Magnetic susceptibility as a B0 field strength independent MRI biomarker of liver iron overload

Magnetic Resonance in Medicine

Volumn 70, Issue 3, 2013, Pages 648-656

  Hernando, Diego ^a   Cook, Rachel J ^b   Diamond, Carol ^b   Reeder, Scott B ^a,b,c  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c University of Wisconsin Madison   (United States)

Author keywords

chemical shift encoded imaging; field map; iron overload; liver; magnetic resonance imaging; susceptibility

Indexed keywords

CHEMICAL SHIFT; CONVOLUTION; LIVER; MAGNETIC RESONANCE IMAGING; MAGNETIC SUSCEPTIBILITY; MAGNETISM; MAPPING; PHANTOMS; TISSUE;

FIELD STRENGTHS; GOOD CORRELATIONS; INDEPENDENT MEASUREMENT; IRON CONCENTRATIONS; IRON OVERLOADS; NON-LOCAL EFFECT; SUBCUTANEOUS ADIPOSE TISSUES; SUSCEPTIBILITY MAPPING;

IRON;

BIOLOGICAL MARKER; SUPERPARAMAGNETIC IRON OXIDE; IRON;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; IMAGE DISPLAY; IMAGE RECONSTRUCTION; IMAGING PHANTOM; IRON OVERLOAD; LIVER; MAGNETIC FIELD; MAGNETISM; MEASUREMENT; NUCLEAR MAGNETIC RESONANCE IMAGING; SUBCUTANEOUS FAT; ADULT; CHEMISTRY; FEASIBILITY STUDY; FEMALE; LIVER DISEASES; MALE; MIDDLE AGED; PROCEDURES;

ADULT; FEASIBILITY STUDIES; FEMALE; HUMANS; IRON; IRON OVERLOAD; LIVER; LIVER DISEASES; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PHANTOMS, IMAGING;

EID: 84883253342     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.24848     Document Type: Article

References (56)

