Synchrotron microbeam radiation therapy induces hypoxia in intracerebral gliosarcoma but not in the normal brain

Radiotherapy and Oncology

Volumn 108, Issue 1, 2013, Pages 143-148

  Bouchet, Audrey ^a,b   Lemasson, Benjamin ^a,b   Christen, Thomas ^a,b   Potez, Marine ^a,b   Rome, Claire ^a,b   Coquery, Nicolas ^a,b   Le Clec'H, Céline ^a   Moisan, Anaick ^a,b   Bräuer Krisch, Elke ^a   Leduc, Géraldine ^a   Rémy, Chantal ^a,b   Laissue, Jean A ^c   Barbier, Emmanuel L ^a,b   Brun, Emmanuel ^a,d   Serduc, Raphaël ^a,b  

^a EUROPEAN SYNCHROTRON RADIATION FACILITY   (France)

^b UNIV GRENOBLE ALPES   (France)

^c UNIVERSITY OF BERN   (Switzerland)

^d UNIVERSITY OF MUNICH   (Germany)

Author keywords

Brain tumors; MRI; Oxygen saturation; Rat; Synchrotron microbeam radiation therapy; Vessel radiation responses

Indexed keywords

BIOLOGICAL MARKER; GELATINASE A; GLUCOSE TRANSPORTER 1; MEMBRANE PROTEIN; RECA 1 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD OXYGEN TENSION; BLOOD VESSEL DENSITY; CANCER RADIOTHERAPY; CONTROLLED STUDY; DENSITY; DISEASE MARKER; GLIOSARCOMA; HYPOXIA; IMMUNOHISTOLOGY; IMMUNOREACTIVITY; INTRACEREBRAL GLIOSARCOMA; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; OXYGENATION; PARAMETERS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RADIOLOGICAL PARAMETERS; RAT; SYNCHROTRON MICROBEAM RADIATION THERAPY; SYNCHROTRON RADIATION; TISSUE REACTION; TUMOR VASCULAR REMODELING; TUMOR VASCULARIZATION;

BRAIN TUMORS; MRI; OXYGEN SATURATION; RAT; SYNCHROTRON MICROBEAM RADIATION THERAPY; VESSEL RADIATION RESPONSES;

ANIMALS; BRAIN; BRAIN NEOPLASMS; GLIOSARCOMA; GLUCOSE TRANSPORTER TYPE 1; MAGNETIC RESONANCE IMAGING; OXYGEN; RATS; SYNCHROTRONS; X-RAY THERAPY;

EID: 84883203453     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2013.05.013     Document Type: Article

References (32)

