Acute ingestion of beetroot bread increases endothelium-independent vasodilation and lowers diastolic blood pressure in healthymen: A randomized controlled trial

Journal of Nutrition

Volumn 143, Issue 9, 2013, Pages 1399-1405

  Hobbs, Ditte A ^a   Goulding, Marie G ^a   Nguyen, Annie ^a   Malaver, Thomas ^a   Walker, Claire F ^a   George, Trevor W ^b,c   Methven, Lisa ^a   Lovegrove, Julie A ^a  

^a UNIVERSITY OF READING   (United Kingdom)

^b Eccentricities Limited   (United Kingdom)

^c NORTHUMBRIA UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

NITRATE; NITRITE;

ADULT; ARTERIAL STIFFNESS; ARTICLE; BEETROOT; BEETROOT BREAD; BLOOD LEVEL; BREAD; COMPARATIVE STUDY; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIASTOLIC BLOOD PRESSURE; ENDOTHELIUM; ENDOTHELIUM INDEPENDENT VASODILATION; HUMAN; IMAGING AND DISPLAY; INGESTION; IONTOPHORESIS; LASER DOPPLER IMAGING; MALE; NORMAL HUMAN; OUTCOME ASSESSMENT; POSTPRANDIAL STATE; PULSE WAVE; RANDOMIZED CONTROLLED TRIAL; URINE LEVEL; VASODILATATION; WHITE BREAD;

ADULT; BETA VULGARIS; BLOOD PRESSURE; BODY MASS INDEX; BREAD; CROSS-OVER STUDIES; DIET; ENDOTHELIUM; HEART RATE; HUMANS; HYPERTENSION; MALE; NITRATES; NITRITES; PLANT ROOTS; SYSTOLE; VASCULAR STIFFNESS; VASODILATION; VEGETABLES;

EID: 84883272189     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.113.175778     Document Type: Article

References (45)