1. Gordeuk VR, Bacon BR, Brittenham GM,. Iron overload: causes and consequences. Annu Rev Nutr 1987; 7: 485-508.
2. Siegelman ES, Mitchell DG, Semelka RC,. Abdominal iron deposition: metabolism, MR findings, and clinical importance. Radiology 1996; 199: 13-22.
3. Olivieri NF, Brittenham GM,. Iron-chelating therapy and the treatment of thalassemia. Blood 1997; 89: 739-761.
4. Alustiza JM, Castiella A, De Juan MD, Emparanza JI, Artetxe J, Uranga M,. Iron overload in the liver diagnostic and quantification. Eur J Radiol 2007; 61: 499-506.
5. McLeod C, Fleeman N, Kirkham J, et al. Deferasirox for the treatment of iron overload associated with regular blood transfusions (transfusional haemosiderosis) in patients suffering with chronic anaemia: a systematic review and economic evaluation. Health Technol Assess 2009; 13:iii-iv, ix-xi, 1-121.
6. Barry M, Sherlock S,. Measurement of liver-iron concentration in needle-biopsy specimens. Lancet 1971; 1: 100-103.
7. Carneiro AA, Baffa O, Fernandes JP, Zago MA,. Theoretical evaluation of the susceptometric measurement of iron in human liver by four different susceptometers. Physiol Meas 2002; 23: 683-693.
8. Brittenham GM, Badman DG,. Noninvasive measurement of iron: report of an NIDDK workshop. Blood 2003; 101: 15-19.
9. Lee MH, Means RT Jr,. Extremely elevated serum ferritin levels in a university hospital: associated diseases and clinical significance. Am J Med 1995; 98: 566-571.
10. Ratziu V, Charlotte F, Heurtier A, Gombert S, Giral P, Bruckert E, Grimaldi A, Capron F, Poynard T,. Sampling variability of liver biopsy in nonalcoholic fatty liver disease. Gastroenterology 2005; 128: 1898-1906.
11. Schenck JF,. The role of magnetic susceptibility in magnetic resonance imaging: MRI magnetic compatibility of the first and second kinds. Med Phys 1996; 23: 815-850.
12. Bauman JH, Hoffman RW,. Magnetic susceptibility meter for in vivo estimation of hepatic iron stores. IEEE Trans Biomed Eng 1967; 14: 239-243.
13. Bauman JH, Harris JW,. Estimation of hepatic iron stores by vivo measurement of magnetic susceptibility. J Lab Clin Med 1967; 70: 246-257.
14. Paulson DN, Fagaly RL, Toussaint RM,. Biomagnetic susceptometer with SQUID instrumentation. IEEE Trans Magn 1991; 27: 3249-3252.
15. Sheth S,. SQUID biosusceptometry in the measurement of hepatic iron. Pediatr Radiol 2003; 33: 373-377.
16. de Rochefort L, Brown R, Prince MR, Wang Y,. Quantitative MR susceptibility mapping using piece-wise constant regularized inversion of the magnetic field. Magn Reson Med 2008; 60: 1003-1009.
17. Langkammer C, Schweser F, Krebs N, et al. Quantitative susceptibility mapping (QSM) as a means to measure brain iron? A post mortem validation study. Neuroimage 2012; 62: 1593-1599.
18. Taylor BA, Loeffler RB, Song R, McCarville MB, Hankins JS, Hillenbrand CM,. Simultaneous field and R2* mapping to quantify liver iron content using autoregressive moving average modeling. J Magn Reson Imaging 2012; 35: 1125-1132 [published erratum appears in J Magn Reson Imaging, early view 2013;37:1254-1255.
19. Gandon Y, Guyader D, Heautot JF, Reda MI, Yaouanq J, Buhe T, Brissot P, Carsin M, Deugnier Y,. Hemochromatosis: diagnosis and quantification of liver iron with gradient-echo MR imaging. Radiology 1994; 193: 533-538.
20. St Pierre TG, Clark PR, Chua-Anusorn W,. Single spin-echo proton transverse relaxometry of iron-loaded liver. NMR Biomed 2004; 17: 446-458.
21. St Pierre TG, Clark PR, Chua-anusorn W, Fleming AJ, Jeffrey GP, Olynyk JK, Pootrakul P, Robins E, Lindeman R,. Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance. Blood 2005; 105: 855-861.
22. Wood JC, Ghugre N,. Magnetic resonance imaging assessment of excess iron in thalassemia, sickle cell disease and other iron overload diseases. Hemoglobin 2008; 32: 85-96.
23. Wood JC, Enriquez C, Ghugre N, Tyzka JM, Carson S, Nelson MD, Coates TD,. MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients. Blood 2005; 106: 1460-1465.
24. Wood JC,. Magnetic resonance imaging measurement of iron overload. Curr Opin Hematol 2007; 14: 183-190.
25. Ghugre NR, Coates TD, Nelson MD, Wood JC,. Mechanisms of tissue-iron relaxivity: nuclear magnetic resonance studies of human liver biopsy specimens. Magn Reson Med 2005; 54: 1185-1193.
26. Anderson LJ, Holden S, Davis B, et al. Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload. Eur Heart J 2001; 22: 2171-2179.
27. Hankins JS, McCarville MB, Loeffler RB, Smeltzer MP, Onciu M, Hoffer FA, Li CS, Wang WC, Ware RE, Hillenbrand CM,. R2* magnetic resonance imaging of the liver in patients with iron overload. Blood 2009; 113: 4853-4855.
28. Ghugre NR, Wood JC,. Relaxivity-iron calibration in hepatic iron overload: probing underlying biophysical mechanisms using a Monte Carlo model. Magn Reson Med 2011; 65: 837-847.
29. Chu Z, Cohen AR, Muthupillai R, Chung T, Wang ZJ,. MRI measurement of hepatic magnetic susceptibility-phantom validation and normal subject studies. Magn Reson Med 2004; 52: 1318-1327.
30. Wang ZJ, Li S, Haselgrove JC,. Magnetic resonance imaging measurement of volume magnetic susceptibility using a boundary condition. J Magn Reson 1999; 140: 477-481.
