Binding of a third metal ion by the human phosphatases PP2Cα and Wip1 is required for phosphatase activity

Biochemistry

Volumn 52, Issue 34, 2013, Pages 5830-5843

  Tanoue, Kan ^a   Miller Jenkins, Lisa M ^a   Durell, Stewart R ^a   Debnath, Subrata ^a   Sakai, Hiroyasu ^a   Tagad, Harichandra D ^a   Ishida, Kazushige ^a   Appella, Ettore ^a   Mazur, Sharlyn J ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTALLOGRAPHIC STRUCTURE; HIGH-AFFINITY SITES; ISOTHERMAL TITRATION CALORIMETRY; MILLIMOLAR CONCENTRATIONS; MUTATIONAL ANALYSIS; PHOSPHATASE ACTIVITY; PHYSIOLOGICAL FUNCTIONS; SUBSTRATE SPECIFICITY;

CATALYST ACTIVITY; MANGANESE; METAL IONS; SUBSTRATES;

PHOSPHATASES;

AMINO ACID; MAGNESIUM ION; MANGANESE; PHOSPHOPEPTIDE; PROTEIN TYROSINE PHOSPHATASE SHP 2; UNCLASSIFIED DRUG; WIP1 ENZYME;

ARTICLE; BINDING AFFINITY; BINDING SITE; CATALYSIS; ENZYME ACTIVITY; ENZYME BINDING; HUMAN; HUMAN CELL; ISOTHERMAL TITRATION CALORIMETRY; MUTATIONAL ANALYSIS; PRIORITY JOURNAL;

ALANINE; AMINO ACID SEQUENCE; ASPARTIC ACID; CATALYSIS; CATALYTIC DOMAIN; HEK293 CELLS; HUMANS; MAGNESIUM; MANGANESE; PHOSPHOPEPTIDES; PHOSPHOPROTEIN PHOSPHATASES; SEQUENCE ALIGNMENT;

EID: 84883219854     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi4005649     Document Type: Article

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