Inhibition of geranylgeranyltransferase attenuates neutrophil accumulation and tissue injury in severe acute pancreatitis

Journal of Leukocyte Biology

Volumn 94, Issue 3, 2013, Pages 493-502

  Merza, Mohammed ^a   Wetterholm, Erik ^a   Zhang, Su ^a   Regner, Sara ^a   Thorlacius, Henrik ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Chemikine; Extravasation; Inflammation; L arginine; Myeloperoxidase; Pancreas

Indexed keywords

ARGININE; CD11B ANTIGEN; CXCL2 CHEMOKINE; GERANYLGERANYLTRANSFERASE; GERANYLTRANSFERASE; GGTI 2133; INTERLEUKIN 6; MYELOPEROXIDASE; TAUROCHOLIC ACID; TRANSFERASE INHIBITOR; TRYPSINOGEN; UNCLASSIFIED DRUG;

ACINAR CELL; ACUTE PANCREATITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATTENUATION; BLEEDING; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; DRUG INFUSION; EDEMA; ENZYME ACTIVITY; ENZYME INHIBITION; IN VITRO STUDY; IN VIVO STUDY; LUNG; MALE; MOUSE; NEUTROPHIL; NONHUMAN; PANCREAS; PANCREAS DUCT; PLASMA; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TISSUE INJURY;

CHEMIKINE; EXTRAVASATION; INFLAMMATION; L-ARGININE; MYELOPEROXIDASE; PANCREAS;

ACINAR CELLS; ACUTE DISEASE; ALKYL AND ARYL TRANSFERASES; ANIMALS; CHEMOKINE CXCL2; IMIDAZOLES; LEUCINE; MACROPHAGE-1 ANTIGEN; MALE; MICE; MICE, INBRED C57BL; NAPHTHALENES; NEUTROPHIL INFILTRATION; NEUTROPHILS; PANCREATITIS; PRENYLATION; RAC1 GTP-BINDING PROTEIN; TRYPSINOGEN;

EID: 84883235825     PISSN: 07415400     EISSN: 19383673     Source Type: Journal    
DOI: 10.1189/jlb.1112546     Document Type: Article

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