Quercetin acutely relaxes airway smooth muscle and potentiates β-agonist-induced relaxation via dual phosphodiesterase inhibition of PLCβ and PDE4

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 305, Issue 5, 2013, Pages

  Townsend, Elizabeth A ^a   Emala Sr , Charles W ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Asthma; Botanical; Bronchodilator; Flavonol; Lung; Phosphodiesterase 4; Phospholipase C

Indexed keywords

ACETYLCHOLINE; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BRADYKININ; HISTAMINE; INOSITOL PHOSPHATE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE PHOSPHODIESTERASE; PHOSPHODIESTERASE IV; PHOSPHOLIPASE C; QUERCETIN;

AIRWAY RESISTANCE; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTHMA; BREATHING MUSCLE; BRONCHODILATATION; BRONCHODILATING ACTIVITY; CALCIUM CELL LEVEL; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONCENTRATION RESPONSE; CONNECTIVE TISSUE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; MYOGRAPHY; NEBULIZATION; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE RELAXATION;

ASTHMA; BOTANICAL; BRONCHODILATOR; FLAVONOL; LUNG; PHOSPHODIESTERASE 4; PHOSPHOLIPASE CΒ;

ACETYLCHOLINE; ADRENERGIC BETA-AGONISTS; AIRWAY RESISTANCE; ANIMALS; ANTIOXIDANTS; BLOTTING, WESTERN; BRONCHOCONSTRICTOR AGENTS; CALCIUM; CELLS, CULTURED; CHOLINERGIC AGONISTS; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; HUMANS; INOSITOL PHOSPHATES; ISOPROTERENOL; MALE; METHACHOLINE CHLORIDE; MICE; MICE, INBRED A; MUSCLE RELAXATION; MYOCYTES, SMOOTH MUSCLE; NITRIC OXIDE; PHOSPHODIESTERASE 4 INHIBITORS; PHOSPHOLIPASE C BETA; PROSTAGLANDINS; QUERCETIN; RESPIRATORY SYSTEM; TYPE C PHOSPHOLIPASES;

EID: 84883342801     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00125.2013     Document Type: Article

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