Reduced stimulation of recombinant DNA polymerase γ and mitochondrial DNA (mtDNA) helicase by variants of mitochondrial single-stranded DNA-binding protein (mtSSB) correlates with defects in mtDNA replication in animal cells

Journal of Biological Chemistry

Volumn 286, Issue 47, 2011, Pages 40649-40658

  Oliveira, Marcos T ^a   Kaguni, Laurie S ^a  

^a Michigan State University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID RESIDUES; ANIMAL CELLS; COPY NUMBER; DNA POLYMERASE; DNA SYNTHESISS; DNA UNWINDING; DROSOPHILA MELANOGASTER; ETHIDIUM BROMIDE; HELICASE ACTIVITIES; HELICASES; IN-VITRO; IN-VIVO; MITOCHONDRIAL DNA (MTDNA); OVER-EXPRESSION; PROTEIN SURFACE; RECOMBINANT DNA; REPLICATION FORK; SINGLE-STRANDED DNA (SS-DNA); SINGLE-STRANDED DNA-BINDING PROTEINS; STRUCTURAL ELEMENTS; WILD TYPES;

AMINO ACIDS; ANIMAL CELL CULTURE; ANIMALS; BROMINE COMPOUNDS; GENETIC ENGINEERING; MITOCHONDRIA; POLYMERS; PROTEINS;

DNA;

DNA BINDING PROTEIN; DNA DIRECTED DNA POLYMERASE GAMMA; HELICASE; MITOCHONDRIAL DNA; MITOCHONDRIAL DNA HELICASE; MITOCHONDRIAL SINGLE STRANDED DNA BINDING PROTEIN; RECOMBINANT DNA DIRECTED DNA POLYMERASE GAMMA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA REPLICATION; DNA SYNTHESIS; DROSOPHILA MELANOGASTER; ENZYME ACTIVITY; GENE DOSAGE; HOMEOSTASIS; IN VITRO STUDY; IN VIVO STUDY; INSECT CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CONSERVED SEQUENCE; DNA HELICASES; DNA REPLICATION; DNA, MITOCHONDRIAL; DNA-BINDING PROTEINS; DNA-DIRECTED DNA POLYMERASE; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; HOMEOSTASIS; HUMANS; MITOCHONDRIA; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTATION; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SPECIES SPECIFICITY;

ANIMALIA; DROSOPHILA MELANOGASTER; METAZOA;

EID: 81755171474     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.289983     Document Type: Article

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