-
1
-
-
0036906177
-
uPAR: a versatile signalling orchestrator
-
Blasi F, Carmeliet P. uPAR: a versatile signalling orchestrator. Nat Rev Mol Cell Biol. 2002; 3: 932-43.
-
(2002)
Nat Rev Mol Cell Biol.
, vol.3
, pp. 932-943
-
-
Blasi, F.1
Carmeliet, P.2
-
2
-
-
40649121508
-
Evolving role of uPA/uPAR system in human cancers
-
doi:S0305-7372(07)00181-8 [pii]10.1016/j.ctrv.2007.10.005
-
Dass K, Ahmad A, Azmi AS, Sarkar SH, Sarkar FH. Evolving role of uPA/uPAR system in human cancers. Cancer Treat Rev. 2008; 34: 122-36. doi:S0305-7372(07)00181-8 [pii]10.1016/j.ctrv.2007.10.005.
-
(2008)
Cancer Treat Rev.
, vol.34
, pp. 122-136
-
-
Dass, K.1
Ahmad, A.2
Azmi, A.S.3
Sarkar, S.H.4
Sarkar, F.H.5
-
3
-
-
53249122047
-
Urokinase plasminogen activator receptor choreographs multiple ligand interactions: implications for tumor progression and therapy
-
Mazar AP. Urokinase plasminogen activator receptor choreographs multiple ligand interactions: implications for tumor progression and therapy. Clin Cancer Res. 2008; 14: 5649-55.
-
(2008)
Clin Cancer Res.
, vol.14
, pp. 5649-5655
-
-
Mazar, A.P.1
-
4
-
-
33947321575
-
uPAR-uPA-PAI-1 interactions and signaling: a vascular biologist's view
-
Binder BR, Mihaly J, Prager GW. uPAR-uPA-PAI-1 interactions and signaling: a vascular biologist's view. Thromb Haemost. 2007; 97: 336-42.
-
(2007)
Thromb Haemost.
, vol.97
, pp. 336-342
-
-
Binder, B.R.1
Mihaly, J.2
Prager, G.W.3
-
5
-
-
38449118343
-
The urokinase-system--role of cell proliferation and apoptosis
-
Hildenbrand R, Gandhari M, Stroebel P, Marx A, Allgayer H, Arens N. The urokinase-system--role of cell proliferation and apoptosis. Histol Histopathol. 2008; 23: 227-36.
-
(2008)
Histol Histopathol.
, vol.23
, pp. 227-236
-
-
Hildenbrand, R.1
Gandhari, M.2
Stroebel, P.3
Marx, A.4
Allgayer, H.5
Arens, N.6
-
6
-
-
74949099621
-
Urokinase plasminogen activator system as a potential target for cancer therapy
-
Mekkawy AH, Morris DL, Pourgholami MH. Urokinase plasminogen activator system as a potential target for cancer therapy. Future Oncol. 2009; 5: 1487-99.
-
(2009)
Future Oncol.
, vol.5
, pp. 1487-1499
-
-
Mekkawy, A.H.1
Morris, D.L.2
Pourgholami, M.H.3
-
7
-
-
80051702732
-
The urokinase receptor interactome
-
Eden G, Archinti M, Furlan F, Murphy R, Degryse B. The urokinase receptor interactome. Curr Pharm Des. 2011; 17: 1874-89.
-
(2011)
Curr Pharm Des.
, vol.17
, pp. 1874-1889
-
-
Eden, G.1
Archinti, M.2
Furlan, F.3
Murphy, R.4
Degryse, B.5
-
8
-
-
80051697374
-
Development of novel therapeutics targeting the urokinase plasminogen activator receptor (uPAR) and their translation toward the clinic
-
Mazar AP, Ahn RW, O'Halloran TV. Development of novel therapeutics targeting the urokinase plasminogen activator receptor (uPAR) and their translation toward the clinic. Curr Pharm Des. 2011; 17: 1970-8.
-
(2011)
Curr Pharm Des.
, vol.17
, pp. 1970-1978
-
-
Mazar, A.P.1
Ahn, R.W.2
O'Halloran, T.V.3
-
9
-
-
78649305580
-
Phase II, two-arm, double-blind, multicenter, randomized study of the combination of oral WX-671 plus capecitabine versus capecitabine in first-line HER2-negative metastatic breast cancer (MBC)
-
abstrTPS131
-
Goldstein LJ, Stemmer SM, Schmalfeldt B, Gottschalk N, Cardoso F, Dushkin H, et al. Phase II, two-arm, double-blind, multicenter, randomized study of the combination of oral WX-671 plus capecitabine versus capecitabine in first-line HER2-negative metastatic breast cancer (MBC). J Clin Oncol. 2010; 28 (Suppl 15s): abstrTPS131.
-
(2010)
J Clin Oncol.
, vol.28
, Issue.SUPPL. 15S
-
-
Goldstein, L.J.1
Stemmer, S.M.2
Schmalfeldt, B.3
Gottschalk, N.4
Cardoso, F.5
Dushkin, H.6
-
10
-
-
78649245011
-
Randomized phase II trial with an uPA inhibitor (WX-671) in patients with locally advanced nonmetastatic pancreatic cancer
-
Heinemann V, Ebert MP, Pinter T, Bevan P, Neville NG, Mala C. Randomized phase II trial with an uPA inhibitor (WX-671) in patients with locally advanced nonmetastatic pancreatic cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2010; 28.
-
(2010)
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
, pp. 28
-
-
Heinemann, V.1
Ebert, M.P.2
Pinter, T.3
Bevan, P.4
Neville, N.G.5
Mala, C.6
-
11
-
-
84883179635
-
-
Wilex. MESUPRON® met its primary objective of demonstrating efficacy in the proof of concept phase II breast cancer trial
-
Wilex. MESUPRON® met its primary objective of demonstrating efficacy in the proof of concept phase II breast cancer trial. 2012.
-
(2012)
-
-
-
12
-
-
0034722898
-
Critical appraisal of the use of matrix metalloproteinase inhibitors in cancer treatment
-
doi:10.1038/sj.onc.1204097
-
Zucker S, Cao J, Chen WT. Critical appraisal of the use of matrix metalloproteinase inhibitors in cancer treatment. Oncogene. 2000; 19: 6642-50. doi:10.1038/sj.onc.1204097.
