메뉴 건너뛰기




Volumn 8, Issue 9, 2013, Pages

Identification of Fat Mass and Obesity Associated (FTO) Protein Expression in Cardiomyocytes: Regulation by Leptin and Its Contribution to Leptin-Induced Hypertrophy

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CATHEPSIN L; CUX1 PROTEIN; FTO PROTEIN; ISOPROTEIN; JANUS KINASE 2; LEPTIN; LEPTIN RECEPTOR; LEPTIN RECEPTOR ANTIBODY; P110CUX1 PROTEIN; REGULATOR PROTEIN; SMALL INTERFERING RNA; STAT3 PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

EID: 84883394714     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0074235     Document Type: Article
Times cited : (39)

References (27)
  • 2
    • 79952474482 scopus 로고    scopus 로고
    • From GWAS to biology: lessons from FTO
    • Tung YC, Yeo GS, (2011) From GWAS to biology: lessons from FTO. Ann N Y Acad Sci 1220: 162-171.
    • (2011) Ann N Y Acad Sci , vol.1220 , pp. 162-171
    • Tung, Y.C.1    Yeo, G.S.2
  • 4
    • 34248594090 scopus 로고    scopus 로고
    • A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
    • Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, et al. (2007) A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316: 889-894.
    • (2007) Science , vol.316 , pp. 889-894
    • Frayling, T.M.1    Timpson, N.J.2    Weedon, M.N.3    Zeggini, E.4    Freathy, R.M.5
  • 5
    • 34249777814 scopus 로고    scopus 로고
    • Variation in FTO contributes to childhood obesity and severe adult obesity
    • Dina C, Meyre D, Gallina S, Durand E, Körner A, et al. (2007) Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet 39: 724-726.
    • (2007) Nat Genet , vol.39 , pp. 724-726
    • Dina, C.1    Meyre, D.2    Gallina, S.3    Durand, E.4    Körner, A.5
  • 6
    • 34547625955 scopus 로고    scopus 로고
    • Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits
    • Scuteri A, Sanna S, Chen WM, Uda M, Albai G, et al. (2007) Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet 3: e115, 2007.
    • (2007) PLoS Genet , vol.3
    • Scuteri, A.1    Sanna, S.2    Chen, W.M.3    Uda, M.4    Albai, G.5
  • 7
    • 78649459183 scopus 로고    scopus 로고
    • Overexpression of Fto leads to increased food intake and results in obesity
    • Church C, Moir L, McMurray F, Girard C, Banks GT, et al. (2010) Overexpression of Fto leads to increased food intake and results in obesity. Nat Genet 42: 1086-1092.
    • (2010) Nat Genet , vol.42 , pp. 1086-1092
    • Church, C.1    Moir, L.2    McMurray, F.3    Girard, C.4    Banks, G.T.5
  • 8
    • 36749041363 scopus 로고    scopus 로고
    • The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase
    • Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, et al. (2007) The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 318: 1469-1472.
    • (2007) Science , vol.318 , pp. 1469-1472
    • Gerken, T.1    Girard, C.A.2    Tung, Y.C.3    Webby, C.J.4    Saudek, V.5
  • 9
    • 0028845877 scopus 로고
    • Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
    • Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, et al. (1995) Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1: 1155-1161.
    • (1995) Nat Med , vol.1 , pp. 1155-1161
    • Maffei, M.1    Halaas, J.2    Ravussin, E.3    Pratley, R.E.4    Lee, G.H.5
  • 10
    • 79957945033 scopus 로고    scopus 로고
    • Involvement of leptin receptor long isoform (LepRb)-STAT3 signaling pathway in brain fat mass- and obesity-associated (FTO) downregulation during energy restriction
    • Wang P, Yang FJ, Du H, Guan YF, Xu TY, et al. (2011) Involvement of leptin receptor long isoform (LepRb)-STAT3 signaling pathway in brain fat mass- and obesity-associated (FTO) downregulation during energy restriction. Mol Med 17: 523-532.
