Prevention of Reg I-induced β-cell apoptosis by IL-6/dexamethasone through activation of HGF gene regulation

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1833, Issue 12, 2013, Pages 2988-2995

  Nakagawa, Kei ^a   Takasawa, Shin ^a,b   Nata, Koji ^a,c   Yamauchi, Akiyo ^b   Itaya Hironaka, Asako ^b   Ota, Hiroyo ^b   Yoshimoto, Kiyomi ^b   Sakuramoto Tsuchida, Sumiyo ^b   Miyaoka, Tomoko ^b   Takeda, Maiko ^b   Unno, Michiaki ^a   Okamoto, Hiroshi ^a,d  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NARA MEDICAL UNIVERSITY   (Japan)

^c IWATE MEDICAL UNIVERSITY   (Japan)

^d TOHOKU UNIVERSITY   (Japan)

Author keywords

Glucocorticoids; HGF gene; IL 6; Pancreatic cell; Reg protein; Transcriptional control

Indexed keywords

DEXAMETHASONE; GA BINDING PROTEIN; INTERLEUKIN 6; MESSENGER RNA; PROTEIN REG1; SCATTER FACTOR; STAT3 PROTEIN; TRANSCRIPTION FACTOR GATA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL REGENERATION; CELL STIMULATION; CHROMATIN IMMUNOPRECIPITATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; GENE ACTIVATION; GENE CONTROL; GENE DELETION; GENE EXPRESSION; GENE MUTATION; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN MOTIF; RAT;

EID: 84883362008     PISSN: 01674889     EISSN: 18792596     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2013.08.004     Document Type: Article

References (38)

