Amino acid residues in the fusion peptide pocket regulate the ph of activation of the H5N1 influenza virus hemagglutinin protein

Journal of Virology

Volumn 83, Issue 8, 2009, Pages 3568-3580

  Reed, Mark L ^a   Yen, Hui Ling ^a,c   DuBois, Rebecca M ^a   Bridges, Olga A ^a   Salomon, Rachelle ^a,d   Webster, Robert G ^a   Russell, Charles J ^a,b  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CELL SURFACE PROTEIN; HISTIDINE; INFLUENZA VIRUS HEMAGGLUTININ; PROTEIN SUBUNIT; VIRUS FUSION PROTEIN; HEMAGGLUTININ, AVIAN INFLUENZA A VIRUS;

ACIDITY; ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; FUSION GENE; INFLUENZA VIRUS A H5N1; MUTATIONAL ANALYSIS; NONHUMAN; PH; PLASMID; POINT MUTATION; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN STABILITY; TRANSIENT TRANSFECTION; UPREGULATION; VIRUS MUTATION; VIRUS PATHOGENESIS; WILD TYPE; AMINO ACID SUBSTITUTION; ANIMAL; CELL LINE; CERCOPITHECUS; CHEMICAL STRUCTURE; GENETIC TRANSFECTION; GENETICS; HAMSTER; METABOLISM; MISSENSE MUTATION; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; SITE DIRECTED MUTAGENESIS; VIRUS ENTRY;

INFLUENZA A VIRUS; ORTHOMYXOVIRIDAE;

AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE; CERCOPITHECUS AETHIOPS; CRICETINAE; DNA MUTATIONAL ANALYSIS; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HYDROGEN-ION CONCENTRATION; INFLUENZA A VIRUS, H5N1 SUBTYPE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION, MISSENSE; POINT MUTATION; PROTEIN STRUCTURE, TERTIARY; TRANSFECTION; VIRUS INTERNALIZATION;

EID: 64049092310     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.02238-08     Document Type: Article

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