1. Lopez AD, Mathers CD, Ezzati M, Jamison DT, Murray CJL. Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data. Lancet. 2006;367:1747-57.
2. Bazzano LA, He J, Ogden LG, Loria CM, Vupputuri S, Myers L, Whelton PK. Fruit and vegetable intake and risk of cardiovascular disease in US adults: the first national health and nutrition examination survey epidemiologic follow-up study. Am J Clin Nutr. 2002;76:93-9.
3. Joshipura KJ, Ascherio A, Manson JE, Stampfer MJ, Rimm EB, Speizer FE, Hennekens CH, Spiegelman D, Willett WC. Fruit and vegetable intake in relation to risk of ischemic stroke. JAMA. 1999;282:1233-9.
4. Joshipura KJ, Hu FB, Manson JE, Stampfer MJ, Rimm EB, Speizer FE, Colditz G, Ascherio A, Rosner B, Spiegelman D, et al. The effect of fruit and vegetable intake on risk for coronary heart disease. Ann Intern Med. 2001;134:1106-14.
5. Ness AR, Powles J. Fruit and vegetables, and cardiovascular disease: a review. Int J Epidemiol. 1997;26:1-13.
6. Miller ER, Erlinger T, Appel L. The effects of macronutrients on blood pressure and lipids: an overview of the DASH and Omniheart trials. Curr Atheroscler Rep. 2006;8:460-5.
7. Liu RH. Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals. Am J Clin Nutr. 2003;78: S517-20.
8. Hord NG, Tang Y, Bryan NS. Food sources of nitrates and nitrites: the physiologic context for potential health benefits. Am J Clin Nutr. 2009; 90:1-10.
9. Pennington JAT. Dietary exposure models for nitrates and nitrites. Food Control. 1998;9:385-95.
10. Carlström M, Larsen FJ, Nyström T, Hezel M, Borniquel S, Weitzberg E, Lundberg JO. Dietary inorganic nitrate reverses features of metabolic syndrome in endothelial nitric oxide synthase-deficient mice. Proc Natl Acad Sci USA. 2010;107:17716-20.
11. Govoni M, Jansson EÅ, Weitzberg E, Lundberg JO. The increase in plasma nitrite after a dietary nitrate load is markedly attenuated by an antibacterial mouthwash. Nitric Oxide. 2008;19:333-7.
12. Jansson EA, Huang L, Malkey R, Govoni M, Nihlen C, Olsson A, Stensdotter M, Petersson J, Holm L, Weitzberg E, et al. A mammalian functional nitrate reductase that regulates nitrite and nitric oxide homeostasis. Nat Chem Biol. 2008;4:411-7.
13. Kapil V, Milsom AB, Okorie M, Maleki-Toyserkani S, Akram F, Rehman F, Arghandawi S, Pearl V, Benjamin N, Loukogeorgakis S, et al. Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO. Hypertension. 2010;56:274-81.
14. Webb AJ, Patel N, Loukogeorgakis S, Okorie M, Aboud Z, Misra S, Rashid R, Miall P, Deanfield J, Benjamin N, et al. Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension. 2008;51:784-90.
15. Hobbs DA, Kaffa N, George TW, Methven L, Lovegrove JA. Blood pressure-lowering effects of beetroot juice and novel beetroot-enriched bread products in normotensive male subjects. Br J Nutr. 2012;108: 2066-74.
16. Larsen FJ, Ekblom B, Sahlin K, Lundberg JO, Weitzberg E. Effects of dietary nitrate on blood pressure in healthy volunteers. N Engl J Med. 2006;355:2792-3.
17. Lundberg JO, Weitzberg E, Cole JA, Benjamin N. Nitrate, bacteria and human health. Nat Rev Microbiol. 2004;2:593-602.
18. Lundberg JO, Weitzberg E, Lundberg JM, Alving K. Intragastric nitric oxide production in humans: measurements in expelled air. Gut. 1994; 35:1543-6.
19. Lundberg JO,Weitzberg E, GladwinMT. The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics. Nat Rev Drug Discov. 2008;7: 156-67.
20. Lundberg JO, Weitzberg E. NO generation from nitrite and its role in vascular control. Arterioscler Thromb Vasc Biol. 2005;25:915-22.
21. Bates B, Lennox A, Prentice A, Bates C, Swan G. National Diet and Nutrition Survey: headline results from years 1, 2 and 3 (combined) of the Rolling Programme (2008/09-2010/11). London: Stationary Office; 2012 [cited 2012 Aug 11]. Available from: http://www.natcen.ac.uk/media/978078/ndns-y3-report_all-text-docs-combined.pdf.
22. Buttriss J. Introduction: plant foods and health. In: Goldberg G, editor. Plants: diet and health: the report of a British nutrition foundation task force. Oxford (UK): Blackwell Science Ltd; 2008. p. 1-26.
23. O'Connor A. An overview of the role of bread in the UK diet. Nutr Bull. 2012;37:193-212.
24. Van Lenthe F, Boreham C, Twisk J, Strain J, Savage J, Smith G. Socioeconomic position and coronary heart disease risk factors in youth. Eur J Public Health. 2001;11:43-50.