    • (2011) Mol Med , vol.17 , pp. 523-532
    • Wang, P.1    Yang, F.J.2    Du, H.3    Guan, Y.F.4    Xu, T.Y.5
  • 11
  • 12
    • 76849089860 scopus 로고    scopus 로고
    • Cardiovascular effects of leptin
    • Sweeney G, (2010) Cardiovascular effects of leptin. Nat Rev Cardiol 7: 22-29.
    • (2010) Nat Rev Cardiol , vol.7 , pp. 22-29
    • Sweeney, G.1
  • 13
    • 82155180640 scopus 로고    scopus 로고
    • Leptin and cardiovascular diseases
    • Hou N, Luo JD, (2011) Leptin and cardiovascular diseases. Clin Exp Pharmacol Physiol 38: 905-913.
    • (2011) Clin Exp Pharmacol Physiol , vol.38 , pp. 905-913
    • Hou, N.1    Luo, J.D.2
  • 14
    • 49849103205 scopus 로고    scopus 로고
    • A neutralizing leptin receptor antibody mitigates hypertrophy and hemodynamic dysfunction in the postinfarcted rat heart
    • Purdham DM, Rajapurohitam V, Zeidan A, Huang C, Gross GJ, et al. (2008) A neutralizing leptin receptor antibody mitigates hypertrophy and hemodynamic dysfunction in the postinfarcted rat heart. Am J Physiol Heart Circ Physiol 295: H441-H446.
    • (2008) Am J Physiol Heart Circ Physiol , vol.295
    • Purdham, D.M.1    Rajapurohitam, V.2    Zeidan, A.3    Huang, C.4    Gross, G.J.5
  • 15
    • 46749087463 scopus 로고    scopus 로고
    • Signalling mechanisms underlying the metabolic and other effects of adipokines on the heart
    • Karmazyn M, Purdham DM, Rajapurohitam V, Zeidan A, (2008) Signalling mechanisms underlying the metabolic and other effects of adipokines on the heart. Cardiovasc Res 79: 279-286.
    • (2008) Cardiovasc Res , vol.79 , pp. 279-286
    • Karmazyn, M.1    Purdham, D.M.2    Rajapurohitam, V.3    Zeidan, A.4
  • 16
    • 0032886705 scopus 로고    scopus 로고
    • Cloning of Fatso (Fto), a novel gene deleted by the Fused toes (Ft) mouse mutation
    • Peters T, Ausmeier K, Rüther U, (1999) Cloning of Fatso (Fto), a novel gene deleted by the Fused toes (Ft) mouse mutation. Mamm Genome 10: 983-986.
    • (1999) Mamm Genome , vol.10 , pp. 983-986
    • Peters, T.1    Ausmeier, K.2    Rüther, U.3
  • 17
    • 78650128393 scopus 로고    scopus 로고
    • The fat-mass and obesity-associated (FTO) gene, physical activity, and risk of incident cardiovascular events in white women
    • Ahmad T, Chasman DI, Mora S, Paré G, Cook NR, et al. (2010) The fat-mass and obesity-associated (FTO) gene, physical activity, and risk of incident cardiovascular events in white women. Am Heart J 160: 1163-1169.
    • (2010) Am Heart J , vol.160 , pp. 1163-1169
    • Ahmad, T.1    Chasman, D.I.2    Mora, S.3    Paré, G.4    Cook, N.R.5
  • 18
    • 42249110521 scopus 로고    scopus 로고
    • FTO: the first gene contributing to common forms of human obesity
    • Loos RJ, Bouchard C, (2008) FTO: the first gene contributing to common forms of human obesity. Obes Rev 9: 246-250.
    • (2008) Obes Rev , vol.9 , pp. 246-250
    • Loos, R.J.1    Bouchard, C.2
  • 19
    • 77649303960 scopus 로고    scopus 로고
    • Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats
    • Tung YC, Ayuso E, Shan X, Bosch F, O'Rahilly S, et al. (2010) Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats. PLoS One 5: e8771.
    • (2010) PLoS One , vol.5
    • Tung, Y.C.1    Ayuso, E.2    Shan, X.3    Bosch, F.4    O'Rahilly, S.5
  • 20
    • 0028845877 scopus 로고
    • Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
    • Maffei M, Halaas JL, Ravussin E, Pratley RE, Lee GH, et al. (1995) Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1: 1155-1161.