31. Wang ZJ, Fischer R, Chu Z, et al. Assessment of cardiac iron by MRI susceptometry and R2* in patients with thalassemia. Magn Reson Imaging 2010; 28: 363-371.
32. Wang ZJ, Chu Z, Chung T, Muthupillai R,. Quantification of the magnetic susceptibility of the heart using MRI: demonstration on normal subjects. In Proceedings of the 13th Annual Meeting of ISMRM, Miami, Florida, USA, 2005. p. 1666.
33. St Pierre TG, Clark PR, Chua-Anusorn W,. Measurement and mapping of liver iron concentrations using magnetic resonance imaging. Ann N Y Acad Sci 2005; 1054: 379-385.
34. Alabousi A, Al-Attar S, Joy TR, Hegele RA, McKenzie CA,. Evaluation of adipose tissue volume quantification with IDEAL fat-water separation. J Magn Reson Imaging 2011; 34: 474-479.
35. Poonawalla AH, Sjoberg BP, Rehm JL, Hernando D, Hines CD, Irarrazaval P, Reeder SB,. Adipose tissue MRI for quantitative measurement of central obesity. J Magn Reson Imaging 2013; 37: 707-716.
36. Schenck JF,. Health and physiological effects of human exposure to whole-body four-tesla magnetic fields during MRI. Ann N Y Acad Sci 1992; 649: 285-301.
37. Fischer R, Piga A, Harmatz P, Nielsen P,. Monitoring long-term efficacy of iron chelation treatment with biomagnetic liver susceptometry. Ann N Y Acad Sci 2005; 1054: 350-357.
38. Bassett ML, Halliday JW, Powell LW,. Value of hepatic iron measurements in early hemochromatosis and determination of the critical iron level associated with fibrosis. Hepatology 1986; 6: 24-29.
39. Hines CD, Yu H, Shimakawa A, McKenzie CA, Brittain JH, Reeder SB,. T1 independent, T2* corrected MRI with accurate spectral modeling for quantification of fat: validation in a fat-water-SPIO phantom. J Magn Reson Imaging 2009; 30: 1215-1222.
40. Meisamy S, Hines CD, Hamilton G, Sirlin CB, McKenzie CA, Yu H, Brittain JH, Reeder SB,. Quantification of hepatic steatosis with T1-independent, T2-corrected MR imaging with spectral modeling of fat: blinded comparison with MR spectroscopy. Radiology 2011; 258: 767-775.
41. Brau AC, Beatty PJ, Skare S, Bammer R,. Comparison of reconstruction accuracy and efficiency among autocalibrating data-driven parallel imaging methods. Magn Reson Med 2008; 59: 382-395.
42. Yu H, Shimakawa A, McKenzie CA, Lu W, Reeder SB, Hinks RS, Brittain JH,. Phase and amplitude correction for multi-echo water-fat separation with bipolar acquisitions. J Magn Reson Imaging 2010; 31: 1264-1271.
43. Walsh DO, Gmitro AF, Marcellin MW,. Adaptive reconstruction of phased array MR imagery. Magn Reson Med 2000; 43: 682-690.
44. Yu H, Shimakawa A, McKenzie CA, Brodsky E, Brittain JH, Reeder SB,. Multiecho water-fat separation and simultaneous R2* estimation with multifrequency fat spectrum modeling. Magn Reson Med 2008; 60: 1122-1134.
45. Hernando D, Liang ZP, Kellman P,. Chemical shift-based water/fat separation: a comparison of signal models. Magn Reson Med 2010; 64: 811-822.
46. Hamilton G, Yokoo T, Bydder M, Cruite I, Schroeder ME, Sirlin CB, Middleton MS,. In vivo characterization of the liver fat (1)H MR spectrum. NMR Biomed 2011; 24: 784-790.
47. Hernando D, Kellman P, Haldar JP, Liang ZP,. Robust water/fat separation in the presence of large field inhomogeneities using a graph cut algorithm. Magn Reson Med 2010; 63: 79-90.
48. Liu CY, McKenzie CA, Yu H, Brittain JH, Reeder SB,. Fat quantification with IDEAL gradient echo imaging: correction of bias from T(1) and noise. Magn Reson Med 2007; 58: 354-364.
49. Jung CW, Jacobs P,. Physical and chemical properties of superparamagnetic iron oxide MR contrast agents: ferumoxides, ferumoxtran, ferumoxsil. Magn Reson Imaging 1995; 13: 661-674.
50. Clark PR, Chua-anusorn W, St Pierre TG,. Bi-exponential proton transverse relaxation rate (R2) image analysis using RF field intensity-weighted spin density projection: potential for R2 measurement of iron-loaded liver. Magn Reson Imaging 2003; 21: 519-530.
51. Storey P, Thompson AA, Carqueville CL, Wood JC, de Freitas RA, Rigsby CK,. R2* imaging of transfusional iron burden at 3T and comparison with 1.5T. J Magn Reson Imaging 2007; 25: 540-547.
52. Kuhn JP, Hernando D, Munoz Del Rio A, Evert M, Kannengiesser S, Volzke H, Mensel B, Puls R, Hosten N, Reeder SB,. Effect of multipeak spectral modeling of fat for liver iron and fat quantification: correlation of biopsy with MR imaging results. Radiology 2012; 265: 133-142.
53. Fischer R, Harmatz PR,. Non-invasive assessment of tissue iron overload. Hematology Am Soc Hematol Educ Program 2009;2009: 215-221.
54. Hernando D, Reeder SB,. Magnetic susceptibility as a field-independent MRI biomarker of liver iron overload. In Proceedings of the 21st Annual Meeting of ISMRM, Salt Lake City, Utah, USA, 2013. p. 3848.
55. Cantillon-Murphy P, Wald LL, Zahn M, Adalsteinsson E,. Measuring SPIO and Gd contrast agent magnetization using 3 T MRI. NMR Biomed 2009; 22: 891-897.
56. Hackett S, Chua-anusorn W, Pootrakul P, St Pierre TG,. The magnetic susceptibilities of iron deposits in thalassaemic spleen tissue. Biochim Biophys Acta 2007; 1772: 330-337.