1. Dor Y., Brown J., Martinez O.I., Melton D.A. Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation. Nature 2004, 429:41-46.
2. Okamoto H., Takasawa S. Recent advances in the Okamoto model. The CD38-cyclic ADP-ribose signal system and the regenerating gene protein (Reg)-Reg receptor system in β-cells. Diabetes 2002, 51:S462-S473.
3. Reers C., Erbel S., Esposito I., Schmied B., Büchler M.W., Nawroth P.P., Ritzel R.A. Impaired islet turnover in human donor pancreata with aging. Eur. J. Endocrinol. 2009, 160:185-191.
4. Yonemura Y., Takashima T., Miwa K., Miyazaki I., Yamamoto H., Okamoto H. Amelioration of diabetes mellitus in partially depancreatized rats by poly(ADP-ribose) synthetase inhibitors: evidence of islet B-cell regeneration. Diabetes 1984, 33:401-404.
5. Terazono K., Yamamoto H., Takasawa S., Shiga K., Yonemura Y., Tochino Y., Okamoto H. A novel gene activated in regenerating islets. J. Biol. Chem. 1988, 263:2111-2114.
6. Okamoto H., Takasawa S. Recent advances in the Okamoto model: the CD38-cyclic ADP-ribose signal system and the regenerating gene protein (Reg)-Reg receptor system in β-cells. Diabetes 2002, 51:S462-S473.
7. Liu J.L., Cui W., Li B., Lu Y. Possible roles of Reg family proteins in pancreatic islet cell growth. Endocrinol. Metab. Immune Disord. Drug Targets 2008, 8:1-10.
8. Watanabe T., Yonemura Y., Yonekura H., Suzuki Y., Miyashita H., Sugiyama K., Moriizumi S., Unno M., Tanaka O., Kondo H., Bone A.J., Takasawa S., Okamoto H. Pancreatic beta-cell replication and amelioration of surgical diabetes by Reg protein. Proc. Natl. Acad. Sci. U. S. A. 1994, 91:3589-3592.
9. Gross D.J., Weiss L., Reibstein I., van den Brand J., Okamoto H., Clark A., Slavin S. Amelioration of diabetes in nonobese diabetic mice with advanced disease by linomide-induced immunoregulation combined with Reg protein treatment. Endocrinology 1998, 139:2369-2374.
10. Unno M., Nata K., Noguchi N., Narushima Y., Akiyama T., Ikeda T., Nakagawa K., Takasawa S., Okamoto H. Production and characterization of Reg knockout mice: reduced proliferation of pancreatic β-cells in Reg knockout mice. Diabetes 2002, 51:S478-S483.
11. Akiyama T., Takasawa S., Nata K., Kobayashi S., Abe M., Shervani N.J., Ikeda T., Nakagawa K., Unno M., Matsuno S., Okamoto H. Activation of Reg gene, a gene for insulin-producing β-cell regeneration: poly(ADP-ribose) polymerase binds Reg promoter and regulates the transcription by autopoly(ADP-ribosyl)ation. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:48-53.
12. Kobayashi S., Akiyama T., Nata K., Abe M., Tajima M., Shervani N.J., Unno M., Matsuno S., Sasaki H., Takasawa S., Okamoto H. Identification of a receptor for Reg (regenerating gene) protein, a pancreatic β-cell regeneration factor. J. Biol. Chem. 2000, 275:10723-10726.
13. Santangelo C., Matarrese P., Masella R., Di Carlo M.C., Di Lillo A., Scazzocchio B., Vecci E., Malorni W., Perfetti R., Anastasi E. Hepatocyte growth factor protects rat RINm5F cell line against free fatty acid-induced apoptosis by counteracting oxidative stress. J. Mol. Endocrinol. 2007, 38:147-158.
14. García-Ocaña A., Takane K.K., Syed M.A., Philbrick W.M., Vasavada R.C., Stewart A.F. Hepatocyte growth factor overexpression in the islet of transgenic mice increases β cell proliferation, enhances islet mass, and induces mild hypoglycemia. J. Biol. Chem. 2000, 275:1226-1232.
15. García-Ocaña A., Takane K.K., Reddy V.T., Lopez-Talavera J.-C., Vasavada R.C., Stewart A.F. Adenovirus-mediated hepatocyte growth factor expression in mouse islets improves pancreatic islet transplant performance and reduces beta cell death. J. Biol. Chem. 2003, 278:343-351.
16. Mellado-Gil J., Rosa T.C., Demirci C., Gonzalez-Pertusa J.A., Valazquez-Garcia S., Ernst S., Valle S., Vasavada R.C., Stewart A.F., Alonso L.C., Garcia-Ocaña A. Disruption of hepatocyte growth factor/c-met signaling enhances pancreatic β-cell death and accelerates the onset of diabetes. Diabetes 2011, 60:525-536.
17. Shervani N.J., Takasawa S., Uchigata Y., Akiyama T., Nakagawa K., Noguchi N., Takeda H., Takahashi I., Yamauchi A., Ikeda T., Iwamoto Y., Nata K., Okamoto H. Autoantibodies to REG, a beta-cell regeneration factor, in diabetic patients. Eur. J. Clin. Invest. 2004, 34:752-728.
18. Takasawa S., Ikeda T., Akiyama T., Nata K., Nakagawa K., Shervani N.J., Noguchi N., Murakami-Kawaguchi S., Yamauchi A., Takahashi I., Tomioka-Kumagai T., Okamoto H. Cyclin D1 activation through ATF-2 in Reg-induced pancreatic β-cell regeneration. FEBS Lett. 2006, 580:585-591.
