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Volumn 18, Issue 3, 2013, Pages 279-290

Emerging drugs for non-alcoholic steatohepatitis

Author keywords

Clinical trial; Non alcoholic fatty liver disease; Non alcoholic steatohepatitis; Pharmacologic therapy

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ACETYLCYSTEINE; ALANINE AMINOTRANSFERASE; ALPHA TOCOPHEROL; ANTILIPEMIC AGENT; ANTIOXIDANT; ASPARTATE AMINOTRANSFERASE; BLX 1002; CHENODEOXYCHOLIC ACID; GFT 505; GRMD 02; ICOSAPENTAENOIC ACID; INSULIN SENSITIZING AGENT; IPRAGLIFLOZIN; MERCAPTAMINE; MITOQUINONE; MONOCLONAL ANTIBODY CD3; NANOVESON; OBETICHOLIC ACID; OLTIPRAZ; OXIDIZING AGENT; PIOGLITAZONE; ROSIGLITAZONE; RP 103; SITAGLIPTIN; UNCLASSIFIED DRUG;

EID: 84883162387     PISSN: 14728214     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728214.2013.811232     Document Type: Review
Times cited : (13)

References (99)
  • 1
    • 0037129380 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Angulo P. Nonalcoholic fatty liver disease. N Engl J Med 2002;346(16):1221-31
    • (2002) N Engl J Med , vol.346 , Issue.16 , pp. 1221-1231
    • Angulo, P.1
  • 2
    • 33748158291 scopus 로고    scopus 로고
    • Natural history of nonalcoholic steatohepatitis
    • Liou I, Kowdley KV. Natural history of nonalcoholic steatohepatitis. J Clin Gastroenterol 2006;40(Suppl 1):S11-16
    • (2006) J Clin Gastroenterol , vol.40 , Issue.SUPPL.1
    • Liou, I.1    Kowdley, K.V.2
  • 3
    • 1942454793 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis
    • Brunt EM. Nonalcoholic steatohepatitis. Semin Liver Dis 2004;24(1):3-20
    • (2004) Semin Liver Dis , vol.24 , Issue.1 , pp. 3-20
    • Brunt, E.M.1
  • 4
    • 2542424767 scopus 로고    scopus 로고
    • Hepatocellular carcinoma with nonalcoholic steatohepatitis
    • Mori S, Yamasaki T, Sakaida I, et al. Hepatocellular carcinoma with nonalcoholic steatohepatitis. J Gastroenterol 2004;39(4):391-6
    • (2004) J Gastroenterol , vol.39 , Issue.4 , pp. 391-396
    • Mori, S.1    Yamasaki, T.2    Sakaida, I.3
  • 5
    • 80053581540 scopus 로고    scopus 로고
    • Frequency and outcomes of liver transplantation for nonalcoholic steatohepatitis in the United States
    • Charlton MR, Burns JM, Pedersen RA, et al. Frequency and outcomes of liver transplantation for nonalcoholic steatohepatitis in the United States. Gastroenterology 2011;131:1249-53
    • (2011) Gastroenterology , vol.131 , pp. 1249-1253
    • Charlton, M.R.1    Burns, J.M.2    Pedersen, R.A.3
  • 6
    • 73449116035 scopus 로고    scopus 로고
    • Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis
    • Promrat K, Kleiner DE, Niemeier HM, et al. Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis. Hepatology 2010;51:121-9
    • (2010) Hepatology , vol.51 , pp. 121-129
    • Promrat, K.1    Kleiner, D.E.2    Niemeier, H.M.3
  • 7
    • 37349053742 scopus 로고    scopus 로고
    • Impact of fatty liver disease on healthcare utilization and costs in a general population: A 5-year observation
    • Baumeister SE, Volzke H, Marchall P, et al. Impact of fatty liver disease on healthcare utilization and costs in a general population: A 5-year observation. Gastroenterology 2008;134:85-94
    • (2008) Gastroenterology , vol.134 , pp. 85-94
    • Baumeister, S.E.1    Volzke, H.2    Marchall, P.3
  • 8
    • 19144372447 scopus 로고    scopus 로고
    • One-year intense nutritional counseling results in histological improvement in patients with non-alcoholic steatohepatitis: A pilot study
    • Huang MA, Greenson JK, Chao C, et al. One-year intense nutritional counseling results in histological improvement in patients with non-alcoholic steatohepatitis: A pilot study. Am J Gastroenterol 2005;100:1072-81
    • (2005) Am J Gastroenterol , vol.100 , pp. 1072-1081
    • Huang, M.A.1    Greenson, J.K.2    Chao, C.3
  • 9
    • 27744490794 scopus 로고    scopus 로고
    • Effect of changes on body weight and lifestyle in nonalcoholic fatty liver disease
    • Suzuki A, Lindor K, St Saver J, et al. Effect of changes on body weight and lifestyle in nonalcoholic fatty liver disease. J Hepatol 2005;43(6):1060-6
    • (2005) J Hepatol , vol.43 , Issue.6 , pp. 1060-1066
    • Suzuki, A.1    Lindor, K.2    St Saver, J.3
  • 10
    • 77952785795 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease from pathogenesis to management: An update
    • Musso G, Gambino R, Cassader M. Non-alcoholic fatty liver disease from pathogenesis to management: An update. Obes Rev 2010;11(6):430-45
    • (2010) Obes Rev , vol.11 , Issue.6 , pp. 430-445
    • Musso, G.1    Gambino, R.2    Cassader, M.3
  • 11
    • 0036718446 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: Pathogenesis and the role of anti-oxidants
    • Mehta K, Van Thiel DH, Shah N, et al. Nonalcoholic fatty liver disease: Pathogenesis and the role of anti-oxidants. Nutr Rev 2002;60:289-93