-
(2000)
Oncogene.
, vol.19
, pp. 6642-6650
-
-
Zucker, S.1
Cao, J.2
Chen, W.T.3
-
13
-
-
84866143444
-
New and paradoxical roles of matrix metalloproteinases in the tumor microenvironment
-
doi:10.3389/fphar.2012.00140
-
Noel A, Gutierrez-Fernandez A, Sounni NE, Behrendt N, Maquoi E, Lund IK, et al. New and paradoxical roles of matrix metalloproteinases in the tumor microenvironment. Frontiers in pharmacology. 2012; 3: 140. doi:10.3389/fphar.2012.00140.
-
(2012)
Frontiers in pharmacology.
, vol.3
, pp. 140
-
-
Noel, A.1
Gutierrez-Fernandez, A.2
Sounni, N.E.3
Behrendt, N.4
Maquoi, E.5
Lund, I.K.6
-
14
-
-
0030907299
-
Involvement of PA/plasmin system in the processing of pro-MMP-9 and in the second step of pro-MMP-2 activation
-
doi:10.1016/s0014-5793(97)00175-0
-
Baramova EN, Bajou K, Remacle A, L'Hoir C, Krell HW, Weidle UH, et al. Involvement of PA/plasmin system in the processing of pro-MMP-9 and in the second step of pro-MMP-2 activation. FEBS Letters. 1997; 405: 157-62. doi:10.1016/s0014-5793(97)00175-0.
-
(1997)
FEBS Letters.
, vol.405
, pp. 157-162
-
-
Baramova, E.N.1
Bajou, K.2
Remacle, A.3
L'Hoir, C.4
Krell, H.W.5
Weidle, U.H.6
-
15
-
-
0030715322
-
ECM and cell surface proteolysis: regulating cellular ecology
-
Werb Z. ECM and cell surface proteolysis: regulating cellular ecology. Cell. 1997; 91: 439-42.
-
(1997)
Cell.
, vol.91
, pp. 439-442
-
-
Werb, Z.1
-
16
-
-
0038049137
-
Tumour-cell invasion and migration: diversity and escape mechanisms
-
doi:10.1038/nrc1075
-
Friedl P, Wolf K. Tumour-cell invasion and migration: diversity and escape mechanisms. Nat Rev Cancer. 2003; 3: 362-74. doi:10.1038/nrc1075.
-
(2003)
Nat Rev Cancer.
, vol.3
, pp. 362-374
-
-
Friedl, P.1
Wolf, K.2
-
18
-
-
0038643516
-
Urokinase receptor and integrin interactions
-
Kugler MC, Wei Y, Chapman HA. Urokinase receptor and integrin interactions. Curr Pharm Des. 2003; 9: 1565-74.
-
(2003)
Curr Pharm Des.
, vol.9
, pp. 1565-1574
-
-
Kugler, M.C.1
Wei, Y.2
Chapman, H.A.3
-
19
-
-
0035830838
-
Urokinase-type plasminogen activator receptor (CD87) is a ligand for integrins and mediates cell-cell interaction
-
doi:10.1074/jbc.M008220200
-
Tarui T, Mazar AP, Cines DB, Takada Y. Urokinase-type plasminogen activator receptor (CD87) is a ligand for integrins and mediates cell-cell interaction. J Biol Chem. 2001; 276: 3983-90. doi:10.1074/jbc.M008220200.
-
(2001)
J Biol Chem.
, vol.276
, pp. 3983-3990
-
-
Tarui, T.1
Mazar, A.P.2
Cines, D.B.3
Takada, Y.4
-
20
-
-
80053135166
-
Crosstalk between the urokinase-type plasminogen activator receptor and EGF receptor variant III supports survival and growth of glioblastoma cells
-
doi:10.1073/pnas.1113416108
-
Hu J, Jo M, Cavenee WK, Furnari F, VandenBerg SR, Gonias SL. Crosstalk between the urokinase-type plasminogen activator receptor and EGF receptor variant III supports survival and growth of glioblastoma cells. Proc Natl Acad Sci U S A. 2011; 108: 15984-9. doi:10.1073/pnas.1113416108.
-
(2011)
Proc Natl Acad Sci U S A.
, vol.108
, pp. 15984-9
-
-
Hu, J.1
Jo, M.2
Cavenee, W.K.3
Furnari, F.4
VandenBerg, S.R.5
Gonias, S.L.6
-
21
-
-
4344614173
-
The soluble D2D3(88-274) fragment of the urokinase receptor inhibits monocyte chemotaxis and integrin-dependent cell adhesion
-
doi:10.1242/jcs.01149
-
Furlan F, Orlando S, Laudanna C, Resnati M, Basso V, Blasi F, et al. The soluble D2D3(88-274) fragment of the urokinase receptor inhibits monocyte chemotaxis and integrin-dependent cell adhesion. J Cell Sci. 2004; 117: 2909-16. doi:10.1242/jcs.01149.
-
(2004)
J Cell Sci.
, vol.117
, pp. 2909-2916
-
-
Furlan, F.1
Orlando, S.2
Laudanna, C.3
Resnati, M.4
Basso, V.5
Blasi, F.6
-
22
-
-
0033959101
-
Extracellular signal-regulated kinase functions in the urokinase receptor-dependent pathway by which neutralization of low density lipoprotein receptor-related protein promotes fibrosarcoma cell migration and matrigel invasion
-
Webb DJ, Nguyen DH, Gonias SL. Extracellular signal-regulated kinase functions in the urokinase receptor-dependent pathway by which neutralization of low density lipoprotein receptor-related protein promotes fibrosarcoma cell migration and matrigel invasion. J Cell Sci. 2000; 113 ( Pt 1): 123-34.
-
(2000)
J Cell Sci.
, vol.113
, Issue.PART 1
, pp. 123-134
-
-
Webb, D.J.1
Nguyen, D.H.2
Gonias, S.L.3
-
23
-
-
31944447012
-
Structure of human urokinase plasminogen activator in complex with its receptor
-
Huai Q, Mazar AP, Kuo A, Parry GC, Shaw DE, Callahan J, Li Y, Yuan C, Bian C, Chen L, Furie B, Furie BC, Cines DB, Huang M. Structure of human urokinase plasminogen activator in complex with its receptor. Science. 2006;311: 656-9.