    • (1995) Nat Med , vol.1 , pp. 1155-1161
    • Maffei, M.1    Halaas, J.L.2    Ravussin, E.3    Pratley, R.E.4    Lee, G.H.5
  • 21
    • 58149499180 scopus 로고    scopus 로고
    • Leptin receptor signaling and the regulation of mammalian physiology
    • Villanueva EC, Myers MG Jr, (2008) Leptin receptor signaling and the regulation of mammalian physiology. Int J Obes (Lond) 32Suppl 7: S8-12.
    • (2008) Int J Obes (Lond) , vol.32 , pp. 8-12
    • Villanueva, E.C.1    Myers Jr., M.G.2
  • 22
    • 79959565386 scopus 로고    scopus 로고
    • Leptin receptor signaling: pathways to leptin resistance Front Biosci
    • Wauman J, Tavernier J, (2011) Leptin receptor signaling: pathways to leptin resistance Front Biosci. 16: 2771-2793.
    • (2011) , vol.16 , pp. 2771-2793
    • Wauman, J.1    Tavernier, J.2
  • 23
    • 84864341714 scopus 로고    scopus 로고
    • The obesity-related peptide leptin sensitizes cardiac mitochondria to calcium-induced permeability transition pore opening and apoptosis
    • Martinez-Abundis E, Rajapurohitam V, Haist JV, Gan XT, Karmazyn M, (2012) The obesity-related peptide leptin sensitizes cardiac mitochondria to calcium-induced permeability transition pore opening and apoptosis. PLoS One 7: e41612.
    • (2012) PLoS One , vol.7
    • Martinez-Abundis, E.1    Rajapurohitam, V.2    Haist, J.V.3    Gan, X.T.4    Karmazyn, M.5
  • 24
    • 78649464259 scopus 로고    scopus 로고
    • Cut-like homeobox 1 (CUX1) regulates expression of the fat mass and obesity-associated and retinitis pigmentosa GTPase regulator-interacting protein-1-like (RPGRIP1L) genes and coordinates leptin receptor signaling
    • Stratigopoulos G, LeDuc CA, Cremona ML, Chung WK, Leibel RL, (2011) Cut-like homeobox 1 (CUX1) regulates expression of the fat mass and obesity-associated and retinitis pigmentosa GTPase regulator-interacting protein-1-like (RPGRIP1L) genes and coordinates leptin receptor signaling. J Biol Chem 286: 2155-2170.
    • (2011) J Biol Chem , vol.286 , pp. 2155-2170
    • Stratigopoulos, G.1    LeDuc, C.A.2    Cremona, M.L.3    Chung, W.K.4    Leibel, R.L.5
  • 25
    • 84857798294 scopus 로고    scopus 로고
    • CUX1 transcription factors: from biochemical activities and cell-based assays to mouse models and human diseases
    • Hulea L, Nepveu A (20123) CUX1 transcription factors: from biochemical activities and cell-based assays to mouse models and human diseases. Gene 497: 18-26.
    • (2012) Gene , vol.497 , pp. 18-26
    • Hulea, L.1    Nepveu, A.2
  • 26
    • 84865628637 scopus 로고    scopus 로고
    • Leptin-induced cardiomyocyte hypertrophy reveals both calcium-dependent and calcium-independent/RhoA-dependent calcineurin activation and NFAT nuclear translocation
    • Rajapurohitam V, Izaddoustdar F, Martinez-Abundis E, Karmazyn M, (2012) Leptin-induced cardiomyocyte hypertrophy reveals both calcium-dependent and calcium-independent/RhoA-dependent calcineurin activation and NFAT nuclear translocation. Cell Signal 24: 2283-2290.
    • (2012) Cell Signal , vol.24 , pp. 2283-2290
    • Rajapurohitam, V.1    Izaddoustdar, F.2    Martinez-Abundis, E.3    Karmazyn, M.4
  • 27
    • 1842579393 scopus 로고    scopus 로고
    • Hypertrophy of the heart: a new therapeutic target?
    • Frey N, Katus HA, Olson EN, Hill JA, (2004) Hypertrophy of the heart: a new therapeutic target? Circulation 109: 1580-1589.
    • (2004) Circulation , vol.109 , pp. 1580-1589
    • Frey, N.1    Katus, H.A.2    Olson, E.N.3    Hill, J.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.