    • (2002) Nutr Rev , vol.60 , pp. 289-293
    • Mehta, K.1    Van Thiel, D.H.2    Shah, N.3
  • 12
    • 77951874018 scopus 로고    scopus 로고
    • Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis
    • Sanyal AJ, Chalasani N, Kowdley KV, et al. Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. N Engl J Med 2010;362:1675-85
    • (2010) N Engl J Med , vol.362 , pp. 1675-1685
    • Sanyal, A.J.1    Chalasani, N.2    Kowdley, K.V.3
  • 13
    • 0344742265 scopus 로고    scopus 로고
    • Vitamin E and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis
    • Harrison SA, Torgerson S, Hayashi P, et al. Vitamin E and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis. Am J Gastroenterol 2003;98:2485-90
    • (2003) Am J Gastroenterol , vol.98 , pp. 2485-2490
    • Harrison, S.A.1    Torgerson, S.2    Hayashi, P.3
  • 14
    • 84861543083 scopus 로고    scopus 로고
    • The diagnosis and management of non-alcoholic fatty liver disease: Practice guideline by the american association for the study of liver diseases, american college of gastroenterology, and the american gastroenterological association
    • Chalasani N, Younossi Z, Lavine JE, et al. The diagnosis and management of non-alcoholic fatty liver disease: Practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Hepatology 2012;55:2005-23
    • (2012) Hepatology , vol.55 , pp. 2005-2023
    • Chalasani, N.1    Younossi, Z.2    Lavine, J.E.3
  • 16
    • 34247384560 scopus 로고    scopus 로고
    • The NAFLD fibrosis score: A noninvasive system that identifies liver fibrosis in patients with NAFLD
    • Augulo P, Hui JM, Marchesini G, et al. The NAFLD fibrosis score: A noninvasive system that identifies liver fibrosis in patients with NAFLD. Hepatology 2007;45:846-54
    • (2007) Hepatology , vol.45 , pp. 846-854
    • Augulo, P.1    Hui, J.M.2    Marchesini, G.3
  • 17
    • 11144351102 scopus 로고    scopus 로고
    • The histological course of nonalcoholic fatty liver disease: A longitudinal study of 103 patients with sequential liver biopsies
    • Adams LA, Sanderson S, Lindor KD, et al. The histological course of nonalcoholic fatty liver disease: A longitudinal study of 103 patients with sequential liver biopsies. J Hepatol 2005;42(1):132-8
    • (2005) J Hepatol , vol.42 , Issue.1 , pp. 132-138
    • Adams, L.A.1    Sanderson, S.2    Lindor, K.D.3
  • 18
    • 22344452893 scopus 로고    scopus 로고
    • The natural history of nonalcoholic fatty liver disease: A population-based cohort study
    • Adams LA, Lymp JF, St Sauver J, et al. The natural history of nonalcoholic fatty liver disease: A population-based cohort study. Gastroenterology 2005;129:113-21
    • (2005) Gastroenterology , vol.129 , pp. 113-121
    • Adams, L.A.1    Lymp, J.F.2    St Sauver, J.3
  • 19
    • 33644759114 scopus 로고    scopus 로고
    • The association between diabetes and hepatocellular carcinoma: A systematic review of epidemiologic evidence
    • El-Seraq HB, Hampel H, Javadi F. The association between diabetes and hepatocellular carcinoma: A systematic review of epidemiologic evidence. Clin Gastroenterol Hepatol 2006;4(3):369-80
    • (2006) Clin Gastroenterol Hepatol , vol.4 , Issue.3 , pp. 369-380
    • El-Seraq, H.B.1    Hampel, H.2    Javadi, F.3
  • 20
    • 19944427642 scopus 로고    scopus 로고
    • Meta-analysis: High dose vitamin E supplementation may increase all cause mortality
    • Miller ER III, Pastor-Barriuso R, Dalal D, et al. Meta-analysis: High dose vitamin E supplementation may increase all cause mortality. Ann Intern Med 2005;142:37-46
    • (2005) Ann Intern Med , vol.142 , pp. 37-46
    • Miller III, E.R.1    Pastor-Barriuso, R.2    Dalal, D.3
  • 21
    • 19244365650 scopus 로고    scopus 로고
    • Thiazolidinediones
    • Yki-Jarvinen H. Thiazolidinediones. N Engl J Med 2004;351:1106-18
    • (2004) N Engl J Med , vol.351 , pp. 1106-1118
    • Yki-Jarvinen, H.1
  • 22
    • 33751545838 scopus 로고    scopus 로고
    • A placebo controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis
    • Belfort R, Harrison SA, Brown K, et al. A placebo controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis. N Engl J Med 2006;355:2297-307
    • (2006) N Engl J Med , vol.355 , pp. 2297-2307
    • Belfort, R.1    Harrison, S.A.2    Brown, K.3
  • 23
    • 53049101877 scopus 로고    scopus 로고
    • Randomized, placebo-controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitis
    • Aithal GP, Thomas JA, Kaye PV, et al. Randomized, placebo-controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitis. Gastroenterology 2008;135:1176-84
    • (2008) Gastroenterology , vol.135 , pp. 1176-1184
    • Aithal, G.P.1    Thomas, J.A.2    Kaye, P.V.3
  • 24
    • 79956217900 scopus 로고    scopus 로고
    • Risk of bladder cancer among diabetic patients treated with pioglitazone: Interim report of a longitudinal cohort study
