Assessment of cardiac iron by MRI susceptometry and R2* in patients with thalassemia

Magnetic Resonance Imaging

Volumn 28, Issue 3, 2010, Pages 363-371

  Wang, Zhiyue J ^a,b   Fischer, Roland ^c,d   Chu, Zili ^a,b   Mahoney Jr , Donald H ^a,b   Mueller, Brigitta U ^a,b   Muthupillai, Raja ^b,e,f   James, Ellen B ^c   Krishnamurthy, Rajesh ^a,b   Chung, Taylor ^a,b,c   Padua, Eric ^c   Vichinsky, Elliott ^c   Harmatz, Paul ^c  

^a TEXAS CHILDREN S HOSPITAL   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c CHILDREN S HOSPITAL OAKLAND   (United States)

^d UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^e PHILIPS HEALTHCARE   (United States)

^f ST LUKE S EPISCOPAL HOSPITAL   (United States)

Author keywords

Heart; Iron overload; Magnetic susceptibility; MRI; R2*; Thalassemia

Indexed keywords

DEFERIPRONE; DEFEROXAMINE; FERRITIN; HEMOSIDERIN; IRON;

ARTICLE; BETA THALASSEMIA; BLOOD TRANSFUSION; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOCARDIUM; EPICARDIUM; HEART; HEART MUSCLE RELAXATION; HEART VENTRICLE SEPTUM; HUMAN; IMAGE ANALYSIS; IRON OVERLOAD; MAGNETISM; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL;

ADULT; ALGORITHMS; BIOLOGICAL MARKERS; FEMALE; HUMANS; IMAGE ENHANCEMENT; IMAGE INTERPRETATION, COMPUTER-ASSISTED; IRON; MAGNETIC RESONANCE IMAGING; MALE; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; THALASSEMIA; YOUNG ADULT;

EID: 77649342535     PISSN: 0730725X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mri.2009.12.001     Document Type: Article

References (31)

