Thiazolidinediones inhibit REG Iα gene transcription in gastrointestinal cancer cells

Biochemical and Biophysical Research Communications

Volumn 379, Issue 3, 2009, Pages 743-748

  Yamauchi, Akiyo ^a,b,c   Takahashi, Iwao ^a   Takasawa, Shin ^a,c   Nata, Koji ^a   Noguchi, Naoya ^a   Ikeda, Takayuki ^a   Yoshikawa, Takeo ^a   Shervani, Nausheen J ^a   Suzuki, Iwao ^b   Uruno, Akira ^a   Unno, Michiaki ^a   Okamoto, Hiroshi ^a   Sugawara, Akira ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

^c NARA MEDICAL UNIVERSITY   (Japan)

Author keywords

Gastrointestinal cancer; PPAR ; REG I ; Thiazolidinedione

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; 2,4 THIAZOLIDINEDIONE DERIVATIVE; CIS ACTING ELEMENT; CYCLOHEXIMIDE; LITHOSTATHINE; MESSENGER RNA; N (2 BENZOYLPHENYL) O [2 (METHYL 2 PYRIDINYLAMINO)ETHYL]TYROSINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN REG 1ALPHA; ROSIGLITAZONE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CANCER CELL; CELL PROLIFERATION; CONTROLLED STUDY; DIGESTIVE SYSTEM CANCER; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN SYNTHESIS;

BASE SEQUENCE; CELL LINE, TUMOR; CELL PROLIFERATION; GASTROINTESTINAL NEOPLASMS; HUMANS; LITHOSTATHINE; PPAR GAMMA; PROMOTER REGIONS, GENETIC; RNA, MESSENGER; THIAZOLIDINEDIONES; TRANSCRIPTION, GENETIC;

EID: 58549111840     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.12.113     Document Type: Article

References (21)

