Vitamin C deficiency and secondary hyperparathyroidism in chronic haemodialysis patients

Nephrology Dialysis Transplantation

Volumn 23, Issue 6, 2008, Pages 2058-2063

  Richter, Anja ^a   Kuhlmann, Martin K ^a,b   Seibert, Eric ^a   Kotanko, Peter ^c   Levin, Nathan W ^a   Handelman, Garry J ^a,d  

^a RENAL RESEARCH INSTITUTE   (United States)

^b VIVANTES KLINIKUM IM FRIEDRICHSHAIN   (Germany)

^c KRANKENHAUS DER BARMHERZIGEN BRÜDER   (Austria)

^d UNIVERSITY OF MASSACHUSETTS LOWELL   (United States)

Author keywords

Haemodialysis; Metabolic bone disease; Secondary hyperparathyroidism; Vitamin C

Indexed keywords

ALKALINE PHOSPHATASE; ASCORBIC ACID; PARATHYROID HORMONE;

ADULT; AGED; ALKALINE PHOSPHATASE BLOOD LEVEL; ANALYSIS OF VARIANCE; ARTICLE; ASCORBIC ACID DEFICIENCY; BLOOD SAMPLING; BONE METABOLISM; DISEASE SEVERITY; ELECTROCHEMICAL ANALYSIS; FEMALE; HEMODIALYSIS; HEMODIALYSIS PATIENT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIPLE REGRESSION; PARATHYROID HORMONE BLOOD LEVEL; PRIORITY JOURNAL; SECONDARY HYPERPARATHYROIDISM; VITAMIN BLOOD LEVEL; VITAMIN INTAKE;

ADULT; AGE DISTRIBUTION; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; ASCORBIC ACID DEFICIENCY; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; HYPERPARATHYROIDISM, SECONDARY; INCIDENCE; LINEAR MODELS; LONG-TERM CARE; MALE; MIDDLE AGED; PARATHYROID HORMONE; PROBABILITY; PROGNOSIS; RENAL DIALYSIS; RENAL OSTEODYSTROPHY; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; SEX DISTRIBUTION; SURVIVAL ANALYSIS;

EID: 44449155997     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfn084     Document Type: Article

References (37)

