White matter microstructure in female to male transsexuals before cross-sex hormonal treatment. A diffusion tensor imaging study

Journal of Psychiatric Research

Volumn 45, Issue 2, 2011, Pages 199-204

  Rametti, Giuseppina ^c,d   Carrillo, Beatriz ^b   Gómez Gil, Esther ^b   Junque, Carme ^b,d   Segovia, Santiago ^a   Gomez, Ángel ^a   Guillamon, Antonio ^a  

^a UNIVERSIDAD NACIONAL DE EDUCACIÓN A DISTANCIA   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

^c HOSPITAL CLÍNIC   (Spain)

^d INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

Author keywords

Corticospinal tract; Diffusion tensor imaging; Forceps minor; Sex differences; Superior longitudinal fasciculus; Transsexualism

Indexed keywords

SEX HORMONE;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIFFUSION TENSOR IMAGING; FEMALE; FEMALE TO MALE TRANSSEXUAL; FRACTIONAL ANISOTROPY; GENDER IDENTITY; HETEROSEXUAL FEMALE; HETEROSEXUAL MALE; HORMONAL THERAPY; HUMAN; MALE; MEDIAL LONGITUDINAL FASCICULUS; PRIORITY JOURNAL; PYRAMIDAL TRACT; WHITE MATTER;

EID: 78650678675     PISSN: 00223956     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2010.05.006     Document Type: Article

References (54)

