Serum Metabolome and Lipidome Changes in Adult Patients with Primary Dengue Infection

PLoS Neglected Tropical Diseases

Volumn 7, Issue 8, 2013, Pages

  Cui, Liang ^a   Lee, Yie Hou ^a   Kumar, Yadunanda ^a,e   Xu, Fengguo ^b,f   Lu, Kun ^c,g   Ooi, Eng Eong ^a,d   Tannenbaum, Steven R ^a,c   Ong, Choon Nam ^b  

^a SINGAPORE MIT ALLIANCE FOR RESEARCH AND TECHNOLOGY   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d DUKE NUS MEDICAL SCHOOL   (Singapore)

^e VISTERRA INC   (United States)

^f Key Laboratory of Drug Quality Control and Pharmacovigilance   (China)

^g UNIVERSITY OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLCARNITINE; ARACHIDONIC ACID; BILE ACID; BILIVERDIN; DIACYLGLYCEROL; GLUCOSE; GLUCOSYLCERAMIDE; HYDROCORTISONE; INOSINE; LIPIDOME; LYSOPHOSPHATIDYLCHOLINE; PHENOL DERIVATIVE; PHENYLALANINE; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID; TRYPTOPHAN;

ADULT; ARTICLE; BLOOD CHEMISTRY; CLINICAL ARTICLE; CONTROLLED STUDY; DENGUE; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; HUMAN; LIQUID CHROMATOGRAPHY; LYMPHOCYTE COUNT; MALE; MASS FRAGMENTOGRAPHY; METABOLITE; METABOLOME; PREDICTION; PROSPECTIVE STUDY; THROMBOCYTE COUNT; VIRUS CELL INTERACTION;

EID: 84883336184     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0002373     Document Type: Article

References (72)