    • Lewis JD, Ferrara A, Peng T, et al. Risk of bladder cancer among diabetic patients treated with pioglitazone: Interim report of a longitudinal cohort study. Diabetes Care 2011;34(4):916-22
    • (2011) Diabetes Care , vol.34 , Issue.4 , pp. 916-922
    • Lewis, J.D.1    Ferrara, A.2    Peng, T.3
  • 25
    • 42949154244 scopus 로고    scopus 로고
    • Diagnosis and therapy of nonalcoholic steatohepatitis
    • Torres DM, Harrison SA. Diagnosis and therapy of nonalcoholic steatohepatitis. Gastroenterology 2008;134:1682-98
    • (2008) Gastroenterology , vol.134 , pp. 1682-1698
    • Torres, D.M.1    Harrison, S.A.2
  • 26
    • 0012785395 scopus 로고    scopus 로고
    • Metformin reverses fatty liver disease in obese leptin-deficient mice
    • Lin HZ, Yang SQ, Chuckaree C, et al. Metformin reverses fatty liver disease in obese leptin-deficient mice. Nat Med 2000;6:998-1003
    • (2000) Nat Med , vol.6 , pp. 998-1003
    • Lin, H.Z.1    Yang, S.Q.2    Chuckaree, C.3
  • 27
    • 19144365586 scopus 로고    scopus 로고
    • A randomized controlled trial of metformin versus vitamin E or prescriptive diet in nonalcoholic fatty liver disease
    • Bugianesi E, Genticore E, Manini R, et al. A randomized controlled trial of metformin versus vitamin E or prescriptive diet in nonalcoholic fatty liver disease. Am J Gastroenterol 2005;100:1082-90
    • (2005) Am J Gastroenterol , vol.100 , pp. 1082-1090
    • Bugianesi, E.1    Genticore, E.2    Manini, R.3
  • 28
    • 70350662659 scopus 로고    scopus 로고
    • Metformin in patients with non-alcoholic fatty liver disease: A randomized, controlled trial
    • Haukeland JW, Konopski Z, Eggesbo HB, et al. Metformin in patients with non-alcoholic fatty liver disease: A randomized, controlled trial. Scand J Gastroenterol 2009;44:853-60
    • (2009) Scand J Gastroenterol , vol.44 , pp. 853-860
    • Haukeland, J.W.1    Konopski, Z.2    Eggesbo, H.B.3
  • 29
    • 79955446251 scopus 로고    scopus 로고
    • Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: The TONIC randomized controlled trial
    • Lavine JE, Schwimmer JB, Van Natta ML, et al. Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: The TONIC randomized controlled trial. JAMA 2011;305:1659-39
    • (2011) JAMA , vol.305 , pp. 1659-1649
    • Lavine, J.E.1    Schwimmer, J.B.2    Van Natta, M.L.3
  • 30
    • 77957375969 scopus 로고    scopus 로고
    • Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease
    • Targher G, Day CP, Bonora E. Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease. N Engl J Med 2010;363:1341-50
    • (2010) N Engl J Med , vol.363 , pp. 1341-1350
    • Targher, G.1    Day, C.P.2    Bonora, E.3
  • 31
    • 84857984149 scopus 로고    scopus 로고
    • Dyslipidemia in patients with nonalcoholic fatty liver disease
    • Chatrath H, Vuppalamchi R, Chalasani N. Dyslipidemia in patients with nonalcoholic fatty liver disease. Semin Liver Dis 2012;32:22-9
    • (2012) Semin Liver Dis , vol.32 , pp. 22-29
    • Chatrath, H.1    Vuppalamchi, R.2    Chalasani, N.3
  • 32
    • 55649083505 scopus 로고    scopus 로고
    • Efficacy of atorvastatin for the treatment of nonalcoholic steatohepatitis with dyslipidemia
    • Hyogo H, Tazuma S, Arihiro K, et al. Efficacy of atorvastatin for the treatment of nonalcoholic steatohepatitis with dyslipidemia. Metabolism 2008;57:1711-18
    • (2008) Metabolism , vol.57 , pp. 1711-1718
    • Hyogo, H.1    Tazuma, S.2    Arihiro, K.3
  • 33
    • 33646553912 scopus 로고    scopus 로고
    • A pilot study of atorvastatin treatment in dyslipidemia, non-alcoholic fatty liver patients
    • Gomez-Dominguez E, Gisbert JP, Moreno-Monteagudo JA, et al. A pilot study of atorvastatin treatment in dyslipidemia, non-alcoholic fatty liver patients. Aliment Pharmacol Ther 2006;23:1643-7
    • (2006) Aliment Pharmacol Ther , vol.23 , pp. 1643-1647
    • Gomez-Dominguez, E.1    Gisbert, J.P.2    Moreno-Monteagudo, J.A.3
  • 34
    • 74949102941 scopus 로고    scopus 로고
    • A pilot study using simvastatin in the treatment of nonalcoholic steatohepatitis: A randomized placebo-controlled trial
    • Nelson A, Torres DM, Morgan AE, et al. A pilot study using simvastatin in the treatment of nonalcoholic steatohepatitis: A randomized placebo-controlled trial. J Clin Gastroenterol 2009;43:990-4
    • (2009) J Clin Gastroenterol , vol.43 , pp. 990-994
    • Nelson, A.1    Torres, D.M.2    Morgan, A.E.3
  • 35
    • 68049123104 scopus 로고    scopus 로고
    • Long-term combination therapy of ezetimibe and acarbose for non-alcoholic fatty liver disease
    • Nozaki Y, Fujita K, Yoneda M, et al. Long-term combination therapy of ezetimibe and acarbose for non-alcoholic fatty liver disease. J Hepatol 2009;51:548-56
    • (2009) J Hepatol , vol.51 , pp. 548-556
    • Nozaki, Y.1    Fujita, K.2    Yoneda, M.3
  • 36
    • 77954366025 scopus 로고    scopus 로고
    • Efficacy of ezetimibe for the treatment of non-alcoholic steatohepatitis: An open-label, pilot study