1. American Psychiatric Association Diagnostic and statistical manual of mental disorders (DSM-IV-TR) 2000, American Psychiatric Press, Washington, DC. 4th, ed.
2. Andersson J.L.R., Jenkinson M., Smith S. Non-linear optimisation. FMRIB technical report TR07JA1 from. http://www.fmrib.ox.ac.uk/analysis/techrep.
3. Andersson J.L.R., Jenkinson M., Smith S. Non-linear registration, aka Spatial normalization. FMRIB technical report TR07JA2 from. http://www.fmrib.ox.ac.uk/analysis/techrep.
4. Blanchard R., Clemmensen L.H., Steiner B.W. Heterosexual and homosexual gender Dysphoria. Archives of Sexual Behavior 1987, 16:139-152.
5. Bobes J., Gutierrez M., Palao D., Ferrando L., Gibert-Rahola J., Lecrubier Y. Validez del M.I.N.I. (Mini International Neuropsychiatric Interview) en tres centros de AP en España. Psiquiatría Biológica 1997, 4(Suppl. 2):79.
6. Claro F., Segovia S., Guillamon A., Del Abril A. Lesions in the medial region of the BST impair sexual behavior in sexually experienced and inexperienced male rats. Brain Research Bulletin 1995, 36:1-10.
7. Carrillo B., Gómez-Gil E., Rametti G., Junque C., Gomez A., Karadi K., et al. Cortical activation during mental rotation in male-to-female and female- to-male transsexuals under hormonal tratment. Psychoneuroendocrinology 2010, accepted. 10.1016/j.psyneuen.2010.02.010.
8. Cheeran B.J., Ritter C., Rothwell J.C., Siebner H.R. Mapping genetic influences on the corticospinal motor system in humans. Neuroscience 2009, 156-163.
9. Cohen-Kettenis P.T., van Goozen S.H.M., Doorn C.D., Gooren L.J.G. Cognitive ability and cerebral lateralisation in transsexuals. Psychoneuroendocrinology 1998, 23:631-641.
10. Cohen-Kettenis P.T., Gooren L.J. Transsexualism: a review of etiology, diagnosis and treatment. Journal of Psychosomatic Research 1999, 46:315-333.
11. Emory L.E., Williams D.H., Cole C.M., Amparo E.G., Meyer W.J. Anatomic variation of the corpus callosum in persons with gender dysphoria. Archives of Sexual Behavior 1991, 20:409-417.
12. García-Falgueras A., Junque C., Jiménez M., Caldo X., Segovia S., y Guillamon A. Sex differences in the human olfactory system. Brain Research 2006, 1116:103-111.
13. Garcia-Falgueras A., Swaab D.F. A sex difference in the hypothalamic uncinate nucleus: relationship to gender identity. Brain 2008, 131:3132-3146.
14. Gizewski E.R., Krause E., Wanke I., Forsting M., Senf W. Gender-specific cerebral activation during cognitive tasks using functional MRI: comparison of women in mid-luteal phase and men. Neuroradiology 2006, 48:14-20.
15. Gizewski E.R., Krause E., Schlamann M., Happich F., Ladd M.E., Forsting M., et al. Specific cerebral activation due to visual erotic stimuli in male-to-female transsexuals compared with male and female controls: an fMRI study. Journal of Sexual Medicine 2009, 6:440-448.
16. Gómez-Gil E., Trilla A., Godás T., Halperin I., Puig M., Vidal A., et al. Estimación de la prevalencia, incidencia y razón de sexos del transexualismo en Cataluña según la demanda asistencial. Actas Españolas de Psiquiatría 2005, 34:295-302.
17. Gómez-Gil E., Trilla A., Salamero M., Godás T., Valdés M. Sociodemographic, clinical, and psychiatric characteristics of transsexuals from Spain. Archives of Sexual Behavior 2009, 38:378-392.
18. Gómez-Gil E., Cañizares S., Torres A., de la Torre F., Halperin I., Salamero M. Androgen treatment effects on memory in female-to-male transsexuals. Psychoneuroendocrinology 2009, 34:110-117.
19. Gooren L. The biology of human psychosexual differentiation. Hormones and Behavior 2006, 50:589-601.
20. Halari R., Sharma T., Hines M., Andrew C., Simmons A., Kumari V. Comparable fMRI activity with differential behavioural performance on mental rotation and overt verbal fluency tasks in healthy men and women. Experimental Brain Research 2006, 169:1-14.
21. Haraldsen I.R., Opjordsmoen S., Egeland T., Finset A. Sex-sensitive cognitive performance in untreated patients with early onset gender identity disorder. Psychoneuroendocrinology 2003, 28:906-915.
22. Hugdahl K., Thomsen T., Ersland L. Sex differences in visuo-spatial processing: an fMRI study of mental rotation. Neuropsychologia 2006, 44:1575-1583.
23. Huster R.J., Westerhausen E., Kreuder F., Schweigere E., Wittling W. Hemispheric and gender related differences in the midcingulum bundle: a DTI study. Human Brain Mapping 2009, 30:383-391.
24. Jordan K., Wüstenberg T., Heinze H.J., Peters M., Jäncke L. Women and men exhibit different cortical activation patterns during mental rotation tasks. Neuropsycologia 2002, 40:2397-2408.
25. Kimura D. Sex and cognition 1999, MIT Press, Cambridge.
26. Konrad C., Engelien A., Schöning S., Zwitserlood P., Jansen A., Pletziger E., et al. Journal of Neural Transmission 2008, 115:1327-1337.
27. Kringelbach M.L., Rolls E.T. The functional neuroanatomy of the human orbitofrontal cortex: evidence from neuroimaging and neuropsychology. Progress in Neurobiology 2004, 72:341-372.
28. Kruijver F.P.M., Zhou N.J., Pool C.W., Hofman M.A., Gooren L.J.G., Swaab D.F. Male-to- female transsexuals have female neuron number in a limbic nucleus. The Journal of Clinical Endocrinology & Metabolism 2000, 85:2034-2041.
