N terminus of type 5 adenylyl cyclase scaffolds Gs heterotrimer

Molecular Pharmacology

Volumn 76, Issue 6, 2009, Pages 1256-1264

  Sadana, Rachna ^a   Dascal, Nathan ^b   Dessauer, Carmen W ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; ADENYLATE CYCLASE TYPE 5; FORSKOLIN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT; HYBRID PROTEIN; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; SCAFFOLD PROTEIN; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; NONHUMAN; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION;

ADENYLATE CYCLASE; BINDING SITES; CELL LINE; CHROMATOGRAPHY, GEL; FLUORESCENCE RESONANCE ENERGY TRANSFER; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; GTP-BINDING PROTEIN BETA SUBUNITS; GTP-BINDING PROTEIN GAMMA SUBUNITS; HUMANS; ISOENZYMES; MULTIPROTEIN COMPLEXES; PROTEIN STRUCTURE, TERTIARY;

EID: 73149101303     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.109.058370     Document Type: Article

References (49)

1. Bar-Sinai A, Marbach I, Shorr RG, and Levitzki A (1992) The GppNHp-activated adenylyl cyclase complex from turkey erythrocyte membranes can be isolated with its beta gamma subunits. Eur J Biochem 207:703-708.
2. Belcheva MM, Gucker S, Chuang DM, Clark WG, Jefcoat LB, McHale RJ, Toth G, Borsodi A, and Coscia CJ (1995) Modulation of opioid binding associated with nuclear matrix and nuclear membranes of NG108-15 cells. J Pharmacol Exp Ther 274:1513-1523.
3. Boivin B, Lavoie C, Vaniotis G, Baragli A, Villeneuve LR, Ethier N, Trieu P, Allen BG, and Hébert TE (2006) Functional beta-adrenergic receptor signalling on nuclear membranes in adult rat and mouse ventricular cardiomyocytes. Cardiovasc Res 71:69-78.
4. Bünemann M, Frank M, and Lohse MJ (2003) Gi protein activation in intact cells involves subunit rearrangement rather than dissociation. Proc Natl Acad Sci U S A 100:16077-16082.
5. Chen-Goodspeed M, Lukan AN, and Dessauer CW (2005) Modeling of Galpha(s) and Galpha(i) regulation of human type V and VI adenylyl cyclase. J Biol Chem 280:1808-1816.
6. Chou JL, Huang CL, Lai HL, Hung AC, Chien CL, Kao YY, and Chern Y (2004) Regulation of type VI adenylyl cyclase by Snapin, a SNAP25-binding protein. J Biol Chem 279:46271-46279.
7. Clancy SM, Fowler CE, Finley M, Suen KF, Arrabit C, Berton F, Kosaza T, Casey PJ, and Slesinger PA (2005) Pertussis-toxin-sensitive Galpha subunits selectively bind to C-terminal domain of neuronal GIRK channels: evidence for a heterotrimeric G-protein-channel complex. Mol Cell Neurosci 28:375-389.
8. Crossthwaite AJ, Ciruela A, Rayner TF, and Cooper DM (2006) A direct interaction between the N terminus of adenylyl cyclase AC8 and the catalytic subunit of protein phosphatase 2A. Mol Pharmacol 69:608-617.
9. Dell EJ, Connor J, Chen S, Stebbins EG, Skiba NP, Mochly-Rosen D, and Hamm HE (2002) The betagamma subunit of heterotrimeric G proteins interacts with RACK1 and two other WD repeat proteins. J Biol Chem 277:49888- 49895.
10. Dessauer CW (2002) Kinetic analysis of the action of P-site analogs. Methods Enzymol 345:112-126.
11. Dessauer CW, Chen-Goodspeed M, and Chen J (2002) Mechanism of Galpha i-mediated inhibition of type V adenylyl cyclase. J Biol Chem 277:28823-28829.
12. Dessauer CW and Gilman AG (1996) Purification and characterization of a soluble form of mammalian adenylyl cyclase. J Biol Chem 271:16967-16974.
13. Dessauer CW, Tesmer JJ, Sprang SR, and Gilman AG (1998) Identification of a Gialpha binding site on type V adenylyl cyclase. J Biol Chem 273:25831-25839.
14. Frank M, Thümer L, Lohse MJ, and Bünemann M (2005) G Protein activation without subunit dissociation depends on a G{alpha}(i)-specific region. J Biol Chem 280:24584-24590.
15. Galés C, Rebois RV, Hogue M, Trieu P, Breit A, Hébert TE, and Bouvier M (2005) Real-time monitoring of receptor and G-protein interactions in living cells. Nat Methods 2:177-184.
16. Gao X, Sadana R, Dessauer CW, and Patel TB (2007) Conditional stimulation of type V and VI adenylyl cyclases by G protein betagamma subunits. J Biol Chem 282:294-302.
17. Gilman AG (1987) G proteins: transducers of receptor-generated signals. Annu Rev Biochem 56:615-649.
18. Harry A, Chen Y, Magnusson R, Iyengar R, and Weng G (1997) Differential regulation of adenylyl cyclases by Galphas. J Biol Chem 272:19017-19021.
19. + channel is important for channel activation. Neuron 15:1133-1143.
20. + channel. J Biol Chem 278:29174-29183.
21. Kao YY, Lai HL, Hwang MJ, and Chern Y (2004) An important functional role of the N terminus domain of type VI adenylyl cyclase in Galphai-mediated inhibition. J Biol Chem 279:34440-34448.