    • Yoneda M, Fujita K, Nozaki Y, et al. Efficacy of ezetimibe for the treatment of non-alcoholic steatohepatitis: An open-label, pilot study. Hepatol Res 2010;40:613-21
    • (2010) Hepatol Res , vol.40 , pp. 613-621
    • Yoneda, M.1    Fujita, K.2    Nozaki, Y.3
  • 37
    • 78651473467 scopus 로고    scopus 로고
    • Efficacy of long-term ezetimibe therapy in patients with nonalcoholic fatty liver disease
    • Park H, Shima T, Yamaguchi K, et al. Efficacy of long-term ezetimibe therapy in patients with nonalcoholic fatty liver disease. J Gastroenterol 2011;46:101-7
    • (2011) J Gastroenterol , vol.46 , pp. 101-107
    • Park, H.1    Shima, T.2    Yamaguchi, K.3
  • 38
    • 1542515099 scopus 로고    scopus 로고
    • Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: Results of a randomized trial
    • Lindor KD, Kowdley KV, Heathocote EJ, et al. Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: Results of a randomized trial. Hepatology 2004;39:770-8
    • (2004) Hepatology , vol.39 , pp. 770-778
    • Lindor, K.D.1    Kowdley, K.V.2    Heathocote, E.J.3
  • 39
    • 77955699301 scopus 로고    scopus 로고
    • High-dose ursodeoxycholic acid therapy for nonalcoholic steatohepatitis: A double-blind, randomized, placebo-controlled trial
    • Leuschner UF, Lindenthal B, Hermann G, et al. High-dose ursodeoxycholic acid therapy for nonalcoholic steatohepatitis: A double-blind, randomized, placebo-controlled trial. Hepatology 2010;52:472-9
    • (2010) Hepatology , vol.52 , pp. 472-479
    • Leuschner, U.F.1    Lindenthal, B.2    Hermann, G.3
  • 40
    • 33845336554 scopus 로고    scopus 로고
    • Randomized placebo-controlled trial of ursodeoxycholic acid with vitamin E in nonalcoholic steatohepatitis
    • Dufour JF, Oneta CM, Gonvers JJ, et al. Randomized placebo-controlled trial of ursodeoxycholic acid with vitamin E in nonalcoholic steatohepatitis. Clin Gastroenterol Hepatol 2006;4:1537-43
    • (2006) Clin Gastroenterol Hepatol , vol.4 , pp. 1537-1543
    • Dufour, J.F.1    Oneta, C.M.2    Gonvers, J.J.3
  • 41
    • 70350043699 scopus 로고    scopus 로고
    • Effects of ursodeoxycholic acid in combination with vitamin E on adipokines and apoptosis in patients with nonalcoholic steatohepatitis
    • Balmer ML, Siegrist K, Zimmermann A, et al. Effects of ursodeoxycholic acid in combination with vitamin E on adipokines and apoptosis in patients with nonalcoholic steatohepatitis. Liver Int 2009;29:1184-8
    • (2009) Liver Int , vol.29 , pp. 1184-1188
    • Balmer, M.L.1    Siegrist, K.2    Zimmermann, A.3
  • 42
    • 84883179857 scopus 로고    scopus 로고
    • Nonalcoholic Steatohepatitis Therapeutics Published on December 8, 2010 by GlobalData
    • Nonalcoholic Steatohepatitis Therapeutics - Pipeline Assessment and Market Forecasts to 2017. Published on December 8, 2010 by GlobalData
    • Pipeline Assessment and Market Forecasts to 2017
  • 43
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • Kleiner DE, Brunt EM, Van Natta M, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005;41:1313-21
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • Kleiner, D.E.1    Brunt, E.M.2    Van Natta, M.3
  • 44
    • 79959573040 scopus 로고    scopus 로고
    • Endpoints and clinical trial design for nonalcoholic steatohepatitis
    • Sanyal AJ, Brunt EM, Kleiner DE, et al. Endpoints and clinical trial design for nonalcoholic steatohepatitis. Hepatology 2011;54:344-53
    • (2011) Hepatology , vol.54 , pp. 344-353
    • Sanyal, A.J.1    Brunt, E.M.2    Kleiner, D.E.3
  • 45
    • 41849148981 scopus 로고    scopus 로고
    • Noninvasive assessment of liver fibrosis by measurement of stiffness in patients with nonalcoholic fatty liver disease (NAFLD
    • Yoneda M, Yoneda M, Mawatari H, et al. Noninvasive assessment of liver fibrosis by measurement of stiffness in patients with nonalcoholic fatty liver disease (NAFLD). Dig Liver Dis 2008;40(5):371-8
    • (2008) Dig Liver Dis , vol.40 , Issue.5 , pp. 371-378
    • Yoneda, M.1    Yoneda, M.2    Mawatari, H.3
  • 46
    • 84883169127 scopus 로고    scopus 로고
    • Transient elastography for monitoring the fibrosis of non-alcoholic fatty liver disease for 4 years
    • published Online 7 January 2013. doi: 10.1111/hepr.12039
    • Suzuki K, Yoneda M, Imajo K, et al. Transient elastography for monitoring the fibrosis of non-alcoholic fatty liver disease for 4 years. Hepatol Res 2013;published online 7 January 2013; doi: 10.1111/hepr.12039
    • (2013) Hepatol Res
    • Suzuki, K.1    Yoneda, M.2    Imajo, K.3
  • 47
    • 79956292596 scopus 로고    scopus 로고
    • Early detection of nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease by using MR elastography
    • Chen J, Talwalkar JA, Yin M, et al. Early detection of nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease by using MR elastography. Radiology 2011;259:749-56
    • (2011) Radiology , vol.259 , pp. 749-756
