메뉴 건너뛰기




Volumn 76, Issue , 2013, Pages 119-131

Functional expression of choline transporter-like protein 1 (CTL1) in small cell lung carcinoma cells: A target molecule for lung cancer therapy

Author keywords

Acetylcholine; Apoptosis; Cell proliferation; Choline; Small cell lung carcinoma; Transporter

Indexed keywords

4 AMINOHIPPURIC ACID; 4 DIPHENYLACETOXY 1 METHYLPIPERIDINE; 5 (N,N DIMETHYL)AMILORIDE; ACETYLCHOLINE; CARRIER PROTEIN; CASPASE 3; CASPASE 7; CATION; CHOLINE TRANSPORTER 1; CHOLINE TRANSPORTER LIKE PROTEIN 1; HEMICHOLINIUM 3; MESSENGER RNA; ORGANIC CATION TRANSPORTER 1; ORGANIC CATION TRANSPORTER 2; ORGANIC CATION TRANSPORTER 3; PHYSOSTIGMINE; PROFENAMINE; SMALL INTERFERING RNA; SODIUM ION; SODIUM PROTON EXCHANGE PROTEIN 1; SODIUM PROTON EXCHANGE PROTEIN 2; SODIUM PROTON EXCHANGE PROTEIN 3; SODIUM PROTON EXCHANGE PROTEIN 4; SODIUM PROTON EXCHANGE PROTEIN 5; UNCLASSIFIED DRUG;

EID: 84883173149     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2013.07.011     Document Type: Article
Times cited : (39)

References (59)
  • 2
    • 84865972826 scopus 로고    scopus 로고
    • Postoperative radiotherapy for elderly patients with stage III lung cancer
    • J.P. Wisnivesky, E.A. Halm, M. Bonomi, C. Smith, G. Mhango, and E. Bagiella Postoperative radiotherapy for elderly patients with stage III lung cancer Cancer 118 2012 4478 4485
    • (2012) Cancer , vol.118 , pp. 4478-4485
    • Wisnivesky, J.P.1    Halm, E.A.2    Bonomi, M.3    Smith, C.4    Mhango, G.5    Bagiella, E.6
  • 3
    • 33845296073 scopus 로고    scopus 로고
    • Development of novel therapeutic strategies for lung cancer: Targeting the cholinergic system
    • P. Russo, A. Catassi, A. Cesario, and D. Servent Development of novel therapeutic strategies for lung cancer: targeting the cholinergic system Curr Med Chem 13 2006 3493 3512
    • (2006) Curr Med Chem , vol.13 , pp. 3493-3512
    • Russo, P.1    Catassi, A.2    Cesario, A.3    Servent, D.4
  • 4
    • 0037229715 scopus 로고    scopus 로고
    • Acetylcholine is synthesized by and acts as an autocrine growth factor for small cell lung carcinoma
    • P. Song, H.S. Sekhon, Y. Jia, J.A. Keller, J.K. Blusztajn, and G.P. Mark Acetylcholine is synthesized by and acts as an autocrine growth factor for small cell lung carcinoma Cancer Res 63 2003 214 221
    • (2003) Cancer Res , vol.63 , pp. 214-221
    • Song, P.1    Sekhon, H.S.2    Jia, Y.3    Keller, J.A.4    Blusztajn, J.K.5    Mark, G.P.6
  • 5
    • 34248597724 scopus 로고    scopus 로고
    • M3 muscarinic receptor antagonists inhibit small cell lung carcinoma growth and mitogen-activated protein kinase phosphorylation induced by acetylcholine secretion
    • P. Song, H.S. Sekhon, A. Lu, J. Arredondo, D. Sauer, and C. Gravett M3 muscarinic receptor antagonists inhibit small cell lung carcinoma growth and mitogen-activated protein kinase phosphorylation induced by acetylcholine secretion Cancer Res 67 2007 3936 3944
    • (2007) Cancer Res , vol.67 , pp. 3936-3944
    • Song, P.1    Sekhon, H.S.2    Lu, A.3    Arredondo, J.4    Sauer, D.5    Gravett, C.6
  • 6
    • 77649266354 scopus 로고    scopus 로고
    • Distinct roles of cholinergic receptors in small cell lung cancer cells
    • S. Zhang, S. Togo, K. Minakata, T. Gu, R. Ohashi, and K. Tajima Distinct roles of cholinergic receptors in small cell lung cancer cells Anticancer Res 30 2010 97 106
    • (2010) Anticancer Res , vol.30 , pp. 97-106
    • Zhang, S.1    Togo, S.2    Minakata, K.3    Gu, T.4    Ohashi, R.5    Tajima, K.6
  • 7
    • 0027499332 scopus 로고
