Some new food for thought: The role of vitamin D in the mental health of older adults

Current Psychiatry Reports

Volumn 11, Issue 1, 2009, Pages 12-19

  Cherniack, E Paul ^a   Troen, Bruce R ^b   Florez, Hermes J ^b   Roos, Bernard A ^b   Levis, Silvina ^b  

^a UNIVERSITY OF MIAMI   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYVITAMIN D; C REACTIVE PROTEIN; CALCITRIOL; CALCIUM; COLECALCIFEROL; ERGOCALCIFEROL; GELATINASE B; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; NEUROTROPHIN; PARATHYROID HORMONE; PLACEBO; VITAMIN D; VITAMIN D RECEPTOR;

ABSENCE OF SIDE EFFECTS; AGING; ALZHEIMER DISEASE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; BIPOLAR DISORDER; BRAIN PROTECTION; CLINICAL TRIAL; COGNITION; COGNITIVE DEFECT; COMBINATION CHEMOTHERAPY; CONGESTIVE HEART FAILURE; DEPRESSION; DISEASE ASSOCIATION; DOSE RESPONSE; DRUG DOSE INCREASE; DRUG EFFICACY; GERIATRIC PATIENT; HUMAN; HYPERCALCEMIA; HYPERTENSION; MENTAL HEALTH; METABOLIC DISORDER; MINI MENTAL STATE EXAMINATION; MONOTHERAPY; MOOD; NONHUMAN; PATIENT COMPLIANCE; PHOTOTHERAPY; REVIEW; SCHIZOPHRENIA; SEASONAL AFFECTIVE DISORDER; SINGLE DRUG DOSE; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; VITAMIN SUPPLEMENTATION;

AGED; BIPOLAR DISORDER; BRAIN; COGNITION DISORDERS; DEPRESSIVE DISORDER; HUMANS; RECEPTORS, CALCITRIOL; SCHIZOPHRENIA; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 59249085916     PISSN: 15233812     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11920-009-0003-3     Document Type: Review

References (58)