1. Salem MM. Hyperparathyroidism in the hemodialysis population: a survey of 612 patients. Am J Kidney Dis 1997; 29: 862-865
2. Brossard JH, Lepage R, Cardinal H et al. Influence of glomerular filtration rate on non-(1-84) parathyroid hormone (PTH) detected by intact PTH assays. Clin Chem 2000; 46: 697-703
3. Gogusev J, Duchambon P, Hory B et al. Depressed expression of calcium receptor in parathyroid gland tissue of patients with hyperparathyroidism. Kidney Int 1997; 51: 328-336
4. Delmez JA, Kelber J, Norwood KY et al. A controlled trial of the early treatment of secondary hyperparathyroidism with calcitriol in hemodialysis patients. Clin Nephrol 2000; 54: 301-308
5. Gupta A, Kallenbach LR, Zasuwa G et al. Race is a major determinant of secondary hyperparathyroidism in uremic patients. J Am Soc Nephrol 2000; 11: 330-334
6. Mehrotra R, Supasyndh O, Berman N et al. Age-related decline in serum parathyroid hormone in maintenance hemodialysis patients is independent of inflammation and dietary nutrient intake. J Ren Nutr 2004; 14: 134-142
7. Vanholder R, De Smet R, Glorieux G et al. Review on uremic toxins: classification, concentration, and interindividual variability. Kidney Int 2003; 63: 1934-1943
8. Nissenson AR. Erythropoietin overview - 1993. Blood Purif 1994; 12: 6-13
9. Drueke TB, Eckardt KU. Role of secondary hyperparathyroidism in erythropoietin resistance of chronic renal failure patients. Nephrol Dial Transplant 2002; 17 (Suppl 5): 28-31
10. Deicher R, Ziai F, Habicht A et al. Vitamin C plasma level and response to erythropoietin in patients on maintenance haemodialysis. Nephrol Dial Transplant 2004; 19: 2319-2324
11. Ganesh SK, Stack AG, Levin NW et al. Association of elevated serum PO(4), CaxPO(4) product, and parathyroid hormone with cardiac mortality risk in chronic hemodialysis patients. J Am Soc Nephrol 2001; 12: 2131-2138
12. Levine M, Rumsey SC, Daruwala R et al. Criteria and recommendations for vitamin C intake. JAMA 1999; 281: 1415-1423
13. Deicher R, Ziai F, Bieglmayer C et al. Low total vitamin C plasma level is a risk factor for cardiovascular morbidity and mortality in hemodialysis patients. J Am Soc Nephrol 2005; 16: 1811-1818
14. Bohm V, Tiroke K, Schneider S et al. Vitamin C status of patients with chronic renal failure, dialysis patients and patients after renal transplantation. Int J Vitam Nutr Res 1997; 67: 262-266
15. Hultqvist M, Hegbrant J, Nilsson-Thorell C et al. Plasma concentrations of vitamin C, vitamin E and/or malondialdehyde as markers of oxygen free radical production during hemodialysis. Clin Nephrol 1997; 47: 37-46
16. Jackson P, Loughrey CM, Lightbody JH et al. Effect of hemodialysis on total antioxidant capacity and serum antioxidants in patients with chronic renal failure. Clin Chem 1995; 41: 1135-1138
17. Gotch F, Kotanko P, Handelman G et al. A kinetic model of calcium mass balance during dialysis therapy. Blood Purif 2007; 25: 139-149
18. Jenab M, Bingham S, Ferrari P et al. Long-term cryoconservation and stability of vitamin C in serum samples of the European prospective investigation into cancer and nutrition. Cancer Epidemiol Biomarkers Prev 2005; 14: 1837-1840
19. Long CL, Maull KI, Krishnan RS et al. Ascorbic acid dynamics in the seriously ill and injured. J Surg Res 2003; 109: 144-148
20. Levine M, Wang Y, Padayatty SJ et al. A new recommended dietary allowance of vitamin C for healthy young women. Proc Natl Acad Sci USA 2001; 98: 9842-9846
21. Fountoulakis A, Martin IG, White KL et al. Plasma and esophageal mucosal levels of vitamin C: role in the pathogenesis and neoplastic progression of Barrett's esophagus. Dig Dis Sci 2004; 49: 914-919
22. Albert MA, Danielson E, Rifai N et al. Effect of statin therapy on C-reactive protein levels: the pravastatin inflammation/CRP evaluation (PRINCE): a randomized trial and cohort study. JAMA 2001; 286: 64-70
23. Washko PW, Welch RW, Dhariwal KR et al. Ascorbic acid and dehydroascorbic acid analyses in biological samples. Anal Biochem 1992; 204: 1-14
24. Jacob RA. Assessment of human vitamin C status. J Nutr 1990; 120 (Suppl 11): 1480-1485
25. Kang JY. The gastrointestinal tract in uremia. Dig Dis Sci 1993; 38: 257-268
26. McCauley LK, Koh AJ, Beecher CA et al. PTH/PTHrP receptor is temporally regulated during osteoblast differentiation and is associated with collagen synthesis. J Cell Biochem 1996; 61: 638-647
27. Friedman PA, Coutermarsh BA, Kennedy SM et al. Parathyroid hormone stimulation of calcium transport is mediated by dual signaling mechanisms involving protein kinase A and protein kinase C. Endocrinology 1996; 137: 13-20
28. Pearce SH, Thakker RV. The calcium-sensing receptor: insights into extracellular calcium homeostasis in health and disease. J Endocrinol 1997; 154: 371-378
29. Abou-Samra AB, Juppner H, Force T et al. Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium. Proc Natl Acad Sci USA 1992; 89: 2732-2736
30. Lopez-Lluch G, Fernandez-Ayala DJ, Alcain FJ et al. Inhibition of COX activity by NSAIDs or ascorbate increases cAMP levels and enhances differentiation in 1alpha, 25-dihydroxyvitamin D3-induced HL-60 cells. Arch Biochem Biophys 2005; 436: 32-39
31. Yang Z, Copolov DL, Lim AT. Ascorbic acid augments the adenylyl cyclase-cAMP system mediated POMC mRNA expression and beta-endorphin secretion from hypothalamic neurons in culture. Brain Res 1996; 706: 243-248
32. Bouschet T, Martin S, Henley JM. Receptor-activity-modifying proteins are required for forward trafficking of the calcium-sensing receptor to the plasma membrane. J Cell Sci 2005; 118: 4709-4720
33. Ferreira MA. Diagnosis of renal osteodystrophy: when and how to use biochemical markers and non-invasive methods; when bone biopsy is needed. Nephrol Dial Transplant 2000; 15 (Suppl 5): 8-14
34. Pierides AM, Skillen AW, Ellis HA. Serum alkaline phosphatase in azotemic and hemodialysis osteodystrophy: a study of isoenzyme patterns, their correlation with bone histology, and their changes in response to treatment with 1alphaOHD3 and 1,25(OH)2D3. J Lab Clin Med 1979; 93: 899-909
35. Magnusson P, Sharp CA, Magnusson M et al. Effect of chronic renal failure on bone turnover and bone alkaline phosphatase isoforms. Kidney Int 2001; 60: 257-265
36. Sergeev IN, Arkhapchev YP, Spirichev VB. Ascorbic acid effects on vitamin D hormone metabolism and binding in guinea pigs. J Nutr 1990; 120: 1185-1190
37. Crivello JF. Oxidative stress limits vitamin D metabolism by bovine proximal tubule cells in vitro. Arch Biochem Biophys 1988; 262: 471-480