Threshold response of initiation of blood coagulation by tissue factor in patterned microfluidic capillaries is controlled by shear rate

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 28, Issue 11, 2008, Pages 2035-2041

  Shen, Feng ^a   Kastrup, Christian J ^a   Liu, Ying ^a   Ismagilov, Rustem F ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Blood coagulation; Blood flow; Coagulation; Vascular biology

Indexed keywords

THROMBOPLASTIN;

ARTICLE; BLOOD; BLOOD CLOTTING; BLOOD FLOW; BLOOD FLOW VELOCITY; BLOOD VOLUME; CAPILLARY; CAPILLARY FLOW; CONTROLLED STUDY; HUMAN; MAXIMUM ALLOWABLE CONCENTRATION; MICROFLUIDIC ANALYSIS; PLASMA; PRIORITY JOURNAL; SHEAR RATE; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOCYTE RICH PLASMA; VEIN THROMBOSIS; VOLUMETRY; BLOOD RHEOLOGY; EQUIPMENT DESIGN; INSTRUMENTATION; MECHANICAL STRESS; METABOLISM; METHODOLOGY; MICROFLUIDICS; PATHOPHYSIOLOGY; THROMBOSIS; TIME;

BLOOD COAGULATION; BLOOD FLOW VELOCITY; BLOOD PLATELETS; BLOOD VOLUME; CAPILLARIES; EQUIPMENT DESIGN; HEMORHEOLOGY; HUMANS; MICROFLUIDICS; REGIONAL BLOOD FLOW; STRESS, MECHANICAL; THROMBOPLASTIN; THROMBOSIS; TIME FACTORS;

EID: 55449124272     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/ATVBAHA.108.173930     Document Type: Article

References (51)