-
(2006)
Science.
, vol.311
, pp. 656-659
-
-
Huai, Q.1
Mazar, A.P.2
Kuo, A.3
Parry, G.C.4
Shaw, D.E.5
Callahan, J.6
Li, Y.7
Yuan, C.8
Bian, C.9
Chen, L.10
Furie, B.11
Furie, B.C.12
Cines, D.B.13
Huang, M.14
-
24
-
-
80051701116
-
The Urokinase Receptor and Integrins Constitute a Cell Migration Signalosome The Cancer Degradome
-
Springer New York
-
Degryse B. The Urokinase Receptor and Integrins Constitute a Cell Migration Signalosome The Cancer Degradome. In: Edwards D, Høyer-Hansen G, Blasi F, Sloane BF, editors.: Springer New York; 2008;: 451-74.
-
Edwards D, Høyer-Hansen G, Blasi F, Sloane BF, editors.
, vol.2008
, pp. 451-474
-
-
Degryse, B.1
-
25
-
-
33646920445
-
Urokinase-type plasminogen activator receptor regulates a novel pathway of fibronectin matrix assembly requiring Src-dependent transactivation of epidermal growth factor receptor
-
doi:10.1074/jbc.M501901200
-
Monaghan-Benson E, McKeown-Longo PJ. Urokinase-type plasminogen activator receptor regulates a novel pathway of fibronectin matrix assembly requiring Src-dependent transactivation of epidermal growth factor receptor. J Biol Chem. 2006; 281: 9450-9. doi:10.1074/jbc.M501901200.
-
(2006)
J Biol Chem.
, vol.281
, pp. 9450-9459
-
-
Monaghan-Benson, E.1
McKeown-Longo, P.J.2
-
26
-
-
33748286819
-
Integrin-regulated FAK-Src signaling in normal and cancer cells
-
Mitra SK, Schlaepfer DD. Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr Opin Cell Biol. 2006;18: 516-23.
-
(2006)
Curr Opin Cell Biol.
, vol.18
, pp. 516-523
-
-
Mitra, S.K.1
Schlaepfer, D.D.2
-
27
-
-
0035008874
-
Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression
-
Hutchinson J, Jin J, Cardiff RD, Woodgett JR, Muller WJ. Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression. Mol Cell Biol. 2001; 21: 2203-12.
-
(2001)
Mol Cell Biol.
, vol.21
, pp. 2203-2212
-
-
Hutchinson, J.1
Jin, J.2
Cardiff, R.D.3
Woodgett, J.R.4
Muller, W.J.5
-
28
-
-
0030926412
-
Recycling of the urokinase receptor upon internalization of the uPA:serpin complexes
-
doi:10.1093/emboj/16.10.2610
-
Nykjaer A, Conese M, Christensen EI, Olson D, Cremona O, Gliemann J, et al. Recycling of the urokinase receptor upon internalization of the uPA:serpin complexes. Embo J. 1997; 16: 2610-20. doi:10.1093/emboj/16.10.2610.
-
(1997)
Embo J.
, vol.16
, pp. 2610-2620
-
-
Nykjaer, A.1
Conese, M.2
Christensen, E.I.3
Olson, D.4
Cremona, O.5
Gliemann, J.6
-
29
-
-
1542503922
-
CD87 (urokinase-type plasminogen activator receptor), function and pathology in hematological disorders: a review
-
doi:10.1038/sj.leu.2403250
-
Bene MC, Castoldi G, Knapp W, Rigolin GM, Escribano L, Lemez P, et al. CD87 (urokinase-type plasminogen activator receptor), function and pathology in hematological disorders: a review. Leukemia. 2004; 18: 394-400. doi:10.1038/sj.leu.2403250.
-
(2004)
Leukemia.
, vol.18
, pp. 394-400
-
-
Bene, M.C.1
Castoldi, G.2
Knapp, W.3
Rigolin, G.M.4
Escribano, L.5
Lemez, P.6
-
30
-
-
0033859145
-
Expression of urokinase plasminogen activator and the urokinase plasminogen activator receptor in myeloma cells
-
Hjertner O, Qvigstad G, Hjorth-Hansen H, Seidel C, Woodliff J, Epstein J, et al. Expression of urokinase plasminogen activator and the urokinase plasminogen activator receptor in myeloma cells. Br J Haematol. 2000; 109: 815-22.
-
(2000)
Br J Haematol.
, vol.109
, pp. 815-822
-
-
Hjertner, O.1
Qvigstad, G.2
Hjorth-Hansen, H.3
Seidel, C.4
Woodliff, J.5
Epstein, J.6
-
31
-
-
16644402997
-
In situ gene expression of urokinase-type plasminogenactivator and its receptor in transitional cell carcinoma of the human bladder
-
Bhuvarahamurthy V, Schroeder J, Denkert C, Kristiansen G, Schnorr D, Loening SA, et al. In situ gene expression of urokinase-type plasminogenactivator and its receptor in transitional cell carcinoma of the human bladder. Oncol Rep. 2004; 12: 909-13.
-
(2004)
Oncol Rep.
, vol.12
, pp. 909-913
-
-
Bhuvarahamurthy, V.1
Schroeder, J.2
Denkert, C.3
Kristiansen, G.4
Schnorr, D.5
Loening, S.A.6
-
32
-
-
0031015122
-
Enhanced expression of urokinase plasminogen activator and its receptor in pancreatic carcinoma
-
Cantero D, Friess H, Deflorin J, Zimmermann A, Brundler MA, Riesle E, et al. Enhanced expression of urokinase plasminogen activator and its receptor in pancreatic carcinoma. Br J Cancer. 1997; 75: 388-95.
-
(1997)
Br J Cancer.
, vol.75
, pp. 388-395
-
-
Cantero, D.1
Friess, H.2
Deflorin, J.3
Zimmermann, A.4
Brundler, M.A.5
Riesle, E.6
-
33
-
-
33845602208
-
The prognostic value of the topographic distribution of uPAR expression in invasive breast carcinomas
-
Giannopoulou I, Mylona E, Kapranou A, Mavrommatis J, Markaki S, Zoumbouli C, et al. The prognostic value of the topographic distribution of uPAR expression in invasive breast carcinomas. Cancer Lett. 2007; 246: 262-7.