1. Autier P, Gandini S: Vitamin D supplementAtion and total mortality: a meta-analysis of randomized controlled trials. Arch Intern Med 2007, 167:1730-1737.
2. Visser M, Deeg DJ, Puts MT, et al.: Low serum concentrations of 25-hydroxyvitamin D in older persons and the risk of nursing home admission. Am J Clin Nutr 2006, 84: 616-622; quiz 671-672.
3. Melamed ML, Michos ED, Post W, Astor B: 25-hydroxyvitamin D levels and the risk of mortality in the general population. Arch Intern Med 2008, 168:1629-1637.
4. Cherniack EP, Florez H, Roos BA, et al.: Hypovitaminosis D in the elderly: From bone to brain. J Nutr Health Aging 2008, 12:366-373.
5. Levis S, Gomez A, Jimenez C, et al.: Vitamin D deficiency and seasonal variation in an adult south Florida population. J Clin Endocrinol Metab 2005, 90:1557-1562.
6. Buell JS, Dawson-Hughes B: Vitamin D and neurocognitive dysfunction: preventing "D" ecline? Mol Aspects Med 2008, 29:415-422.
7. Riddle DR: Brain Aging: Models, Methods, and Mechanisms. Boca Raton, FL: CRC Press; 2007.
8. Przybelski RJ, Binkley NC: Is vitamin D important for preserving cognition? A positive correlation of serum 25-hydroxyvitamin D concentration with cognitive function. Arch Biochem Biophys 2007, 460:202-205.
9. Oudshoorn C, Mattace-Raso FU, van der Velde N, et al.: Higher serum vitamin D3 levels are associated with better cognitive test performance in patients with Alzheimer's disease. Dement Geriatr Cogn Disord 2008, 25:539-543.
10. Rondanelli M, Trotti R, Opizzi A, Solerte SB: Relationship among nutritional status, pro/antioxidant balance and cognitive performance in a group of free-living healthy elderly. Minerva Med 2007, 98:639-645.
11. Wilkins CH, Sheline YI, Roe CM, et al.: Vitamin D deficiency is associated with low mood and worse cognitive performance in older adults. Am J Geriatr Psychiatry 2006, 14:1032-1040.
12. Roth RM, Isquith PK, Gioia GA: Assessment of and intervention for executive dysfunction. In Psychologist's Desk Reference, edn 2. Edited by Koocher GP, Norcross JC, Hill SS. New York: Oxford University Press; 2005:38-41.
13. Scott TM, Peter I, Tucker KL, et al.: The Nutrition, Aging, and Memory in Elders (NAME) study: Design and methods for a study of micronutrients and cognitive function in a homebound elderly population. Int J Geriatr Psychiatry 2006, 21:519-528.
14. McGrath J, Scragg R, Chant D, et al.: No association between serum 25-hydroxyvitamin D3 level and performance on psychometric tests in NHANES III. Neuroepidemiology 2007, 29:49-54.
15. Jorde R, Waterloo K, Saleh F, et al.: Neuropsychological function in relation to serum parathyroid hormone and serum 25-hydroxyvitamin D levels. The Tromso study. J Neurol 2006, 253:464-470.
16. Hoogendijk WJ, Lips P, Dik MG, et al.: Depression is associated with decreased 25-hydroxyvitamin D and increased parathyroid hormone levels in older adults. Arch Gen Psychiatry 2008, 65:508-512.
17. Berk M, Sanders KM, Pasco JA, et al.: Vitamin D deficiency may play a role in depression. Med Hypotheses 2007, 69:1316-1319.
18. McGratI J: Hypothesis: is low prenatal vitamin D a risk-modifying factor for schizophrenia? Schizophr Res 1999, 40:173-177.
19. McGrath J, Saari K, Hakko H, et al.: Vitamin D supplementation during the first year of life and risk of schizophrenia: A Finnish birth cohort study. Schizophr Res 2004, 67:237-245.
20. Schaffer A, Levitt AJ, Boyle M: Influence of season and latitude in a community sample of subjects with bipolar disorder. Can J Psychiatry 2003, 48:277-280.
21. Armstrong DJ, Meenagh GK, Bickle I, et al.: Vitamin D deficiency is associated with anxiety and depression in fibromyalgia. Clin Rheumatol 2007, 26:551-554.
22. Gloth FM 3rd, Alam W, Hollis B: Vitamin D vs broad spectrum phototherapy in the treatment of seasonal affective disorder. J Nutr Health Aging 1999, 3:5-7.
23. Lansdowne AT, Provost SC: Vitamin D3 enhances mood in healthy subjects during winter. Psychopharmacology (Berl) 1998, 135:319-323.
24. Harris S, Dawson-Hughes B: Seasonal mood changes in 250 normal women. Psychiatry Res 1993, 49:77-87.
25. Eyles D, Brown J, Mackay-Sim A, et al.: Vitamin D3 and brain development. Neuroscience 2003, 118:641-653.
26. Dumville JC, Miles JN, Porthouse J, et al.: Can vitamin D supplementation prevent winter-time blues? A randomised trial among older women. J Nutr Health Aging 2006, 10:151-153.
27. Pasco JA, Henry MJ, Nicholson GC, et al.: Vitamin D status of women in the Geelong Osteoporosis Study: Association with diet and casual exposure to sunlight. Med J Aust 2001, 175:401-405.
28. Torrey EF, Torrey BB, Peterson MR: Seasonality of schizophrenic births in the United States. Arch Gen Psychiatry 1977, 34:1065-1070.
29. Jarvis E: Schizophrenia in BritRsh immigrants: recent findings, issues and implications. Transcult Psychiatry 1998, 35:39-74.