22. Kapiloff MS, Piggott LA, Sadana R, Li J, Heredia LA, Henson E, Efendiev R, and Dessauer CW (2009) A novel adenylyl cyclase-mAKAPbeta signaling complex maintains basal cAMP levels in cardiac myocytes. J Biol Chem 284:23540-23546.
23. Kozasa T and Gilman AG (1995) Purification of recombinant G proteins from Sf9 cells by hexahistidine tagging of associated subunits. Characterization of alpha 12 and inhibition of adenylyl cyclase by alpha z. J Biol Chem 270:1734-1741.
24. Lai HL, Lin TH, Kao YY, Lin WJ, Hwang MJ, and Chern Y (1999) The N terminus domain of type VI adenylyl cyclase mediates its inhibition by protein kinase C. Mol Pharmacol 56:644-650.
25. Lai HL, Yang TH, Messing RO, Ching YH, Lin SC, and Chern Y (1997) Protein kinase C inhibits adenylyl cyclase type VI activity during desensitization of the A2a-adenosine receptor-mediated cAMP response. J Biol Chem 272:4970-4977.
26. Levitzki A (1988) From epinephrine to cyclic AMP. Science 241:800-806.
27. Levitzki A and Klein S (2002) G-protein subunit dissociation is not an integral part of G-protein action. Chembiochem 3:815-818.
28. Lin TH, Lai HL, Kao YY, Sun CN, Hwang MJ, and Chern Y (2002) Protein kinase C inhibits type VI adenylyl cyclase by phosphorylating the regulatory N domain and two catalytic C1 and C2 domains. J Biol Chem 277:15721-15728.
29. Peleg S, Varon D, Ivanina T, Dessauer CW, and Dascal N (2002) G(alpha)(i) controls the gating of the G protein-activated K(+) channel, GIRK. Neuron 33:87-99.
30. Piggott LA, Bauman AL, Scott JD, and Dessauer CW (2008) The A-kinase anchoring protein Yotiao binds and regulates adenylyl cyclase in brain. Proc Natl Acad Sci U S A 105:13835-13840.
31. Rebois RV, Robitaille M, Galés C, Dupré DJ, Baragli A, Trieu P, Ethier N, Bouvier M, and Hébert TE (2006) Heterotrimeric G proteins form stable complexes with adenylyl cyclase and Kir3.1 channels in living cells. J Cell Sci 119:2807-2818.
32. + channels. J Biol Chem 280:16685-16694.
33. Riven I, Iwanir S, and Reuveny E (2006) GIRK channel activation involves a local rearrangement of a preformed G protein channel complex. Neuron 51:561-573.
34. + channel by GalphaiGDP and Gbetagamma. J Physiol 587:3473-3491.
35. Sadana R and Dessauer CW (2009) Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies. Neurosignals 17:5-22.
36. Salim S, Sinnarajah S, Kehrl JH, and Dessauer CW (2003) Identification of RGS2 and type V adenylyl cyclase interaction sites. J Biol Chem 278:15842-15849.
37. Sarvazyan NA, Lim WK, and Neubig RR (2002) Fluorescence analysis of receptor-G protein interactions in cell membranes. Biochemistry 41:12858-12867.
38. Scholich K, Mullenix JB, Wittpoth C, Poppleton HM, Pierre SC, Lindorfer MA, Garrison JC, and Patel TB (1999) Facilitation of signal onset and termination by adenylyl cyclase. Science 283:1328-1331.
39. 2+ stimulation of adenylyl cyclase type 8. J Biol Chem 281:17379-17389.
40. Smrcka AV (2008) G protein betagamma subunits: central mediators of G protein-coupled receptor signaling. Cell Mol Life Sci 65:2191-2214.
41. Sunahara RK, Dessauer CW, Whisnant RE, Kleuss C, and Gilman AG (1997) Interaction of Gsalpha with the cytosolic domains of mammalian adenylyl cyclase. J Biol Chem 272:22265-22271.
42. Vanderklish PW, Krushel LA, Holst BH, Gally JA, Crossin KL, and Edelman GM (2000) Marking synaptic activity in dendritic spines with a calpain substrate exhibiting fluorescence resonance energy transfer. Proc Natl Acad Sci U S A 97:2253-2258.
43. Wall MA, Coleman DE, Lee E, Iñ iguez-Lluhi JA, Posner BA, Gilman AG, and Sprang SR (1995) The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2. Cell 83:1047-1058.
44. Wang SC, Lai HL, Chiu YT, Ou R, Huang CL, and Chern Y (2007) Regulation of type V adenylate cyclase by Ric8a, a guanine nucleotide exchange factor. Biochem J 406:383-388.
45. Weitmann S, Schultz G, and Kleuss C. (2001) Adenylyl cyclase type II domains involved in Gbetagamma stimulation. Biochemistry 40:10853-10858.
46. Whisnant RE, Gilman AG, and Dessauer CW (1996) Interaction of the two cytosolic domains of mammalian adenylyl cyclase. Proc Natl Acad Sci U S A 93:6621-6625.
47. Xia Z and Liu Y (2001) Reliable and global measurement of fluorescence resonance energy transfer using fluorescence microscopes. Biophys J 81:2395-2402.
48. Yamamoto S, Kawamura K, and James TN (1998) Intracellular distribution of adenylate cyclase in human cardiocytes determined by electron microscopic cytochemistry. Microsc Res Tech 40:479-487.
49. Yuan C, Sato M, Lanier SM, and Smrcka AV (2007) Signaling by a non-dissociated complex of G Protein betagamma and alpha subunits stimulated by a receptor-independent activator of G protein signaling, AGS8. J Biol Chem 282:19938-19947.