Effects of vitamin C and vitamin D administration on mood and distress in acutely hospitalized patients

American Journal of Clinical Nutrition

Volumn 98, Issue 3, 2013, Pages 705-711

  Wang, Yifan ^a   Liu, Xing Jian ^a   Robitaille, Line ^a   Eintracht, Shaun ^b   MacNamara, Elizabeth ^b   John Hoffer, L ^a,b,c  

^a MCGILL UNIVERSITY   (Canada)

^b Department of Internal Medicine ^*  (United States)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYVITAMIN D; ASCORBIC ACID; VITAMIN D;

ADULT; AGED; ARTICLE; ASCORBIC ACID DEFICIENCY; CONTROLLED STUDY; DISTRESS SYNDROME; DOUBLE BLIND PROCEDURE; DRUG MEGADOSE; FEMALE; GINGIVA BLEEDING; HOSPITAL PATIENT; HUMAN; MAJOR CLINICAL STUDY; MALE; MOOD DISORDER; PROFILE OF MOOD STATES; RANDOMIZED CONTROLLED TRIAL; SKIN BRUISING; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; VITAMIN SUPPLEMENTATION;

AGED; ASCORBIC ACID; AVITAMINOSIS; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; HOSPITALIZATION; HUMANS; MALE; MIDDLE AGED; MOOD DISORDERS; STRESS, PSYCHOLOGICAL; VITAMIN D; VITAMINS;

EID: 84883150017     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.112.056366     Document Type: Article

References (66)

