Epitope mapping of the hemagglutinin molecule of a highly pathogenic H5N1 influenza virus by using monoclonal antibodies

Journal of Virology

Volumn 81, Issue 23, 2007, Pages 12911-12917

  Kaverin, Nikolai V ^a   Rudneva, Irina A ^a   Govorkova, Elena A ^a,b   Timofeeva, Tatyana A ^a   Shilov, Aleksandr A ^a   Kochergin Nikitsky, Konstantin S ^a   Krylov, Piotr S ^a   Webster, Robert G ^b,c  

^a D I IVANOVSKY INSTITUTE OF VIROLOGY   (Russian Federation)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; SIALIDASE; VIRUS HEMAGGLUTININ;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ARTICLE; EPITOPE MAPPING; FEMALE; GENE SEQUENCE; INFLUENZA VIRUS A H5N1; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; VIRUS HEMAGGLUTINATION; VIRUS MUTANT; VIRUS PATHOGENESIS; VIRUS RECOMBINANT;

AMINO ACID SUBSTITUTION; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, VIRAL; ANTIGENS, VIRAL; CHICK EMBRYO; EPITOPE MAPPING; HEMAGGLUTINATION INHIBITION TESTS; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA A VIRUS, H5N1 SUBTYPE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; PROTEIN STRUCTURE, TERTIARY;

ORTHOMYXOVIRIDAE;

EID: 36349018925     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.01522-07     Document Type: Article

References (31)

