Probucol inhibits JAK2-STAT pathway activation and protects human glomerular mesangial cells from tert-butyl hydroperoxide induced premature senescence

Canadian Journal of Physiology and Pharmacology

Volumn 91, Issue 9, 2013, Pages 671-679

  Zhou, Hongli ^a   Huang, Bo ^a   Han, Yarong ^a   Jin, Ruixia ^a   Chen, Shuo ^a  

^a JINZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Glomerular mesangial cell; JAK2 STAT pathway; Probucol; Senescence; Tert butyl hydroperoxide

Indexed keywords

BETA GALACTOSIDE; JANUS KINASE 2 INHIBITOR; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PROBUCOL; PROTEIN BAX; PROTEIN BCL 2; PROTEIN INHIBITOR OF ACTIVATED STAT; STAT1 PROTEIN; STAT3 PROTEIN; TERT BUTYL HYDROPEROXIDE;

ARTICLE; CELL AGING; CELL CYCLE G0 PHASE; CELL PROTECTION; ENZYME ACTIVITY; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MESANGIUM CELL; PREMATURE AGING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION;

BCL-2-ASSOCIATED X PROTEIN; BETA-GALACTOSIDASE; CELL AGING; CELL CYCLE CHECKPOINTS; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; HUMANS; JANUS KINASE 2; MESANGIAL CELLS; PHOSPHORYLATION; PROBUCOL; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION; STAT TRANSCRIPTION FACTORS; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; TERT-BUTYLHYDROPEROXIDE;

EID: 84883270497     PISSN: 00084212     EISSN: 12057541     Source Type: Journal    
DOI: 10.1139/cjpp-2012-0343     Document Type: Article

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