1. Halstead SB, Suaya JA, Shepard DS, (2007) The burden of dengue infection. Lancet 369: 1410-1411.
2. Gubler DJ, (2002) The global emergence/resurgence of arboviral diseases as public health problems. Arch Med Res 33: 330-342.
3. Guzman MG, Halstead SB, Artsob H, Buchy P, Farrar J, et al. (2010) Dengue: a continuing global threat. Nat Rev Microbiol 8: S7-16.
4. Gubler DJ, (1998) Dengue and dengue hemorrhagic fever. Clin Microbiol Rev 11: 480-496.
5. Nicholson JK, Lindon JC, Holmes E, (1999) 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 29: 1181-1189.
6. Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, et al. (2009) Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature 457: 910-914.
7. Wang Z, Klipfell E, Bennett BJ, Koeth R, Levison BS, et al. (2011) Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature 472: 57-63.
8. Vinayavekhin N, Homan EA, A S, (2010) Exploring disease through metabolomics. ACS Chem Biol 15: 91-103.
9. Al-Mubarak R, Vander Heiden J, Broeckling CD, Balagon M, Brennan PJ, et al. (2011) Serum metabolomics reveals higher levels of polyunsaturated fatty acids in lepromatous leprosy: potential markers for susceptibility and pathogenesis. PLoS Negl Trop Dis 5: e1303.
10. Laiakis EC, Morris GA, Fornace AJ, Howie SR, (2010) Metabolomic analysis in severe childhood pneumonia in the Gambia, West Africa: findings from a pilot study. PLoS One 5: e12655.
11. Heaton NS, Perera R, Berger KL, Khadka S, Lacount DJ, et al. (2010) Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis. Proc Natl Acad Sci U S A 107: 17345-17350.
12. Rothwell C, Lebreton A, Young Ng C, Lim JY, Liu W, et al. (2009) Cholesterol biosynthesis modulation regulates dengue viral replication. Virology 389: 8-19.
13. Zaitseva E, Yang ST, Melikov K, Pourmal S, Chernomordik LV, (2010) Dengue virus ensures its fusion in late endosomes using compartment-specific lipids. PLoS Pathog 6: e1001131.
14. Birungi G, Chen SM, Loy BP, Ng ML, Li SF, (2010) Metabolomics approach for investigation of effects of dengue virus infection using the EA.hy926 cell line. J Proteome Res 9: 6523-6534.
15. Diamond DL, Syder AJ, Jacobs JM, Sorensen CM, Walters KA, et al. (2010) Temporal proteome and lipidome profiles reveal hepatitis C virus-associated reprogramming of hepatocellular metabolism and bioenergetics. PLoS Pathog 6: e1000719.
16. Kumar Y, Liang C, Bo Z, Rajapakse JC, Ooi EE, et al. (2012) Serum Proteome and Cytokine Analysis in a Longitudinal Cohort of Adults with Primary Dengue Infection Reveals Predictive Markers of DHF. PLoS Negl Trop Dis 6: e1887.
17. Low JG, Ooi EE, Tolfvenstam T, Leo YS, Hibberd ML, et al. (2006) Early Dengue infection and outcome study (EDEN)- study design and preliminary findings. Ann Acad Med Singapore 35: 783-789.
18. Low JG, Ong A, Tan LK, Chaterji S, Chow A, et al. (2011) The early clinical features of dengue in adults: challenges for early clinical diagnosis. PLoS Negl Trop Dis 5: e1191.
19. WHO (1997) Dengue Hemorrhagic Fever: diagnosis, treatment, prevention, and control. Geneva: World Health Organization.
20. Bligh EG, Dyer WJ, (1959) A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37: 911-917.
21. Ng DP, Salim A, Liu Y, Zou L, Xu FG, et al. (2012) A metabolomic study of low estimated GFR in non-proteinuric type 2 diabetes mellitus. Diabetologia 55: 499-508.
22. Han X, Gross RW, (2005) Shotgun lipidomics: electrospray ionization mass spectrometric analysis and quantitation of cellular lipidomes directly from crude extracts of biological samples. Mass Spectrom Rev 24: 367-412.
23. Shaner RL, Allegood JC, Park H, Wang E, Kelly S, et al. (2009) Quantitative analysis of sphingolipids for lipidomics using triple quadrupole and quadrupole linear ion trap mass spectrometers. J Lipid Res 50: 1692-1707.
24. Brugger B, Erben G, Sandhoff R, Wieland FT, Lehmann WD, (1997) Quantitative analysis of biological membrane lipids at the low picomole level by nano-electrospray ionization tandem mass spectrometry. Proc Natl Acad Sci U S A 94: 2339-2344.
