Metal allergens induce nitric oxide production by mouse dermal fibroblasts via the hypoxia-inducible factor-2α-dependent pathway

Toxicological Sciences

Volumn 135, Issue 1, 2013, Pages 119-128

  Kuroishi, Toshinobu ^a   Bando, Kanan ^a   Endo, Yasuo ^a   Sugawara, Shunji ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

Dermal fibroblasts; HIF; IL 1 ; Ni; NO

Indexed keywords

ALLERGEN; COBALT; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; NICKEL; NITRIC OXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL PROLIFERATION; CELL STIMULATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; INFLAMMATION; MALE; MOUSE; NICKEL HYPERSENSITIVITY; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SKIN FIBROBLAST; SUPERNATANT; SWELLING;

DERMAL FIBROBLASTS.; HIF; IL-1Β; NI; NO;

ALLERGENS; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELLS, CULTURED; COBALT; FEMALE; FIBROBLASTS; INTERLEUKIN-1BETA; MALE; MICE; MICE, INBRED BALB C; NICKEL; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; SIGNAL TRANSDUCTION; SKIN;

EID: 84883150978     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kft142     Document Type: Article

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