Repeated oral administration of capsaicin increases anxiety-like behaviours with prolonged stress-response in rats

Journal of Biosciences

Volumn 38, Issue 3, 2013, Pages 561-571

  Choi, Y J ^a,b   Kim, J Y ^a   Yoo, S B ^a   Lee, J H ^a   Jahng, J W ^a  

^a Seoul National University   (South Korea)

^b Chung Ang University   (South Korea)

Author keywords

Anxiety; depression; hypothalamic pituitary adrenal axis; oral capsaicin; stress

Indexed keywords

CAPSAICIN; CORTICOSTERONE; PROTEIN C FOS;

BEHAVIORAL RESPONSE; DRUG PRESCRIBING; HORMONE; PATHOLOGY; PHYSIOLOGY; PLASMA; RODENT;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DISEASE EXACERBATION; EMOTION; FORCED SWIMMING TEST; GROOMING; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMOBILIZATION; MALE; MAZE TEST; NONHUMAN; OUTCOME ASSESSMENT; PARAVENTRICULAR THALAMIC NUCLEUS; PATHOPHYSIOLOGY; PEPPER; PROTEIN EXPRESSION; PSYCHOLOGICAL ASPECT; RAT; SOLITARY TRACT NUCLEUS; STEREOTYPY; STRESS; TASK PERFORMANCE;

CAPSICUM FRUTESCENS; RATTUS;

ADMINISTRATION, ORAL; ANIMALS; ANXIETY; BEHAVIOR, ANIMAL; CAPSAICIN; GENE EXPRESSION REGULATION; PHYSICAL EXERTION; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, WISTAR; STRESS, PHYSIOLOGICAL;

EID: 84883176422     PISSN: 02505991     EISSN: 09737138     Source Type: Journal    
DOI: 10.1007/s12038-013-9340-9     Document Type: Article

References (66)

