Quercetin relaxes rat tail main artery partly via a PKG-mediated stimulation of KCa1.1 channels

Acta Physiologica

Volumn 208, Issue 4, 2013, Pages 329-339

  Iozzi, D ^a   Schubert, R ^b   Kalenchuk, V U ^b,c   Neri, A ^a   Sgaragli, G ^a   Fusi, F ^a   Saponara, S ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c MOSCOW STATE UNIVERSITY   (Russian Federation)

Author keywords

Large conductance Ca2+ activated K+ channels; Quercetin; Rat tail main artery myocyte; Spontaneous transient outward currents; Whole cell patch clamp

Indexed keywords

CYCLIC GMP DEPENDENT PROTEIN KINASE; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; QUERCETIN; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; MALE; MEMBRANE POTENTIAL; MUSCLE CELL; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; SARCOPLASMIC RETICULUM; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE FIBER; SPONTANEOUS TRANSIENT OUTWARD CURRENT; VASODILATATION;

LARGE CONDUCTANCE CA2+-ACTIVATED K+ CHANNELS; QUERCETIN; RAT TAIL MAIN ARTERY MYOCYTE; SPONTANEOUS TRANSIENT OUTWARD CURRENTS; WHOLE-CELL PATCH-CLAMP;

ANIMALS; ANTIOXIDANTS; ARTERIES; CELLS, CULTURED; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASES; GENE EXPRESSION REGULATION; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNITS; MEMBRANE POTENTIALS; MUSCLE, SMOOTH, VASCULAR; PATCH-CLAMP TECHNIQUES; QUERCETIN; RATS; TAIL; THIONUCLEOTIDES;

EID: 84880333460     PISSN: 17481708     EISSN: 17481716     Source Type: Journal    
DOI: 10.1111/apha.12083     Document Type: Article

References (40)