-
(2007)
Cancer Lett.
, vol.246
, pp. 262-267
-
-
Giannopoulou, I.1
Mylona, E.2
Kapranou, A.3
Mavrommatis, J.4
Markaki, S.5
Zoumbouli, C.6
-
34
-
-
79551718325
-
Targeting the urokinase plasminogen activator receptor inhibits ovarian cancer metastasis
-
doi:1078-0432.CCR-10-2258 [pii]10.1158/1078-0432.CCR-10-2258
-
Kenny HA, Leonhardt P, Ladanyi A, Yamada SD, Montag A, Im HK, et al. Targeting the urokinase plasminogen activator receptor inhibits ovarian cancer metastasis. Clin Cancer Res. 2011; 17: 459-71. doi:1078-0432.CCR-10-2258 [pii]10.1158/1078-0432.CCR-10-2258.
-
(2011)
Clin Cancer Res.
, vol.17
, pp. 459-471
-
-
Kenny, H.A.1
Leonhardt, P.2
Ladanyi, A.3
Yamada, S.D.4
Montag, A.5
Im, H.K.6
-
35
-
-
34548414532
-
Targeting uPA/uPAR in prostate cancer
-
doi:10.1016/j.ctrv.2007.06.003
-
Li Y, Cozzi PJ. Targeting uPA/uPAR in prostate cancer. Cancer Treat Rev. 2007; 33: 521-7. doi:10.1016/j.ctrv.2007.06.003.
-
(2007)
Cancer Treat Rev.
, vol.33
, pp. 521-527
-
-
Li, Y.1
Cozzi, P.J.2
-
36
-
-
51049094210
-
Imaging of Urokinase-Type Plasminogen Activator Receptor Expression Using a 64Cu-Labeled Linear Peptide Antagonist by microPET
-
Li Z-B, Niu G, Wang H, He L, Yang L, Ploug M, et al. Imaging of Urokinase-Type Plasminogen Activator Receptor Expression Using a 64Cu-Labeled Linear Peptide Antagonist by microPET. Clin Cancer Res. 2008; 14: 4758-66.
-
(2008)
Clin Cancer Res.
, vol.14
, pp. 4758-4766
-
-
Li, Z.-B.1
Niu, G.2
Wang, H.3
He, L.4
Yang, L.5
Ploug, M.6
-
37
-
-
0028357266
-
Immunohistochemical detection of the receptor for urokinase plasminogen activator in human colon cancer
-
Pyke C, Ralfkiaer E, Ronne E, Hoyer-Hansen G, Kirkeby L, Dano K. Immunohistochemical detection of the receptor for urokinase plasminogen activator in human colon cancer. Histopathology. 1994; 24: 131-8.
-
(1994)
Histopathology.
, vol.24
, pp. 131-138
-
-
Pyke, C.1
Ralfkiaer, E.2
Ronne, E.3
Hoyer-Hansen, G.4
Kirkeby, L.5
Dano, K.6
-
38
-
-
34547107592
-
Hypoxia-driven selection of the metastatic phenotype
-
doi:10.1007/s10555-007-9062-2
-
Sullivan R, Graham CH. Hypoxia-driven selection of the metastatic phenotype. Cancer Metastasis Rev. 2007; 26: 319-31. doi:10.1007/s10555-007-9062-2.
-
(2007)
Cancer Metastasis Rev.
, vol.26
, pp. 319-331
-
-
Sullivan, R.1
Graham, C.H.2
-
39
-
-
55349148006
-
Identification of uPAR-positive chemoresistant cells in small cell lung cancer
-
doi:10.1371/journal.pone.0000243
-
Gutova M, Najbauer J, Gevorgyan A, Metz MZ, Weng Y, Shih CC, et al. Identification of uPAR-positive chemoresistant cells in small cell lung cancer. PLoS One. 2007; 2: e243. doi:10.1371/journal.pone.0000243.
-
(2007)
PLoS One.
, vol.2
-
-
Gutova, M.1
Najbauer, J.2
Gevorgyan, A.3
Metz, M.Z.4
Weng, Y.5
Shih, C.C.6
-
40
-
-
78449305061
-
Cell signaling by urokinase-type plasminogen activator receptor induces stem cell-like properties in breast cancer cells
-
doi:10.1158/0008-5472.CAN-10-1936
-
Jo M, Eastman BM, Webb DL, Stoletov K, Klemke R, Gonias SL. Cell signaling by urokinase-type plasminogen activator receptor induces stem cell-like properties in breast cancer cells. Cancer Res. 2010; 70: 8948-58. doi:10.1158/0008-5472.CAN-10-1936.
-
(2010)
Cancer Res.
, vol.70
, pp. 8948-8958
-
-
Jo, M.1
Eastman, B.M.2
Webb, D.L.3
Stoletov, K.4
Klemke, R.5
Gonias, S.L.6
-
41
-
-
65549141305
-
Acquisition of Epithelial-Mesenchymal Transition Phenotype of Gemcitabine-Resistant Pancreatic Cancer Cells Is Linked with Activation of the Notch Signaling Pathway
-
doi:10.1158/0008-5472.can-08-4312
-
Wang Z, Li Y, Kong D, Banerjee S, Ahmad A, Azmi AS, et al. Acquisition of Epithelial-Mesenchymal Transition Phenotype of Gemcitabine-Resistant Pancreatic Cancer Cells Is Linked with Activation of the Notch Signaling Pathway. Cancer Res. 2009; 69: 2400-7. doi:10.1158/0008-5472.can-08-4312.
-
(2009)
Cancer Res.
, vol.69
, pp. 2400-2407
-
-
Wang, Z.1
Li, Y.2
Kong, D.3
Banerjee, S.4
Ahmad, A.5
Azmi, A.S.6
-
42
-
-
68049102312
-
Receptor-targeted nanoparticles for in vivo imaging of breast cancer
-
doi:10.1158/1078-0432.CCR-08-3289
-
Yang L, Peng XH, Wang YA, Wang X, Cao Z, Ni C, et al. Receptor-targeted nanoparticles for in vivo imaging of breast cancer. Clin Cancer Res. 2009; 15: 4722-32. doi:10.1158/1078-0432.CCR-08-3289.