1. Albenidou-Farmaki E, Poulopoulos AK, Epivatianos A, Farmakis K, Karamouzis M and Antoniades D 2008 Increased anxiety level and high salivary and serum cortisol concentrations in patients with recurrent aphthous stomatitis. Tohoku J. Exp. Med. 214 291-296
2. Ara I and Bano S 2012 Citalopram decreases tryptophan 2,3-dioxygenase activity and brain 5-HT turnover in swim stressed rats. Pharmacol. Rep. 64 558-566
3. Barros HM, Tannhauser SL, Tannhauser MA and Tannhauser M 1994 The effects of GABAergic drugs on grooming behaviour in the open field. Pharmacol. Toxicol. 74 339-344
4. Berthoud HR and Neuhuber WL 2000 Functional and chemical anatomy of the afferent vagal system. Auton. Neurosci. 85 1-17
5. Bevan S and Szolcsányi J 1990 Sensory neuron-specific actions of capsaicin: mechanisms and application. Trends Pharmacol. Sci. 11 330-333
6. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levin JD and Julius D 1997 The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 380 816-824
7. Daniels WM, Pietersen CY, Carstens ME and Stein DJ 2004 Maternal separation in rats lead to anxiety-like behavior and a blunted ACTH response and altered neurotransmitter levels in response to a subsequent stressor. Metab. Brain Dis. 19 3-14
8. Di Marzo V, Lastres-Becker I, Bisogno T, De Petrocellis L, Milone A, Davis JB and Fernandez-Ruiz JJ 2001a Hypolocomotor effects in rats of capsaicin and two long chain capsaicin homologues. Eur. J. Pharmacol. 420 123- 131
9. Di Marzo V, Bisogno T and De Petrocellis L 2001b Anandamide: some like it hot. Trends Pharmacol. Sci. 22 346-349
10. Di Marzo V, Gobbi G and Szallasi A 2008 Brain TRPV1: a depressing TR(i)P down memory lane? Trends Pharmacol. Sci. 29 594-600
11. Djordjevic J, Djordjevic A, Adzic M and Radojcic MB 2012 Effects of chronic social isolation on Wistar rat behavior and brain plasticity markers. Neuropsychobiology 66 112-119
12. Ferre P, Fernandez-Teruel A, Escorihuela RM, Driscoll P, Corda MG, Giorgi O and Tobena A 1995 Behavior of the Roman/Verh high- and low-avoidance rat lines in anxiety tests: relationship with defecation and self grooming. Physiol. Behav. 58 1209-1213
13. Fraser KA, Raizada E, Davison JS 1995 Oral-pharyngeal-esophageal and gastric cues contribute to meal-induced c-fos expression. Am. J. Physiol. 268 R223-R230
14. Green BG and Hayes JE 2003 Capsaicin as a probe of the relationship between bitter taste and chemesthesis. Physiol. Behav. 79 811-821
15. Green BG and Schullery MT 2003 Stimulation of bitterness by capsaicin and menthol: differences between lingual areas innervated by the glossopharyngeal and chorda tympani nerves. Chem. Senses 28 45-55
16. Gu XF, Lee JH, Yoo SB, Moon YW and Jahng JW 2009 Intra-oral pre-treatment with capsaicin increases consumption of sweet solutions in rats. Nutr. Neurosci. 12 149-154
17. Guo A, Vulchanova L, Wang J, Li X and Elde R 1999 Immunocytochemical localization of the vanilloid receptor 1 (VR1): relationship to neuropeptides, the P2X3 purinoceptor and IB4 binding sites. Eur. J. Neurosci. 11 946-958
18. Hajos M, Svensson K, Nissbrandt H, Obal Jr F and Carlsson A 1986 Effects of capsaicin on central monoaminergic mechanisms in the rat. J. Neural Transm. 66 221-242
19. Harrer MI and Travers SP 1996 Topographic organization of Fos-like immunoreactivity in the rostral nucleus of the solitary tract evoked by gustatory stimulation with sucrose and quinine. Brain Res. 711 125-137
20. Hayase T 2012 Differential effects of TRPV1 receptor ligands against nicotine-induced depression-like behaviors. BMC Pharmacol. 11 6
21. Hayes P, Meadows HJ, Gunthorpe MJ, Harries MH, Duckworth DM, Cairns W, Harrison DC, Clarke CE, et al. 2000 Cloning and functional expression of a human orthologue of rat vanilloid receptor-1. Pain 88 205-215
22. Heath TP, Melichar JK, Nutt DJ and Donaldson LF 2006 Human taste thresholds are modulated by serotonin and noradrenaline. J. Neurosci. 26 12664-12671