25. Pluskal T, Castillo S, Villar-Briones A, Oresic M, (2010) MZmine 2: modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data. BMC Bioinformatics 11: 395.
26. Chen J, Zhao X, Fritsche J, Yin P, Schmitt-Kopplin P, et al. (2008) Practical approach for the identification and isomer elucidation of biomarkers detected in a metabonomic study for the discovery of individuals at risk for diabetes by integrating the chromatographic and mass spectrometric information. Anal Chem 80: 1280-1289.
27. Zuniga A, Li L, (2011) Ultra-high performance liquid chromatography tandem mass spectrometry for comprehensive analysis of urinary acylcarnitines. Anal Chim Acta 689: 77-84.
28. Xia J, Psychogios N, Young N, Wishart DS, (2009) MetaboAnalyst: a web server for metabolomic data analysis and interpretation. Nucleic Acids Res 37: W652-660.
29. Nevalainen TJ, Losacker W, (1997) Serum phospholipase A2 in dengue. J Infect 35: 251-252.
30. Klassen P, Furst P, Schulz C, Mazariegos M, Solomons NW, (2001) Plasma free amino acid concentrations in healthy Guatemalan adults and in patients with classic dengue. Am J Clin Nutr 73: 647-652.
31. Herz J, Pardo J, Kashkar H, Schramm M, Kuzmenkina E, et al. (2009) Acid sphingomyelinase is a key regulator of cytotoxic granule secretion by primary T lymphocytes. Nat Immunol 10: 761-768.
32. Nixon GF, (2009) Sphingolipids in inflammation: pathological implications and potential therapeutic targets. Br J Pharmacol 158: 982-993.
33. Hannun YA, (2000) Luberto (2000) Ceramide in the eukaryotic stress response. Trends Cell Biol 10: 73-80.
34. Gagnon SJ, Zeng W, Kurane I, Ennis FA, (1996) Identification of two epitopes on the dengue 4 virus capsid protein recognized by a serotype-specific and a panel of serotype-cross-reactive human CD4+ cytotoxic T-lymphocyte clones. J Virol 70: 141-147.
35. Sandalova E, Laccabue D, Boni C, Tan AT, Fink K, et al. (2010) Contribution of herpesvirus specific CD8 T cells to anti-viral T cell response in humans. PLoS Pathog 6: e1001051.
36. Mathew A, Rothman AL, (2008) Understanding the contribution of cellular immunity to dengue disease pathogenesis. Immunol Rev 225: 300-313.
37. Lewis RA, Austen KF, Soberman RJ, (1990) Leukotrienes and other products of the 5-lipoxygenase pathway. Biochemistry and relation to pathobiology in human diseases. N Engl J Med 323: 645-655.
38. Serhan CN, (2011) The resolution of inflammation: the devil in the flask and in the details. Faseb J 25: 1441-1448.
39. Calder PC, (2001) Polyunsaturated fatty acids, inflammation, and immunity. Lipids 36: 1007-1024.
40. Seet RC, Lee CY, Lim EC, Quek AM, Yeo LL, et al. (2009) Oxidative damage in dengue fever. Free Radic Biol Med 47: 375-380.
41. Serhan CN, Brain SD, Buckley CD, Gilroy DW, Haslett C, et al. (2007) Resolution of inflammation: state of the art, definitions and terms. Faseb J 21: 325-332.
42. Myo K, Soe T, Thein Thein M, Than Nu S, Tin Tin S, et al. (1995) Serum cortisol levels in children with dengue haemorrhagic fever. J Trop Pediatr 41: 295-297.
43. Ruzek MC, Pearce BD, Miller AH, Biron CA, (1999) Endogenous glucocorticoids protect against cytokine-mediated lethality during viral infection. J Immunol 162: 3527-3533.
44. Gil L, Martinez G, Tapanes R, Castro O, Gonzalez D, et al. (2004) Oxidative stress in adult dengue patients. Am J Trop Med Hyg 71: 652-657.
45. Hellewell PG, Pearson JD, (1983) Metabolism of circulating adenosine by the porcine isolated perfused lung. Circ Res 53: 1-7.
46. Hasko G, Kuhel DG, Nemeth ZH, Mabley JG, Stachlewitz RF, et al. (2000) Inosine inhibits inflammatory cytokine production by a posttranscriptional mechanism and protects against endotoxin-induced shock. J Immunol 164: 1013-1019.
47. Brennan PJ, Tatituri RV, Brigl M, Kim EY, Tuli A, et al. (2011) Invariant natural killer T cells recognize lipid self antigen induced by microbial danger signals. Nat Immunol 12: 1202-1211.
48. Facciotti F, Ramanjaneyulu GS, Lepore M, Sansano S, Cavallari M, et al. (2012) Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus. Nat Immunol 13: 474-480.
49. Kawano T, Cui J, Koezuka Y, Toura I, Kaneko Y, et al. (1997) CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides. Science 278: 1626-1629.