1. Hunt C, Chakravorty NK, Annan G. The clinical and biochemical effects of vitamin C supplementation in short-stay hospitalized geriatric patients. Int J Vitam Nutr Res 1984;54:65-74.
2. Cunha DF, da Cunha SF, Unamuno MR, Vannucchi H. Serum levels assessment of vitamin A, E, C, B2 and carotenoids in malnourished and non-malnourished hospitalized elderly patients. Clin Nutr 2001;20: 167-70.
3. Fain O, Paries J, Jacquart B, Le Moel G, Kettaneh A, Stirnemann J, Heron C, Sitbon M, Taleb C, Letellier E, et al. Hypovitaminosis C in hospitalized patients. Eur J Intern Med 2003;14:419-25.
4. Gariballa S, Forster S. Effects of acute-phase response on nutritional status and clinical outcome of hospitalized patients. Nutrition 2006;22: 750-7.
5. Gan R, Eintracht S, Hoffer LJ. Vitamin C deficiency in a university teaching hospital. J Am Coll Nutr 2008;27:428-33.
6. Evans-Olders R, Eintracht S, Hoffer LJ. Metabolic origin of hypovitaminosis C in acutely hospitalized patients. Nutrition 2010;26:1070-4.
7. Raynaud-Simon A, Cohen-Bittan J, Gouronnec A, Pautas E, Senet P, Verny M, Boddaert J. Scurvy in hospitalized elderly patients. J Nutr Health Aging 2010;14:407-10.
8. Zhang M, Robitaille L, Eintracht S, Hoffer LJ. Vitamin C provision improves mood in acutely hospitalized patients. Nutrition 2011;27:530-3.
9. Thomas MK, Lloyd-Jones DM, Thadhani RI, Shaw AC, Deraska DJ, Kitch BT, Vamvakas EC, Dick IM, Prince RL, Finkelstein JS. Hypovitaminosis D in medical inpatients. N Engl J Med 1998;338:777-83.
10. Chatfield SM, Brand C, Ebeling PR, Russell DM. Vitamin D deficiency in general medical inpatients in summer and winter. Intern Med J 2007; 37:377-82.
11. Hunt C, Chakravorty NK, Annan G, Habibzadeh N, Schorah CJ. The clinical effects of vitamin C supplementation in elderly hospitalised patients with acute respiratory infections. Int J Vitam Nutr Res 1994; 64:212-9.
12. Smythies JR. The role of ascorbate in brain: therapeutic implications. J R Soc Med 1996;89:241.
13. Rebec GV. Ascorbate: an antioxidant neuroprotectant and extracellular neuromodulator. In: Connor JR, ed. Metals and oxidative damage in neurological disorders. New York, NY: Plenum Press, 1997:149-73.
14. Quinn J, Suh J, Moore MM, Kaye J, Frei B. Antioxidants in Alzheimer's disease-vitamin C delivery to a demanding brain. J Alzheimers Dis 2003; 5:309-13.
15. Castro MA, Beltran FA, Brauchi S, Concha II. A metabolic switch in brain: glucose and lactate metabolism modulation by ascorbic acid. J Neurochem 2009;110:423-40.
16. Wilkins CH, Sheline YI, Roe CM, Birge SJ, Morris JC. Vitamin D deficiency is associated with low mood and worse cognitive performance in older adults. Am J Geriatr Psychiatry 2006;14:1032-40.
17. McCann JC, Ames BN. Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain dysfunction? FASEB J 2008;22:982-1001.
18. Cherniack EP, Troen BR, Florez HJ, Roos BA, Levis S. Some new food for thought: the role of vitamin D in the mental health of older adults. Curr Psychiatry Rep 2009;11:12-9.
19. Stechschulte SA, Kirsner RS, Federman DG. Vitamin D: bone and beyond, rationale and recommendations for supplementation. Am J Med 2009;122:793-802.
20. Tuohimaa P, Keisala T, Minasyan A, Cachat J, Kalueff A. Vitamin D, nervous system and aging. Psychoneuroendocrinology 2009;34:S278-86.
21. Gale CR, Martyn CN, Cooper C. Cognitive impairment and mortality in a cohort of elderly people. BMJ 1996;312:608-11.
22. Oudshoorn C, Mattace-Raso FU, van der Velde N, Colin EM, van der Cammen TJ. Higher serum vitamin D3 levels are associated with better cognitive test performance in patients with Alzheimer's disease. Dement Geriatr Cogn Disord 2008;25:539-43.
23. Przybelski RJ, Binkley NC. Is vitamin D important for preserving cognition? A positive correlation of serum 25-hydroxyvitamin D concentration with cognitive function. Arch Biochem Biophys 2007;460: 202-5.
24. Llewellyn DJ, Lang IA, Langa KM, Muniz-Terrera G, Phillips CL, Cherubini A, Ferrucci L, Melzer D. Vitamin D and risk of cognitive decline in elderly persons. Arch Intern Med 2010;170:1135-41.
25. Miller JW. Vitamin D and cognitive function in older adults: are we concerned about vitamin D-mentia? Neurology 2010;74:13-5.
26. Armstrong DJ, Meenagh GK, Bickle I, Lee AS, Curran ES, Finch MB. Vitamin D deficiency is associated with anxiety and depression in fibromyalgia. Clin Rheumatol 2007;26:551-4.
27. Hoogendijk WJ, Lips P, Dik MG, Deeg DJ, Beekman AT, Penninx BW. Depression is associated with decreased 25-hydroxyvitamin D and increased parathyroid hormone levels in older adults. Arch Gen Psychiatry 2008;65:508-12.
28. Milaneschi Y, Shardell M, Corsi AM, Vazzana R, Bandinelli S, Guralnik JM, Ferrucci L. Serum 25-hydroxyvitamin D and depressive symptoms in older women and men. J Clin Endocrinol Metab 2010;95:3225-33.
29. Anglin RES, Samaan Z, Walter SD, McDonald SD. Vitamin D deficiency and depression in adults: systematic review and meta-analysis. Br J Psychiatry 2013;202:100-7.
30. Lansdowne ATG, Provost SC. Vitamin D3 enhances mood in healthy subjects during winter. Psychopharmacology (Berl) 1998;135:319-23.
31. Vieth R, Kimball S, Hu A, Walfish PG. Randomized comparison of the effects of the vitamin D3 adequate intake versus 100 mcg (4000 IU) per day on biochemical responses and the wellbeing of patients. Nutr J 2004;3:8.
32. Jorde R, Sneve M, Figenschau Y, Svartberg J, Waterloo K. Effects of vitamin D supplementation on symptoms of depression in overweight and obese subjects: randomized double blind trial. J Intern Med 2008; 264:599-609.