25. George TW, Paterson E, Waroonphan S, Gordon MH, Lovegrove JA. Effects of chronic consumption of fruit and vegetable puree-based drinks on vasodilation, plasma oxidative stability and antioxidant status. J Hum Nutr Diet. 2012;25:477-87.
26. O'Brien E, Beevers G, Lip GY. ABC of hypertension. Blood pressure measurement. Part III-automated sphygmomanometry: ambulatory blood pressure measurement. BMJ. 2001;322:1110-4.
27. Laurent S, Cockcroft J, Van Bortel L, Boutouyrie P, Giannattasio C, Hayoz D, Pannier B, Vlachopoulos C, Wilkinson I, Struijker-Boudier H. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J. 2006;27:2588-605.
28. Pauca AL, O'Rourke MF, Kon ND. Prospective evaluation of a method for estimating ascending aortic pressure from the radial artery pressure waveform. Hypertension. 2001;38:932-7.
29. Ignarro LJ, Fukuto JM, Griscavage JM, Rogers NE, Byrns RE. Oxidation of nitric oxide in aqueous solution to nitrite but not nitrate: comparison with enzymatically formed nitric oxide from L-arginine. Proc Natl Acad Sci USA. 1993;90:8103-7.
30. Hald PM. Flame photometry for measurement of sodium and potassium in biological materials. J Biol Chem. 1947;167:499-510.
31. Turner J, Belch JF, Khan F. Current concepts in assessment of microvascular endothelial function using laser Doppler imaging and iontophoresis. Trends Cardiovasc Med. 2008;18:109-16.
32. Stehouwer CD. Is measurement of endothelial dysfunction clinically useful? Eur J Clin Invest. 1999;29:459-61.
33. Bondonno CP, Yang X, Croft KD, Considine MJ, Ward NC, Rich L, Puddey IB, Swinny E, Mubarak A, Hodgson JM. Flavonoid-rich apples and nitrate-rich spinach augment nitric oxide status and improve endothelial function in healthy men and women: a randomized controlled trial. Free Radic Biol Med. 2012;52:95-102.
34. Bahra M, Kapil V, Pearl V, Ghosh S, Ahluwalia A. Inorganic nitrate ingestion improves vascular compliance but does not alter flowmediated dilatation in healthy volunteers. Nitric Oxide. 2012;26: 197-202.
35. Shimizu M, Kario K. Review: role of the augmentation index in hypertension. Ther Adv Cardiovasc Dis. 2008;2:25-35.
36. Kenjale AA, Ham KL, Stabler T, Robbins JL, Johnson JL, VanBruggen M, Privette G, Yim E, Kraus WE, Allen JD. Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. J Appl Physiol. 2011;110:1582-91.
37. Vanhatalo A, Bailey SJ, Blackwell JR, DiMenna FJ, Pavey TG, Wilkerson DP, Benjamin N, Winyard PG, Jones AM. Acute and chronic effects of dietary nitrate supplementation on blood pressure and the physiological responses to moderate-intensity and incremental exercise. Am J Physiol Regul Integr Comp Physiol. 2010;299:R1121-31.
38. Sobko T, Marcus C, Govoni M, Kamiya S. Dietary nitrate in Japanese traditional foods lowers diastolic blood pressure in healthy volunteers. Nitric Oxide. 2010;22:136-40.
39. Collins R, Peto R, MacMahon S, Godwin J, Qizilbash N, Hebert P, Eberlein KA, Taylor JO, Hennekens CH, Fiebach NH. Blood pressure, stroke, and coronary heart disease: part 2, short-term reductions in blood pressure: overview of randomised drug trials in their epidemiological context. Lancet. 1990;335:827-38.
40. Gladwin MT. Does eNOS stand for erythrocytic NO synthase? Blood. 2006;107:2595-6.
41. Appel LJ, Moore TJ, Obarzanek E, Vollmer WM, Svetkey LP, Sacks FM, Bray GA, Vogt TM, Cutler JA, Windhauser MM, et al. A clinical trial of the effects of dietary patterns on blood pressure. N Engl J Med. 1997;336:1117-24.
42. Berry SE, Mulla UZ, Chowienczyk PJ, Sanders TAB. Increased potassium intake from fruit and vegetables or supplements does not lower blood pressure or improve vascular function in UK men and women with early hypertension: a randomised controlled trial. Br J Nutr. 2010; 104:1839-47.
43. Tesoriere L, Butera D, Pintaudi AM, Allegra M, Livrea MA. Supplementation with cactus pear (Opuntia ficus-indica) fruit decreases oxidative stress in healthy humans: a comparative study with vitamin C. Am J Clin Nutr. 2004;80:391-5.
44. Charles MA, Eschwege E, Thibult N, Claude JR, Warnet JM, Rosselin GE, Girard J, Balkau B. The role of non-esterified fatty acids in the deterioration of glucose tolerance in Caucasian subjects: results of the Paris Prospective Study. Diabetologia. 1997;40:1101-6.
45. Wilding JPH. The importance of free fatty acids in the development of Type 2 diabetes. Diabet Med. 2007;24:934-45.