30. Ziegler EE, Hollis BW, Nelson SE, Jeter JM: Vitamin D deficiency in breastfed infants in Iowa. Pediatrics 2006, 118:603-610.
31. Kalueff AV, Tuohimaa P: Neurosteroid hormone vitamin D and its utility in clinical nutrition. Curr Opin Clin Nutr Metab Care 2007, 10:12-19.
32. Burne TH, McGrath JJ, Eyles DW, Mackay-Sim A: Behavioural characterization of vitamin D receptor knockout mice. Behav Brain Res 2005, 157:299-308.
33. Kuningas M, Mooijaart SP, Jolles J, et al.: VDR gene variants associate with cognitive function and depressive symptoms in old age. Neurobiol Aging 2007 Aug 20 (Epub ahead of print).
34. Gezen-Ak D, Dursun E, Ertan T, et al.: Association between vitamin D receptor gene polymorphism and Alzheimer's disease. Tohoku J Exp Med 2007, 212:275-282.
35. Wion D, MacGrogan D, Neveu I, et al.: 1,25-Dihydroxyvitamin D3 is a potent inducer of nerve growth factor synthesis. J Neurosci Res 1991, 28:110-114.
36. Naveilhan P, Neveu I, Wion D, Brachet P: 1,25-Dihydroxyvitamin D3, an inducer of glial cell line-derived neurotrophic factor. Neuroreport 1996, 7:2171-2175.
37. Landfield PW, Cadwallader-Neal L: Long-term treatment with calcitriol (1,25(OH)2 vit D3) retards a biomarker of hippocampal aging in rats. Neurobiol Aging 1998, 19:469-477.
38. Brewer LD, Thibault V, Chen KC, et al.: Vitamin D hormone confers neuroprotection in parallel with downregulation of L-type calcium channel expression in hippocampal neurons. J Neurosci 2001, 21:98-108.
39. Zittermann A, Schleithoff SS, Koerfer R: Vitamin D and vascular calcification. Curr Opin Lipidol 2007, 18:41-46.
40. Zittermann A, Schleithoff SS, Koerfer R: Putting cardiovascular disease and vitamin D insufficiency into perspective. Br J Nutr 2005, 94:483-492.
41. Timms PM, Mannan N, Hitman GA, et al.: Circulating MMP9, vitamin D and variation in the TIMP-1 response with VDR genotype: Mechanisms for inflammatory damage in chronic disorders? QJM 2002, 95:787-796.
42. Cherniack EP, Troen BR: Calciotropic hormones. In Senile Osteoporosis: Advances in Pathophysiology and Therapeutic Approach. Edited by Duque G, Kiel DP. London: Springer-Verlag; 2008:34-46.
43. Judd SE, Nanes MS, Ziegler TR, et al.: Optimal vitamin D status attenuates the age-associated increase in systolic blood pressure in white Americans: Results from the third National Health and Nutrition Examination Survey. Am J Clin Nutr 2008, 87:136-141.
44. Zittermann A, Schleithoff SS, Tenderich G, et al.: Low vitamin D status: a contributing factor in the pathogenesis of congestive heart failure? J Am Coll Cardiol 2003, 41:105-112.
45. Li YC, Kong J, Wei M, et al.: 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. J Clin Invest 2002, 110:229-238.
46. Pfeifer M, Begerow B, Minne HW, et al.: Effects of a short-term vitamin D(3) and calcium supplementation on blood pressure and parathyroid hormone levels in elderly women. J Clin Endocrinol Metab 2001, 86:1633-1637.
47. Heaney RP: Functional indices of vitamin D status and ramifications of vitamin D deficiency. Am J Clin Nutr 2004, 80(6 Suppl):1706S-1709S.
48. Heaney RP: The vitamin D requirement in health and disease. J Steroid Biochem Mol Biol 2005, 97:13-19.
49. Cherniack EP, Florez H, Hollis B, et al.: High dose of vitamin D3 reduces the prevalence of hypovitaminosis D in elderly veterans. Gerontologist 2007, 47:13-14.
50. Vieth R: Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr 1999, 69:842-856.
51. Ish-Shalom S, Salganik T, Segal E, et al.: Daily, weekly or monthly protocols to reach the desired serum 25-hydroxyvitamin D concentration for the elderly. J Bone Miner Res 2005, 20(Suppl 1):S288.
52. Mocanu V, Stitt PA, Costan A, et al.: Safety and bone mineral density effects of bread fortified with 125 mcg vitamin D3/day in Romanian nursing-home residents [abstract]. J Bone Miner Res 2005, 20(Suppl 1):S288.
53. Diamond TH, Ho KW, Rohl PG, Meerkin M: Annual intramuscular injection of a megadose of cholecalciferol for treatment of vitamin D deficiency: efficacy and safety data. Med J Aust 2005, 183:10-12.
54. Trang HM, Cole DE, Rubin LA, et al.: Evidence that vitamin D3 increases serum 25-hydroxyvitamin D more efficiently than does vitamin D2. Am J Clin Nutr 1998, 68:854-858.
55. Armas LA, Hollis BW, Heaney RP: Vitamin D2 is much less effective than vitamin D3 in humans. J Clin Endocrinol Metab 2004, 89:5387-5391.
56. Holick MF, Biancuzzo RM, Chen TC, et al.: Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D. J Clin Endocrinol Metab 2008, 93:677-681.
57. Giovannucci E: The epidemiology of vitamin D and cancer incidence and mortality: A review (United States). Cancer Causes Control 2005, 16:83-95.
58. Bischoff-Ferrari HA, Giovannucci E, Willett WC, et al.: Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr 2006, 84:18-28.