Glucocorticoids oppose translational control by leucine in skeletal muscle

American Journal of Physiology - Endocrinology and Metabolism

Volumn 279, Issue 5 42-5, 2000, Pages

  Shah, O Jameel ^a   Anthony, Joshua C ^a   Kimball, Scot R ^a   Jefferson, Leonard S ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

4E binding protein 1; Eukaryotic initiation factor 4E; Ribosomal protein S6 kinase; Translation initiation

Indexed keywords

BINDING PROTEIN; DEXAMETHASONE; GLUCOCORTICOID; INITIATION FACTOR 4E; LEUCINE; MESSENGER RNA; S6 KINASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEPHOSPHORYLATION; MALE; MUSCLE METABOLISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; PROTEIN SYNTHESIS; RAT; REGULATORY MECHANISM; SKELETAL MUSCLE; TRANSLATION INITIATION; TRANSLATION REGULATION;

EID: 0033672938     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.2000.279.5.e1185     Document Type: Article

References (31)

1. Orally administered leucine stimulates protein synthesis in skeletal muscle of postabsorptive rats in association with increased eIF4F formation
2. Leucine supplementation enhances skeletal muscle recovery in rats following exercise
3. Target of rapamycin (TOR): Balancing the opposing forces of protein synthesis and degradation
4. Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation
5. Reconstitution and purification of eukaryotic initiation factor 2B (eIF2B) expressed in Sf21 insect cells
6. 3H]phenylalanine
7. 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt (PKB) signaling pathway
8. Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini
9. Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism
10. Effects of dexamethasone on protein degradation and protease gene expression in rat L8 myotube cultures
11. Rapamycin suppresses 5' TOP mRNA translation through inhibition of p70(S6k)
12. Rapamycin selectively represses translation of the 'polypyrimidine tract' mRNA family
13. Identification and characterization of a mitogen-activated S6 kinase
14. Purification and characterization of eukaryotic initiation factor eIF-2B from liver
15. Age-dependent decrease in the amount of eukaryotic imitation factor 2 in various tissues
16. Regulation of translation initiation factors by signal transduction
17. Influence of amino acid availability on protein turnover in perfused skeletal muscle
18. Inhibition of p70/p85 S6 kinase activities in T cells by dexamethasone
19. Rapamycin-sensitive phosphorylation of ribosomal protein S17 by p70 S6 kinase
20. Effects of glucocorticoids on peptide chain initiation in heart and skeletal muscle
21. Effects of glucocorticoids on muscle protein turnover in perfused rat hemicorpus
22. Glucocorticoid effects on peptide-chain initiation in skeletal muscle and heart
23. Effect of glucocorticoid excess on skeletal muscle and heart protein synthesis in adult and old rats
24. Acute attenuation of translation initiation and protein synthesis by glucocorticoids in skeletal muscle
25. Among translational effectors, p70(S6k) is uniquely sensitive to inhibition by glucocorticoids
26. Glucocorticoids abate p70(S6k) and eIF4E function in L6 skeletal myoblasts
27. Increased proteolysis. An effect of increases in plasma cortisol within the physiologic range
28. TOR signalling and control of cell growth
29. Does leucine, leucyl-tRNA, or some metabolite of leucine regulate protein synthesis and degradation in skeletal and cardiac muscle?
30. Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies
31. Modulation of translation initiation in rat skeletal muscle and liver in response to food intake