-
(2009)
Clin Cancer Res.
, vol.15
, pp. 4722-4732
-
-
Yang, L.1
Peng, X.H.2
Wang, Y.A.3
Wang, X.4
Cao, Z.5
Ni, C.6
-
43
-
-
77954150259
-
Putative cancer stem cells in malignant pleural mesothelioma show resistance to cisplatin and pemetrexed
-
Cortes-Dericks L, Carboni GL, Schmid RA, Karoubi G. Putative cancer stem cells in malignant pleural mesothelioma show resistance to cisplatin and pemetrexed. Int J Oncol. 2010; 37: 437-44.
-
(2010)
Int J Oncol.
, vol.37
, pp. 437-444
-
-
Cortes-Dericks, L.1
Carboni, G.L.2
Schmid, R.A.3
Karoubi, G.4
-
44
-
-
33748053952
-
Plasticity in Urokinase-Type Plasminogen Activator Receptor (uPAR) Display in Colon Cancer Yields Metastable Subpopulations Oscillating in Cell Surface uPAR Density,ÄîImplications in Tumor Progression
-
doi:10.1158/0008-5472.can-05-3208
-
Yang L, Avila H, Wang H, Trevino J, Gallick GE, Kitadai Y, et al. Plasticity in Urokinase-Type Plasminogen Activator Receptor (uPAR) Display in Colon Cancer Yields Metastable Subpopulations Oscillating in Cell Surface uPAR Density,ÄîImplications in Tumor Progression. Cancer Res. 2006; 66: 7957-67. doi:10.1158/0008-5472.can-05-3208.
-
(2006)
Cancer Res.
, vol.66
, pp. 7957-7967
-
-
Yang, L.1
Avila, H.2
Wang, H.3
Trevino, J.4
Gallick, G.E.5
Kitadai, Y.6
-
45
-
-
59449107891
-
Targeted knockdown of Notch1 inhibits invasion of human prostate cancer cells concomitant with inhibition of matrix metalloproteinase-9 and urokinase plasminogen activator
-
doi:10.1158/1078-0432.CCR-08-1631
-
Bin Hafeez B, Adhami VM, Asim M, Siddiqui IA, Bhat KM, Zhong W, et al. Targeted knockdown of Notch1 inhibits invasion of human prostate cancer cells concomitant with inhibition of matrix metalloproteinase-9 and urokinase plasminogen activator. Clin Cancer Res. 2009; 15: 452-9. doi:10.1158/1078-0432.CCR-08-1631.
-
(2009)
Clin Cancer Res.
, vol.15
, pp. 452-459
-
-
Bin Hafeez, B.1
Adhami, V.M.2
Asim, M.3
Siddiqui, I.A.4
Bhat, K.M.5
Zhong, W.6
-
47
-
-
0028885643
-
Individual development and uPA-receptor expression of disseminated tumour cells in bone marrow: a reference to early systemic disease in solid cancer
-
Heiss MM, Allgayer H, Gruetzner KU, Funke I, Babic R, Jauch KW, et al. Individual development and uPA-receptor expression of disseminated tumour cells in bone marrow: a reference to early systemic disease in solid cancer. Nat Med. 1995; 1: 1035-9.
-
(1995)
Nat Med.
, vol.1
, pp. 1035-1039
-
-
Heiss, M.M.1
Allgayer, H.2
Gruetzner, K.U.3
Funke, I.4
Babic, R.5
Jauch, K.W.6
-
48
-
-
33751215245
-
uPAR and HER-2 gene status in individual breast cancer cells from blood and tissues
-
doi:10.1073/pnas.0608113103
-
Meng S, Tripathy D, Shete S, Ashfaq R, Saboorian H, Haley B, et al. uPAR and HER-2 gene status in individual breast cancer cells from blood and tissues. Proc Natl Acad Sci U S A. 2006; 103: 17361-5. doi:10.1073/pnas.0608113103.
-
(2006)
Proc Natl Acad Sci U S A.
, vol.103
, pp. 17361-5
-
-
Meng, S.1
Tripathy, D.2
Shete, S.3
Ashfaq, R.4
Saboorian, H.5
Haley, B.6
-
49
-
-
0035266243
-
ErbB2 overexpression on occult metastatic cells in bone marrow predicts poor clinical outcome of stage I-III breast cancer patients
-
Braun S, Schlimok G, Heumos I, Schaller G, Riethdorf L, Riethmuller G, et al. ErbB2 overexpression on occult metastatic cells in bone marrow predicts poor clinical outcome of stage I-III breast cancer patients. Cancer Res. 2001; 61: 1890-5.
-
(2001)
Cancer Res.
, vol.61
, pp. 1890-1895
-
-
Braun, S.1
Schlimok, G.2
Heumos, I.3
Schaller, G.4
Riethdorf, L.5
Riethmuller, G.6
-
50
-
-
77956594900
-
RNAi-mediated downregulation of uPAR synergizes with targeting of HER2 through the ERK pathway in breast cancer cells
-
doi:10.1002/ijc.25159
-
Li C, Cao S, Liu Z, Ye X, Chen L, Meng S. RNAi-mediated downregulation of uPAR synergizes with targeting of HER2 through the ERK pathway in breast cancer cells. International journal of cancer Journal international du cancer. 2010; 127: 1507-16. doi:10.1002/ijc.25159.
-
(2010)
International journal of cancer Journal international du cancer.
, vol.127
, pp. 1507-1516
-
-
Li, C.1
Cao, S.2
Liu, Z.3
Ye, X.4
Chen, L.5
Meng, S.6
-
51
-
-
84862987061
-
Dual Targeting of the Epidermal Growth Factor Receptor Using the Combination of Cetuximab and Erlotinib: Preclinical Evaluation and Results of the Phase II DUX Study in Chemotherapy-Refractory, Advanced Colorectal Cancer
-
doi:10.1200/jco.2011.38.6599
-
Weickhardt AJ, Price TJ, Chong G, Gebski V, Pavlakis N, Johns TG, et al. Dual Targeting of the Epidermal Growth Factor Receptor Using the Combination of Cetuximab and Erlotinib: Preclinical Evaluation and Results of the Phase II DUX Study in Chemotherapy-Refractory, Advanced Colorectal Cancer. Journal of Clinical Oncology. 2012; 30: 1505-12. doi:10.1200/jco.2011.38.6599.
