Post-exercise whey protein hydrolysate supplementation induces a greater increase in muscle protein synthesis than its constituent amino acid content

British Journal of Nutrition

Volumn 110, Issue 6, 2013, Pages 981-987

  Kanda, Atsushi ^a   Nakayama, Kyosuke ^a   Fukasawa, Tomoyuki ^a   Koga, Jinichiro ^a   Kanegae, Minoru ^a   Kawanaka, Kentaro ^b   Higuchi, Mitsuru ^c  

^a MEIJI DAIRIES CORPORATION   (Japan)

^b NIIGATA UNIVERSITY OF HEALTH AND WELFARE   (Japan)

^c WASEDA UNIVERSITY   (Japan)

Author keywords

Amino acids; Mammalian target of rapamycin; Protein synthesis; Whey protein hydrolysates

Indexed keywords

AMINO ACID; CARBOHYDRATE; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; MUSCLE PROTEIN; PROTEIN HYDROLYSATE; S6 KINASE; UNCLASSIFIED DRUG; WHEY PROTEIN HYDROLYSATE;

AMINO ACID BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARBOHYDRATE DIET; CONTROLLED STUDY; DIET SUPPLEMENTATION; EXERCISE; MALE; NONHUMAN; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RAT; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; TRANSLATION INITIATION;

AMINO ACIDS; ANIMALS; CARRIER PROTEINS; DIETARY SUPPLEMENTS; GENE EXPRESSION REGULATION; INSULIN; MALE; MILK PROTEINS; MUSCLE PROTEINS; MUSCLE, SKELETAL; PHOSPHOPROTEINS; PHOSPHORYLATION; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, SPRAGUE-DAWLEY; RIBOSOMAL PROTEIN S6 KINASES; SWIMMING; TOR SERINE-THREONINE KINASES;

EID: 84883320736     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114512006174     Document Type: Article

References (33)