    • Free choline and choline metabolites in rat brain and body fluids: Sensitive determination and implications for choline supply to the brain
    • J. Klein, R. Gonzalez, A. Köppen, and K. Löffelholz Free choline and choline metabolites in rat brain and body fluids: sensitive determination and implications for choline supply to the brain Neurochem Int 22 1993 293 300
    • (1993) Neurochem Int , vol.22 , pp. 293-300
    • Klein, J.1    Gonzalez, R.2    Köppen, A.3    Löffelholz, K.4
  • 9
    • 0034004554 scopus 로고    scopus 로고
    • Identification and characterization of the high-affinity choline transporter
    • T. Okuda, T. Haga, Y. Kanai, H. Endou, T. Ishihara, and I. Katsura Identification and characterization of the high-affinity choline transporter Nat Neurosci 3 2000 120 125
    • (2000) Nat Neurosci , vol.3 , pp. 120-125
    • Okuda, T.1    Haga, T.2    Kanai, Y.3    Endou, H.4    Ishihara, T.5    Katsura, I.6
  • 10
    • 0033921479 scopus 로고    scopus 로고
    • Structure of renal organic anion and cation transporters
    • G. Burckhardt, and N.A. Wolff Structure of renal organic anion and cation transporters Am J Physiol Renal Physiol 278 2000 F853 F866
    • (2000) Am J Physiol Renal Physiol , vol.278
    • Burckhardt, G.1    Wolff, N.A.2
  • 11
    • 34249943356 scopus 로고    scopus 로고
    • Polyspecific organic cation transporters: Structure, function, physiological roles, and biopharmaceutical implications
    • H. Koepsell, K. Lips, and C. Volk Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications Pharm Res 24 2007 1227 1251
    • (2007) Pharm Res , vol.24 , pp. 1227-1251
    • Koepsell, H.1    Lips, K.2    Volk, C.3
  • 13
    • 0032150876 scopus 로고    scopus 로고
    • Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter
    • D. Gründemann, B. Schechinger, G.A. Rappold, and E. Schömig Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter Nat Neurosci 1 1998 349 351
    • (1998) Nat Neurosci , vol.1 , pp. 349-351
    • Gründemann, D.1    Schechinger, B.2    Rappold, G.A.3    Schömig, E.4
  • 15
    • 0032569029 scopus 로고    scopus 로고
    • Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta
    • R. Kekuda, P.D. Prasad, X. Wu, H. Wang, Y.J. Fei, and F.H. Leibach Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta J Biol Chem 273 1998 15971 15979
    • (1998) J Biol Chem , vol.273 , pp. 15971-15979
    • Kekuda, R.1    Prasad, P.D.2    Wu, X.3    Wang, H.4    Fei, Y.J.5    Leibach, F.H.6
  • 16
    • 0032484146 scopus 로고    scopus 로고
    • Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain
    • X. Wu, R. Kekuda, W. Huang, Y.J. Fei, F.H. Leibach, and J. Chen Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain J Biol Chem 273 1998 32776 32786
    • (1998) J Biol Chem , vol.273 , pp. 32776-32786
    • Wu, X.1    Kekuda, R.2    Huang, W.3    Fei, Y.J.4    Leibach, F.H.5    Chen, J.6
  • 17
    • 0034652249 scopus 로고    scopus 로고
    • An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins
    • S. O'Regan, E. Traiffort, M. Ruat, N. Cha, D. Compaore, and F.M. Meunier An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins Proc Natl Acad Sci USA 97 2000 1835 1840
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 1835-1840
    • O'Regan, S.1    Traiffort, E.2    Ruat, M.3    Cha, N.4    Compaore, D.5    Meunier, F.M.6
  • 18
    • 0037375474 scopus 로고    scopus 로고
    • Selection and characterization of the choline transport mutation suppressor from Torpedo electric lobe, CTL1
    • S. O'Regan, and F.M. Meunier Selection and characterization of the choline transport mutation suppressor from Torpedo electric lobe, CTL1 Neurochem Res 28 2003 551 555