-
(2012)
Journal of Clinical Oncology.
, vol.30
, pp. 1505-1512
-
-
Weickhardt, A.J.1
Price, T.J.2
Chong, G.3
Gebski, V.4
Pavlakis, N.5
Johns, T.G.6
-
52
-
-
77949884661
-
Randomized Study of Lapatinib Alone or in Combination With Trastuzumab in Women With ErbB2-Positive, Trastuzumab-Refractory Metastatic Breast Cancer
-
doi:10.1200/jco.2008.21.4437
-
Blackwell KL, Burstein HJ, Storniolo AM, Rugo H, Sledge G, Koehler M, et al. Randomized Study of Lapatinib Alone or in Combination With Trastuzumab in Women With ErbB2-Positive, Trastuzumab-Refractory Metastatic Breast Cancer. Journal of Clinical Oncology. 2010; 28: 1124-30. doi:10.1200/jco.2008.21.4437.
-
(2010)
Journal of Clinical Oncology.
, vol.28
, pp. 1124-1130
-
-
Blackwell, K.L.1
Burstein, H.J.2
Storniolo, A.M.3
Rugo, H.4
Sledge, G.5
Koehler, M.6
-
53
-
-
36849005923
-
Development and evaluation of peptidic ligands targeting tumour-associated urokinase plasminogen activator receptor (uPAR) for use in alpha-emitter therapy for disseminated ovarian cancer
-
doi:10.1007/s00259-007-0582-3
-
Knor S, Sato S, Huber T, Morgenstern A, Bruchertseifer F, Schmitt M, et al. Development and evaluation of peptidic ligands targeting tumour-associated urokinase plasminogen activator receptor (uPAR) for use in alpha-emitter therapy for disseminated ovarian cancer. Eur J Nucl Med Mol Imaging. 2008; 35: 53-64. doi:10.1007/s00259-007-0582-3.
-
(2008)
Eur J Nucl Med Mol Imaging.
, vol.35
, pp. 53-64
-
-
Knor, S.1
Sato, S.2
Huber, T.3
Morgenstern, A.4
Bruchertseifer, F.5
Schmitt, M.6
-
54
-
-
84855392303
-
Quantitative PET of human urokinase-type plasminogen activator receptor with 64Cu-DOTA-AE105: implications for visualizing cancer invasion
-
doi:10.2967/jnumed.110.083386
-
Persson M, Madsen J, Ostergaard S, Jensen MM, Jorgensen JT, Juhl K, et al. Quantitative PET of human urokinase-type plasminogen activator receptor with 64Cu-DOTA-AE105: implications for visualizing cancer invasion. J Nucl Med. 2012; 53: 138-45. doi:10.2967/jnumed.110.083386.
-
(2012)
J Nucl Med.
, vol.53
, pp. 138-145
-
-
Persson, M.1
Madsen, J.2
Ostergaard, S.3
Jensen, M.M.4
Jorgensen, J.T.5
Juhl, K.6
-
55
-
-
79151486380
-
Use of molecular markers for predicting therapy response in cancer patients
-
doi:10.1016/j.ctrv.2010.07.004
-
Duffy MJ, O'Donovan N, Crown J. Use of molecular markers for predicting therapy response in cancer patients. Cancer Treat Rev. 2011; 37: 151-9. doi:10.1016/j.ctrv.2010.07.004.
-
(2011)
Cancer Treat Rev.
, vol.37
, pp. 151-159
-
-
Duffy, M.J.1
O'Donovan, N.2
Crown, J.3
-
56
-
-
0026528747
-
Domain analysis of urokinase plasminogen activator (u-PA): Preparation and characterization of intact A-chain molecules
-
doi:10.1016/0268-9499(92)90094-x
-
Mazar AP, Buko A, Petros AM, Barnathan ES, Henkin J. Domain analysis of urokinase plasminogen activator (u-PA): Preparation and characterization of intact A-chain molecules. Fibrinolysis. 1992; 1: 49-55. doi:10.1016/0268-9499(92)90094-x.
-
(1992)
Fibrinolysis.
, vol.1
, pp. 49-55
-
-
Mazar, A.P.1
Buko, A.2
Petros, A.M.3
Barnathan, E.S.4
Henkin, J.5
-
57
-
-
0034677918
-
Recombinant toxins that bind to the urokinase receptor are cytotoxic without requiring binding to the alpha(2)-macroglobulin receptor
-
Rajagopal V, Kreitman RJ. Recombinant toxins that bind to the urokinase receptor are cytotoxic without requiring binding to the alpha(2)-macroglobulin receptor. J Biol Chem. 2000; 275: 7566-73.
-
(2000)
J Biol Chem.
, vol.275
, pp. 7566-7573
-
-
Rajagopal, V.1
Kreitman, R.J.2
-
58
-
-
0026690341
-
The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds and internalizes Pseudomonas exotoxin A
-
Kounnas MZ, Morris RE, Thompson MR, FitzGerald DJ, Strickland DK, Saelinger CB. The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds and internalizes Pseudomonas exotoxin A. J Biol Chem. 1992; 267:12420-3.
-
(1992)
J Biol Chem.
, vol.267
, pp. 12420-3
-
-
Kounnas, M.Z.1
Morris, R.E.2
Thompson, M.R.3
FitzGerald, D.J.4
Strickland, D.K.5
Saelinger, C.B.6
-
59
-
-
33747187531
-
Efficacy of antiangiogenic targeted toxins against glioblastoma multiforme
-
doi:10.3171/foc.2006.20.4.15
-
Hall WA, Vallera DA. Efficacy of antiangiogenic targeted toxins against glioblastoma multiforme. Neurosurg Focus. 2006; 20: E23. doi:10.3171/foc.2006.20.4.15.
-
(2006)
Neurosurg Focus.