23. Heim C, Newport DJ, Heit S, Graham YP, Wilcox M, Bonsall R, Miller AH and Nemeroff CB 2000 Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood. JAMA 284 593-597
24. Ishida Y, Ugawa S, Ueda T, Murakami S and Shimada S 2002 Vanilloid receptor subtype-1 (VR1) is specifically localized to taste papillae. Mol. Brain Res. 107 17-22
25. Jahng JW 2011 An animal model of eating disorders associated with stressful experience in early life. Horm. Behav. 59 213-220
26. Jahng JW, Lee JH, Lee S, Lee JY, Kim GT, Houpt TA and Kim D 2004 N(omega)-nitro-L-arginine methyl ester attenuates lithium-induced c-Fos, but not conditioned taste aversion in rats. Neurosci. Res. 50 485-492
27. Jahng JW, Moon YW and Lee JH 2010 Immunohistochemical detection of capsaicin receptors in taste cells of human circumvallate papillae. Asian J. Oral Maxillofac. Surg. 22 193-197
28. Jones NG, Slater R, Cadiou H, McNaughton P and McMahon SB 2004 Acid induced pain and its modulation in humans. J. Neurosci. 24 10974-10979
29. Kalueff AV, Aldridge JW, LaPorte JL, Murphy DL and Tuohimaa P 2007 Analyzing grooming microstructure in neurobehavioral experiments. Nat. Protoc. 2 2538-2544
30. Kalueff AV and Tuohimaa P 2004 Grooming analysis algorithm for neurobehavioural stress research. Brain Res. Brain Res. Protoc. 13 151-158
31. Kalueff AV and Tuohimaa P 2005 Contrasting grooming phenotypes in three mouse strains markedly different in anxiety and activity (129S1, BALB/c and NMRI). Behav. Brain Res. 160 1-10
32. Kasckow JW, Mulchahey JJ and Geracioti Jr TD 2004 Effects of the vanilloid agonist olvanil and antagonist capsazepine on rat behaviors. Prog. Neuropsychopharmacol. Biol. Psychiatry 28 291-295
33. Kido MA, Muroya H, Yamaza T, Terada Y and Tanaka T 2003 Vanilloid receptor expression in the rat tongue and palate. J. Dent. Res. 82 393-397
34. Kompagne H, Bardos G, Szenasi G, Gacsalyi I, Harsing LG and Levay G 2008 Chronic mild stress generates clear depressive but ambiguous anxiety-like behaviour in rats. Behav. Brain Res. 192 311-314
35. Lastres-Becker I, de Miguel R, De Petrocellis L, Makriyannis A, Di Marzo V and Fernandez-Ruiz J 2003 Compounds acting at the endocannabinoid and/or endovanilloid systems reduce hyperkinesia in a rat model of Huntington's disease. J. Neurochem. 84 1097-1109
36. Lee J, Di Marzo V and Brotchie JM 2006 A role for vanilloid receptor 1 (TRPV1) and endocannabinnoid signalling in the regulation of spontaneous and L-DOPA induced locomotion in normal and reserpine-treated rats. Neuropharmacology 51 557-565
37. Liu L and Simon SA 2001 Acidic stimuli activates two distinct pathways in taste receptor cells from rat fungiform papillae. Brain Res. 923 58-70
38. Marsch R, Foeller E, Rammes G, Bunck M, Kössl M, Holsboer F, Zieglgansberger W, Landgraf R, et al. 2007 Reduced anxiety, conditioned fear, and hippocampal long-term potentiation in transient receptor potential vanilloid type 1 receptor-deficient mice. J. Neurosci. 27 832-839
39. Mezey E, Toth ZE, Cortright DN, Arzubi MK, Krause JE, Elde R, Guo A, Blumberg PM and Szallasi A 2000 Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human. Proc. Natl. Acad. Sci. USA 97 3655-3660
40. Micale V, Cristino L, Tamburella A, Petrosino S, Leggio GM, Drago F and Di Marzo V 2009 Anxiolytic effects in mice of a dual blocker of fatty acid amide hydrolase and transient receptor potential vanilloid Type-1 channels. Neuropsychopharmacology 34 593-606
41. Moon YW, Lee J-H, Yoo SB and Jahng JW 2010 Capsaicin receptors are colocalized with sweet/bitter receptors in the taste sensing cells of circumvallate papillae. Genes Nutr. 5 251-255
42. Moreira FA, Aguiar DC, Terzian ALB, Guimaraes FS and Wotjak CT 2012 Cannabinoid type 1 receptors and transient receptor potential vanilloid type 1 channels in fear and anxiety-two sides of one coin? Neuroscience 204 186-192
43. Nosek K, Dennis K, Andrus BM, Ahmadiyeh N, Baum AE, Solberg Woods LC and Redei EE 2008 Context and strain-dependent behavioral response to stress. Behav. Brain Funct. 4 23