19. Ota H., Tamaki S., Itaya-Hironaka A., Yamauchi A., Sakuramoto-Tsuchida S., Morioka T., Takasawa S., Kimura H. Attenuation of glucose-induced insulin secretion by intermittent hypoxia via down-regulation of CD38. Life Sci. 2012, 90:206-211.
20. Takasawa S., Nata K., Yonekura H., Okamoto H. Cyclic ADP-ribose in insulin secretion from pancreatic β cells. Science 1993, 259:370-373.
21. Takasawa S., Kuroki M., Nata K., Noguchi N., Ikeda T., Yamauchi A., Ota H., Itaya-Hironaka A., Sakuramoto-Tsuchida S., Takahashi I., Yoshikawa T., Shimosegawa T., Okamoto H. A novel ryanodine receptor expressed in pancreatic islets by alternative splicing from type 2 ryanodine receptor gene. Biochem. Biophys. Res. Commun. 2010, 397:140-145.
22. McCluskey J.T., Hamid M., Guo-Parke H., McClenaghan N.H., Gomis R., Flatt P.R. Development and functional characterization of insulin-releasing human pancreatic beta cell lines produced by electrofusion. J. Biol. Chem. 2011, 286:21982-21992.
23. Yamauchi A., Takahashi I., Takasawa S., Nata K., Noguchi N., Ikeda T., Yoshikawa T., Shervani N.J., Suzuki I., Uruno A., Unno M., Okamoto H., Sugawara A. Thiazolidinediones inhibit REG Iα gene transcription in gastrointestinal cancer cells. Biochem. Biophys. Res. Commun. 2009, 379:743-748.
24. Sun W., Funakoshi H., Nakamura T. Differential expression of hepatocyte growth factor and its receptor, c-Met in the rat retina during development. Brain Res. 1999, 851:46-53.
25. Masui T., Ota I., Itaya-Hironaka A., Takeda M., Kasai T., Yamauchi A., Sakuramoto-Tsuchida S., Mikami S., Yane K., Takasawa S., Hosoi H. Expression of REG III and prognosis in head and neck cancer. Oncol. Rep. 2013, 30:573-578.
26. Okajima A., Miyazawa K., Kitamura N N. Characterization of the promoter region of the rat hepatocyte-growth-factor/scatter-factor gene. Eur. J. Biochem. 1993, 213:113-119.
27. Viterbo D., Callender G.E., DiMaio T., Mueller C.M., Smith-Norowitz T., Aenilman M.E., Bluth M.H. Administration of anti-Reg I and anti-PAPII antibodies worsens pancreatitis. JOP 2009, 10:13-23.
28. Stella M.C., Comoglio P.M. HGF: a multifunctional growth factor controlling cell scattering. Int. J. Biochem. Cell Biol. 1999, 31:1357-1362.
29. Otonkoski T., Cirulli V., Beattie M., Mally M.I., Soto G., Rubin J.S., Hayek A. A role for hepatocyte growth factor/scatter factor in fetal mesenchyme-induced pancreatic β-cell growth. Endocrinology 1996, 137:3131-3139.
30. Demirci C., Ernst S., Alvarez-Perez J.C., Rosa T., Valle S., Shridhar V., Casinelli G.P., Alonso L.C., Vasavada R.C., García-Ocana A. Loss of HGF/c-Met signaling in pancreatic β-cells leads to incomplete maternal β-cell adaptation and gestational diabetes mellitus. Diabetes 2012, 61:1143-1152.
31. Otonkoski T., Mally M.I., Hayek A. Opposite effects of β-cell differentiation and growth on reg expression in human fetal pancreatic cells. Diabetes 1994, 43:1164-1166.
32. Dai C., Li Y., Yang J., Liu Y. Hepatocyte growth factor preserves beta cell mass and mitigates hyperglycemia in streptozotocin-induced diabetic mice. J. Biol. Chem. 2003, 278:27080-27087.
33. Nakano M., Yasunami Y., Maki T., Kodama S., Ikehara Y., Nakmura T., Tanaka M., Ikeda S. Hepatocyte growth factor is essential for amelioration of hyperglycemia in streptozotocin-induced diabetic mice receiving a marginal mass of intrahepatic islet grafts. Transplantation 2000, 69:214-221.
34. Anastasi E., Ponte E., Gradini R., Bulotta A., Sale P., Tiberti C., Okamoto H., Dotta F., Di Mario U. Expression of Reg and cytokeratin 20 during ductal cell differentiation and proliferation in mouse model of autoimmune diabetes. Eur. J. Endocrinol. 1999, 141:644-652.
35. Zioncheck T.F., Richardson L., DeGuzman G.G., Modi N.B., Hansen S.E., Godowski P.J. The pharmacokinetics, tissue localization, and metabolic processing of recombinant human hepatocyte growth factor after intravenous administration in rats. Endocrinology 1994, 134:1879-1887.
36. Nakamura T., Sakai K., Nakamura T., Matsumoto K. Hepatocyte growth factor twenty years on: much more than a growth factor. J. Gastroenterol. Hepatol. 2011, 26:188-202.
37. Kordula T., Travis J. The role of Stat and C/EBP transcription factors in the synergistic activation of rat serine protease inhibitor-3 gene by interleukin-6 and dexamethasone. Biochem. J. 1996, 313:1019-1027.
38. Mihara M., Hashizume M., Yoshida H., Suzuki M., Shiina M. IL-6/IL-6 receptor system and its role in physiological and pathological conditions. Clin. Sci. 2012, 122:143-159.