, vol.20
-
-
Hall, W.A.1
Vallera, D.A.2
-
60
-
-
84866021530
-
Intracerebral infusion of the bispecific targeted toxin DTATEGF in a mouse xenograft model of a human metastatic non-small cell lung cancer
-
doi:10.1007/s11060-012-0904-6
-
Huang J, Li YM, Massague J, Sicheneder A, Vallera DA, Hall WA. Intracerebral infusion of the bispecific targeted toxin DTATEGF in a mouse xenograft model of a human metastatic non-small cell lung cancer. J Neurooncol. 2012; doi:10.1007/s11060-012-0904-6.
-
(2012)
J Neurooncol.
-
-
Huang, J.1
Li, Y.M.2
Massague, J.3
Sicheneder, A.4
Vallera, D.A.5
Hall, W.A.6
-
61
-
-
79951955120
-
Enhanced noscapine delivery using uPAR-targeted optical-MR imaging trackable nanoparticles for prostate cancer therapy
-
doi:10.1016/j.jconrel.2010.10.030
-
Abdalla MO, Karna P, Sajja HK, Mao H, Yates C, Turner T, et al. Enhanced noscapine delivery using uPAR-targeted optical-MR imaging trackable nanoparticles for prostate cancer therapy. J Control Release. 2011; 149: 314-22. doi:10.1016/j.jconrel.2010.10.030.
-
(2011)
J Control Release.
, vol.149
, pp. 314-322
-
-
Abdalla, M.O.1
Karna, P.2
Sajja, H.K.3
Mao, H.4
Yates, C.5
Turner, T.6
-
62
-
-
78049351925
-
A Reexamination of Active and Passive Tumor Targeting by Using Rod-Shaped Gold Nanocrystals and Covalently Conjugated Peptide Ligands
-
doi:10.1021/nn102055s
-
Huang X, Peng X, Wang Y, Wang Y, Shin DM, El-Sayed MA, et al. A Reexamination of Active and Passive Tumor Targeting by Using Rod-Shaped Gold Nanocrystals and Covalently Conjugated Peptide Ligands. ACS Nano. 2010; 4: 5887-96. doi:10.1021/nn102055s.
-
(2010)
ACS Nano.
, vol.4
, pp. 5887-5896
-
-
Huang, X.1
Peng, X.2
Wang, Y.3
Wang, Y.4
Shin, D.M.5
El-Sayed, M.A.6
-
63
-
-
33746172167
-
Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models
-
doi:10.1158/0008-5472.CAN-05-4199
-
Kirpotin DB, Drummond DC, Shao Y, Shalaby MR, Hong K, Nielsen UB, et al. Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models. Cancer Res. 2006; 66: 6732-40. doi:10.1158/0008-5472.CAN-05-4199.
-
(2006)
Cancer Res.
, vol.66
, pp. 6732-6740
-
-
Kirpotin, D.B.1
Drummond, D.C.2
Shao, Y.3
Shalaby, M.R.4
Hong, K.5
Nielsen, U.B.6
-
64
-
-
61849132133
-
Targeting the Urokinase Plasminogen Activator Receptor with Synthetic Self-Assembly Nanoparticles
-
doi:10.1021/bc8001908
-
Wang M, Loãàwik DWPM, Miller AD, Thanou M. Targeting the Urokinase Plasminogen Activator Receptor with Synthetic Self-Assembly Nanoparticles. Bioconjugate Chemistry. 2008; 20: 32-40. doi:10.1021/bc8001908.
-
(2008)
Bioconjugate Chemistry.
, vol.20
, pp. 32-40
-
-
Wang, M.1
Loãàwik, D.W.P.M.2
Miller, A.D.3
Thanou, M.4
-
65
-
-
77951216201
-
Structure-based engineering of species selectivity in the interaction between urokinase and its receptor: implication for preclinical cancer therapy
-
doi:10.1074/jbc.M109.093492
-
Lin L, Gardsvoll H, Huai Q, Huang M, Ploug M. Structure-based engineering of species selectivity in the interaction between urokinase and its receptor: implication for preclinical cancer therapy. J Biol Chem. 2010; 285: 10982-92. doi:10.1074/jbc.M109.093492.
-
(2010)
J Biol Chem.
, vol.285
, pp. 10982-92
-
-
Lin, L.1
Gardsvoll, H.2
Huai, Q.3
Huang, M.4
Ploug, M.5
-
66
-
-
1642362625
-
Drug delivery systems: entering the mainstream
-
Allen TM, Cullis PR. Drug delivery systems: entering the mainstream. Science (New York, NY. 2004; 303: 1818-22.
-
(2004)
Science (New York, NY.
, vol.303
, pp. 1818-1822
-
-
Allen, T.M.1
Cullis, P.R.2
-
67
-
-
36849067019
-
Nanocarriers as an emerging platform for cancer therapy
-
Peer D, Karp JM, Hong S, Farokhzad OC, Margalit R, Langer R. Nanocarriers as an emerging platform for cancer therapy. Nat Nano. 2007; 2: 751-60.
-
(2007)
Nat Nano.
, vol.2
, pp. 751-760
-
-
Peer, D.1
Karp, J.M.2
Hong, S.3
Farokhzad, O.C.4
Margalit, R.5
Langer, R.6
-
68
-
-
0034000453
-
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review
-
doi:10.1016/s0168-3659(99)00248-5
-
Maeda H, Wu J, Sawa T, Matsumura Y, Hori K. Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. J Control Release. 2000; 65: 271-84. doi:10.1016/s0168-3659(99)00248-5.
-
(2000)
J Control Release.
, vol.65
, pp. 271-284
-
-
Maeda, H.1
Wu, J.2
Sawa, T.3
Matsumura, Y.4
Hori, K.5
-
69
-
-
77954735171
-
A Novel Nanoparticulate Formulation of Arsenic Trioxide with Enhanced Therapeutic Efficacy in a Murine Model of Breast Cancer
-
doi:10.1158/1078-0432.ccr-10-0068
-
Ahn RW, Chen F, Chen H, Stern ST, Clogston JD, Patri AK, et al. A Novel Nanoparticulate Formulation of Arsenic Trioxide with Enhanced Therapeutic Efficacy in a Murine Model of Breast Cancer. Clin Cancer Res. 2010; 16: 3607-17. doi:10.1158/1078-0432.ccr-10-0068.