1. Cohen A.R., Galanello R., Pennell D.J., Cunningham M.J., and Vichinsky E. Thalassemia. Hematology, the American Society of Hematology Education Program Book (2004) 14-34
2. Borgna-Pignatti C., Rugolotto S., De Stefano P., Zhao H., Cappellini M.D., Del Vecchio G.C., et al. Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine. Haematologica 89 (2004) 1187-1193
3. Fischer R., Tiemann C., Engelhardt R., Nielsen P., Durken M., Gabbe E., et al. Assessment of iron stores in children with transfusion siderosis by biomagnetic liver susceptometry. Am J Hematol 60 (1999) 289-299
4. Olivieri N.F., and Brittenham G.M. Iron-chelating therapy and the treatment of thalassemia. Blood 89 (1997) 739-761
5. Anderson L.J., Holden S., Davis B., Prescott E., Charrier C.C., Bunce N.H., et al. Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload. Eur Heart J 22 (2001) 2171-2179
6. Brittenham G.M., and Badman D.G. Noninvasive measurement of iron: report of an NIDDK workshop. Blood 101 (2003) 15-19
7. Ghugre N.R., Enriquez C.M., Coates T.D., Nelson M.D.J., and Wood J.C. Improved R2* measurements in myocardial iron overload. J Magn Reson Imaging 23 (2006) 9-16
8. Wood J.C., Tyszka J.M., Carson S., Nelson M.D., and Coates T.D. Myocardial iron loading in transfusion-dependent thalassemia and sickle cell disease. Blood 103 (2004) 1934-1936
9. Maris T.G., Papakonstantinou O., Chatzimanoli V., Papadakis A., Pagonidis K., Papanikolaou N., et al. Myocardial and liver iron status using a fast T*2 quantitative MRI (T*2qMRI) technique. Magn Reson Med 57 (2007) 742-753
10. Di Tucci A.A., Matta G., Deplano S., Gabbas A., Depau C., Derudas D., et al. Myocardial iron overload assessment by T2* magnetic resonance imaging in adult transfusion dependent patients with acquired anemias. Haematologica 93 (2008) 1385-1388
11. Tanner M.A., Galanello R., Dessi C., Smith G.C., Westwood M.A., Agus A., et al. A randomized, placebo-controlled, bouble-blind trial of the effect of combined therapy with deferoxamine and deferiprone on myocardial iron in thalassemia major using cardiovascular magnetic resonance. Circulation 115 (2007) 1876-1884
12. Fischer R., and Engelhardt R. Deferiprone versus desferrioxamine in thalassemia, and T2* validation and utility. Lancet 361 (2003) 182-183
13. Bauman J.H., and Harris J.W. Estimation of hepatic iron stores by in vivo measurement of magnetic susceptibility. J Lab Clin Med 70 (1967) 246-257
14. Brittenham G.M., Farrell D.E., Harris J.W., Feldman E.S., Danish E.H., Muir W.A., et al. Magnetic-susceptibility measurement of human iron stores. N Engl J Med 307 (1982) 1671-1675
15. Fischer R., Piga A., Harmatz P., and Nielsen P. Monitoring long-term efficacy of iron chelation treatment with biomagnetic liver susceptometry. Ann NY Acad Sci 1054 (2005) 350-357
16. Wang Z.J., Lian L., Chen Q., Zhao H., Asakura T., and Cohen A.R. 1/T2 and magnetic susceptibility measurements in a gerbil cardiac iron overload model. Radiology 234 (2005) 749-755
17. Bluemke D.A., and Liddell R.P. Science to practice: can MR imaging provide a noninvasive "biopsy" of the heart to measure iron levels?. Radiology 234 (2005) 647-648
18. Ogg R., Langston J., Haacke E., Steen R., and Taylor J. The correlation between phase shifts in gradient-echo MR images and regional brain iron concentration. Magn Reson Imaging 17 (1999) 1141-1148
19. Haacke E.M., Cheng N.Y., House M.J., Liu Q., Neelavalli J., Ogg R.J., et al. Imaging iron stores in the brain using magnetic resonance imaging. Magn Reson Imaging 23 (2005) 1-25
20. Chu Z., Cohen A.R., Muthupillai R., Chung T., and Wang Z.J. MRI measurement of hepatic magnetic susceptibility-phantom validation and normal subject studies. Magn Reson Med 52 (2004) 1318-1327
21. de Rochefort L., Brown R., Prince M.R., and Wang Y. Quantitative MR susceptibility mapping using piece-wise constant regularized inversion of the magnetic field. Magn Reson Med 60 (2008) 1003-1009
22. Wang Z.J., Li S., and Haselgrove J.C. Magnetic resonance imaging measurement of volume magnetic susceptibility using a boundary condition. J Magn Reson 140 (1999) 477-481
23. Dixon R.M., Styles P., Al-Refaie F.N., Kemp G.J., Donohue S.M., Wonke B., et al. Assessment of hepatic iron overload in thalassemic patients by magnetic resonance spectroscopy. Hepatology 19 (1994) 904-910
24. Bush V.J., Moyer T.P., Batts K.P., and Parisi J.E. Essential and toxic element concentrations in fresh and formalin-fixed human autopsy tissues. Clin Chem 41 (1995) 284-294
25. Weisskoff R.M., and Kiihne S. MRI susceptometry: image-based measurement of absolute susceptibility of MR contrast agents and human blood. Magnetic Resonance in Medicine 24 (1992) 375-383
26. Ghugre N.R., Enriquez C.M., Gonzalez I., Nelson M.D.J., Coates T.D., and Wood J.C. MRI detects myocardial iron in the human heart. Magn Reson Med 56 (2006) 681-686
27. Pennell D.J., Anderson L.J., Paul K., Forni G.L., Ellis G., Walker J.M., et al. Calibration of myocardial T2* values in post-mortem hearts. Blood 106 (2005) [abstract 3837]
28. Buja L.M., and Roberts W.C. Iron in the heart. Etiology and clinical significance. Am J Med 51 (1971) 209-221
29. Sanyal S.K., Johnson W., Jayalakshmamma B., and Green A.A. Fatal "iron heart" in an adolescent: biochemical and ultrastructural aspects of the heart. Pediatrics 55 (1975) 336-341
30. Olson L.J., Edwards W.D., McCall J.T., Ilstrup D.M., and Gersh B.J. Cardiac iron deposition in idiopathic hemochromatosis: histologic and analytic assessment of 14 hearts from autopsy. J Am Coll Cardiol 10 (1987) 1239-1243
31. Pennell D.J., Berdoukas V., Karagiorga M., Ladis V., Piga A., Aessopos A., et al. Randomized controlled trial of deferiprone or deferoxamine in beta-thalassemia major patients with asymptomatic myocardial siderosis. Blood 107 (2006) 3738-3744