    • Chen, J.1    Talwalkar, J.A.2    Yin, M.3
  • 48
    • 0037566201 scopus 로고    scopus 로고
    • Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values
    • Mofrad P, Contos MJ, Haque M, et al. Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values. Hepatology 2003;37:1286-92
    • (2003) Hepatology , vol.37 , pp. 1286-1292
    • Mofrad, P.1    Contos, M.J.2    Haque, M.3
  • 49
    • 33644607568 scopus 로고    scopus 로고
    • Diagnostic value of biochemical markers (Fibro Test-FibroSURE) for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease
    • Ratziu V, Massard J, Charlotte F, et al. Diagnostic value of biochemical markers (Fibro Test-FibroSURE) for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease. BMC Gastroenterol 2006;6:6
    • (2006) BMC Gastroenterol , vol.6 , pp. 6
    • Ratziu, V.1    Massard, J.2    Charlotte, F.3
  • 50
    • 52649112178 scopus 로고    scopus 로고
    • Development and validation of a simple NAFLD clinical scoring system for identifying patients without advanced disease
    • Harrison SA, Oliver D, Arnold HL, et al. Development and validation of a simple NAFLD clinical scoring system for identifying patients without advanced disease. Gut 2008;57:1441-7
    • (2008) Gut , vol.57 , pp. 1441-1447
    • Harrison, S.A.1    Oliver, D.2    Arnold, H.L.3
  • 51
    • 33745547388 scopus 로고    scopus 로고
    • Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfection
    • Sterling RK, Lissen E, Clumeck N, et al. Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfection. Hepatology 2006;43:1317-25
    • (2006) Hepatology , vol.43 , pp. 1317-1325
    • Sterling, R.K.1    Lissen, E.2    Clumeck, N.3
  • 52
    • 70350046669 scopus 로고    scopus 로고
    • Cytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: A multicenter validation study
    • Feldstein AE, Wieckowska A, Lopez R, et al. Cytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: A multicenter validation study. Hepatology 2009;50:1072-8
    • (2009) Hepatology , vol.50 , pp. 1072-1078
    • Feldstein, A.E.1    Wieckowska, A.2    Lopez, R.3
  • 53
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: A tale of two hits"?
    • Day C, James O. Steatohepatitis: A tale of two "hits"? Gastroenterology 1998;114:842-5
    • (1998) Gastroenterology , vol.114 , pp. 842-845
    • Day, C.1    James, O.2
  • 54
    • 79959517565 scopus 로고    scopus 로고
    • Human fatty liver disease: Pld questions and new insights
    • Cohen JC, Horton JD, Hobbs HH. Human fatty liver disease: Pld questions and new insights. Science 2011;332:1519-23
    • (2011) Science , vol.332 , pp. 1519-1523
    • Cohen, J.C.1    Horton, J.D.2    Hobbs, H.H.3
  • 55
    • 33744990181 scopus 로고    scopus 로고
    • Oral CD3-specific antibody suppresses autoimmune encephalomyelitis by inducing CD4+CD25-LAP+ T cells
    • Ochi H, Abraham M, Ishikawa H, et al. Oral CD3-specific antibody suppresses autoimmune encephalomyelitis by inducing CD4+CD25-LAP+ T cells. Nat Med 2006;12(6):627-35
    • (2006) Nat Med , vol.12 , Issue.6 , pp. 627-635
    • Ochi, H.1    Abraham, M.2    Ishikawa, H.3
  • 57
    • 0037101810 scopus 로고    scopus 로고
    • 6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity
    • Pellicciari R, Fiorucci S, Camaioni E, et al. 6alpha-ethyl- chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity. J Med Chem 2002;45(17):3569-72
    • (2002) J Med Chem , vol.45 , Issue.17 , pp. 3569-3572
    • Pellicciari, R.1    Fiorucci, S.2    Camaioni, E.3
  • 58
    • 58249110568 scopus 로고    scopus 로고
    • Role of bile acids and bile acid receptors in metabolic regulation
    • Lefebvre P, Cariou B, Lien F, et al. Role of bile acids and bile acid receptors in metabolic regulation. Physiol Rev 2009;89(1):147-91
    • (2009) Physiol Rev , vol.89 , Issue.1 , pp. 147-191
    • Lefebvre, P.1    Cariou, B.2    Lien, F.3
  • 59
    • 84865499656 scopus 로고    scopus 로고
    • Farnesoid X receptor targeting to treat nonalcoholic steatohepatitis
    • Adirini L, Pruzanski M, Shapiro D, et al. Farnesoid X receptor targeting to treat nonalcoholic steatohepatitis. Drug Discov Today 2012;17:988-97
    • (2012) Drug Discov Today , vol.17 , pp. 988-997
    • Adirini, L.1    Pruzanski, M.2    Shapiro, D.3
  • 60
    • 84883191272 scopus 로고    scopus 로고
    • INT-747 - The First FXR Hepatic Therapeutic Study [abstract 183]. The 60th Annual Meeting Of The American Association For The Study Of Liver Diseases (AASLD) (The Liver Meeting 30 October - 3 November 2009; Boston
    • Sanyal A, Mudaliar S, Henry R, et al. A new therapy for nonalcoholic fatty liver disease and diabetes? INT-747 - The first FXR hepatic therapeutic study [abstract 183]. The 60th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) (The Liver Meeting 2009); 30 October - 3 November 2009; Boston
    • (2009) A New Therapy For Nonalcoholic Fatty Liver Disease And Diabetes?