1. E. Brauer-Krisch, R. Serduc, and E.A. Siegbahn Effects of pulsed, spatially fractionated, microscopic synchrotron X-ray beams on normal and tumoral brain tissue Mutat Res 704 2010 160 166
2. J.A. Laissue, G. Geiser, and P.O. Spanne Neuropathology of ablation of rat gliosarcomas and contiguous brain tissues using a microplanar beam of synchrotron-wiggler-generated X rays Int J Cancer 78 1998 654 660
3. A. Bouchet, B. Lemasson, and G. Leduc Preferential effect of synchrotron microbeam radiation therapy on intracerebral 9L gliosarcoma vascular networks Int J Radiat Oncol Biol Phys 78 2010 1503 1512
4. R. Serduc, T. Christen, and J. Laissue Brain tumor vessel response to synchrotron microbeam radiation therapy: a short-term in vivo study Phys Med Biol 53 2008 3609 3622
5. R. Serduc, P. Verant, and J.C. Vial In vivo two-photon microscopy study of short-term effects of microbeam irradiation on normal mouse brain microvasculature Int J Radiat Oncol Biol Phys 64 2006 1519 1527
6. J.A. Laissue, H. Blattmann, and H.P. Wagner Prospects for microbeam radiation therapy of brain tumours in children to reduce neurological sequelae Dev Med Child Neurol 49 2007 577 581
7. J.C. Crosbie, R.L. Anderson, and K. Rothkamm Tumor cell response to synchrotron microbeam radiation therapy differs markedly from cells in normal tissues Int J Radiat Oncol Biol Phys 77 2010 886 894
8. J.H. Kim, Y.G. Chung, and C.Y. Kim Upregulation of VEGF and FGF2 in normal rat brain after experimental intraoperative radiation therapy J Korean Med Sci 19 2004 879 886
9. K.E. Hovinga, L.J. Stalpers, and C. Van Bree Radiation-enhanced vascular endothelial growth factor (VEGF) secretion in glioblastoma multiforme cell lines - a clue to radioresistance? J Neurooncol 74 2005 99 103
10. J. Brieger, P. Schroeder, and J. Gosepath VEGF-subtype specific protection of SCC and HUVECs from radiation induced cell death Int J Mol Med 15 2005 145 151
11. J. Brieger, P. Schroeder, and J. Gosepath Vascular endothelial growth factor and basic fibroblast growth factor are released by squamous cell carcinoma cells after irradiation and increase resistance to subsequent irradiation Int J Mol Med 16 2005 159 164
12. C. Magnon, P. Opolon, and M. Ricard Radiation and inhibition of angiogenesis by canstatin synergize to induce HIF-1alpha-mediated tumor apoptotic switch J Clin Invest 117 2007 1844 1855
13. M. Kioi, H. Vogel, and G. Schultz Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice J Clin Invest 120 2010 694 705
14. B.J. Moeller, Y. Cao, and C.Y. Li Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules Cancer Cell 5 2004 429 441
15. D. Zhao, A. Constantinescu, and C.-H. Chang Correlation of tumor oxygen dynamics with radiation response of the dunning prostate R3327-HI tumor Radiat Res 159 2003 621 631
16. A.W. Fyles, M. Milosevic, and R. Wong Oxygenation predicts radiation response and survival in patients with cervix cancer Radiother Oncol 48 1998 149 156
17. T. Christen, B. Lemasson, and N. Pannetier Evaluation of a quantitative bold approach to map local blood oxygen saturation NMR Biomed 24 2011 393 403
18. Q.T. Le, and D. Courter Clinical biomarkers for hypoxia targeting Cancer Metastasis Rev 27 2008 351 362
19. R. Serduc, E. Brauer-Krisch, and A. Bouchet First trial of spatial and temporal fractionations of the delivered dose using synchrotron microbeam radiation therapy J Synchrotron Radiat 16 2009 587 590
20. N. Otsu A threshold selection method from gray-level histograms IEEE Trans Syst Man Cybern 9 1979 62 66
21. B. Lemasson, T. Christen, and R. Serduc Evaluation of the relationship between MR estimates of blood oxygen saturation and hypoxia: effect of an antiangiogenic treatment on a gliosarcoma model Radiology 265 2012 743 752
22. - enough to assess oxygenation? Quantitative blood oxygen level-dependent analysis in brain tumor Radiology 262 2012 495 502
23. M.A. Mintun, B.N. Lundstrom, and A.Z. Snyder Blood flow and oxygen delivery to human brain during functional activity: theoretical modeling and experimental data Proc Natl Acad Sci USA 98 2001 6859 6864
24. N. Lyubimova, and J.W. Hopewell Experimental evidence to support the hypothesis that damage to vascular endothelium plays the primary role in the development of late radiation-induced CNS injury Br J Radiol 77 2004 488 492
25. N.V. Lyubimova, P.G. Coultas, and K. Yuen In vivo radioprotection of mouse brain endothelial cells by Hoechst 33342 Br J Radiol 74 2001 77 82
26. A.L. Harris Hypoxia - a key regulatory factor in tumour growth Nat Rev Cancer 2 2002 38 47
27. E.L. Lund, A. Hog, and M.W. Olsen Differential regulation of VEGF, HIF1alpha and angiopoietin-1, -2 and -4 by hypoxia and ionizing radiation in human glioblastoma Int J Cancer 108 2004 833 838
28. Y. Yoshii, and K. Sugiyama Intercapillary distance in the proliferating area of human glioma Cancer Res 48 1988 2938 2941
29. P. Carmeliet, and R.K. Jain Angiogenesis in cancer and other diseases Nature 407 2000 249 257
30. A. Bouchet, A. Boumendjel, and E. Khalil Chalcone JAI-51 improves efficacy of synchrotron microbeam radiation therapy of brain tumors J Synchrotron Radiat 19 2012 478 482
31. O. Cuisnier, R. Serduc, and J.P. Lavieille Chronic hypoxia protects against gamma-irradiation-induced apoptosis by inducing bcl-2 up-regulation and inhibiting mitochondrial translocation and conformational change of bax protein Int J Oncol 23 2003 1033 1041
32. A.E. Greijer, and E. Van der Wall The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis J Clin Pathol 57 2004 1009 1014