1. Caton, A. J., G. G. Brownlee, J. M. Yewdell, and W. Gerhard. 1982. The antigenic structure of the influenza virus A/PR/8/34 hemagglutinin (H3 subtype). Cell 31:417-427.
2. Chan, K. H., S. Y. Lam, P. Puthavathana, T. D. Nguyen, H. T. Long, C. M. Pang, K. M. Chan, C. Y. Cheung, W. H. Seto, and J. S. Peiris. 2007. Comparative analytical sensitivities of six rapid influenza A antigen detection test kits for detection of influenza A subtypes H1N1, H3N2, and H5N1. J. Clin. Virol. 38:169-171.
3. Chen, H., Y. Li, Z. Li, J. Shi, K. Shinya, G. Deng, Q. Qi, G. Tian, S. Fan, H. Zhao, Y. Sun, and Y. Kawaoka. 2006. Properties and dissemination of H5N1 viruses isolated during an influenza outbreak in migratory waterfowl in Western China. J. Virol. 80:5976-5983.
4. Chen, H., G. J. Smith, K. S. Li, J. Wang, X. H. Fan, J. M. Rayner, D. Vijaikrishna, J. X. Zhang, C. T. Guo, C. L. Cheung, K. M. Xu, L. Duan, K. Huang, K. Qin, Y. H. Leung, W. L. Wu, H. R. Lu, Y. Chen, N. S. Xia, T. S. Naipospos, K. Y. Yuen, S. S. Hassan, S. Bahri, and T. D. Nguyen. 2006. Establishment of multiple sublineages of H5N1 influenza virus in Asia: implications for pandemic control. Proc. Natl. Acad. Sci. USA 103:2845-2850.
5. Govorkova, E. A., R. J. Webby, J. Humberd, J. P. Seiler, and R. G. Webster. 2006. Immunization with reverse-genetics-produced H5N1 influenza vaccine protects ferrets against homologous and heterologous challenge. J. Infect. Dis. 194:159-167.
6. Ha, Y., D. J. Stevens, J. J. Skehel, and D. C. Wiley. 2001. X-ray structures of H5 avian and H9 swine influenza virus hemagglutinins bound to avian and human receptor analogs. Proc. Natl. Acad. Sci. USA 98:11181-11186.
7. Ha, Y., D. J. Stevens, J. J. Skehel, and D. C. Wiley. 2002. H5 avian and H9 swine influenza virus hemagglutinin structures: possible origin of influenza subtypes. EMBO J. 21:865-875.
8. Hoffmann, E., A. S. Lipatov, R. J. Webby, E. A. Govorkova, and R. G. Webster. 2005. Role of specific hemagglutinin amino acids in the immunogenicity and protection of H5N1 influenza virus vaccines. Proc. Natl. Acad. Sci. USA 102:12915-12920.
9. Joannis, T., L. H. Lombin, P. De Benedictis, G. Cattoli, and I. Capua. 2006. Confirmation of H5N1 avian influenza in Africa. Vet. Rec. 158:309-310.
10. Kaverin, N. V., I. A. Rudneva, N. A. Ilyushina, N. L. Varich, A. S. Lipatov, Y. A. Smirnov, E. A. Govorkova, A. S. Gitelman, D. K. Lvov, and R. G. Webster. 2002. Structure of antigenic sites on the haemagglutinin molecule of H5 influenza virus and phenotypic variation of escape mutants. J. Gen. Virol. 83:2497-2505.
11. Kaverin, N. V., I. A. Rudneva, N. A. Ilyushina, A. S. Lipatov, S. Krauss, and R. G. Webster. 2004. Structural differences among hemagglutinins of influenza A virus subtypes are reflected in their antigenic architecture: analysis of H9 escape mutants. J. Virol. 78:240-249.
12. Kohler, G., and C. Milstein. 1976. Derivation of specific antibody-producing tissue culture and tumor lines by cell fusion. Eur. J. Immunol. 6:511-519.
13. Lipatov, A. S., E. A. Govorkova, R. J. Webby, H. Ozaki, M. Peiris, Y. Guan, L. Poon, and R. G. Webster. 2004. Influenza: emergence and control. J. Virol. 78:8951-8959.
14. Nicolson, C., D. Major, J. M. Wood, and J. S. Robertson. 2005. Generation of influenza vaccine viruses on Vero cells by reverse genetics: an H5N1 candidate vaccine strain produced under a quality system. Vaccine 23:2943-2952.
15. Oncul, O., V. Turhan, and S. Cavuslu. 2006. H5N1 avian influenza: the Turkish dimension. Lancet Infect. Dis. 6:186-187.
16. Palmer, D. F., W. R. Dowdle, M. T. Coleman, and G. C. Schild. 1975. Advanced laboratory techniques for influenza diagnosis. U.S. Department of Health, Education, and Welfare, immunology series no. 6. Centers for Disease Control, Atlanta, GA.
17. Philpott, M., C. Hioe, M. Sheerar, and V. Hinshaw. 1990. Hemagglutinin mutations related to attenuation altered cell tropism of a virulent avian influenza A virus. J. Virol. 64:2941-2947.
18. Shestopalov, A. M., A. G. Durimanov, V. A. Evseenko, V. A. Ternovoi, Y. N. Rassadkin, Y. V. Razumova, A. V. Zaykovskaya, S. I. Zolotykh, and S. V. Netesov. 2006. H5N1 influenza virus, domestic birds, Western Siberia, Russia. Emerg. Infect. Dis. 12:1167-1168.
19. Simmons, C. P., N. L. Bernasconi, A. M. Suguitan, Jr., K. Mills, J. M. Ward, N. V. V. Chau, T. T. Hien, F. Sallusto, D. Q. Ha, J. Farrar, M. D. de Jong, A. Lanzavecchia, and K. Subbarao. 2007. Prophylactic and therapeutic efficacy of human monoclonal antibodies against H5N1 viruses. PLoS Med. 4:928-936.
20. Sims, L. D., J. Domenech, C. Benigno, S. Kahn, A. Kamata, J. Lubroth, V. Martin, and P. Roeder. 2005. Origin and evolution of highly pathogenic H5N1 avian influenza in Asia. Vet. Rec. 157:159-164.
21. Skehel, J. J., D. J. Stevens, R. S. Daniels, A. R. Douglas, M. Knossow, I. A. Wilson, and D. C. Wiley. 1984. A carbohydrate side chain on hemagglutinins of Hong Kong influenza viruses inhibits recognition by a monoclonal antibody. Proc. Natl. Acad. Sci. USA 81:1779-1783.
22. Smirnov, Y. A., A. S. Lipatov, R. A. van Beek, A. K. Gitelman, A. D. M. E. Osterhaus, and E. C. J. Claas. 2000. Characterization of adaptation of an avian influenza A (H5N2) virus to a mammalian host. Acta Virol. 44:1-8.
23. Smith, G. J., T. S. Naipospos, T. D. Nguyen, M. D. de Jong, D. Vrjaykrishna, T. B. Usman, S. S. Hassan, T. V. Nguyen, T. V. Dao, N. A. Bui, Y. H. Leung, C. L. Cheung, J. M. Rayner, J. X. Zhang, L. J. Zhang, L. L. Poon, K. S. Li, V. C. Nguyen, T. T. Hien, J. Farrar, R. G. Webster, H. Chen, J. S. Peiris, and Y. Guan. 2006. Evolution and adaptation of H5N1 influenza virus in avian and human hosts in Indonesia and Vietnam. Virology 350:258-268.
24. Stevens, J., O. Blixt, T. M. Tumpey, J. K. Tauhenberger, J. C. Paulson, and I. A. Wilson. 2006. Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus. Science 312:404-410.
25. Subarrao, K., H. Chen, D. Swayne, L. Mingay, E. Fodor, G. Brownlee, X. Xu, X. Lu, J. Katz, N. Cox, and Y. Matsuoka. 2003. Evaluation of a genetically modified reassortant H5N1 influenza virus vaccine candidate generated by plasmid-based reverse genetics. Virology 305:192-200.
26. Tian, G., S. Zhang, Y. Li, Z. Bu, P. Liu, J. Zhou, C. Li, J. Shi, K. Yu, and H. Chen. 2005. Protective efficacy in chickens, geese and ducks of an H5N1-inactivated vaccine developed by reverse genetics. Virology 341:153-162.
27. Tsuchiya, E., K. Sugawara, S. Hongo, Y. Matsuzaki, Y. Muraki, Z.-N. Li, and K. Nakamura. 2001. Antigenic structure of the haemagglutinin of human influenza A/H2N2 virus. J. Gen. Virol. 82:2475-2484.
28. Webster, R. G., and E. A. Govorkova. 2006. H5N1 influenza-continuing evolution and spread. N. Engl. J. Med. 355:2174- 2177.
29. Wiley, D. C., I. A. Wilson, and J. J. Skehel. 1981. Structural identification of the antibody-binding sites of Hong Kong influenza hemagglutinin and their involvement in antigenic variation. Nature 289:373-378.
30. World Health Organization Epidemic and Pandemic Alert and Response. 2007. Cumulative number of confirmed human cases of avian influenza A(H5N1) reported to WHO on 11 April 2007. [Online.] http://www.who.int/csr/disease/avian_influenza/country/cases_table_2007_04_11/ en/index.html.
31. Yewdell, J. W., R. G. Wehster, and W. Gerhard. 1979. Antigenic variation in three distinct determinants of an influenza type A hemagglutinin molecule. Nature 279:246-248.