    • Sanyal, A.1    Mudaliar, S.2    Henry, R.3
  • 61
    • 84883148894 scopus 로고    scopus 로고
    • Available from Last accessed 27 May
    • Available from: Http://www.clinicaltrials. gov/ct2/show/NCT01265498 [Last accessed 27 May 2013
    • (2013)
  • 62
    • 84883185497 scopus 로고    scopus 로고
    • Available from Last accessed 27 May
    • Available from: Http://www.ds-pharma. com/rd/clinical/pipeline-profile. html[Last accessed 27 May 2013
    • (2013)
  • 63
    • 23644456172 scopus 로고    scopus 로고
    • Therapeutic roles of peroxisome proliferator-activated receptor agonists
    • Staels B, Fruchart JC. Therapeutic roles of peroxisome proliferator-activated receptor agonists. Diabetes 2005;54:2460-70
    • (2005) Diabetes , vol.54 , pp. 2460-2470
    • Staels, B.1    Fruchart, J.C.2
  • 64
    • 37349007681 scopus 로고    scopus 로고
    • PPAR delta as a therapeutic target in metabolic disease
    • Reilly SM, Lee CH. PPAR delta as a therapeutic target in metabolic disease. FEBS Lett 2008;582:26-31
    • (2008) FEBS Lett , vol.582 , pp. 26-31
    • Reilly, S.M.1    Lee, C.H.2
  • 65
    • 79954513236 scopus 로고    scopus 로고
    • GFT505 efficacy and safety in healthy volunteers and patients suffering from atherogenic dyslipidemia
    • Hanf R, Darteli R, Hum DW, et al. GFT505 efficacy and safety in healthy volunteers and patients suffering from atherogenic dyslipidemia. Diabetes 2010;59(Suppl 1):A185
    • (2010) Diabetes , vol.59 , Issue.SUPPL.1
    • Hanf, R.1    Darteli, R.2    Hum, D.W.3
  • 66
    • 79960988152 scopus 로고    scopus 로고
    • Effects of the new dual PPARa/d agonist GFT505 on lipid and glucose homeostasis in abdominally obese patients with combined dyslipidemia or impaired glucose metabolism
    • Cariou B, Zair Y, Steals B, et al. Effects of the new dual PPARa/d agonist GFT505 on lipid and glucose homeostasis in abdominally obese patients with combined dyslipidemia or impaired glucose metabolism. Diabetes Care 2011;34:2008-14
    • (2011) Diabetes Care , vol.34 , pp. 2008-2014
    • Cariou, B.1    Zair, Y.2    Steals, B.3
  • 67
    • 84883203050 scopus 로고    scopus 로고
    • Available from [Last accessed 27 May 2013
    • Available from: Http://www.clinicaltrials. gov/ct2/show/NCT01694849 [Last accessed 27 May 2013
  • 68
    • 0036124659 scopus 로고    scopus 로고
    • N-3 polyunsaturated fatty acids in coronary heart disease: A meta-analysis of randomized controlled trials
    • Bucher HC, Hengstler P, Schindler C, et al. N-3 polyunsaturated fatty acids in coronary heart disease: A meta-analysis of randomized controlled trials. Am J Med 2002;112:298-304
    • (2002) Am J Med , vol.112 , pp. 298-304
    • Bucher, H.C.1    Hengstler, P.2    Schindler, C.3
  • 69
    • 33646882162 scopus 로고    scopus 로고
    • Prolonged n-3 polyunsaturated fatty acid supplementation ameliorates hepatic steatosis in patients with non-alcoholic fatty liver disease: A pilot study
    • Capanni M, Calella F, Biagini MR, et al. Prolonged n-3 polyunsaturated fatty acid supplementation ameliorates hepatic steatosis in patients with non-alcoholic fatty liver disease: A pilot study. Aliment Pharmacol Ther 2006;23:1143-51
    • (2006) Aliment Pharmacol Ther , vol.23 , pp. 1143-1151
    • Capanni, M.1    Calella, F.2    Biagini, M.R.3
  • 70
    • 33748794808 scopus 로고    scopus 로고
    • A model of insulin resistance and nonalcoholic steatohepatitis in rats: Role of peroxisome proliferator-activated receptor - A and n-3 polyunsaturated fatty liver acid treatment on liver injury
    • Svegliati-Baroni G, Candelaresi C, Saccomanno S, et al. A model of insulin resistance and nonalcoholic steatohepatitis in rats: Role of peroxisome proliferator-activated receptor-a and n-3 polyunsaturated fatty liver acid treatment on liver injury. Am J Pathol 2006;169:846-60
    • (2006) Am J Pathol , vol.169 , pp. 846-860
    • Svegliati-Baroni, G.1    Candelaresi, C.2    Saccomanno, S.3
  • 71
    • 41349102802 scopus 로고    scopus 로고
    • Highly purified eicosapentaenoic acid treatment improves nonalcoholic steatohepatitis
    • Tanaka N, Sano K, Horiuchi A, et al. Highly purified eicosapentaenoic acid treatment improves nonalcoholic steatohepatitis. J Clin Gastroenterol 2008;42(4):413-18
    • (2008) J Clin Gastroenterol , vol.42 , Issue.4 , pp. 413-418
    • Tanaka, N.1    Sano, K.2    Horiuchi, A.3
  • 72
    • 84883168389 scopus 로고    scopus 로고
    • Available From Last accessed 27 May
    • Available from: Http://www.clinicaltrials. gov/ct2/show/NCT01154985 [Last accessed 27 May 2013
    • (2013)
  • 73
    • 74149085153 scopus 로고    scopus 로고
    • Oxidative stress and glutathione in TGF-beta-mediated fibrogenesis