29. Lebel C., Walker L., Leemans A., Phillips L., Beaulieu C. Microstructural maturation of the human brain from chilhood to adulthood. Neuroimage 2008, 40:1044-1055.
30. Lippa R.A., Collaer M.L., Peters M. Sex differences in mental rotation and line angle judgments are positively associated with gender equality and economic development across 53 nations. Archives of Sexual Behavior 2009, [Epub ahead of print]. 10.1007/s10508-008-9460-8.
31. Luders E., Sánchez F.J., Gaser C., Toga A.W., Narr L., Hamilton L.S., et al. Regional gray matter in male-to-females transsexualism. Neuroimage 2009, 46:904-907.
32. Martin J.H., Friel K.M., Salimi I., Chakrabarty S. Activity- and use-dependent plasticity of the developing corticospinal system. Neuroscience and Biobehavioral Reviews 2007, 31:1125-1131.
33. Meyer W., Bockting W.O., Cohen-Kettenis P., Coleman E., DiCeglie D., Devor H., et al. The Harry Benjamin gender dysphoria association's standards of care for gender identity disorders, sixth version. Journal of Psychology and Human Sexuality 2002, 13:1-30.
34. Nucifora P.G., Verma R., Lee S.-K., Melhem E.R. Diffusion-tensor MR imaging and tractography: exploring brain microstructure and connectivity. Radiology 2007, 245:367-384.
35. Park H.-J., Kim J.J., Lee S.-K., Seok J.H., Chun J., Kim D.I., et al. Corpus callosal connection mapping using cortical gray matter parcellation and DT-MRI. Human Brain Mapping 2008, 29:503-516.
36. Rueckert D., Sonoda L.I., Hayes C., Hill D.L., Leach M.O., Hawkes D.J. Nonrigid registration using free-form deformations: application to breast MR images. IEEE Transactions on Medical Imaging 1999, 18:712-721.
37. Schmahmann J.D., Pandya D.N. Fiber pathways of the brain 2006, Oxford University Press, Oxford.
38. Schmithorst V.J., Holland S.K., Dardzinski B. Developmental differences in white matter architecture between boys and girls. Human Brain Mapping 2008, 29:696-710.
39. Schoenen J., Grant G. Spinal cord: connections. The human nervous system 2004, 233-249. Elsevier, Amsterdam. G. Paxinos, J.K. Mai (Eds.).
40. Schöning S., Engelien A., Bauer C., Kugel H., Kersting A., Roestel C., et al. Neuroimaging differences in spatial cognition between men and male-to-female transsexuals before and during hormone therapy. Journal on Sexual Medicine 2009, DOI: 10.1111./j.1743-6109.2009.01484.x [Epub ahead of print].
41. Segovia S., Guillamón A. Sexual dimorphism in the vomeronasal pathway and sex differences in reproductive behaviors. Brain Research Reviews 1993, 18:51-74.
42. Sheehan D.V., Lecrubier Y., Sheehan K.H., Amorim P., Janavs J., Weiller E. The Mini-International Neuropsychiatric Interview (MINI): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. Journal of Clinical Psychiatry 1998, 59:22-33.
43. Slabbekoorn D., Van Goozen S.H.M., Megens J., Gooren L.J.G., Cohen-Kettenis P.T. Activating effects of cross-sex hormones on cognitive functioning: a study of short-term and long-term hormone effects in transsexuals. Psychoneuroendocrinology 1999, 24:423-447.
44. Smith S.M. Fast robust automated brain extraction. Human Brain Mapping 2002, 17:143-155.
45. Smith S.M., Jenkinson M., Woolrich M.W., Beckmann C.F., Behrens T.E.J., Johansen-Berg H., et al. Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage 2004, 23:S208-S219.
46. Smith S.M., Jenkinson M., Johansen-Berg H., Rueckert D., Nichols T.E., Mackay C.E., et al. Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data. Neuroimage 2006, 31:1487-1505.
47. Smith Y.L.S., van Goozen S.H.M., Kuiper A.J., Cohen-Kettenis P.T. Transsexual subtypes: clinical and theoretical significance. Psychiatry Research 2005, 137:151-160.
48. Sommer I.E.C., Cohen-Kettenis P.T., van Raalten T., vd Veer A.J., Ramsey L.E., Gooren L.J.G., et al. Effects of cross-sex hormones on cerebral activation during language and mental rotation: an fMRI study in transsexuals. European Neuropsychopharmcol 2008, 18:215-221.
49. Swaab D.F. Sexual differentiation of the human brain: relevance for gender identity, transsexualism and sexual orientation. Gynecological Endocrinology 2004, 19:301-312.
50. Westerhausen R., Walter C., Kreuder F., Wittling R.A., Schweiger E., Wittling W. The influence of handedness and gender on microstructure of the human corpus callosum: a diffusion-tensor magnetic resonance imaging study. Neuroscience Letters 2003, 351:99-102.
51. Witelson S.F., Kigar D.L., Scamvougeras A., Kideckel D.M., Buck B., Stanchev P.L., et al. Corpus callosum anatomy in right-handed homosexual and heterosexual men. Archives of Sexual Behavior 2008, 37:857-863.
52. World Health Organization: The ICD-10. Classification of mental and behavioural disorders. Diagnostic criteria for research. Geneva, 1993.
53. Yokota Y., Kawamura Y., Kameya Y. Callosal shapes at the midsagittal plane: MRI differences of normal males, normal females, and GID. Proceedings of the IEEE 2005, 3055-3058. Engineering in Medicine and Biology 27th Annual Conference.
54. Zhou J.N., Hofman M.A., Gooren L.J., Swaab D.F. A sex difference in the human brain and its relation to transsexuality. Nature 1995, 378:68-70.