Dynamics of Gαi1 interaction with type 5 adenylate cyclase reveal the molecular basis for high sensitivity of Gi-mediated inhibition of cAMP production

Biochemical Journal

Volumn 454, Issue 3, 2013, Pages 515-523

  Milde, Markus ^a   Rinne, Andreas ^a   Wunder, Frank ^b   Engelhardt, Stefan ^c   Bünemann, Moritz ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b BAYER PHARMA AG   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Adenylate cyclase; FRET; G i; GIRK (G protein activated inwardly rectifying K +) G protein coupled receptor; RGS4 (regulator of G protein signalling type 4)

Indexed keywords

ADENYLATE CYCLASE; ADENYLATE CYCLASE 5; CYCLIC AMP; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN GALPHAI1; RGS4 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; DISSOCIATION; ENZYME INHIBITION; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN PROTEIN INTERACTION; SECOND MESSENGER; SIGNAL TRANSDUCTION;

ADENYLATE CYCLASE; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; CYCLIC AMP; FLUORESCENCE RESONANCE ENERGY TRANSFER; G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; HEK293 CELLS; HUMANS; KINETICS; MEMBRANE POTENTIALS; PATCH-CLAMP TECHNIQUES; PROTEIN BINDING; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; SINGLE-CELL ANALYSIS;

EID: 84883376328     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20130554     Document Type: Article

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