    • Liu RM, Gaston Pravia KA. Oxidative stress and glutathione in TGF-beta-mediated fibrogenesis. Free Radic Biol Med 2010;48:1-15
    • (2010) Free Radic Biol Med , vol.48 , pp. 1-15
    • Liu, R.M.1    Gaston Pravia, K.A.2
  • 74
    • 53749089841 scopus 로고    scopus 로고
    • A novel approach to enhancing cellular glutathione levels
    • Maher P, Lewerenz J, Lozano C, et al. A novel approach to enhancing cellular glutathione levels. J Neurochem 2008;107:690-700
    • (2008) J Neurochem , vol.107 , pp. 690-700
    • Maher, P.1    Lewerenz, J.2    Lozano, C.3
  • 75
    • 84883170892 scopus 로고    scopus 로고
    • Available From
    • Available from: Http://ir.raptorpharma.com/releasedetail.cfm?ReleaseID= 686051 [Last accessed 27 May 2013
    • (2013) Last accessed 27 May
  • 76
    • 79953723142 scopus 로고    scopus 로고
    • Enteric-coated cysteamine for the treatment of pediatric non-alcoholic fatty liver disease
    • Dohil R, Schmeltzer S, Cabrera BL, et al. Enteric-coated cysteamine for the treatment of pediatric non-alcoholic fatty liver disease. Aliment Pharmacol Ther 2011;33:1036-44
    • (2011) Aliment Pharmacol Ther , vol.33 , pp. 1036-1044
    • Dohil, R.1    Schmeltzer, S.2    Cabrera, B.L.3
  • 77
    • 84883199625 scopus 로고    scopus 로고
    • Available from [Last accessed 27 May
    • Available from: Http://www.clinicaltrials. gov/ct2/show/NCT01529268 [Last accessed 27 May 2013
    • (2013)
  • 78
    • 33847071146 scopus 로고    scopus 로고
    • Targeting antioxidants to mitochondria by conjugation to lipophilic cations
    • Murphy MP, Smith RA. Targeting antioxidants to mitochondria by conjugation to lipophilic cations. Annu Rev Pharmacol Toxicol 2007;47:629-56
    • (2007) Annu Rev Pharmacol Toxicol , vol.47 , pp. 629-656
    • Murphy, M.P.1    Smith, R.A.2
  • 79
    • 77956496245 scopus 로고    scopus 로고
    • The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase ii study of hepatitis c patients
    • Gane EJ, Weilert F, Orr DW, et al. The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients. Liver Int 2010;30(7):1019-26
    • (2010) Liver Int , vol.30 , Issue.7 , pp. 1019-1026
    • Gane, E.J.1    Weilert, F.2    Orr, D.W.3
  • 80
    • 32844458032 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in NASH: Causes, consequences and possible means to prevent it
    • Begriche K, Igoudjil A, Pessayre D, et al. Mitochondrial dysfunction in NASH: Causes, consequences and possible means to prevent it. Mitochondrion 2003;6:1-28
    • (2003) Mitochondrion , vol.6 , pp. 1-28
    • Begriche, K.1    Igoudjil, A.2    Pessayre, D.3
  • 81
    • 84883170892 scopus 로고    scopus 로고
    • Available From
    • Available from: Http://www.clinicaltrials. gov/ct2/show/NCT01167088 [Last accessed 27 May 2013
    • (2013) Last accessed 27 May
  • 82
    • 79957635306 scopus 로고    scopus 로고
    • Amino acid conjugated, orally active, novel anti-diabetic compound BLX-1002 has no affinity to PPARg
    • Dey D, Pandey B, Nag A, et al. Amino acid conjugated, orally active, novel anti-diabetic compound BLX-1002 has no affinity to PPARg. Diabetes 2004;53(Suppl 2):A483
    • (2004) Diabetes , vol.53 , Issue.SUPPL.2
    • Dey, D.1    Pandey, B.2    Nag, A.3
  • 83
    • 60849119549 scopus 로고    scopus 로고
    • BLX-1002, a novel thiazolidinedione with no PPAR affinity, stimulates AMP-activated protein kinase activity, raises cytosolic Ca2+, and enhances glucose-stimulated insulin secretion in a PI3K-dependent manner
    • Zhang F, Dey D, Branstorm R, et al. BLX-1002, a novel thiazolidinedione with no PPAR affinity, stimulates AMP-activated protein kinase activity, raises cytosolic Ca2+, and enhances glucose-stimulated insulin secretion in a PI3K-dependent manner. Am J Physiol Cell Physiol 2009;296:C346-54
    • (2009) Am J Physiol Cell Physiol , vol.296
    • Zhang, F.1    Dey, D.2    Branstorm, R.3
  • 85
    • 68949146859 scopus 로고    scopus 로고
    • Therapeutic potential of dithiolethiones for hepatic diseases
    • Brools SC III, Brooks JS, Lee WH, et al. Therapeutic potential of dithiolethiones for hepatic diseases. Pharmacol Ther 2009;124(1):31-43
    • (2009) Pharmacol Ther , vol.124 , Issue.1 , pp. 31-43
    • Brools III, S.C.1    Brooks, J.S.2    Lee, W.H.3
  • 86
    • 68949091995 scopus 로고    scopus 로고
    • Role of adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway in repression of liver X receptor-alpha-dependent lipogenic gene induction and hepatic steatosis by a novel class of dithiolethiones
    • Hwahng SH, Ki SH, Bae EJ, et al. Role of adenosine monophosphate- activated protein kinase-p70 ribosomal S6 kinase-1 pathway in repression of liver X receptor-alpha-dependent lipogenic gene induction and hepatic steatosis by a novel class of dithiolethiones. Hepatology 2009;49(6):1913-25