    • (2003) Neurochem Res , vol.28 , pp. 551-555
    • O'Regan, S.1    Meunier, F.M.2
  • 19
    • 24144434422 scopus 로고    scopus 로고
    • +-independent choline transporter in rat astrocytes
    • +-independent choline transporter in rat astrocytes J Neurochem 94 2005 1427 1437
    • (2005) J Neurochem , vol.94 , pp. 1427-1437
    • Inazu, M.1    Takeda, H.2    Matsumiya, T.3
  • 20
    • 58649108306 scopus 로고    scopus 로고
    • Expression and functional characterization of choline transporter in human keratinocytes
    • Y. Uchida, M. Inazu, H. Takeda, T. Yamada, H. Tajima, and T. Matsumiya Expression and functional characterization of choline transporter in human keratinocytes J Pharm Sci 109 2009 102 109
    • (2009) J Pharm Sci , vol.109 , pp. 102-109
    • Uchida, Y.1    Inazu, M.2    Takeda, H.3    Yamada, T.4    Tajima, H.5    Matsumiya, T.6
  • 21
    • 59849096790 scopus 로고    scopus 로고
    • Molecular and functional characterization of choline transporter in human colon carcinoma HT-29 cells
    • H. Kouji, M. Inazu, T. Yamada, H. Tajima, T. Aoki, and T. Matsumiya Molecular and functional characterization of choline transporter in human colon carcinoma HT-29 cells Arch Biochem Biophys 483 2009 90 98
    • (2009) Arch Biochem Biophys , vol.483 , pp. 90-98
    • Kouji, H.1    Inazu, M.2    Yamada, T.3    Tajima, H.4    Aoki, T.5    Matsumiya, T.6
  • 22
    • 64549087547 scopus 로고    scopus 로고
    • Molecular and functional characterization of choline transporter in rat renal tubule epithelial NRK-52E cells
    • M. Yabuki, M. Inazu, T. Yamada, H. Tajima, and T. Matsumiya Molecular and functional characterization of choline transporter in rat renal tubule epithelial NRK-52E cells Arch Biochem Biophys 485 2009 88 96
    • (2009) Arch Biochem Biophys , vol.485 , pp. 88-96
    • Yabuki, M.1    Inazu, M.2    Yamada, T.3    Tajima, H.4    Matsumiya, T.5
  • 23
    • 1242319259 scopus 로고    scopus 로고
    • Identification and characterization of choline transporter-like protein 2, an inner ear glycoprotein of 68 and 72 kDa that is the target of antibody-induced hearing loss
    • T.S. Nair, K.E. Kozma, N.L. Hoefling, P.K. Kommareddi, Y. Ueda, and T.W. Gong Identification and characterization of choline transporter-like protein 2, an inner ear glycoprotein of 68 and 72 kDa that is the target of antibody-induced hearing loss J Neurosci 24 2004 1772 1779
    • (2004) J Neurosci , vol.24 , pp. 1772-1779
    • Nair, T.S.1    Kozma, K.E.2    Hoefling, N.L.3    Kommareddi, P.K.4    Ueda, Y.5    Gong, T.W.6
  • 24
    • 77950913732 scopus 로고    scopus 로고
    • Involvement of choline transporter-like proteins, CTL1 and CTL2, in glucocorticoid-induced acceleration of phosphatidylcholine synthesis via increased choline uptake
    • T. Nakamura, R. Fujiwara, N. Ishiguro, M. Oyabu, T. Nakanishi, and Y. Shirasaka Involvement of choline transporter-like proteins, CTL1 and CTL2, in glucocorticoid-induced acceleration of phosphatidylcholine synthesis via increased choline uptake Biol Pharm Bull 33 2010 691 696
    • (2010) Biol Pharm Bull , vol.33 , pp. 691-696
    • Nakamura, T.1    Fujiwara, R.2    Ishiguro, N.3    Oyabu, M.4    Nakanishi, T.5    Shirasaka, Y.6
  • 26
    • 0030017723 scopus 로고    scopus 로고
    • Kinetics of choline transport and phosphorylation in human breast cancer cells; NMR application of the zero trans method
    • R. Katz-Brull, and H. Degani Kinetics of choline transport and phosphorylation in human breast cancer cells; NMR application of the zero trans method Anticancer Res 16 1996 1375 1380