33. Zanetidou S, Murri MB, Buffa A, Malavolta N, Anzivino F, Bertakis K. Vitamin D supplements in geriatric major depression. Int J Geriatr Psychiatry 2011;26:1209-10.
34. Rosen CJ. Vitamin D insufficiency. N Engl J Med 2011;364:248-54.
35. Canadian Institutes of Health Research, Natural Sciences and Engineering Research Council of Canada, Social Sciences and Humanities Research Council of Canada. Tri-Council Policy Statement: ethical conduct for research involving humans. Ottawa, Canada: Her Majesty the Queen in Right of Canada, 2010.
36. Temple R, Ellenberg SS. Placebo-controlled trials and active-control trials in the evaluation of new treatments. Part 1: ethical and scientific issues. Ann Intern Med 2000;133:455-63.
37. Emanuel EJ, Miller FG. The ethics of placebo-controlled trials-a middle ground. N Engl J Med 2001;345:915-9.
38. Daugherty CK, Ratain MJ, Emanuel EJ, Farrell AT, Schilsky RL. Ethical, scientific, and regulatory perspectives regarding the use of placebos in cancer clinical trials. J Clin Oncol 2008;26:1371-8.
39. Ellenberg SS, Temple R. Placebo-controlled trials and active-control trials in the evaluation of new treatments. Part 2: practical issues and specific cases. Ann Intern Med 2000;133:464-70.
40. Stratton RJ, King CL, Stroud MA, Jackson AA, Elia M. 'Malnutrition Universal Screening Tool' predicts mortality and length of hospital stay in acutely ill elderly. Br J Nutr 2006;95:325-30.
41. Nyenhuis DL, Yamamoto C, Luchetta T, Terrien A, Parmentier A. Adult and geriatric normative data and validation of the profile of mood states. J Clin Psychol 1999;55:79-86.
42. McNair DM, Heuchert JW. Profile of mood states technical update. Toronto, Canada: MHS, 2005.
43. Stanga Z, Field J, Iff S, Stucki A, Lobo DN, Allison SP. The effect of nutritional management on the mood of malnourished patients. Clin Nutr 2007;26:379-82.
44. Baker F, Denniston M, Zabora J, Polland A, Dudley WN. A POMS short form for cancer patients: psychometric and structural evaluation. Psychooncology 2002;11:273-81.
45. Yeun EJ, Shin-Park KK. Verification of the Profile of Mood States-Brief: cross-cultural analysis. J Clin Psychol 2006;62:1173-80.
46. Holland JC, Bultz BD. National comprehensive Cancer Network (NCCN). The NCCN guideline for distress management: a case for making distress the sixth vital sign. J Natl Compr Canc Netw 2007;5:3-7.
47. Mitchell AJ. Short screening tools for cancer-related distress: a review and diagnostic validity meta-analysis. J Natl Compr Canc Netw 2010; 8:487-94.
48. Kinsman RA, Hood J. Some behavioral effects of ascorbic acid deficiency. Am J Clin Nutr 1971;24:455-64.
49. Levine M, Conry-Cantilena C, Wang Y, Welch RW, Washko PW, Dhariwal KR, Park JB, Lazarev A, Graumlich JF, King J, et al. Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. Proc Natl Acad Sci USA 1996;93:3704-9.
50. Fain O. Musculoskeletal manifestations of scurvy. Joint Bone Spine 2005;72:124-8.
51. Heaney RP. Vitamin D-baseline status and effective dose. N Engl J Med 2012;367:77-8.
52. Zwarenstein M, Treweek S. What kind of randomised trials do patients and clinicians need? Evid Based Med 2009;14:101-3.
53. Hotopf M. The pragmatic randomised controlled trial. Adv Psychiatr Treat 2002;8:326-33.
54. Carlson LE, Groff SL, Maciejewski O, Bultz BD. Screening for distress in lung and breast cancer outpatients: a randomized controlled trial. J Clin Oncol 2010;28:4884-91.
55. Bardes CL. Defining "patient-centered" medicine. N Engl J Med 2012; 366:782-3.
56. Richter A, Kuhlmann MK, Seibert E, Kotanko P, Levin NW, Handelman GJ. Vitamin C deficiency and secondary hyperparathyroidism in chronic haemodialysis patients. Nephrol Dial Transplant 2008;23: 2058-63.
57. Sanadgol H, Bayani M, Mohammadi M, Bayani B, Mashhadi MA. Effect of vitamin C on parathyroid hormone in hemodialysis patients with mild to moderate secondary hyperparathyroidism. Iran J Kidney Dis 2011;5:410-5.
58. Ioannidis JP. Why most published research findings are false. PLoS Med 2005;2:e124.
59. Matthews JN. Small clinical trials: are they all bad? Stat Med 1995;14: 115-26.
60. Vieth R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr 1999;69:842-56.
61. Boullata JI. Vitamin D supplementation: a pharmacologic perspective. Curr Opin Clin Nutr Metab Care 2010;13:677-84.
62. Vashi PG, Trukova K, Lammersfeld CA, Braun DP, Gupta D. Impact of oral vitamin D supplementation on serum 25-hydroxyvitamin D levels in oncology. Nutr J 2010;9:60.
63. Peppone LJ, Huston AJ, Reid ME, Rosier RN, Zakharia Y, Trump DL, Mustian KM, Janelsins MC, Purnell JQ, Morrow GR. The effect of various vitamin D supplementation regimens in breast cancer patients. Breast Cancer Res Treat 2011;127:171-7.
64. Vieth R. The pharmacology of vitamin D. In: Feldman D, Pike JW, eds. Vitamin D. 3rd ed. London, United Kingdom: Elsevier, 2011:1041-66.
65. Amrein K, Sourij H, Wagner G, Holl A, Pieber TR, Smolle KH, Stojakovic T, Schnedl C, Dobnig H. Short-term effects of high-dose oral vitamin D3 in critically ill vitamin D deficient patients: a randomized, double-blind, placebo-controlled pilot study. Crit Care 2011.15:R104.
66. Lasco A, Catalano A, Benvenga S. Improvement of primary dysmenorrhea caused by a single oral dose of vitamin D: results of a randomized, double-blind, placebo-controlled Study. Arch Intern Med 2012;172:366-7.