1. + channel, Hslo, is a target of cGMP-dependent protein kinase phosphorylation in vivo. J Biol Chem 273, 32950-32956.
2. Ca channel activity. Am J Physiol 275, H1283-H1289.
3. Benham, C.D. & Bolton, T.B. 1986. Spontaneous transient outward currents in single visceral and vascular smooth muscle cells of the rabbit. J Physiol 381, 385-406.
4. Boots, A.W., Haenen, G.R. & Bast, A. 2008. Health effects of quercetin: from antioxidant to nutraceutical. Eur J Pharmacol 585, 325-337.
5. Butt, E., Pohler, D., Genieser, H.-G., Huggins, J.P. & Bucher, B. 1995. Inhibition of cyclic GMP-dependent protein kinase-mediated effects by (Rp)-8-bromo-PET-cyclic GMPS. Br J Pharmacol 116, 3110-3116.
6. Ca currents in coronary arteries via production of H(2)O(2). Role in vasodilatation. Cardiovasc Res 73, 424-431.
7. Duarte, J., Pérez-Vizcaìno, F., Zarzuelo, A., Jiménez, J. & Tamargo, J. 1993. Vasodilator effect of quercetin in isolated rat vascular smooth muscle. Eur J Pharmacol 239, 1-7.
8. Eichhorn, B. & Dobrev, D. 2007. Vascular large conductance calcium-activated potassium channels: functional role and therapeutic potential. Naunyn Schmiedebergs Arch Pharmacol 376, 145-155.
9. Fabiato, A. & Fabiato, F. 1979. Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells. J Physiol 75, 463-505.
10. Fernandez-Fernandez, J.M., Tomas, M., Vazquez, E., Orio, P., Latorre, R., Senti, M., Marrugat, J. & Valverde, M.A. 2004. Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension. J Clin Invest 113, 1032-1039.
11. Ca1.1 in rat tail artery myocytes. J Pharmacol Exp Ther 332, 531-540.
12. Galindo, P., Rodriguez-Gómez, I., González-Manzano, S., Dueñas, M., Jiménez, R., Menéndez, C., Vargas, F., Tamargo, J., Santos-Buelga, C., Pérez-Vizcaíno, F. & Duarte, J. 2012. Glucuronidated quercetin lowers blood pressure in spontaneously hypertensive rats via deconjugation. PLoS ONE 7, e32673.
13. Galvez, A., Gimenez-Gallego, G., Reuben, J.P., Roy-Contancin, L., Feigenbaum, P., Kaczorowski, G.J. & Garcia, M.L. 1990. Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus. J Biol Chem 265, 11083-11090.
14. Halliwell, B. & Whiteman, M. 2004. Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean? Br J Pharmacol 142, 231-255.
15. Hamill, O.P., Marty, A., Neher, E., Sakmann, B. & Sigworth, F.J. 1981. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch 391, 85-100.
16. +) channels and ryanodine receptors in guinea-pig urinary bladder myocytes. J Physiol 541, 483-492.
17. Lubomirov, L., Gagov, H., Petkova-Kirova, P., Duridanova, D., Kalentchuk, V.U. & Schubert, R. 2001. Urocortin relaxes rat tail arteries by a PKA-mediated reduction of the sensitivity of the contractile apparatus for calcium. Br J Pharmacol 134, 1564-1570.
18. Manach, C., Williamson, G., Morand, C., Scalbert, A. & Remesy, C. 2005. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr 81, 230-242.
19. Mauban, J.R., Lamont, C., Balke, C.W. & Wier, W.G. 2001. Adrenergic stimulation of rat resistance arteries affects Ca(2+) sparks, Ca(2+) waves, and Ca(2+) oscillations. Am J Physiol Heart Circ Physiol 280, H2399-H2405.
20. Menendez, C., Dueñas, M., Galindo, P., González-Manzano, S., Jimenez, R., Moreno, L., Zarzuelo, M.J., Rodríguez-Gómez, I., Duarte, J., Santos-Buelga, C. & Perez-Vizcaino, F. 2011. Vascular deconjugation of quercetin glucuronide: the flavonoid paradox revealed? Mol Nutr Food Res 55, 1780-1790.
21. Mulvany, M.J. & Halpern, W. 1977. Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ Res 41, 19-26.
22. Nelson, M.T., Cheng, H., Rubart, M., Santana, L.F., Bonev, A.D., Knot, H.J. & Lederer, W.J. 1995. Relaxation of arterial smooth muscle by calcium sparks. Science 270, 633-637.
23. Persson, P.B. & Henriksson, J. 2011. Good publication practise in physiology. Acta Physiol 203, 403-407.
24. 2+ sparks is involved in regulation of arterial diameter by cyclic nucleotides. Am J Physiol Cell Physiol 274, 1346-1355.
25. Procházková, D., Boušová, I. & Wilhelmová, N. 2011. Antioxidant and prooxidant properties of flavonoids. Fitoterapia 82, 513-523.
26. Robertson, B.E., Schubert, R., Hescheler, J. & Nelson, M.T. 1993. cGMP-dependent protein kinase activates Ca-activated K channels in cerebral artery smooth muscle cells. Am J Physiol 265, C299-C303.
27. 2+ channels in rat tail artery smooth muscle cells. Br J Pharmacol 135, 1819-1827.
28. Ca) channel opener in vascular smooth muscle cells. Br J Pharmacol 149, 1013-1021.
29. Saponara, S., Carosati, E., Mugnai, P., Sgaragli, G. & Fusi, F. 2011. The flavonoid scaffold as a template for the design of vascular Ca(v) 1.2 channels modulators. Br J Pharmacol 164, 1684-1697.
30. Scholz, E.P., Zitron, E., Katus, H.A. & Karle, C.A. 2010. Cardiovascular ion channels as a molecular target of flavonoids. Cardiovasc Ther 28, 46-52.
31. Ca channel in smooth muscle. Trends Pharmacol Sci 22, 505-512.
32. Ca channels of vascular smooth muscle cells: role of cAMP-dependent protein kinase. Am J Physiol 271, 1203-1211.
33. Schubert, R., Serebryakov, V.N., Mewes, H. & Hopp, H.H. 1997. Iloprost dilates rat small arteries: role of K(ATP)- and K(Ca)-channel activation by cAMP-dependent protein kinase. Am J Physiol 272, 1147-1156.
34. Ca current of rat tail artery smooth muscle cells. Am J Physiol 276, 648-658.
35. Schubert, R., Saponara, S., Fusi, F. & Iozzi, D. 2007. The flavonoid quercetin relaxes arteries by decreasing cytosolic and stored calcium. Acta Physiol 189(suppl. 653).
36. Sofi, F., Abbate, R., Gensini, G.F. & Casini, A. 2010. Accruing evidence on benefits of adherence to the Mediterranean diet on health: an updated systematic review and meta-analysis. Am J Clin Nutr 92, 1189-1196.
37. Szado, T., McLarnon, M., Wang, X. & van Breemen, C. 2001. Role of sarcoplasmic reticulum in regulation of tonic contraction of rabbit basilar artery. Am J Physiol Heart Circ Physiol 281, 1481-1489.
38. Tang, X.D., Daggett, H., Hanner, M., Garcia, M.L., McManus, O.B., Brot, N., Weissbach, H., Heinemann, S.H. & Hoshi, T. 2001. Oxidative regulation of large conductance calcium-activated potassium channels. J Gen Physiol 117, 253-274.
39. Thorneloe, K.S. & Nelson, M.T. 2005. Ion channels in smooth muscle: regulators of intracellular calcium and contractility. Can J Physiol Pharmacol 83, 215-242.
40. 2+-sensitive ion channels. Cell Calcium 34, 211-229.