    • (2009) Hepatology , vol.49 , Issue.6 , pp. 1913-1925
    • Hwahng, S.H.1    Ki, S.H.2    Bae, E.J.3
  • 87
    • 84883202705 scopus 로고    scopus 로고
    • Available From Last accessed 27 May
    • Available from: Http://www.clinicaltrials. gov/ct2/show/NCT01373554 [Last accessed 27 May 2013
    • (2013)
  • 88
    • 84883144114 scopus 로고    scopus 로고
    • Ipraglifozin (ASP1941) a novel sglt2 inhibitor demonstrates beneficial effects on nonalcoholic fatty liver disease
    • abstract P998]. 72nd Annual Meeting And Scientific Sessions Of The American Diabetes Association; 8 - 12 June 2012; Philadelphia
    • Kurosaki E, Takasu T, Yamazaki S, et al. Ipraglifozin (ASP1941), a novel SGLT2 inhibitor, demonstrates beneficial effects on nonalcoholic fatty liver disease in animal models [abstract P998]. 72nd Annual Meeting and Scientific Sessions of the American Diabetes Association; 8 - 12 June 2012; Philadelphia
    • Animal Models
    • Kurosaki, E.1    Takasu, T.2    Yamazaki, S.3
  • 89
    • 84883170597 scopus 로고    scopus 로고
    • Treatment with anti-vascular endothelial growth factor receptor 2 (avegfr2) antibodies attenuates steatosis and inflammation
    • NASH) [abstract 248]. 63rd Ann Meet AASLD; Boston
    • Coulon SH, Heindryckx F, Colle I, et al. Treatment with anti-vascular endothelial growth factor receptor 2 (aVEGFR2) antibodies attenuates steatosis and inflammation in a diet-induced mouse model for non-alcoholic steatohepatitis (NASH) [abstract 248]. 63rd Ann Meet AASLD; Boston; 2012
    • (2012) A Diet-induced Mouse Model For Non-Alcoholic Steatohepatitis
    • Coulon, S.H.1    Heindryckx, F.2    Colle, I.3
  • 91
    • 84883146478 scopus 로고    scopus 로고
    • Available From Last accessed 27 May
    • Available from: Http://ir.isispharm.com/ phoenix.zhtml?c=222170&p= irolnewsArticle& id=1639873 [Last accessed 27 May 2013
    • (2013)
  • 92
    • 84883156297 scopus 로고    scopus 로고
    • Available from Last accessed 27 May
    • Available from: Http://www.phynova. com/Research-Development- ProductPipeline.asp#PYN22 [Last accessed 27 May 2013
    • (2013)
  • 93
    • 84883178844 scopus 로고    scopus 로고
    • Available from Last accessed 27 May
    • Available from: Http://www.phynova. com/Research-Development-Obesity.asp [Last accessed 27 May 2013
    • (2013)
  • 94
    • 84883138941 scopus 로고    scopus 로고
    • Available from Last accessed 27 May
    • Available from: Http://www. alplifesciences.com/News.aspx [Last accessed 27 May 2013
    • (2013)
  • 95
    • 84857677922 scopus 로고    scopus 로고
    • Sitagliptin as a novel treatment agent for non-alcoholic fatty liver disease patients with type 2 diabetes mellitus
    • Iwasaki T, Yoneda M, Inamori M, et al. Sitagliptin as a novel treatment agent for non-alcoholic fatty liver disease patients with type 2 diabetes mellitus. Hepatogastroenterology 2011;58(112):2103-5
    • (2011) Hepatogastroenterology , vol.58 , Issue.112 , pp. 2103-2105
    • Iwasaki, T.1    Yoneda, M.2    Inamori, M.3
  • 96
    • 78650336759 scopus 로고    scopus 로고
    • Association of the rs738409 polymorphism in PNPLA3 with liver damage and the development of nonalcoholic fatty liver disease
    • Hotta K, Yoneda M, Hyogo H, et al. Association of the rs738409 polymorphism in PNPLA3 with liver damage and the development of nonalcoholic fatty liver disease. BMC Med Genet 2010;11:172
    • (2010) BMC Med Genet , vol.11 , pp. 172
    • Hotta, K.1    Yoneda, M.2    Hyogo, H.3
  • 97
    • 79957462315 scopus 로고    scopus 로고
    • Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease
    • Sookoian S, Pirola CJ. Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease. Hepatology 2011;53(6):1883-94
    • (2011) Hepatology , vol.53 , Issue.6 , pp. 1883-1894
    • Sookoian, S.1    Pirola, C.J.2
  • 98
    • 84879499129 scopus 로고    scopus 로고
    • Genome-wide scan revealed that polymorphisms in the pnpla3 samm50 and parvb genes are associated with development and progression of nonalcoholic fatty liver disease in japan
    • Published Online 28 March 2013
    • Kitamoto T, Kitamoto A, Yoneda M, et al. Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan. Hum Genet 2013; published online 28 March 2013
    • (2013) Hum Genet
    • Kitamoto, T.1    Kitamoto, A.2    Yoneda, M.3
  • 99
    • 58849134985 scopus 로고    scopus 로고
    • Long-term follow-up of patients with nonalcoholic fatty liver
    • Rafiq N, Bai C, Fang Y, et al. Long-term follow-up of patients with nonalcoholic fatty liver. Clin Gastroenterol Hepatol 2009;7:234-8
    • (2009) Clin Gastroenterol Hepatol , vol.7 , pp. 234-238
    • Rafiq, N.1    Bai, C.2    Fang, Y.3


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