1. Parkin D.M., Bray F., Ferlay J., and Pisani P. Global Cancer Statistics, 2002. CA Cancer J. Clin. 55 (2005) 74-108
2. Yonemura Y., Sakurai S., Yamamoto H., Endou Y., Kawamura T., Bandou E., Elnemr A., Sugiyama K., Sasaki T., Akiyama T., Takasawa S., and Okamoto H. REG gene expression is associated with the infiltrating growth of gastric carcinoma. Cancer 98 (2003) 1394-1400
3. Dhar D.K., Udagawa J., Ishihara S., Otani H., Kinoshita Y., Takasawa S., Okamoto H., Kubota H., Fujii T., Tachibana M., and Nagasue N. Expression of Regenerating gene I in gastric adenocarcinomas: correlation with tumor differentiation status and patient survival. Cancer 100 (2004) 1130-1136
4. Macadam R.C.A., Sarela A.I., Farmery S.M., Robinson P.A., Markham A.F., and Guillou P.J. Death from early colorectal cancer is predicted by the presence of transcripts of the REG gene family. Br. J. Cancer 83 (2000) 188-195
5. Terazono K., Yamamoto H., Takasawa S., Shiga K., Yonemura Y., Tochino Y., and Okamoto H. A novel gene activated in regenerating islets. J. Biol. Chem. 263 (1988) 2111-2114
6. Watanabe T., Yonekura H., Terazono K., Yamamoto H., and Okamoto H. Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues: the reg protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene. J. Biol. Chem. 265 (1990) 7432-7439
7. Akiyama T., Takasawa S., Nata K., Kobayashi S., Abe M., Shervani N.J., Ikeda T., Nakagawa K., Unno M., Matsuno S., and Okamoto H. Activation of Reg gene, a gene for insulin-producing β-cell regeneration: poly(ADP-ribose) polymerase binds Reg promoter and regulates the transcription by autopoly(ADP-ribosyl)ation. Proc. Natl. Acad. Sci. USA 98 (2001) 48-53
8. Miyaoka Y., Kadowaki Y., Ishihara S., Ose T., Fukuhara H., Kazumori H., Takasawa S., Okamoto H., Chiba T., and Kinoshita Y. Transgenic overexpression of Reg protein caused gastric cell proliferation and differentiation along parietal cell and chief cell lineages. Oncogene 23 (2004) 3572-3579
9. Sekikawa A., Fukui H., Fujii S., Nanakin A., Kanda N., Uenoyama Y., Sawabu T., Hisatsune H., Kusaka T., Ueno S., Nakase H., Seno H., Fujimori T., and Chiba T. Possible role of REG Iα protein in ulcerative colitis and colitic cancer. Gut 54 (2005) 1437-1444
10. Kadowaki Y., Ishihara S., Miyaoka Y., Rumi M.A.K., Sato H., Kazumori H., Adachi K., Takasawa S., Okamoto H., Chiba T., and Kinoshita Y. Reg protein is overexpressed in gastric cancer cells, where it activates a signal transduction pathway that converges on ERK1/2 to stimulate growth. FEBS Lett. 530 (2002) 59-64
11. Sekikawa A., Fukui H., Fujii S., Takeda J., Nanakin A., Hisatsune H., Seno H., Takasawa S., Okamoto H., Fujimori T., and Chiba T. REG Iα protein may function as a trophic and/or anti-apoptotic factor in the development of gastric cancer. Gastroenterology 128 (2005) 642-653
12. Yki-Järvinen H. Thiazolidinediones. N. Engl. J. Med. 351 (2004) 1106-1118
13. Voutsadakis I.A. Peroxisome proliferator-activated receptor γ (PPARγ) and colorectal carcinogenesis. J. Cancer Res. Clin. Oncol. 133 (2007) 917-928
14. Takahashi N., Okumura T., Motomura W., Fujimoto Y., Kawabata I., and Kohgo Y. Activation of PPARγ inhibits cell growth and induces apoptosis in human gastric cancer cells. FEBS Lett. 455 (1999) 135-139
15. Leung W.K., Bai A.H.C., Chan V.Y.W., Yu J., Chan M.W.Y., To K.F., Wu J.R., Chan K.K., Fu Y.G., Chan F.K.L., and Sung J.J.Y. Effect of peroxisome proliferator activated receptor γ ligands on growth and gene expression profiles of gastric cancer cells. Gut 53 (2004) 331-338
16. Cip/WAF1 through the ERK pathway in HCT15 human colorectal cancer cells. Cancer Lett. 179 (2002) 185-195
17. Moriizumi S., Watanabe T., Unno M., Nakagawara K., Suzuki Y., Miyashita H., Yonekura H., and Okamoto H. Isolation, structural determination and expression of a novel reg gene, human reg Iβ. Biochim. Biophys. Acta 1217 (1994) 199-202
18. Miyashita H., Yonekura H., Unno M., Suzuki Y., Watanabe T., Moriizumi S., Takasawa S., and Okamoto H. Characterization of the 5′-regulatory region of rat Reg I gene. Biochim. Biophys. Acta 1219 (1994) 241-243
19. Unno M., Yonekura H., Nakagawara K., Watanabe T., Miyashita H., Moriizumi S., Okamoto H., Itoh T., and Teraoka H. Structure, chromosomal localization, and expression of mouse reg genes, reg I and reg II: a novel type of reg gene, reg II, exists in the mouse genome. J. Biol. Chem. 268 (1993) 15974-15982
20. Willson T.M., Brown P.J., Sternbach D.D., and Henke B.R. The PPARs: from orphan receptors to drug discovery. J. Med. Chem. 43 (2000) 527-550
21. Leesnitzer L.M., Parks D.J., Bledsoe R.K., Cobb J.E., Collins J.L., Consler T.G., Davis R.G., Hull-Ryde E.A., Lenhard J.M., Patel L., Plunket K.D., Shenk J.L., Stimmel J.B., Therapontos C., Willson T.M., and Blanchard S.G. Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662. Biochemistry 41 (2002) 6640-6650