1. Welle S, Thornton C, Statt M, et al. (1994) Postprandial myofibrillar and whole body protein synthesis in young and old human subjects. Am J Physiol 267, E599-E604.
2. Davis TA & Karl IE (1986) Response of muscle protein turnover to insulin after acute exercise and training. Biochem J 240, 651-657.
3. Dohm GL, Kasperek GJ, Tapscott EB, et al. (1980) Effect of exercise on synthesis and degradation of muscle protein. Biochem J 188, 255-262.
4. Gautsch TA, Anthony JC, Kimball SR, et al. (1998) Availability of eIF4E regulates skeletal muscle protein synthesis during recovery from exercise. Am J Physiol 274, C406-C414.
5. Williamson DL, Kubica N, Kimball SR, et al. (2006) Exerciseinduced alterations in extracellular signal-regulated kinase 1/2 and mammalian target of rapamycin (mTOR) signalling to regulatory mechanisms of mRNA translation in mouse muscle. J Physiol 573, 497-510.
6. Crozier SJ, Kimball SR, Emmert SW, et al. (2005) Oral leucine administration stimulates protein synthesis in rat skeletal muscle. J Nutr 135, 376-382.
7. Anthony JC, Lang CH, Crozier SJ, et al. (2002) Contribution of insulin to the translational control of protein synthesis in skeletal muscle by leucine. Am J Physiol Endocrinol Metab 282, E1092-E1101.
8. Anthony TG, McDaniel BJ, Knoll P, et al. (2007) Feeding meals containing soy or whey protein after exercise stimulates protein synthesis and translation initiation in the skeletal muscle of male rats. J Nutr 137, 357-362.
9. Norton LE, Layman DK, Bunpo P, et al. (2009) The leucine content of a complete meal directs peak activation but not duration of skeletal muscle protein synthesis and mammalian target of rapamycin signaling in rats. J Nutr 139, 1103-1109.
10. Tang JE, Moore DR, Kujbida GW, et al. (2009) Ingestion of whey hydrolysate, casein, or soy protein isolate: effects on mixed muscle protein synthesis at rest and following resistance exercise in young men. J Appl Physiol 107, 987-992.
11. Katsanos CS, Chinkes DL, Paddon-Jones D, et al. (2008) Whey protein ingestion in elderly persons results in greater muscle protein accrual than ingestion of its constituent essential amino acid content. Nutr Res 28, 651-658.
12. Morifuji M, Kanda A, Koga J, et al. (2010) Post-exercise carbohydrate plus whey protein hydrolysates supplementation increases skeletal muscle glycogen level in rats. Amino Acids 38, 1109-1115.
13. Bradstreet RB (1954) Kjeldahl method for organic nitrogen. Anal Chem 26, 185-187.
14. Morifuji M, Ishizaka M, Baba S, et al. (2010) Comparison of different sources and degrees of hydrolysis of dietary protein: effect on plasma amino acids, dipeptides, and insulin responses in human subjects. J Agric Food Chem 58, 8788-8797.
15. Bark TH, McNurlan MA, Lang CH, et al. (1998) Increased protein synthesis after acute IGF-I or insulin infusion is localized to muscle in mice. Am J Physiol 275, E118-E123.
16. Morifuji M, Kanda A, Koga J, et al. (2011) Preexercise ingestion of carbohydrate plus whey protein hydrolysates attenuates skeletal muscle glycogen depletion during exercise in rats. Nutrition 27, 833-837.
17. Escobar J, Frank JW, Suryawan A, et al. (2005) Physiological rise in plasma leucine stimulates muscle protein synthesis in neonatal pigs by enhancing translation initiation factor activation. Am J Physiol Endocrinol Metab 288, E914-E921.
18. Blomstrand E, Eliasson J, Karlsson HK, et al. (2006) Branched-chain amino acids activate key enzymes in protein synthesis after physical exercise. J Nutr 136, 269S-273S.
19. Anthony JC, Anthony TG & Layman DK (1999) Leucine supplementation enhances skeletal muscle recovery in rats following exercise. J Nutr 129, 1102-1106.
20. Koopman R, Wagenmakers AJ, Manders RJ, et al. (2005) Combined ingestion of protein and free leucine with carbohydrate increases postexercise muscle protein synthesis in vivo in male subjects. Am J Physiol Endocrinol Metab 88, E645-E653.
21. Morifuji M, Koga J, Kawanaka K, et al. (2009) Branchedchain amino acid-containing dipeptides, identified from whey protein hydrolysates, stimulate glucose uptake rate in L6 myotubes and isolated skeletal muscles. J Nutr Sci Vitaminol (Tokyo) 55, 81-86.
22. Drummond MJ, Dreyer HC, Fry CS, et al. (2009) Nutritional and contractile regulation of human skeletal muscle protein synthesis and mTORC1 signaling. J Appl Physiol 106, 1374-1384.
23. Byfield MP, Murray JT & Backer JM (2005) hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase. J Biol Chem 280, 33076-33082.
24. Findlay GM, Yan L, Procter J, et al. (2007) A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling. Biochem J 403, 13-20.
25. Baar K & Esser K (1999) Phosphorylation of p70(S6k) correlates with increased skeletal muscle mass following resistance exercise. Am J Physiol 276, C120-C127.
26. Wang X & Proud CG (2006) The mTOR pathway in the control of protein synthesis. Physiology (Bethesda) 21, 362-369.
27. Karlsson HK, Nilsson PA, Nilsson J, et al. (2004) Branchedchain amino acids increase p70S6k phosphorylation in human skeletal muscle after resistance exercise. Am J Physiol Endocrinol Metab 287, E1-E7.
28. Hornberger TA, Stuppard R, Conley KE, et al. (2004) echanical stimuli regulate rapamycin-sensitive signalling by a phosphoinositide 3-kinase-, protein kinase B-and growth factor-independent mechanism. Biochem J 380, 795-804.
29. Kimball SR, Farrell PA & Jefferson LS (2002) Invited Review: role of insulin in translational control of protein synthesis in skeletal muscle by amino acids or exercise. J Appl Physiol 93, 1168-1180.
30. Korz V & Frey JU (2003) Stress-related modulation of hippocampal long-term potentiation in rats: involvement of adrenal steroid receptors. J Neurosci 23, 7281-7287.
31. Rannels SR & Jefferson LS (1980) Effects of glucocorticoids on muscle protein turnover in perfused rat hemicorpus. Am J Physiol 238, E564-E572.
32. Odedra BR, Bates PC & Millward DJ (1983) Time course of the effect of catabolic doses of corticosterone on protein turnover in rat skeletal muscle and liver. Biochem J 214, 617-627.
33. Shah OJ, Anthony JC, Kimball SR, et al. (2000) Glucocorticoids oppose translational control by leucine in skeletal muscle. Am J Physiol Endocrinol Metab 279, E1185-E1190.