Antioxidants in Alzheimer's disease-vitamin C delivery to a demanding brain

Journal of Alzheimer's Disease

Volumn 5, Issue 4, 2003, Pages 309-313

  Quinn, Joseph ^a,c   Suh, Jung ^b   Moore, M Milar ^a   Kaye, Jeffrey ^a   Frei, Balz ^b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON STATE UNIVERSITY   (United States)

^c PORTLAND VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN METABOLISM; BRAIN SIZE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; FEMALE; HIPPOCAMPUS; HUMAN; MALE; OXIDATIVE STRESS; PRIORITY JOURNAL; VITAMIN SUPPLEMENTATION;

EID: 0242467835     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2003-5406     Document Type: Article

References (15)

1. R. Clarke, A.D. Smith, K.A. Jobst, H. Refsum, L. Sutton and P.M. Ueland, Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease, Arch Neurol 55 (1998), 1449-1455.
2. P.E Jacques, S.I. Sulsky, J.A. Sadowski, J.C. Phillips, D. Rush and W.C. Willett, Comparison of micronutrient intake measured by a dietary questionnaire and biochemical indicators of micronutrient status, Am J Clin Nutr 57 (1993), 182-189.
3. J.A. Kaye, T. Swihart, D. Howieson, A. Dame, M.M. Moore, T. Karnos, R. Camicioli, M. Ball, B. Oken and G. Sexton, Volume loss of the hippocampus and temporal lobe in healthy elderly persons destined to develop dementia, Neurology 48 (1997), 1297-1304.
4. W.R. Markesbery and J.M. Carney, Oxidative alterations in Alzheimer's disease, Brain Pathol 9 (1999), 133-146.
5. A. McCaddon, G. Davies, P. Hudson, S. Tandy and H. Cattell, Total serum homocysteine in senile dementia of Alzheimer type, Int J Geriatr Psychiatry 13 (1998), 235-239.
6. E.L. McGown, M.G. Rusnak, C.M. Lewis and J.A. Tillotson, Tissue ascorbic acid analysis using ferrozine compared with the dinitrophenylhydrazine method, Anal Biochem 119 (1982), 55-61.
7. G.D.D. McKhann, M. Folstein, R. Katzman, D. Price and E.M. Stadlan, Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's Diseae, Neurology 34 (1984), 939-944.
8. J.W. Miller, Homocysteine and Alzheimer's disease, Nutr Rev 57 (1999), 126-129.
9. K.W. Miller and C.S. Yang, An isocratic high-performance liquid chromatography method for the simultaneous analysis of plasma retinol, alpha-tocopherol, and various carotenoids, Anal Biochem 145 (1985), 21-26.
10. E.A. Mueller, M.M. Moore, D.C. Kerr, G. Sexton, R.M. Camicioli, D.B. Howieson, J.E Quinn and J.A. Kaye, Brain volume preserved in healthy elderly through the eleventh decade, Neurology 51 (1998), 1555-1562.
11. G.P. Paraskevas, E. Kapaki, G. Libitaki, C. Zoumas, I. Segditsa and C. Papageorgiou, Ascorbate in healthy subjects, amyotrophic lateral sclerosis and Alzheimer's disease, Acta Neurol Scand 96 (1997), 88-90.
12. H. Reiber, M. Ruff and M. Uhr, Ascorbate concentration in human cerebrospinal fluid (CSF) and serum. Intrathecal accumulation and CSF flow rate, Clin Chim Acta 217 (1993), 163-173.
13. S. Riviere, I. Birlouez-Aragon, F. Nourhashemi and B. Vellas, Low plasma vitamin C in Alzheimer patients despite an adequate diet, Int J Geriatr Psychiatry 13 (1998), 749-754.
14. D.A. Snowdon, C.L. Tully, C.D. Smith, K.P. Riley and W.R. Markesbery, Serum folate and the severity of atrophy of the neocortex in Alzheimer disease: findings from the Nun study, Am J Clin Nutr 71 (2000), 993-998.
15. C.M. Tallaksen, T. Bohmer and H. Bell, Concentrations of the water-soluble vitamins thiamin, ascorbic acid, and folic acid in serum and cerebrospinal fluid of healthy individuals, Am J Clin Nutr 56(1992), 559-564.