    • (1996) Anticancer Res , vol.16 , pp. 1375-1380
    • Katz-Brull, R.1    Degani, H.2
  • 27
    • 33750435528 scopus 로고    scopus 로고
    • Therapeutic targets and biomarkers identified in cancer choline phospholipid metabolism
    • K. Glunde, and N.J. Serkova Therapeutic targets and biomarkers identified in cancer choline phospholipid metabolism Pharmacogenomics 7 2006 1109 1123
    • (2006) Pharmacogenomics , vol.7 , pp. 1109-1123
    • Glunde, K.1    Serkova, N.J.2
  • 28
    • 0027488642 scopus 로고
    • Hydrolysis of phosphatidylcholine couples Ras to activation of Raf protein kinase during mitogenic signal transduction
    • H. Cai, P. Erhardt, J. Troppmair, M.T. Diaz-Meco, G. Sithanandam, and U.R. Rapp Hydrolysis of phosphatidylcholine couples Ras to activation of Raf protein kinase during mitogenic signal transduction Mol Cell Biol 13 1993 7645 7651
    • (1993) Mol Cell Biol , vol.13 , pp. 7645-7651
    • Cai, H.1    Erhardt, P.2    Troppmair, J.3    Diaz-Meco, M.T.4    Sithanandam, G.5    Rapp, U.R.6
  • 29
  • 30
    • 23844457954 scopus 로고    scopus 로고
    • In vivo magnetic resonance spectroscopy in cancer
    • R.J. Gillies, and D.L. Morse In vivo magnetic resonance spectroscopy in cancer Annu Rev Biomed Eng 7 2005 287 326
    • (2005) Annu Rev Biomed Eng , vol.7 , pp. 287-326
    • Gillies, R.J.1    Morse, D.L.2
  • 31
    • 79960821542 scopus 로고    scopus 로고
    • Magnetic Resonance Spectroscopy and Imaging Guidance in Molecular Medicine: Targeting and Monitoring of Choline and Glucose Metabolism in Cancer
    • K. Glunde, L. Jiang, S.A. Moestue, and I.S. Gribbestad Magnetic Resonance Spectroscopy and Imaging Guidance in Molecular Medicine: Targeting and Monitoring of Choline and Glucose Metabolism in Cancer NMR Biomed 24 2011 673 690
    • (2011) NMR Biomed , vol.24 , pp. 673-690
    • Glunde, K.1    Jiang, L.2    Moestue, S.A.3    Gribbestad, I.S.4
  • 32
    • 33745390716 scopus 로고    scopus 로고
    • Localization of primary prostate cancer with dual-phase 18F-fluorocholine PET
    • S.A. Kwee, H. Wei, I. Sesterhenn, D. Yun, and M.N. Coel Localization of primary prostate cancer with dual-phase 18F-fluorocholine PET J Nucl Med 47 2006 262 269
    • (2006) J Nucl Med , vol.47 , pp. 262-269
    • Kwee, S.A.1    Wei, H.2    Sesterhenn, I.3    Yun, D.4    Coel, M.N.5
  • 33
    • 0042922752 scopus 로고    scopus 로고
    • 11C-choline as contrast agents in positron emission tomography imaging-guided stereotactic biopsy sampling of gliomas
    • 11C-choline as contrast agents in positron emission tomography imaging-guided stereotactic biopsy sampling of gliomas J Neurosurg 99 2003 474 479
    • (2003) J Neurosurg , vol.99 , pp. 474-479
    • Hara, T.1    Kondo, T.2    Hara, T.3    Kosaka, N.4
  • 34
    • 3042562283 scopus 로고    scopus 로고
    • Molecular causes of the aberrant choline phospholipid metabolism in breast cancer
    • K. Glunde, C. Jie, and Z.M. Bhujwalla Molecular causes of the aberrant choline phospholipid metabolism in breast cancer Cancer Res 64 2004 4270 4276
    • (2004) Cancer Res , vol.64 , pp. 4270-4276
    • Glunde, K.1    Jie, C.2    Bhujwalla, Z.M.3
  • 35
    • 33845383242 scopus 로고    scopus 로고
    • Choline metabolism in cancer: Implications for diagnosis and therapy
    • K. Glunde, M.A. Jacobs, and Z.M. Bhujwalla Choline metabolism in cancer: implications for diagnosis and therapy Expert Rev Mol Diagn 6 2006 821 829
    • (2006) Expert Rev Mol Diagn , vol.6 , pp. 821-829
    • Glunde, K.1    Jacobs, M.A.2    Bhujwalla, Z.M.3
  • 36
    • 33947127063 scopus 로고    scopus 로고
