516.
87. Stoller R.J. Sex and Gender 1968, Science House, New York.
88. Stoller R.J. Presentations of Gender 1985, Yale University Press, New Haven.
89. Swaab D.F., Garcia-Falgueras A. Sexual differentiation of the human brain in relation to gender identity and sexual orientation. Funct. Neurol. 2009, 24:17-28.
90. T'Sjoen G., De Cuypere G., Monstery S., Hoebeke P., Freedman F.K., Appari M., Holterhus P.M., Van Borsel J., Cools M. Male gender identity in complete androgen insensitivity syndrome. Arch. Sex. Behav. 2011, 40:635-638.
91. Tobin D.D., Menon M., Menon M., Spatta B.C., Hodges E.V.E., Perry D.G. The intrapsychics of gender: a model of self-socialization. Psychol. Rev. 2010, 117:601-622.
92. Van Goozen S.H., Slabbekoorn D., Gooren L.J., Sanders G., Cohen-Kettenis P.T. Organizing and activating effects of sex hormones in homosexual transsexuals. Behav. Neurosci. 2002, 116:982-988.
93. Wallen K. Nature nees nurture: the interaction of hormonal and social influences on the development of behavioral se differences in rhesus monkeys. Horm. Behav. 1996, 30:364-378.
94. Wallien, M.S.C., 2008. Gender identity dysphoria in childhood: causes and consequences. Unpublished doctoral dissertation. VU University medical center, Amsterdam.
95. Wallien M.S., Cohen-Kettenis P.T. Psychosexual outcome of gender-dysphoric children. J. Am. Acad. Child Adolesc. Psychiatry 2008, 47:1413-1423.
96. Wallien M.S., van Goozen S.H., Cohen-Kettenis P.T. Physiological correlates of anxiety in children with gender identity disorder. Eur. Child Adolesc. Psychiatry 2007, 2007(16):309-315.
97. Warne G.L. Long-term outcome of disorders of sex development. Sex. Dev. 2008, 2:268-277.
98. Wassersug R.J., Zelenietz B.S., Squire G.F. New age eunuchs: motivation and rationale for voluntary castration. Arch. Sex. Behav. 2004, 33:433-442.
99. Wolfe, S.M., 1990. Psychopathology and psychodynamis of parents of boys with a gender identity disorder. Unpublished doctoral dissertation. City University of New York, New York.
100. Wood H., Sasaki S., Bradley S.J., Singh D., Fantus S., Owen-Anderson A., Di Giacomo A., Bain J., Zucker K.J. Patterns of referral to a gender identity service for children and adolescents (1976-2011): age, sex ratio, and sexual orientation. J. Sex Marital Ther. 2013, 39:1-6.
101. World Health Organisation The ICD 10 classification of mental and behavioural disorders: clinical descriptions and diagnostic guidelines 1992, Author, Geneva.
102. Yoder A.E. Barriers to ego identity status formation: a contextual qualification of Marcia's identity status paradigm. J. Adolesc. 2000, 23:95-106.
103. Zosuls K.M., Ruble D.N., Tamis-LeMonda C.S., Shrout P.E., Bornstein M.H., Greulich F.K. The acquisition of gender labels in infancy: implications for gender-typed play. Dev. Psychol. 2009, 45:688-701.
104. Zubiaurre-Elorza L., Junque C., Gómez-Gil E., Segovia S., Carrillo B., Rametti G., Guillamon A. Cortical thickness in untreated transsexuals. Cereb. Cortex 2012, 10.1093/cercor/bhs267.
105. Zucker K.J., Bradley S. Gender Identity Disorder and Psychosexual Problems in Children and Adolescents 1995, Guilford, New York.
106. Zucker K.J., Wild J., Bradley S.J., Lowry C.B. Physical attractiveness of boys with gender identity disorder. Arch. Sex. Behav. 1993, 22:23-36.
107. Zucker K.J., Bradley S.J., Lowry Sullivan C.B. Traits of seperation anxiety in boys with gender identity disorder. J. Am. Acad. Child Adolesc. Psychiatry 1996, 35:791-798.
108. Zucker K.J., Bradley S.J., Kuksis M., Pecore K., Birkenfeld-Adams A., Doering R.W., Mitchell J.N., Wild J. Gender constancy judgments in children with gender identity disorder: evidence for a developmental lag. Arch. Sex. Behav. 1999, 28:475-502.
109. Zucker K.J., Bradley S.J., Owen-Anderson A., Kibblewhite S.J., Wood H., Singh D., Choi K. Demographics, behavior problems, and psychosexual characteristics of adolescents with gender identity disorder or transvestic fetishism. J. Sex Marital Ther. 2012, 38:151-189.