-
(2010)
Clin Cancer Res.
, vol.16
, pp. 3607-3617
-
-
Ahn, R.W.1
Chen, F.2
Chen, H.3
Stern, S.T.4
Clogston, J.D.5
Patri, A.K.6
-
70
-
-
72949088654
-
Coencapsulation of Arsenic- and Platinum-based Drugs for Targeted Cancer Treatment
-
Chen H, Pazicni S, Krett NL, Ahn RW, Penner-Hahn JE, Rosen ST, et al. Coencapsulation of Arsenic- and Platinum-based Drugs for Targeted Cancer Treatment. Angew Chem Int Ed. 2009; 121: 9459-63.
-
(2009)
Angew Chem Int Ed.
, vol.121
, pp. 9459-9463
-
-
Chen, H.1
Pazicni, S.2
Krett, N.L.3
Ahn, R.W.4
Penner-Hahn, J.E.5
Rosen, S.T.6
-
71
-
-
37049010752
-
Polymer-caged liposomes: a pH-responsive delivery system with high stability
-
Lee S-M, Chen H, Dettmer CM, O'Halloran TV, Nguyen ST. Polymer-caged liposomes: a pH-responsive delivery system with high stability. J Am Chem Soc. 2007; 129: 15096-7.
-
(2007)
J Am Chem Soc.
, vol.129
, pp. 15096-7
-
-
Lee, S.-M.1
Chen, H.2
Dettmer, C.M.3
O'Halloran, T.V.4
Nguyen, S.T.5
-
72
-
-
77957321135
-
Biological evaluation of pH-responsive polymer-caged nanobins for breast cancer therapy
-
doi:10.1021/nn100560p
-
Lee S-M, Ahn RW, Chen F, Fought AJ, O'Halloran TV, Cryns VL, et al. Biological evaluation of pH-responsive polymer-caged nanobins for breast cancer therapy. ACS Nano. 2010; 4: 4971-8. doi:10.1021/nn100560p.
-
(2010)
ACS Nano.
, vol.4
, pp. 4971-4978
-
-
Lee, S.-M.1
Ahn, R.W.2
Chen, F.3
Fought, A.J.4
O'Halloran, T.V.5
Cryns, V.L.6
-
73
-
-
78650077255
-
Polymer-Caged Nanobins for Synergistic Cisplatin-Doxorubicin Combination Chemotherapy
-
doi:10.1021/ja107333g
-
Lee S-M, O'Halloran TV, Nguyen ST. Polymer-Caged Nanobins for Synergistic Cisplatin-Doxorubicin Combination Chemotherapy. J Am Chem Soc. 2010. doi:10.1021/ja107333g.
-
(2010)
J Am Chem Soc.
-
-
Lee, S.-M.1
O'Halloran, T.V.2
Nguyen, S.T.3
-
74
-
-
33745951677
-
Spectral imaging perspective on cytomics
-
doi:10.1002/cyto.a.20292
-
Levenson RM. Spectral imaging perspective on cytomics. Cytometry A. 2006; 69: 592-600. doi:10.1002/cyto.a.20292.
-
(2006)
Cytometry A.
, vol.69
, pp. 592-600
-
-
Levenson, R.M.1
-
75
-
-
24744449559
-
Targeting of urokinase plasminogen activator receptor in human pancreatic carcinoma cells inhibits c-Met- and insulin-like growth factor-I receptor-mediated migration and invasion and orthotopic tumor growth in mice
-
Bauer TW, Liu W, Fan F, Camp ER, Yang A, Somcio RJ, Bucana CD, Callahan J, Parry GC, Evans DB, Boyd DD, Mazar AP, Ellis LM. Targeting of urokinase plasminogen activator receptor in human pancreatic carcinoma cells inhibits c-Met- and insulin-like growth factor-I receptor-mediated migration and invasion and orthotopic tumor growth in mice. Cancer Res. 2005; 65: 7775-81.
-
(2005)
Cancer Res.
, vol.65
, pp. 7775-7781
-
-
Bauer, T.W.1
Liu, W.2
Fan, F.3
Camp, E.R.4
Yang, A.5
Somcio, R.J.6
Bucana, C.D.7
Callahan, J.8
Parry, G.C.9
Evans, D.B.10
Boyd, D.D.11
Mazar, A.P.12
Ellis, L.M.13
-
76
-
-
68549133353
-
Targeting the urokinase plasminogen activator receptor with a monoclonal antibody impairs the growth of human colorectal cancer in the liver
-
doi: 10.1002/cncr.24371
-
Van Buren G, Gray MJ, Dallas NA, Xia L, Lim SJ, Fan F, Mazar AP, Ellis LM. Targeting the urokinase plasminogen activator receptor with a monoclonal antibody impairs the growth of human colorectal cancer in the liver. Cancer. 2009;115: 3360-8. doi: 10.1002/cncr.24371.
-
(2009)
Cancer.
, vol.115
, pp. 3360-3368
-
-
Van Buren, G.1
Gray, M.J.2
Dallas, N.A.3
Xia, L.4
Lim, S.J.5
Fan, F.6
Mazar, A.P.7
Ellis, L.M.8
-
77
-
-
77957797120
-
An anti-urokinase plasminogen activator receptor antibody (ATN-658) blocks prostate cancer invasion, migration, growth, and experimental skeletal metastasis in vitro and in vivo
-
Rabbani SA, Ateeq B, Arakelian A, Valentino ML, Shaw DE, Dauffenbach LM, Kerfoot CA, Mazar AP. An anti-urokinase plasminogen activator receptor antibody (ATN-658) blocks prostate cancer invasion, migration, growth, and experimental skeletal metastasis in vitro and in vivo. Neoplasia 2010; 12: 778-88.
-
(2010)
Neoplasia
, vol.12
, pp. 778-788
-
-
Rabbani, S.A.1
Ateeq, B.2
Arakelian, A.3
Valentino, M.L.4
Shaw, D.E.5
Dauffenbach, L.M.6
Kerfoot, C.A.7
Mazar, A.P.8
|