50. Mattner J, Debord KL, Ismail N, Goff RD, Cantu C 3rd, et al. (2005) Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature 434: 525-529.
51. Azeredo EL, De Oliveira-Pinto LM, Zagne SM, Cerqueira DI, Nogueira RM, et al. (2006) NK cells, displaying early activation, cytotoxicity and adhesion molecules, are associated with mild dengue disease. Clin Exp Immunol 143: 345-356.
52. Zigmond E, Preston S, Pappo O, Lalazar G, Margalit M, et al. (2007) Beta-glucosylceramide: a novel method for enhancement of natural killer T lymphoycte plasticity in murine models of immune-mediated disorders. Gut 56: 82-89.
53. Miller ME, Adhikary S, Kolokoltsov AA, Davey RA, (2012) Ebolavirus requires acid sphingomyelinase activity and plasma membrane sphingomyelin for infection. J Virol 86: 7473-7483.
54. Avota E, Gulbins E, Schneider-Schaulies S, (2011) DC-SIGN mediated sphingomyelinase-activation and ceramide generation is essential for enhancement of viral uptake in dendritic cells. PLoS Pathog 7: e1001290.
55. Izawa K, Yamanishi Y, Maehara A, Takahashi M, Isobe M, et al. (2012) The Receptor LMIR3 Negatively Regulates Mast Cell Activation and Allergic Responses by Binding to Extracellular Ceramide. Immunity 37: 827-839.
56. St John AL, Rathore AP, Yap H, Ng ML, Metcalfe DD, et al. (2011) Immune surveillance by mast cells during dengue infection promotes natural killer (NK) and NKT-cell recruitment and viral clearance. Proc Natl Acad Sci U S A 108: 9190-9195.
57. Lu C, Jiang Z, Fan X, Liao G, Li S, et al. (2012) A metabonomic approach to the effect evaluation of treatment in patients infected with influenza A (H1N1). Talanta 15;100: 51-56.
58. Tilley SL, (2011) Methylxanthines in asthma. Handb Exp Pharmacol 200: 439-456.
59. Guarner J, Falcón-Escobedo R, (2009) Comparison of the pathology caused by H1N1, H5N1, and H3N2 influenza viruses. Arch Med Res 40: 655-661.
60. Yang JH, Luo X, Nie Y, Su Y, Zhao Q, (2003) Widespread inosine-containing mRNA in lymphocytes regulated by ADAR1 in response to inflammation. Immunology 109: 15-23.
61. Mangerich A, Knutson CG, Parry NM, Muthupalani S, Ye W, et al. (2012) Infection-induced colitis in mice causes dynamic and tissue-specific changes in stress response and DNA damage leading to colon cancer. Proc Natl Acad Sci USA 109: E1820-1829.
62. Shi W, Meininger CJ, Haynes TE, Hatakeyama K, Wu G, (2004) Regulation of tetrahydrobiopterin synthesis and bioavailability in endothelial cells. Cell Biochem Biophys 41: 415-434.
63. Neves-Souza PC, Azeredo EL, Zagne SM, Valls-de-Souza R, Reis SR, et al. (2005) Inducible nitric oxide synthase (iNOS) expression in monocytes during acute Dengue Fever in patients and during in vitro infection. BMC Infect Dis 5: 64.
64. Takhampunya R, Padmanabhan R, Ubol S, (2006) Antiviral action of nitric oxide on dengue virus type 2 replication. J Gen Virol 87: 3003-3011.
65. Wannemacher RW Jr, Klainer AS, Dinterman RE, Beisel WR, (1976) The significance and mechanism of an increased serum phenylalanine-tyrosine ratio during infection. Am J Clin Nutr 29: 997-1006.
66. Nathan CF, Hibbs JB Jr, (1991) Role of nitric oxide synthesis in macrophage antimicrobial activity. Curr Opin Immunol 3: 65-70.
67. Akaike T, Maeda H, (2000) Nitric oxide and virus infection. Immunology 101: 300-308.
68. Suvarna JC, Rane PP, (2009) Serum lipid profile: a predictor of clinical outcome in dengue infection. Trop Med Int Health 14: 576-585.
69. Goh WW, Lee YH, Chung M, Wong L, (2012) How advancement in biological network analysis methods empowers proteomics. Proteomics 12: 550-563.
70. Jessie K, Fong MY, Devi S, Lam SK, Wong KT, (2004) Localization of dengue virus in naturally infected human tissues, by immunohistochemistry and in situ hybridization. J Infect Dis 189: 1411-1418.
71. Noisakran S, Onlamoon N, Songprakhon P, Hsiao HM, Chokephaibulkit K, et al. (2010) Cells in dengue virus infection in vivo. Adv Virol 2010: 164878.
72. Murphy BR, Whitehead SS, (2011) Immune response to dengue virus and prospects for a vaccine. Annu Rev Immunol 29: 587-619.