44. Park K, Brown PD, Kim YB and Kim J-S 2003 Capsaicin modulates K+ currents from dissociated rat taste receptor cells. Brain Res. 962 135-143
45. Park ES, Jo S, Yi SJ, Kim JS, Lee HS, Lee IS, Seo KM, Sung JK, et al. 2004 Effect of capsaicin on cholecystokinin and neuropeptide Y expressions in the brain of high-fat diet fed rats. J. Vet. Med. Sci. 66 107-114
46. Paxinos G and Watson C 2005 The rat brain in stereotaxic coordinates (San Diego: Elsevier Academic Press)
47. Pecoraro N and Dallman MF 2005 c-Fos after incentive shifts: expectancy, incredulity, and recovery. Behav. Neurosci. 119 366-387
48. Piato AL, Detanico BC, Jesus JF, Lhullier FL, Nunes DS and Elisabetsky E 2008 Effects of Marapuama in the chronic mild stress model: Further indication of antidepressant properties. J. Ethnopharmacol. 118 300-304
49. Porsolt RD, Le Pichon M and Jalfre M 1977 Depression: a new animal model sensitive to antidepressant treatments. Nature 266 730-732
50. Prescott J and Stevenson RJ 1995 Effects of oral chemical irritation on tastes and flavors in frequent and infrequent users of chili. Physiol. Behav. 58. 1117-1127
51. Rinaman L, Baker EA, Hoffman GE, Stricker EM and Verbalis JG 1998 Medullary c-Fos activation in rats after ingestion of a satiating meal. Am. J. Physiol. 275 R262- 268
52. Rubino T, Realini N, Castiglioni C, Guidali C, Vigano' D, Marras E, Petrosino S, Perletti G, et al. 2008 Role in anxiety behavior of the endocannabinoid system in the prefrontal cortex. Cereb. Cortex 18 1292-1301
53. Simons CT, O'Mahony M and Carstens E 2002 Taste suppression following lingual capsaicin pre-treatment in humans. Chem. Senses 27 353-365
54. Scinska A, Sienkiewicz-Jarosz H, Kuran W, Ryglewicz D, Rogowski A, Wrobel E, Korkosz A, Kukwa A, Kostowski W and Bienkowski P 2004 Depressive symptoms and taste reactivity in humans. Physiol. Behav. 82 899-904
55. Starowicz K, Cristino L and Di Marzo V 2008 TRPV1 receptors in the central nervous system: potential for previously unforeseen therapeutic applications. Curr. Pharm. Des. 14 42-54
56. Szabo T, Biro T, Gonzalez AF, Palkovits M and Blumberg PM 2002 Pharmacological characterization of vanilloid receptor located in the brain. Brain Res. Mol. Brain. Res. 98 51-57
57. Tominaga M, Caterina MJ, Malmberg AB, Rosen TA, Gilbert H, Skinner K, Raumann BE, Basbaum AI and Julius D 1998 The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron 21 531-543
58. Tsukamoto G and Adachi A 1994 Neural responses of rat area postrema to stimuli producing nausea. J. Auton. Nerv. Syst. 49 55-60
59. Watanabe T, Kawada T and Iwai K 1987 Enhancement by capsaicin of energy metabolism in rats through secretion of catecholamine from adrenal medulla. Agric. Biol. Chem. 51 75-79
60. Westerterp-Plantenga MS, Smeets A and Lejeune MPG 2005 Sensory and gastrointestinal satiety effects of capsaicin on food intake. Int. J. Obesity 29 682-688
61. Wood J 1993 Capsaicin in the study of pain (New York: Academic Press)
62. Yalcin I, Aksu F, Bodard S, Chalon S and Belzung C 2007 Antidepressant-like effect of tramadol in the unpredictable chronic mild stress procedure: possible involvment of the noradrenergic system. Behav. Pharmacol. 18 623-631
63. Yamamoto T 1998 Electrophysiology of CTA; in Conditioned Taste Aversion: Memory of a special kind (eds) J Bures, F Bermúdez-Rattoni and T Yamamoto (New York: Oxford University Press) pp 76-107
64. Yoshioka M, St-Pierre S, Suzuki M and Tremblay A 1998 Effects of red pepper added to high-fat and high-carbohydrate meals on energy metabolism and substrate utilization in Japanese women. Br. J. Nutr. 80 503-510
65. Yoshioka M, St-Pierre S, Drapeau V, Dionne I, Doucet E, Suzuki M and Tremblay A 1999 Effects of red pepper on appetite and energy intake. Br. J. Nutr. 82 115-123
66. Yoshioka M, Doucet E, Drapeau V, Dionne I and Tremblay A 2001 Combined effects of red pepper and caffeine consumption on 24 h energy balance in subjects given free access to foods. Br. J. Nutr. 85 203-211