4,5-diaryl-3-aminopyrazole derivatives as analogs of combretastatin A-4: Synthesis and biological evaluation

Archiv der Pharmazie

Volumn 344, Issue 5, 2011, Pages 279-286

  Liu, Tao ^a   Cui, Rong ^a,b   Chen, Jing ^a   Zhang, Jun ^a   He, Qiaojun ^a   Yang, Bo ^a   Hu, Yongzhou ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b Jinhua College of Vocation and Technology   (China)

Author keywords

4,5 Diaryl 3 aminopyrazole derivatives; Antitumor agents; Combretastatin A 4 analogs; Cytotoxicity

Indexed keywords

1 (3 AMINO 4 (3,4 DIMETHOXYPHENYL) 5 (3,4,5 TRIMETHOXYPHENYL) 1H PYRAZOL 1 YL)ETHANONE; 1 (3 AMINO 4 (4 CHLOROPHENYL) 5 (3,4,5 TRIMETHOXYPHENYL) 1H PYRAZOL 1 YL)ETHANONE; 1 (3 AMINO 4 (4 METHOXYPHENYL) 5 (3,4,5 TRIMETHOXYPHENYL) 1H PYRAZOL 1 YL)ETHANONE; 1 (3 AMINO 4 (THIOPHEN 3 YL) 5 (3,4,5 TRIMETHOXYPHENYL) 1H PYRAZOL 1 YL)ETHANONE; 1 (3 AMINO 4,5 BIS(3,4,5 TRIMETHOXYPHENYL) 1H PYRAZOL 1 YL)ETHANONE; 1 (3 AMINO 5 (4 METHOXYPHENYL) 4 (3,4,5 TRIMETHOXYPHENYL) 1H PYRAZOL 1 YL)ETHANONE; 4 (3,4 DIMETHOXYPHENYL) 5 (3,4,5 TRIMETHOXYPHENYL) 1H PYRAZOL 3 AMINE; 4 (4 CHLOROPHENYL) 5 (3,4,5 TRIMETHOXYPHENYL) 1H PYRAZOL 3 AMINE; 4 (4 METHOXYPHENYL) 5 (3,4,5 TRIMETHOXYPHENYL) 1H PYRAZOL 3 AMINE; 4 (THIOPHEN 3 YL) 5 (3,4,5 TRIMETHOXYPHENYL) 1H PYRAZOL 3 AMINE; 4,5 BIS(3,4,5 TRIMETHOXYPHENYL) 1H PYRAZOL 3 AMINE; 4,5 DIARYL 3 AMINOPYRAZOLE; 5 (4 METHOXYPHENYL) 4 (3,4,5-TRIMETHOXYPHENYL) 1H PYRAZOL 3 AMINE; COMBRETASTATIN A4; PYRAZOLE DERIVATIVE; TUBULIN; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CANCER CELL CULTURE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL STRAIN K 562; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOTOXICITY; DRUG CONFORMATION; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; ESOPHAGUS CARCINOMA; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL; LIVER CELL CARCINOMA; LUNG NON SMALL CELL CANCER; MICROTUBULE ASSEMBLY; MOLECULAR DOCKING; PRIORITY JOURNAL; PROSTATE CARCINOMA; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BINDING SITES; CELL CYCLE; CELL DIVISION; CELL LINE, TUMOR; HUMANS; POLYMERIZATION; PYRAZOLES; STILBENES; TUBULIN;

EID: 79955390539     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.201000069     Document Type: Article

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