    • Phosphocholine as a biomarker of breast cancer: Molecular and biochemical studies
    • G. Eliyahu, T. Kreizman, and H. Degani Phosphocholine as a biomarker of breast cancer: molecular and biochemical studies Int J Cancer 120 2007 1721 1730
    • (2007) Int J Cancer , vol.120 , pp. 1721-1730
    • Eliyahu, G.1    Kreizman, T.2    Degani, H.3
  • 38
    • 0031865378 scopus 로고    scopus 로고
    • PET imaging of prostate cancer using carbon-11-choline
    • T. Hara, N. Kosaka, and H. Kishi PET imaging of prostate cancer using carbon-11-choline J Nucl Med 39 1998 990 995
    • (1998) J Nucl Med , vol.39 , pp. 990-995
    • Hara, T.1    Kosaka, N.2    Kishi, H.3
  • 40
    • 0033216658 scopus 로고    scopus 로고
    • 18F-fluorodeoxyglucose: A novel method of preoperative lymph node staging
    • 18F-fluorodeoxyglucose: a novel method of preoperative lymph node staging Cancer 86 1999 1638 1648
    • (1999) Cancer , vol.86 , pp. 1638-1648
    • Kobori, O.1    Kirihara, Y.2    Kosaka, N.3    Hara, T.4
  • 41
    • 79951579758 scopus 로고    scopus 로고
    • Functional expression of choline transporter-like protein 1 (CTL1) in human neuroblastoma cells and its link to acetylcholine synthesis
    • T. Yamada, M. Inazu, H. Tajima, and T. Matsumiya Functional expression of choline transporter-like protein 1 (CTL1) in human neuroblastoma cells and its link to acetylcholine synthesis Neurochem Int 58 2011 354 365
    • (2011) Neurochem Int , vol.58 , pp. 354-365
    • Yamada, T.1    Inazu, M.2    Tajima, H.3    Matsumiya, T.4
  • 43
    • 0141954157 scopus 로고    scopus 로고
    • Choline phospholipid metabolism: A target in cancer cells
    • E. Ackerstaff, K. Glunde, and Z.M. Bhujwalla Choline phospholipid metabolism: a target in cancer cells J Cell Biochem 90 2003 525 533
    • (2003) J Cell Biochem , vol.90 , pp. 525-533
    • Ackerstaff, E.1    Glunde, K.2    Bhujwalla, Z.M.3
  • 45
    • 33645962844 scopus 로고    scopus 로고
    • Choline kinase: An important target for cancer
    • S. Janardhan, P. Srivani, and G.N. Sastry Choline kinase: an important target for cancer Curr Med Chem 13 2006 1169 1186
    • (2006) Curr Med Chem , vol.13 , pp. 1169-1186
    • Janardhan, S.1    Srivani, P.2    Sastry, G.N.3
  • 46
    • 79954565999 scopus 로고    scopus 로고
    • Involvement of human choline kinase alpha and beta in carcinogenesis: A different role in lipid metabolism and biological functions
    • D. Gallego-Ortega, T. Gómez del Pulgar, F. Valdés-Mora, A. Cebrián, and J.C. Lacal Involvement of human choline kinase alpha and beta in carcinogenesis: a different role in lipid metabolism and biological functions Adv Enzyme Regul 51 2011 183 194
    • (2011) Adv Enzyme Regul , vol.51 , pp. 183-194
    • Gallego-Ortega, D.1    Gómez Del Pulgar, T.2    Valdés-Mora, F.3    Cebrián, A.4    Lacal, J.C.5
  • 47
    • 1242295185 scopus 로고    scopus 로고
    • The SLC22 drug transporter family
    • H. Koepsell, and H. Endou The SLC22 drug transporter family Pflugers Arch 447 2004 666 676
    • (2004) Pflugers Arch , vol.447 , pp. 666-676
    • Koepsell, H.1    Endou, H.2
  • 48
    • 14844283742 scopus 로고    scopus 로고
    • Molecular characterization of the family of choline transporter-like proteins and their splice variants
    • E. Traiffort, M. Ruat, S. O'Regan, and F.M. Meunier Molecular characterization of the family of choline transporter-like proteins and their splice variants J Neurochem 92 2005 1116 1125
    • (2005) J Neurochem , vol.92 , pp. 1116-1125
    • Traiffort, E.1    Ruat, M.2    O'Regan, S.3    Meunier, F.M.4
  • 49