1. Morrissey JH. Tissue factor: An enzyme cofactor and a true receptor. Thromb Haemost. 2001;86:66-74.
2. Mackman N. Triggers, targets and treatments for thrombosis. Nature. 2008;451:914-918.
3. Mackman N. Role of tissue factor in hemostasis, thrombosis, and vascular development. Arterioscler Thromb Vasc Biol. 2004;24:1015-1022.
4. Cotran RS, Kumar V, Collins T. Robbins Pathological Basis of Disease. New York: W.B. Saunders Company: 1999.
5. Okorie UM, Denney WS, Chatterjee MS, Neeves KB, Diamond SL. Determination of surface tissue factor thresholds that trigger coagulation at venous and arterial shear rates: amplification of 100 fM circulating tissue factor requires flow. Blood. 2008;111:3507-3513.
6. Gemmell CH, Turitto VT, Nemerson Y. Flow as a regulator of the activation of factor-X by tissue factor. Blood. 1988;72:1404-1406.
7. Gemmell CH, Nemerson Y, Turitto V. The effects of shear rate on the enzymatic-activity of the tissue factor factor-VIIa complex. Microvasc Res. 1990;40:327-340.
8. Nemerson Y, Turitto VT. The effect of flow on hemostasis and thrombosis. Thromb Haemost. 1991;66:272-276.
9. Tseng PY, Rele SS, Sun XL. Chaikof EL. Membrane-mimetic films containing thrombomodulin and heparin inhibit tissue factor-induced thrombin generation in a flow model. Biomaterials. 2006;27:2637-2650.
10. Contino P, Andree H, Nemerson Y. Flow dependence of factor X activation by tissue factor-factor VIIa. J Physiol Pharmacol. 1994;45:81-90.
11. Repke D, Gemmell CH, Guha A, Turitto VT, Broze GJ, Nemerson Y. Hemophilia as a defect of the tissue factor pathway of blood-coagulation-effect of factor-VIII and factor-IX on factor-X activation in a continuous-flow reactor. Proc Natl Acad Sci U S A. 1990;87:7623-7627.
12. Andree HAM, Contino PB, Repke D, Gentry R, Nemerson Y. Transport rate limited catalysis on macroscopic surfaces - the activation of factor-X in a continuous-flow enzyme reactor. Biochemistry. 1994;33:4368-4374.
13. Roth GJ. Developing relationships - arterial platelet-adhesion, glycoprolein Ib, and leucine-rich glycoproteins. Blood. 1991;77:5-19.
14. Turitto VT, Baumgartner HR. Platelet interaction with subendothelium in flowing rabbit-blood-effect of blood shear rate. Microvasc Res. 1979;17:38-54.
15. Beltrami E, Jesty J. The role of membrane patch size and flow in regulating a proteolytic feedback threshold on a membrane: possible application in blood coagulation. Math Biosci. 2001;172:1-13.
16. Agu O, Hamilton G, Baker D. Graduated compression stockings in the prevention of venous thromboembolisrn. Br J Surg. 1999;86:992-1004.
17. Weiss HJ, Turitto VT, Baumgartner HR. Role of shear rate and platelets in promoting fibrin formation on rabbit subendothelium-studies utilizing patients with quantitative and qualitative platelet defects. J Clin Invest. 1986;78:1072-1082.
18. Tijburg PNM, Ijsseldijk MJW, Sixma JJ, Degroot PG. Quantification of fibrin deposition in flowing blood with peroxidase-labeled fibrinogen-high shear rates induce decreased fibrin deposition and appearance of fibrin monomers. Arterioscler Thromb. 1991;11:211-220.
19. Runyon MK, Johnson-Kerner BL, Ismagilov RF. Minimal functional model of hemostasis in a biomimetic microfluidic system. Angew Chem-Int Edit. 2004;43:1531-1536.
20. Kastrup CJ, Runyon MK, Shen F, Ismagilov RF. Modular chemical mechanism predicts spatiotemporal dynamics of initiation in the complex network of hemostasis. Proc Natl Acad Sci U S A. 2006;103:15747-15752.
21. Runyon MK, Johnson-Kerner BL, Kastrup CJ, Van Ha TG, Ismagilov RF. Propagation of blood clotting in the complex biochemical network of hemostasis is described by a simple mechanism. J Am Chem Soc. 2007;129:7014-7015.
22. Runyon MK, Kastrup CJ, Johnson-Kerner BL, Van Ha TG, Ismagilov RF. The effects of shear rate on propagation of blood clotting determined using microfluidics and numerical simulations. J Am Chem Soc. 2008;130:3458-3464.
23. Sakariassen KS, Hanson SR, Cadroy Y. Methods and models to evaluate shear-dependent and surface reactivity-dependent antithrombotic efficacy. Thromb Res. 2001;104:149-174.
24. Leveque MA. Transmission de chaleur par convection. 1928;13:201-2.39.
25. Ismagilov RF, Stroock AD, Kerns PJA, Whitesides G, Stone HA. Experimental and theoretical scaling laws for transverse diffusive broadening in two-phase laminar flows in microchannels. Appl Phys Lett. 2000;76:2376-2378.
26. Nishimura N, Schaffer CB, Friedman B, Tsai PS, Lyden PD, Kleinfeld D. Targeted insult to subsurface cortical blood vessels using ultrashort laser pulses: three models of stroke. Nat Methods. 2006;3:99-108.
27. Furie B, Furie BC. Thrombus formation in vivo. J Clin Invest. 2005;115:3355-3362.
28. Rowland MC, Sapuri-Butti AR, Dixit SS, Dattelbaum AM, Shreve AP, Parikh AN. Phospholipid morphologies on photochemically patterned silane monolayers. J Am Chem Soc. 2005;127:6752-6765.
29. Rand MD, Lock JB, vantVeer C, Gaffney DP, Mann KG. Blood clotting in minimally altered whole blood. Blood. 1996;88:3432-3445.
30. Lo K, Diamond SL. Blood coagulation kinetics: high throughput method for real-time reaction monitoring. Thromb Haemost. 2004;92:874-882.
31. Kastrup CJ, Shen F, Runyon MK, Ismagilov RF. Characterization of the threshold response of Initiation of blood clotting to stimulus patch size. Biophys J. 2007;93:2969-2977.
32. Kastrup CJ, Shen F, Ismagilov RF. Response to shape emerges in a complex biochemical network and its simple chemical analogue. Angew Chem-Int Edit. 2007;46:3660-3662.
33. Hathcock JJ. Flow effects on coagulation and thrombosis. Arterioscler Thromb Vasc Biol. 2006;26:1729-1737.
34. Blood Viscosity: Hyperviscosity and Hyperviscosaemia. Boston: MTP Press; 1985.
35. Song H, Chen DL, Ismagilov RF. Reactions in droplets in microflulidic channels. Angew Chem-Int Edit. 2006;45:7336-7356.
36. Basmadjian D. The effect of flow and mass-transport in thrombogenesis. 1990;18:685-709.
37. Koyayash. T, Laidler KJ. Theory of kinetics of reactions catalyzed by enzymes attached to interior surfaces of tubes. Biotechnol Bioeng. 1974;16:99-118.
38. Ataullakhanov FI, Panteleev MA. Mathematical modeling and computer simulation in blood coagulation. Pathophysiol Haemost Thromb. 2005;34:60-70.
39. Hall CL, Slack SM, Turitto VT. A computational analysis of FXa generation by TF: FVIIa on the surface of rat vascular smooth muscle cells. Ann Biomed Eng. 1998;26:28-36.
40. Fogelson AL, Tania N. Coagulation under flow: the influence of flow-mediated transport on the initiation and inhibition of coagulation. Pathophysiol Haemost Thromb. 2005;34:91-108.
41. Thomas DP. Effect of catecholamines on platelet aggregation caused by thrombin. Nature. 1967;215:298-299.
42. Neeves KB, Diamond SL. A membrane-based microfluidic device for controlling the flux of platelet agonists into flowing blood. Lab Chip. 2008;8:701-709.
43. Marsik C, Quehenberger P, Mackman N, Osterud B, Luther T, Jilma B. Validation of a novel tissue factor assay in experimental human endotoxemia. Thromb Res. 2003;111:311-315.
44. Tilley RE, Holscher T, Belani R, Nieva J, Mackman N. Tissue factor activity is increased in a combined platelet and microparticle sample from cancer patients. Thromb Res. In press.
45. Mann KG, Whelihan MF, Butenas S, Orfeo T. Citrate anticoagulation and the dynamics of thrombin generation. J Thromb Haemost. 2007;5:2055-2061.
46. Lowe GDO. Virchow's triad revisited: Abnormal flow. Pathophysiol Haemost Thromb. 2003;33:455-457.
47. Jamieson R, Calderwood CJ, Greer IA. The effect of graduated compression stockings on blood velocity in the deep venous system of the lower limb in the postnatal period. Bjog. 2007;114:1292-1294.
48. Esmon CT. The roles of protein-C and thrombomodulin in the regulation of blood-coagulation. J Biol Chem. 1989;264:4743-4746.
49. Murray CD. The physiological principle of minimum work I. The vascular system and the cost of blood volume. Proc Natl Acad Sci U S A. 1926;12:207-214.
50. Rao LVM, Pendurthi UR. Regulation of tissue factor-factor VIIa expression on cell surfaces: A role for tissue factor-factor Vila endocytosis. Mol Cell Biochem. 2003;253:131-140.
51. Lin MC, AlmusJacobs F, Chen HH, Parry GCN, Mackman N, Shyy JYJ, Chien S. Shear stress induction of the tissue factor gene. J Clin Invest. 1997;99:737-744.