Phosphoproteomics of collagen receptor networks reveals SHP-2 phosphorylation downstream of wild-type DDR2 and its lung cancer mutants

Biochemical Journal

Volumn 454, Issue 3, 2013, Pages 501-513

  Iwai, Leo K ^a   Payne, Leo S ^a   Luczynski, Maciej T ^a   Chang, Francis ^a   Xu, Huifang ^b   Clinton, Ryan W ^c   Paul, Angela ^a   Esposito, Edward A ^a   Gridley, Scott ^a   Leitinger, Birgit ^b   Naegle, Kristen M ^d   Huang, Paul H ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^c Blue Sky Biotech Inc   (United States)

^d WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

Author keywords

Cell signalling; Collagen; Discoidin domain receptor; Lung cancer; Mass spectrometry; Phosphoproteomics

Indexed keywords

BETA1 INTEGRIN; COLLAGEN RECEPTOR; COLLAGEN TYPE 1; DISCOIDIN DOMAIN RECEPTOR 2; MEMBRANE PROTEIN; MEMBRANE RECEPTOR; PHOSPHATIDYLINOSITOL 4 PHOSPHATE 3 KINASE; PHOSPHOLIPASE C LIKE 2; PHOSPHOPEPTIDE; PROTEIN SH2; SH2 (SRC HOMOLOGY 2) DOMAIN CONTAINING INOSITOL PHOSPHATASE 2; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HEK293; ENZYME ACTIVE SITE; ENZYME ASSAY; FLOW CYTOMETRY; GENOME; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; LUNG CANCER; LUNG SQUAMOUS CELL CARCINOMA; MASS SPECTROMETRY; POINT MUTATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEOMICS; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; CARCINOMA, SQUAMOUS CELL; CLUSTER ANALYSIS; COLLAGEN TYPE I; HEK293 CELLS; HUMANS; LUNG NEOPLASMS; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 11; PROTEOMICS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, COLLAGEN; RECEPTORS, MITOGEN; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; TANDEM MASS SPECTROMETRY;

EID: 84883338990     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20121750     Document Type: Article

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