    • 29244467701 scopus 로고    scopus 로고
    • +-independent choline transport in primary cultures of neurons from mouse cerebral cortex
    • +-independent choline transport in primary cultures of neurons from mouse cerebral cortex Neurosci Lett 393 2006 216 221
    • (2006) Neurosci Lett , vol.393 , pp. 216-221
    • Fujita, T.1    Shimada, A.2    Okada, N.3    Yamamoto, A.4
  • 50
    • 34548733106 scopus 로고    scopus 로고
    • Choline transporters in human lung adenocarcinoma: Expression and functional implications
    • T. Wang, J. Li, F. Chen, Y. Zhao, X. He, and D. Wan Choline transporters in human lung adenocarcinoma: expression and functional implications Acta Biochim Biophys Sin (Shanghai) 39 2007 668 674
    • (2007) Acta Biochim Biophys Sin (Shanghai) , vol.39 , pp. 668-674
    • Wang, T.1    Li, J.2    Chen, F.3    Zhao, Y.4    He, X.5    Wan, D.6
  • 51
    • 0033746761 scopus 로고    scopus 로고
    • + exchanger-dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation-associated phenotypes
    • + exchanger-dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation-associated phenotypes FASEB J 14 2000 2185 2197
    • (2000) FASEB J , vol.14 , pp. 2185-2197
    • Reshkin, S.J.1    Bellizzi, A.2    Caldeira, S.3    Albarani, V.4    Malanchi, I.5    Poignee, M.6
  • 54
    • 0029985230 scopus 로고    scopus 로고
    • Choline deficiency induces apoptosis in SV40-immortalized CWSV-1 rat hepatocytes in culture
    • C.D. Albright, R. Liu, T.C. Bethea, K.A. Da Costa, R.I. Salganik, and S.H. Zeisel Choline deficiency induces apoptosis in SV40-immortalized CWSV-1 rat hepatocytes in culture FASEB J 10 1996 510 516
    • (1996) FASEB J , vol.10 , pp. 510-516
    • Albright, C.D.1    Liu, R.2    Bethea, T.C.3    Da Costa, K.A.4    Salganik, R.I.5    Zeisel, S.H.6
  • 55
    • 0031416805 scopus 로고    scopus 로고
    • Choline deficiency selects for resistance to p53-independent apoptosis and causes tumorigenic transformation of rat hepatocytes
    • S.H. Zeisel, C.D. Albright, O.H. Shin, M.H. Mar, R.I. Salganik, and K.A. Da Costa Choline deficiency selects for resistance to p53-independent apoptosis and causes tumorigenic transformation of rat hepatocytes Carcinogenesis 18 1997 731 738
    • (1997) Carcinogenesis , vol.18 , pp. 731-738
    • Zeisel, S.H.1    Albright, C.D.2    Shin, O.H.3    Mar, M.H.4    Salganik, R.I.5    Da Costa, K.A.6
  • 56
  • 57
    • 81855226152 scopus 로고    scopus 로고
    • Choline metabolism in malignant transformation
    • K. Glunde, Z.M. Bhujwalla, and S.M. Ronen Choline metabolism in malignant transformation Nat Rev Cancer 11 2011 835 848
    • (2011) Nat Rev Cancer , vol.11 , pp. 835-848
    • Glunde, K.1    Bhujwalla, Z.M.2    Ronen, S.M.3
  • 58
    • 40549083717 scopus 로고    scopus 로고
    • Basic and clinical aspects of non-neuronal acetylcholine: Expression of non-neuronal acetylcholine in lung cancer provides a new target for cancer therapy
    • P. Song, and E.R. Spindel Basic and clinical aspects of non-neuronal acetylcholine: expression of non-neuronal acetylcholine in lung cancer provides a new target for cancer therapy J Pharm Sci 106 2008 180 185
    • (2008) J Pharm Sci , vol.106 , pp. 180-185
    • Song, P.1    Spindel, E.R.2
  • 59
    • 84856679714 scopus 로고    scopus 로고
    • Muscarinic receptor agonists and antagonists: Effects on cancer
    • E.R. Spindel Muscarinic receptor agonists and antagonists: effects on cancer Handb Exp Pharmacol 208 2012 451 468
    • (2012) Handb Exp Pharmacol , vol.208 , pp. 451-468
    • Spindel, E.R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.